The Sestrins interact with GATOR2 to negatively regulate the amino-acid-sensing pathway upstream of mTORC1.
Chantranupong L, Wolfson RL, Orozco JM, Saxton RA, Scaria SM, Bar-Peled L, Spooner E, Isasa M, Gygi SP, Sabatini DM
Cell Rep. 2014 Oct 9;9(1):1-8. doi: 10.1016/j.celrep.2014.09.014. Epub 2014 Sep 25.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 72592 | pRK5-FLAG-Sestrin3 | overexpression, codon optimized for mammalian expression |
| 72593 | pRK5-HA-Sestrin2 | overexpression, codon optimized for mammalian expression |
| 72594 | pRK5-FLAG-Sestrin1 isoform1 | overexpression, codon optimized for mammalian expression |
| 72595 | pRK5-FLAG-Sestrin2 | overexpression |