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Institute for Protein Innovation Antibody Collection

Welcome to the Institute for Protein Innovation (IPI) Collection!

Here, you’ll find unique recombinant antibodies targeting families of cell surface and secreted proteins (glypicans and integrins) and common epitope tags, as well as antibody plasmids to create or express plasmid-based antibodies.

The majority of antibodies in the collection have been developed using a platform (Link opens in a new window)based on yeast display technology (Link opens in a new window)and an optimized sorting process. This combination allows IPI to generate antibodies to highly conserved proteins and other difficult-to-target antigens that are intractable via animal immunization.

IPI is a nonprofit research organization with a mission to advance protein science to accelerate research and improve human health. As part of that mission, IPI is providing access to high-quality, well-characterized antibodies in an open science model.

Learn more about IPI (Link opens in a new window)

Glypican Antibodies

Glypicans are a family of highly conserved proteoglycans crucial for regulating cell signaling during development. The IPI collection includes anti-glypicans that accurately detect glypican presence and explore glypican function, providing a reliable and accessible toolset for scientists worldwide.

Schematic of a glypican protein, shown as three domains (the cysteine-rich N-terminal N-Lobe, central M-Lobe, and C-terminal protease C-lobe, anchored to the surface of a cell by a GPI-anchor with two heparan sulfate chains between the GPI-anchor and C-Lobe (protease) domain. Unbound glypican antibody is also shown.
Figure courtesy of IPI

Browse Glypican Antibodies

ID Recombinant Antibody Description Isotype Reactivity Recommended Applications

Integrin Antibodies

Integrins are a family of mechanotransduction receptors, comprised of alpha-beta subunit heterodimers. The IPI collection contains antibodies that uniquely:

  1. Bind to the alpha subunit, outside the ligand-binding pocket
  2. Bind to the beta subunit, outside the ligand-binding pocket
  3. Bind specific subunit pairs, outside the ligand-binding pocket
  4. Bind specific subunit pairs, blocking ligand binding and receptor function
Integrin antibody can be one of fours types, as described in text.
Figure courtesy of IPI

Browse Integrin Antibodies

ID Recombinant Antibody Description Isotype Reactivity Recommended Applications

Browse Epitope Tag Antibodies

IPI has developed recombinant versions of antibodies that recognize common epitope tags to help purify, detect, or localize particular proteins. Browse or search the table below to find antibodies targeting V5, Protein C, DYKDDDDK, Rho, His, Biotin, EE, GCN4 and Strep.

Please visit our Tags and Other Markers Antibody Collection page to browse Addgene’s full catalog of antibodies that target epitope tags and other common cellular proteins.

ID Recombinant Antibody Description Isotype Reactivity Recommended Applications

Browse Antibody Plasmids

The following plasmids can be used to create or express plasmid-based antibodies.

ID Plasmid Description