William Wisden Lab Materials

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Title	Authors	Publication
A Neuronal Hub Binding Sleep Initiation and Body Cooling in Response to a Warm External Stimulus.	Harding EC, Yu X, Miao A, Andrews N, Ma Y, Ye Z, Lignos L, Miracca G, Ba W, Yustos R, Vyssotski AL, Wisden W, Franks NP	Curr Biol. 2018 Jul 23;28(14):2263-2273.e4. doi: 10.1016/j.cub.2018.05.054. Epub 2018 Jul 12.
A specific circuit in the midbrain detects stress and induces restorative sleep.	Yu X, Zhao G, Wang D, Wang S, Li R, Li A, Wang H, Nollet M, Chun YY, Zhao T, Yustos R, Li H, Zhao J, Li J, Cai M, Vyssotski AL, Li Y, Dong H, Franks NP, Wisden W	Science. 2022 Jul;377(6601):63-72. doi: 10.1126/science.abn0853. Epub 2022 Jun 30.
Bottom-Up versus Top-Down Induction of Sleep by Zolpidem Acting on Histaminergic and Neocortex Neurons.	Uygun DS, Ye Z, Zecharia AY, Harding EC, Yu X, Yustos R, Vyssotski AL, Brickley SG, Franks NP, Wisden W	J Neurosci. 2016 Nov 2;36(44):11171-11184.
GABA and glutamate neurons in the VTA regulate sleep and wakefulness.	Yu X, Li W, Ma Y, Tossell K, Harris JJ, Harding EC, Ba W, Miracca G, Wang D, Li L, Guo J, Chen M, Li Y, Yustos R, Vyssotski AL, Burdakov D, Yang Q, Dong H, Franks NP, Wisden W	Nat Neurosci. 2019 Jan;22(1):106-119. doi: 10.1038/s41593-018-0288-9. Epub 2018 Dec 17.
Neuronal ensembles sufficient for recovery sleep and the sedative actions of alpha2 adrenergic agonists.	Zhang Z, Ferretti V, Guntan I, Moro A, Steinberg EA, Ye Z, Zecharia AY, Yu X, Vyssotski AL, Brickley SG, Yustos R, Pillidge ZE, Harding EC, Wisden W, Franks NP	Nat Neurosci. 2015 Apr;18(4):553-61. doi: 10.1038/nn.3957. Epub 2015 Feb 23.
NMDA Receptors in the Lateral Preoptic Hypothalamus Are Essential for Sustaining NREM and REM Sleep.	Miracca G, Anuncibay-Soto B, Tossell K, Yustos R, Vyssotski AL, Franks NP, Wisden W	J Neurosci. 2022 May 31. pii: JNEUROSCI.0350-21.2022. doi: 10.1523/JNEUROSCI.0350-21.2022.
Wakefulness Is Governed by GABA and Histamine Cotransmission.	Yu X, Ye Z, Houston CM, Zecharia AY, Ma Y, Zhang Z, Uygun DS, Parker S, Vyssotski AL, Yustos R, Franks NP, Brickley SG, Wisden W	Neuron. 2015 Jun 17. pii: S0896-6273(15)00516-4. doi: 10.1016/j.neuron.2015.06.003.

Showing 1 to 10 of 20 entries

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	ID	Plasmid	Gene/Insert	Vector Type	Publication
100.8.647094.66794	66794	pAAV-cFos-tTA-pA	cfos promoter linked to the tet activator gene	Mammalian Expression, AAV	Neuronal ensembles sufficient for recovery sleep and the sedative actions of alpha2 adrenergic agonists. Nat Neurosci. 2015 Apr;18(4):553-61. doi: 10.1038/nn.3957. Epub 2015 Feb 23.
100.7.582508.66795	66795	pAAV-PTRE-tight-hM3Dq-mCherry	pTIGHT promoter-hM3Dq-mCherry	Mammalian Expression, AAV	Neuronal ensembles sufficient for recovery sleep and the sedative actions of alpha2 adrenergic agonists. Nat Neurosci. 2015 Apr;18(4):553-61. doi: 10.1038/nn.3957. Epub 2015 Feb 23.
50.20.914468.71383	71383	pAAV-hysn-flex-dsRed-shscramble	human synapsin promoter-flex switch-dsRed-shscramble	Mammalian Expression, AAV, RNAi, Cre/Lox	Wakefulness Is Governed by GABA and Histamine Cotransmission. Neuron. 2015 Jun 17. pii: S0896-6273(15)00516-4. doi: 10.1016/j.neuron.2015.06.003.
50.17.943898.67845	67845	pAAV-hsyn-flex-dsRed-shvgat	AAV-hsyn-flexed-dsRed-miR30-vgat2.shRNA	Mammalian Expression, Mouse Targeting, AAV, RNAi, Cre/Lox	Wakefulness Is Governed by GABA and Histamine Cotransmission. Neuron. 2015 Jun 17. pii: S0896-6273(15)00516-4. doi: 10.1016/j.neuron.2015.06.003.
	67879	AAV-actin prom-dsRed-scramble shRNA	actin prom-dsRed-scramble shRNA	Mammalian Expression, AAV, RNAi	Neuronal ensembles sufficient for recovery sleep and the sedative actions of alpha2 adrenergic agonists. Nat Neurosci. 2015 Apr;18(4):553-61. doi: 10.1038/nn.3957. Epub 2015 Feb 23.
	67880	AAV-actin prom-dsRed-adra2a.1227.shRNA	dsRed and shRNA to knock down the mouse adra2 receptor	Mammalian Expression, AAV	Neuronal ensembles sufficient for recovery sleep and the sedative actions of alpha2 adrenergic agonists. Nat Neurosci. 2015 Apr;18(4):553-61. doi: 10.1038/nn.3957. Epub 2015 Feb 23.
	71384	pPRIME-dsRed-shscramble	CMV promoter-dsRed-mir30-shscramble	Mammalian Expression, Lentiviral, RNAi	Wakefulness Is Governed by GABA and Histamine Cotransmission. Neuron. 2015 Jun 17. pii: S0896-6273(15)00516-4. doi: 10.1016/j.neuron.2015.06.003.
	71385	pPRIME-dsRed-shvgat	CMV promoter-dsRed-mir30-shvgat	Mammalian Expression, Lentiviral, RNAi	Wakefulness Is Governed by GABA and Histamine Cotransmission. Neuron. 2015 Jun 17. pii: S0896-6273(15)00516-4. doi: 10.1016/j.neuron.2015.06.003.
	71410	pAAV-flex-rev-g2-2A-Venus		Mammalian Expression, AAV, Cre/Lox	Bottom-Up versus Top-Down Induction of Sleep by Zolpidem Acting on Histaminergic and Neocortex Neurons. J Neurosci. 2016 Nov 2;36(44):11171-11184.
	115161	pAAV-PTRE-tight-flex-hM3Dq-mCherry-WPRE-pA	PTRE - tet activator responsive promoter, flex sequence, hM3dq-mCherry (inverted), flex sequence	Mammalian Expression, AAV	A Neuronal Hub Binding Sleep Initiation and Body Cooling in Response to a Warm External Stimulus. Curr Biol. 2018 Jul 23;28(14):2263-2273.e4. doi: 10.1016/j.cub.2018.05.054. Epub 2018 Jul 12.