A diverse array of cancer-associated MTOR mutations are hyperactivating and can predict rapamycin sensitivity.
Grabiner BC, Nardi V, Birsoy K, Possemato R, Shen K, Sinha S, Jordan A, Beck AH, Sabatini DM
Cancer Discov. 2014 May;4(5):554-63. doi: 10.1158/2159-8290.CD-13-0929. Epub 2014 Mar 14.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 69006 | pcDNA3-FLAG-MTOR-L1460P | activating MTOR mutation |
| 69008 | pcDNA3-FLAG-MTOR-C1483F | activating MTOR mutation |
| 69009 | pcDNA3-FLAG-MTOR-E1799K | activating MTOR mutation |
| 69010 | pcDNA3-FLAG-MTOR-F1888L | activating MTOR mutation |
| 69011 | pcDNA3-FLAG-MTOR-T1977R | activating MTOR mutation |
| 69012 | pcDNA3-FLAG-MTOR-V2006I | activating MTOR mutation |
| 69013 | pcDNA3-FLAG-MTOR-S2215Y | activating MTOR mutation |
| 69014 | pcDNA3-FLAG-MTOR-I2500F | activating MTOR mutation |
| 69015 | pcDNA3-FLAG-MTOR-R2505P | activating MTOR mutation |
| 69017 | pcDNA3-FLAG-MTOR-D2512H | activating MTOR mutation |
| 69018 | pRK5-HA-GST-4EBP1-Low GC | expresses tagged 4EBP1 |