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A single nucleotide in the SMN gene regulates splicing and is responsible for spinal muscular atrophy.

Lorson CL, Hahnen E, Androphy EJ, Wirth B
Proc Natl Acad Sci U S A. 1999 May 25;96(11):6307-11. (Link opens in a new window) PubMed

Plasmids from Article

ID Plasmid Purpose
72286pCI SMN1SMN1 exon 7 splicing cassette
72287pCI SMN2SMN2 exon 7 splicing cassette

Antibodies from Article