An active form of Vav1 induces migration of mammary epithelial cells by stimulating secretion of an epidermal growth factor receptor ligand. | Wilsbacher JL, Moores SL, Brugge JS | Cell Commun Signal. 2006 . 4():5. |
Autocrine CSF-1R activation promotes Src-dependent disruption of mammary epithelial architecture. | Wrobel CN, Debnath J, Lin E, Beausoleil S, Roussel MF, Brugge JS | J Cell Biol. 2004 Apr 26. 165(2):263-73. |
Breast cancer-associated PIK3CA mutations are oncogenic in mammary epithelial cells. | Isakoff SJ, Engelman JA, Irie HY, Luo J, Brachmann SM, Pearline RV, Cantley LC, Brugge JS | Cancer Res. 2005 Dec 1. 65(23):10992-1000. |
Cycling cancer persister cells arise from lineages with distinct programs. | Oren Y, Tsabar M, Cuoco MS, Amir-Zilberstein L, Cabanos HF, Hutter JC, Hu B, Thakore PI, Tabaka M, Fulco CP, Colgan W, Cuevas BM, Hurvitz SA, Slamon DJ, Deik A, Pierce KA, Clish C, Hata AN, Zaganjor E, Lahav G, Politi K, Brugge JS, Regev A | Nature. 2021 Aug 11. pii: 10.1038/s41586-021-03796-6. doi: 10.1038/s41586-021-03796-6. |
Distinct roles of Akt1 and Akt2 in regulating cell migration and epithelial-mesenchymal transition. | Irie HY, Pearline RV, Grueneberg D, Hsia M, Ravichandran P, Kothari N, Natesan S, Brugge JS | J Cell Biol. 2005 Dec 19. 171(6):1023-34. |
Functional role and oncogene-regulated expression of the BH3-only factor Bmf in mammary epithelial anoikis and morphogenesis. | Schmelzle T, Mailleux AA, Overholtzer M, Carroll JS, Solimini NL, Lightcap ES, Veiby OP, Brugge JS | Proc Natl Acad Sci U S A. 2007 Mar 6. 104(10):3787-92. |
Requirements for Vav guanine nucleotide exchange factors and Rho GTPases in FcgammaR- and complement-mediated phagocytosis. | Hall AB, Gakidis MA, Glogauer M, Wilsbacher JL, Gao S, Swat W, Brugge JS | Immunity. 2006 Mar . 24(3):305-16. |
src plasmids | (unpublished) | |
Transforming properties of YAP, a candidate oncogene on the chromosome 11q22 amplicon. | Overholtzer M, Zhang J, Smolen GA, Muir B, Li W, Sgroi DC, Deng CX, Brugge JS, Haber DA | Proc Natl Acad Sci U S A. 2006 Aug 15. 103(33):12405-10. |
Vav family proteins couple to diverse cell surface receptors. | Moores SL, Selfors LM, Fredericks J, Breit T, Fujikawa K, Alt FW, Brugge JS, Swat W | Mol Cell Biol. 2000 Sep . 20(17):6364-73. |