A cell-based screening for TAZ activators identifies ethacridine, a widely used antiseptic and abortifacient, as a compound that promotes dephosphorylation of TAZ and inhibits adipogenesis in C3H10T1/2 cells.
Kawano S, Maruyama J, Nagashima S, Inami K, Qiu W, Iwasa H, Nakagawa K, Ishigami-Yuasa M, Kagechika H, Nishina H, Hata Y
J Biochem. 2015 May 14. pii: mvv051.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 128348 | pCIneoLuc-PP1A | Vector for LUMIER assay |
| 128349 | pCIneoLuc-PP2A | Vector for LUMIER assay |
| 139648 | pLL3.7-K122-TEAD-p-H2B-mCherry | Reporter assay |
| 139649 | pLL3.7-K122-FH-TAZ-TEAD-p-H2B-mCherry | Reporter assay |