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Dysferlin forms a dimer mediated by the C2 domains and the transmembrane domain in vitro and in living cells.

Xu L, Pallikkuth S, Hou Z, Mignery GA, Robia SL, Han R
PLoS One. 2011;6(11):e27884. doi: 10.1371/journal.pone.0027884. Epub 2011 Nov 14. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
72582pEYFP-hDF-C2Ahuman dysferlin C2A domain tagged with YFP
72583pEYFP-hDF C2Bhuman dysferlin C2B domain tagged with YFP
72584pEYFP-hDFhuman dysferlin full length tagged with YFP
72585pHis6-hDFhuman dysferlin full length tagged with His
72586EYFP-hDF-deltaTM-pCMV-9human dysferlin no transmembrane domain tagged with YFP
72587pHis6-hDF-deltaTM-pCMV-9human dysferlin no transmembrane domain tagged with his tag

Antibodies from Article