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Ras-GTP dimers activate the Mitogen-Activated Protein Kinase (MAPK) pathway.

Nan X, Tamguney TM, Collisson EA, Lin LJ, Pitt C, Galeas J, Lewis S, Gray JW, McCormick F, Chu S
Proc Natl Acad Sci U S A. 2015 Jun 30;112(26):7996-8001. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
177320pLenti-TO/CMV-puro-DD-PAmCherry1-KRas G12DLentiviral vector expressing PAmCherry1-tagged KRas 4B G12D mutant, with an N-terminal dimerization domain (DD).

Antibodies from Article