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Bryan Roth Lab Materials
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Log in to manage alerts| Title | Authors | Publication |
|---|---|---|
| A Chemogenetic Platform for Spatio-temporal Control of β-arrestin Translocation and Signaling at G protein-Coupled Receptors | Roth BL, Gotoh Y, Giguere P, Nichols D | bioRxiv 251769 |
| A New DREADD Facilitates the Multiplexed Chemogenetic Interrogation of Behavior. | Vardy E, Robinson JE, Li C, Olsen RH, DiBerto JF, Giguere PM, Sassano FM, Huang XP, Zhu H, Urban DJ, White KL, Rittiner JE, Crowley NA, Pleil KE, Mazzone CM, Mosier PD, Song J, Kash TL, Malanga CJ, Krashes MJ, Roth BL | Neuron. 2015 Apr 29. pii: S0896-6273(15)00289-5. doi: 10.1016/j.neuron.2015.03.065. |
| Evolving the lock to fit the key to create a family of G protein-coupled receptors potently activated by an inert ligand. | Armbruster BN, Li X, Pausch MH, Herlitze S, Roth BL | Proc Natl Acad Sci U S A. 2007 Mar 20;104(12):5163-8. Epub 2007 Mar 2. |
| Morphine paradoxically prolongs neuropathic pain in rats by amplifying spinal NLRP3 inflammasome activation. | Grace PM, Strand KA, Galer EL, Urban DJ, Wang X, Baratta MV, Fabisiak TJ, Anderson ND, Cheng K, Greene LI, Berkelhammer D, Zhang Y, Ellis AL, Yin HH, Campeau S, Rice KC, Roth BL, Maier SF, Watkins LR | Proc Natl Acad Sci U S A. 2016 Jun 14;113(24):E3441-50. doi: 10.1073/pnas.1602070113. Epub 2016 May 31. |
| PRESTO-Tango as an open-source resource for interrogation of the druggable human GPCRome. | Kroeze WK, Sassano MF, Huang XP, Lansu K, McCorvy JD, Giguere PM, Sciaky N, Roth BL | Nat Struct Mol Biol. 2015 May;22(5):362-9. doi: 10.1038/nsmb.3014. Epub 2015 Apr 20. |
| Rapid, reversible activation of AgRP neurons drives feeding behavior in mice. | Krashes MJ, Koda S, Ye C, Rogan SC, Adams AC, Cusher DS, Maratos-Flier E, Roth BL, Lowell BB | J Clin Invest. 2011 Apr;121(4):1424-8. doi: 10.1172/JCI46229. |
| Roth lab DREADDs | (unpublished) | |
| Structure-guided design of a peripherally restricted chemogenetic system. | Kang HJ, Krumm BE, Tassou A, Geron M, DiBerto JF, Kapolka NJ, Gumpper RH, Sakamoto K, Dewran Kocak D, Olsen RHJ, Huang XP, Zhang S, Huang KL, Zaidi SA, Nguyen MT, Jo MJ, Katritch V, Fay JF, Scherrer G, Roth BL | Cell. 2024 Dec 26;187(26):7433-7449.e20. doi: 10.1016/j.cell.2024.11.001. Epub 2024 Dec 3. |
| TRUPATH, an open-source biosensor platform for interrogating the GPCR transducerome. | Olsen RHJ, DiBerto JF, English JG, Glaudin AM, Krumm BE, Slocum ST, Che T, Gavin AC, McCorvy JD, Roth BL, Strachan RT | Nat Chem Biol. 2020 May 4. pii: 10.1038/s41589-020-0535-8. doi: 10.1038/s41589-020-0535-8. |
| VEGAS as a Platform for Facile Directed Evolution in Mammalian Cells. | English JG, Olsen RHJ, Lansu K, Patel M, White K, Cockrell AS, Singh D, Strachan RT, Wacker D, Roth BL | Cell. 2019 Jul 2. pii: S0092-8674(19)30622-1. doi: 10.1016/j.cell.2019.05.051. |
| ID | Service | Name | |
|---|---|---|---|
100.3178.562543.44362-AAV5 | 44362-AAV5 | AAV5 | pAAV-hSyn-DIO-hM4D(Gi)-mCherry (AAV5) |
100.2337.546291.50475-AAV5 | 50475-AAV5 | AAV5 | pAAV-hSyn-hM4D(Gi)-mCherry (AAV5) |
100.2138.244567.50455-AAV8 | 50455-AAV8 | AAV8 | pAAV-hSyn-DIO-HA-hM4D(Gi)-IRES-mCitrine (AAV8) |
100.1535.913127.50459-AAV9 | 50459-AAV9 | AAV9 | pAAV-hSyn-DIO-mCherry (AAV9) |
100.1426.975255.44361-AAV9 | 44361-AAV9 | AAV9 | pAAV-hSyn-DIO-hM3D(Gq)-mCherry (AAV9) |
100.1424.957245.50465-AAVrg | 50465-AAVrg | AAV Retrograde | pAAV-hSyn-EGFP (AAV Retrograde) |
100.1329.570332.50465-AAV9 | 50465-AAV9 | AAV9 | pAAV-hSyn-EGFP (AAV9) |
100.1210.497932.50459-AAVrg | 50459-AAVrg | AAV Retrograde | pAAV-hSyn-DIO-mCherry (AAV Retrograde) |
100.1150.839339.50465-AAV1 | 50465-AAV1 | AAV1 | pAAV-hSyn-EGFP (AAV1) |
100.1149.815081.50457-AAV1 | 50457-AAV1 | AAV1 | pAAV-hSyn-DIO-EGFP (AAV1) |
100.1121.668768.44361-AAV8 | 44361-AAV8 | AAV8 | pAAV-hSyn-DIO-hM3D(Gq)-mCherry (AAV8) |
100.1102.243712.50465-AAVrg.T | 50465-AAVrg.T | AAV Retrograde trial size | pAAV-hSyn-EGFP (AAV Retrograde trial size) |
100.1086.864003.50459-AAV1 | 50459-AAV1 | AAV1 | pAAV-hSyn-DIO-mCherry (AAV1) |
100.1037.769380.50454-AAV8 | 50454-AAV8 | AAV8 | pAAV-hSyn-DIO-HA-hM3D(Gq)-IRES-mCitrine (AAV8) |
100.1021.944287.50459-AAV5 | 50459-AAV5 | AAV5 | pAAV-hSyn-DIO-mCherry (AAV5) |
100.835.896144.44362-AAV8 | 44362-AAV8 | AAV8 | pAAV-hSyn-DIO-hM4D(Gi)-mCherry (AAV8) |
100.696.840016.44361-AAV5 | 44361-AAV5 | AAV5 | pAAV-hSyn-DIO-hM3D(Gq)-mCherry (AAV5) |
100.569.481334.44361-AAVrg | 44361-AAVrg | AAV Retrograde | pAAV-hSyn-DIO-hM3D(Gq)-mCherry (AAV Retrograde) |
100.544.794621.50459-AAV2 | 50459-AAV2 | AAV2 | pAAV-hSyn-DIO-mCherry (AAV2) |
100.520.567864.44362-AAVrg | 44362-AAVrg | AAV Retrograde | pAAV-hSyn-DIO-hM4D(Gi)-mCherry (AAV Retrograde) |
100.519.899927.50475-AAV2 | 50475-AAV2 | AAV2 | pAAV-hSyn-hM4D(Gi)-mCherry (AAV2) |
100.456.535404.44361-AAV2 | 44361-AAV2 | AAV2 | pAAV-hSyn-DIO-hM3D(Gq)-mCherry (AAV2) |
100.441.544477.44362-AAV9 | 44362-AAV9 | AAV9 | pAAV-hSyn-DIO-hM4D(Gi)-mCherry (AAV9) |
100.408.402205.50457-AAV8 | 50457-AAV8 | AAV8 | pAAV-hSyn-DIO-EGFP (AAV8) |
100.408.056125.50477-AAV9 | 50477-AAV9 | AAV9 | pAAV-CaMKIIa-hM4D(Gi)-mCherry (AAV9) |
100.341.957901.44362-AAV2 | 44362-AAV2 | AAV2 | pAAV-hSyn-DIO-hM4D(Gi)-mCherry (AAV2) |
100.299.197757.50459-AAV8 | 50459-AAV8 | AAV8 | pAAV-hSyn-DIO-mCherry (AAV8) |
100.298.621235.50457-AAVrg | 50457-AAVrg | AAV Retrograde | pAAV-hSyn-DIO-EGFP (AAV Retrograde) |
100.203.744171.44361-AAV1 | 44361-AAV1 | AAV1 | pAAV-hSyn-DIO-hM3D(Gq)-mCherry (AAV1) |
100.172.178648.50479-AAV5 | 50479-AAV5 | AAV5 | pAAV-GFAP-hM4D(Gi)-mCherry (AAV5) |
100.161.055171.50474-AAV5 | 50474-AAV5 | AAV5 | pAAV-hSyn-hM3D(Gq)-mCherry (AAV5) |
100.144.895482.50476-AAV8 | 50476-AAV8 | AAV8 | pAAV-CaMKIIa-hM3D(Gq)-mCherry (AAV8) |
100.143.779357.50474-AAV8 | 50474-AAV8 | AAV8 | pAAV-hSyn-hM3D(Gq)-mCherry (AAV8) |
100.132.263253.50457-AAV2 | 50457-AAV2 | AAV2 | pAAV-hSyn-DIO-EGFP (AAV2) |
100.126.866491.50474-AAV2 | 50474-AAV2 | AAV2 | pAAV-hSyn-hM3D(Gq)-mCherry (AAV2) |
100.122.249162.44361-PHPeB | 44361-PHPeB | AAV PHP.eB | pAAV-hSyn-DIO-hM3D(Gq)-mCherry (AAV PHP.eB) |
100.121.785878.50465-AAV5 | 50465-AAV5 | AAV5 | pAAV-hSyn-EGFP (AAV5) |
100.113.323475.50477-AAV8 | 50477-AAV8 | AAV8 | pAAV-CaMKIIa-hM4D(Gi)-mCherry (AAV8) |
100.108.922604.50474-AAVrg | 50474-AAVrg | AAV Retrograde | pAAV-hSyn-hM3D(Gq)-mCherry (AAV Retrograde) |
100.100.112117.44362-PHPeB | 44362-PHPeB | AAV PHP.eB | pAAV-hSyn-DIO-hM4D(Gi)-mCherry (AAV PHP.eB) |
100.98.861166.50474-AAV9 | 50474-AAV9 | AAV9 | pAAV-hSyn-hM3D(Gq)-mCherry (AAV9) |
100.97.834876.50475-AAV9 | 50475-AAV9 | AAV9 | pAAV-hSyn-hM4D(Gi)-mCherry (AAV9) |
100.97.105601.50475-AAV8 | 50475-AAV8 | AAV8 | pAAV-hSyn-hM4D(Gi)-mCherry (AAV8) |
100.87.573873.50476-AAV5 | 50476-AAV5 | AAV5 | pAAV-CaMKIIa-hM3D(Gq)-mCherry (AAV5) |
100.81.581043.50465-AAV2 | 50465-AAV2 | AAV2 | pAAV-hSyn-EGFP (AAV2) |
100.81.182607.50475-AAVrg | 50475-AAVrg | AAV Retrograde | pAAV-hSyn-hM4D(Gi)-mCherry (AAV Retrograde) |
100.79.084163.50477-AAV5 | 50477-AAV5 | AAV5 | pAAV-CaMKIIa-hM4D(Gi)-mCherry (AAV5) |
100.78.341798.50478-AAV5 | 50478-AAV5 | AAV5 | pAAV-GFAP-hM3D(Gq)-mCherry (AAV5) |
100.64.044967.50465-AAV9.T | 50465-AAV9.T | AAV9 trial size | pAAV-hSyn-EGFP (AAV9 trial size) |
100.59.542414.50469-AAV8 | 50469-AAV8 | AAV8 | pAAV-CaMKIIa-EGFP (AAV8) |
| ID | Kit | |
|---|---|---|
100.72.656295.1000000163 | 1000000163 | TRUPATH |
100.60.234603.1000000068 | 1000000068 | PRESTO-Tango Kit |