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Activated mutant forms of PIK3CA cooperate with RasV12 or c-Met to induce liver tumor formation in mice via AKT2/mTORC1 cascade.

Wang C, Che L, Hu J, Zhang S, Jiang L, Latte G, Demartis MI, Tao J, Gui B, Pilo MG, Ribback S, Dombrowski F, Evert M, Calvisi DF, Chen X
Liver Int. 2015 Dec 30. doi: 10.1111/liv.13055. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
180031pT3-EF1aH-PIK3CA H1047R This plasmid is in the pT3-EF1a vector without loxP sites flanking the inverted repeats of SB (sleeping beauty) sequence. Therefore this plasmid can be used in LoxP mice.
180032pENTR1A-PIK3CA E545KEntry vector of PIK3CA E545K for gateway cloning.
180034pT3EF5a-PIK3CA H1047REntry vector of PIK3CA H1047R for gateway cloning.

Antibodies from Article