Reuben Shaw Lab Materials

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Title	Authors	Publication
AMPK governs lineage specification through Tfeb-dependent regulation of lysosomes.	Young NP, Kamireddy A, Van Nostrand JL, Eichner LJ, Shokhirev MN, Dayn Y, Shaw RJ	Genes Dev. 2016 Mar 1;30(5):535-52. doi: 10.1101/gad.274142.115.
AMPK phosphorylation of raptor mediates a metabolic checkpoint.	Gwinn DM, Shackelford DB, Egan DF, Mihaylova MM, Mery A, Vasquez DS, Turk BE, Shaw RJ	Mol Cell. 2008 Apr 25. 30(2):214-26.
An AMPK-independent signaling pathway downstream of the LKB1 tumor suppressor controls Snail1 and metastatic potential.	Goodwin JM, Svensson RU, Lou HJ, Winslow MM, Turk BE, Shaw RJ	Mol Cell. 2014 Aug 7;55(3):436-50. doi: 10.1016/j.molcel.2014.06.021. Epub 2014 Jul 17.
Class IIa histone deacetylases are hormone-activated regulators of FOXO and mammalian glucose homeostasis.	Mihaylova MM, Vasquez DS, Ravnskjaer K, Denechaud PD, Yu RT, Alvarez JG, Downes M, Evans RM, Montminy M, Shaw RJ	Cell. 2011 May 13;145(4):607-21.
Metabolism. AMP-activated protein kinase mediates mitochondrial fission in response to energy stress.	Toyama EQ, Herzig S, Courchet J, Lewis TL Jr, Loson OC, Hellberg K, Young NP, Chen H, Polleux F, Chan DC, Shaw RJ	Science. 2016 Jan 15;351(6270):275-81. doi: 10.1126/science.aab4138.
Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy.	Egan DF, Shackelford DB, Mihaylova MM, Gelino SR, Kohnz RA, Mair W, Vasquez DS, Joshi A, Gwinn DM, Taylor R, Asara JM, Fitzpatrick J, Dillin A, Viollet B, Kundu M, Hansen M, Shaw RJ	Science. 2010 Dec 23. ():.
The AMPK-Related Kinases SIK1 and SIK3 Mediate Key Tumor-Suppressive Effects of LKB1 in NSCLC.	Hollstein PE, Eichner LJ, Brun SN, Kamireddy A, Svensson RU, Vera LI, Ross DS, Rymoff TJ, Hutchins A, Galvez HM, Williams AE, Shokhirev MN, Screaton RA, Berdeaux R, Shaw RJ	Cancer Discov. 2019 Nov;9(11):1606-1627. doi: 10.1158/2159-8290.CD-18-1261. Epub 2019 Jul 26.

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	ID	Plasmid	Gene/Insert	Vector Type	Publication
100.888.092220.74444	74444	pLenti.PGK.blast-Renilla_Luciferase	Renilla Luciferase	Mammalian Expression, Lentiviral	Metabolism. AMP-activated protein kinase mediates mitochondrial fission in response to energy stress. Science. 2016 Jan 15;351(6270):275-81. doi: 10.1126/science.aab4138.
100.4.335414.79014	79014	pCIP-Flag-TfebAA	Tfeb (Tfeb Mouse)	Mammalian Expression	AMPK governs lineage specification through Tfeb-dependent regulation of lysosomes. Genes Dev. 2016 Mar 1;30(5):535-52. doi: 10.1101/gad.274142.115.
100.3.240803.27632	27632	pEBG‐AMPK α1(1‐312)	AMPK α1(1‐312) (Prkaa1 Rat)	Mammalian Expression	Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy. Science. 2010 Dec 23. ():.
50.5.056130.79010	79010	pCIP-AMPKa1_WT	AMPK alpha 1 (PRKAA1 Human)	Mammalian Expression	AMPK governs lineage specification through Tfeb-dependent regulation of lysosomes. Genes Dev. 2016 Mar 1;30(5):535-52. doi: 10.1101/gad.274142.115.
50.4.226629.79011	79011	pCIP-AMPKa1_KD	AMPK alpha 1 (PRKAA1 Human)	Mammalian Expression	AMPK governs lineage specification through Tfeb-dependent regulation of lysosomes. Genes Dev. 2016 Mar 1;30(5):535-52. doi: 10.1101/gad.274142.115.
50.1.551828.79013	79013	pCIP-caTfeb	Tfeb (TFEB Human)	Mammalian Expression	AMPK governs lineage specification through Tfeb-dependent regulation of lysosomes. Genes Dev. 2016 Mar 1;30(5):535-52. doi: 10.1101/gad.274142.115.
50.1.460202.27636	27636	pcdna3 flag - ULK1 wt	mouse ULK1 (Ulk1 Mouse)	Mammalian Expression	Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy. Science. 2010 Dec 23. ():.
50.1.246272.27633	27633	pLKO human ULK1 shRNA 8	human ULK1 shRNA 8	Mammalian Expression, Lentiviral, RNAi	Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy. Science. 2010 Dec 23. ():.
50.0.863538.32211	32211	GFP HDAC5 WT	HDAC5 (HDAC5 Human)	Mammalian Expression	Class IIa histone deacetylases are hormone-activated regulators of FOXO and mammalian glucose homeostasis. Cell. 2011 May 13;145(4):607-21.
20.19.734887.74446	74446	pLenti.CMV/TO_PRKAA1	AMPK alpha 1 (PRKAA1 Human)	Mammalian Expression, Lentiviral	Metabolism. AMP-activated protein kinase mediates mitochondrial fission in response to energy stress. Science. 2016 Jan 15;351(6270):275-81. doi: 10.1126/science.aab4138.