Andrea Ventura Lab Materials

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Title	Authors	Publication
Engineered extrachromosomal oncogene amplifications promote tumorigenesis.	Pradella D, Zhang M, Gao R, Yao MA, Gluchowska KM, Cendon-Florez Y, Mishra T, La Rocca G, Weigl M, Jiao Z, Nguyen HHM, Lisi M, Ozimek MM, Mastroleo C, Chen K, Grimm F, Luebeck J, Zhang S, Zolli AA, Sun EG, Dameracharla B, Zhao Z, Pritykin Y, Sigel C, Chang HY, Mischel PS, Bafna V, Antonescu CR, Ventura A	Nature. 2024 Dec 18. doi: 10.1038/s41586-024-08318-8.
In vivo engineering of oncogenic chromosomal rearrangements with the CRISPR/Cas9 system.	Maddalo D, Manchado E, Concepcion CP, Bonetti C, Vidigal JA, Han YC, Ogrodowski P, Crippa A, Rekhtman N, de Stanchina E, Lowe SW, Ventura A	Nature. 2014 Dec 18;516(7531):423-7. doi: 10.1038/nature13902. Epub 2014 Oct 22.
Rapid and efficient one-step generation of paired gRNA CRISPR-Cas9 libraries.	Vidigal JA, Ventura A	Nat Commun. 2015 Aug 17;6:8083. doi: 10.1038/ncomms9083.
Somatic chromosomal engineering identifies BCAN-NTRK1 as a potent glioma driver and therapeutic target.	Cook PJ, Thomas R, Kannan R, de Leon ES, Drilon A, Rosenblum MK, Scaltriti M, Benezra R, Ventura A	Nat Commun. 2017 Jul 11;8:15987. doi: 10.1038/ncomms15987.

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	ID	Plasmid	Gene/Insert	Vector Type	Publication
100.38.925083.64073	64073	pX333		Mammalian Expression	In vivo engineering of oncogenic chromosomal rearrangements with the CRISPR/Cas9 system. Nature. 2014 Dec 18;516(7531):423-7. doi: 10.1038/nature13902. Epub 2014 Oct 22.
100.2.050603.69350	69350	pDonor_mU6	mU6 promoter and sgRNA scaffold flanked by BbsI sites	CRISPR	Rapid and efficient one-step generation of paired gRNA CRISPR-Cas9 libraries. Nat Commun. 2015 Aug 17;6:8083. doi: 10.1038/ncomms9083.
50.9.278397.64072	64072	Adeno Cas9		Adenoviral	In vivo engineering of oncogenic chromosomal rearrangements with the CRISPR/Cas9 system. Nature. 2014 Dec 18;516(7531):423-7. doi: 10.1038/nature13902. Epub 2014 Oct 22.
50.4.428136.69312	69312	pDonor_hU6	hU6 promoter and sgRNA scaffold flanked by BbsI sites	CRISPR	Rapid and efficient one-step generation of paired gRNA CRISPR-Cas9 libraries. Nat Commun. 2015 Aug 17;6:8083. doi: 10.1038/ncomms9083.
50.1.725213.69351	69351	pDonor_sU6	sU6 promoter and sgRNA scaffold flanked by BbsI sites	CRISPR	Rapid and efficient one-step generation of paired gRNA CRISPR-Cas9 libraries. Nat Commun. 2015 Aug 17;6:8083. doi: 10.1038/ncomms9083.
20.3.912467.64071	64071	Adeno EA	U6_sgRNA(Alk)_U6_sgRNA(Eml4)_CBh_FLAG-Cas9	Adenoviral	In vivo engineering of oncogenic chromosomal rearrangements with the CRISPR/Cas9 system. Nature. 2014 Dec 18;516(7531):423-7. doi: 10.1038/nature13902. Epub 2014 Oct 22.
	101823	Adeno BN	U6_sgRNA(Bcan)_U6_sgRNA(Ntrk1)_CBh_FLAG-Cas9 (Bcan, Ntrk1 Mouse)	Adenoviral	Somatic chromosomal engineering identifies BCAN-NTRK1 as a potent glioma driver and therapeutic target. Nat Commun. 2017 Jul 11;8:15987. doi: 10.1038/ncomms15987.
	101824	Adeno FT	U6_sgRNA(Fgfr3)_U6_sgRNA(Tacc3)_CBh_FLAG-Cas9 (Fgfr3, Tacc3 Mouse)	Adenoviral	Somatic chromosomal engineering identifies BCAN-NTRK1 as a potent glioma driver and therapeutic target. Nat Commun. 2017 Jul 11;8:15987. doi: 10.1038/ncomms15987.
	219563	5` CC: Puro – loxP – GFP-C	hPGK-promoter_PuroR_2A_loxP_GFP-C	Unspecified	Engineered extrachromosomal oncogene amplifications promote tumorigenesis. Nature. 2024 Dec 18. doi: 10.1038/s41586-024-08318-8.
	219564	3` CC: Hygro – GFP-N – loxP – mScarlet	3` CC: Hygro – GFP-N – loxP – mScarlet	Unspecified	Engineered extrachromosomal oncogene amplifications promote tumorigenesis. Nature. 2024 Dec 18. doi: 10.1038/s41586-024-08318-8.