Suppressor of cytokine signaling 6 (SOCS6) negatively regulates Flt3 signal transduction through direct binding to phosphorylated tyrosines 591 and 919 of Flt3.
Kazi JU, Sun J, Phung B, Zadjali F, Flores-Morales A, Ronnstrand L
J Biol Chem. 2012 Oct 19;287(43):36509-17. doi: 10.1074/jbc.M112.376111. Epub 2012 Sep 5.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 74496 | pMSCV-SOCS6-WT | Overexpression of SOCS6 in mammalian cells |
| 74497 | pcDNA3-Flt3-Y591F/Y919F | Overexpression of FLT3 Y591F/Y919F mutant in mammalian cells |
| 74498 | pMSCV-Flt3-Y591F/Y919F | Retroviral expression of FLT3 Y591F/Y919F |
| 74499 | pMSCV-Flt3-ITD-Y591F/Y919F | Retroviral expression of FLT3 ITD-Y591F/Y919F |