The folliculin tumor suppressor is a GAP for the RagC/D GTPases that signal amino acid levels to mTORC1.
Tsun ZY, Bar-Peled L, Chantranupong L, Zoncu R, Wang T, Kim C, Spooner E, Sabatini DM
Mol Cell. 2013 Nov 21;52(4):495-505. doi: 10.1016/j.molcel.2013.09.016. Epub 2013 Oct 3.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 72289 | FLCN-eGFP | Expresses human FLCN tagged with eGFP at C terminus |
| 72290 | pRK5-FLAG-FLCN | overexpression |
| 72291 | pRK5-HA-FLCN | overexpression |
| 72292 | pRK5-FLAG-FNIP1 | overexpression |
| 72293 | pRK5-HA-FNIP1 | overexpression |
| 72294 | pRK5-FLAG-FNIP2 | overexpression |
| 72295 | pRK5-HA-FNIP2 | overexpression |
| 72296 | pRK5-FLAG-FLCN (C terminus) | overexpression |
| 72297 | pRK5-HA-FLCN (C terminus) | overexpression |