lentiCRISPRv2 blast Citations (35)
Originally described in: A reference collection of patient-derived cell line and xenograft models of proneural, classical and mesenchymal glioblastoma.Stringer BW, Day BW, D'Souza RCJ, Jamieson PR, Ensbey KS, Bruce ZC, Lim YC, Goasdoue K, Offenhauser C, Akgul S, Allan S, Robertson T, Lucas P, Tollesson G, Campbell S, Winter C, Do H, Dobrovic A, Inglis PL, Jeffree RL, Johns TG, Boyd AW Sci Rep. 2019 Mar 20;9(1):4902. doi: 10.1038/s41598-019-41277-z. PubMed Journal
Articles Citing lentiCRISPRv2 blast
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| LIM and SH3 protein 1 induces glioma growth and invasion through PI3K/AKT signaling and epithelial-mesenchymal transition. Zhong C, Li X, Tao B, Peng L, Peng T, Yang X, Xia X, Chen L. Biomed Pharmacother. 2019 Aug;116:109013. doi: 10.1016/j.biopha.2019.109013. Epub 2019 May 27. PubMed |
| BACH1 Stabilization by Antioxidants Stimulates Lung Cancer Metastasis. Wiel C, Le Gal K, Ibrahim MX, Jahangir CA, Kashif M, Yao H, Ziegler DV, Xu X, Ghosh T, Mondal T, Kanduri C, Lindahl P, Sayin VI, Bergo MO. Cell. 2019 Jul 11;178(2):330-345.e22. doi: 10.1016/j.cell.2019.06.005. Epub 2019 Jun 27. PubMed |
| Functional metagenomics-guided discovery of potent Cas9 inhibitors in the human microbiome. Forsberg KJ, Bhatt IV, Schmidtke DT, Javanmardi K, Dillard KE, Stoddard BL, Finkelstein IJ, Kaiser BK, Malik HS. Elife. 2019 Sep 10;8. pii: 46540. doi: 10.7554/eLife.46540. PubMed |
| IL-36gamma drives skin toxicity induced by EGFR/MEK inhibition and commensal Cutibacterium acnes. Satoh TK, Mellett M, Meier-Schiesser B, Fenini G, Otsuka A, Beer HD, Rordorf T, Maul JT, Hafner J, Navarini AA, Contassot E, French LE. J Clin Invest. 2020 Feb 4. pii: 128678. doi: 10.1172/JCI128678. PubMed |
Spatiotemporal control of phosphatidic acid signaling with optogenetic, engineered phospholipase Ds.
Tei R, Baskin JM.
J Cell Biol. 2020 Mar 2;219(3). pii: 133675. doi: 10.1083/jcb.201907013.
PubMed
Associated Plasmids |
| MCM8IP activates the MCM8-9 helicase to promote DNA synthesis and homologous recombination upon DNA damage. Huang JW, Acharya A, Taglialatela A, Nambiar TS, Cuella-Martin R, Leuzzi G, Hayward SB, Joseph SA, Brunette GJ, Anand R, Soni RK, Clark NL, Bernstein KA, Cejka P, Ciccia A. Nat Commun. 2020 Jun 11;11(1):2948. doi: 10.1038/s41467-020-16718-3. PubMed |
| Regulation of cytokine signaling through direct interaction between cytokine receptors and the ATG16L1 WD40 domain. Serramito-Gomez I, Boada-Romero E, Villamuera R, Fernandez-Cabrera A, Cedillo JL, Martin-Regalado A, Carding S, Mayer U, Powell PP, Wileman T, Garcia-Higuera I, Pimentel-Muinos FX. Nat Commun. 2020 Nov 20;11(1):5919. doi: 10.1038/s41467-020-19670-4. PubMed |
| MARK2 phosphorylates eIF2alpha in response to proteotoxic stress. Lu YN, Kavianpour S, Zhang T, Zhang X, Nguyen D, Thombre R, He L, Wang J. PLoS Biol. 2021 Mar 11;19(3):e3001096. doi: 10.1371/journal.pbio.3001096. eCollection 2021 Mar. PubMed |
| CRISPRi screens reveal a DNA methylation-mediated 3D genome dependent causal mechanism in prostate cancer. Ahmed M, Soares F, Xia JH, Yang Y, Li J, Guo H, Su P, Tian Y, Lee HJ, Wang M, Akhtar N, Houlahan KE, Bosch A, Zhou S, Mazrooei P, Hua JT, Chen S, Petricca J, Zeng Y, Davies A, Fraser M, Quigley DA, Feng FY, Boutros PC, Lupien M, Zoubeidi A, Wang L, Walsh MJ, Wang T, Ren S, Wei GH, He HH. Nat Commun. 2021 Mar 19;12(1):1781. doi: 10.1038/s41467-021-21867-0. PubMed |
| Sensitivity of cells to ATR and CHK1 inhibitors requires hyperactivation of CDK2 rather than endogenous replication stress or ATM dysfunction. Ditano JP, Donahue KL, Tafe LJ, McCleery CF, Eastman A. Sci Rep. 2021 Mar 29;11(1):7077. doi: 10.1038/s41598-021-86490-x. PubMed |
| A robust vasculogenic microfluidic model using human immortalized endothelial cells and Thy1 positive fibroblasts. Wan Z, Zhang S, Zhong AX, Shelton SE, Campisi M, Sundararaman SK, Offeddu GS, Ko E, Ibrahim L, Coughlin MF, Liu T, Bai J, Barbie DA, Kamm RD. Biomaterials. 2021 Sep;276:121032. doi: 10.1016/j.biomaterials.2021.121032. Epub 2021 Jul 16. PubMed |
| Entinostat induces antitumor immune responses through immune editing of tumor neoantigens. Truong AS, Zhou M, Krishnan B, Utsumi T, Manocha U, Stewart KG, Beck W, Rose TL, Milowsky MI, He X, Smith CC, Bixby LM, Perou CM, Wobker SE, Bailey ST, Vincent BG, Kim WY. J Clin Invest. 2021 Aug 16;131(16). pii: e138560. doi: 10.1172/JCI138560. PubMed |
| Proximity labeling identifies a repertoire of site-specific R-loop modulators. Yan Q, Wulfridge P, Doherty J, Fernandez-Luna JL, Real PJ, Tang HY, Sarma K. Nat Commun. 2022 Jan 10;13(1):53. doi: 10.1038/s41467-021-27722-6. PubMed |
| The arginine methyltransferase PRMT7 promotes extravasation of monocytes resulting in tissue injury in COPD. Gunes Gunsel G, Conlon TM, Jeridi A, Kim R, Ertuz Z, Lang NJ, Ansari M, Novikova M, Jiang D, Strunz M, Gaianova M, Hollauer C, Gabriel C, Angelidis I, Doll S, Pestoni JC, Edelmann SL, Kohlhepp MS, Guillot A, Bassler K, Van Eeckhoutte HP, Kayalar O, Konyalilar N, Kanashova T, Rodius S, Ballester-Lopez C, Genes Robles CM, Smirnova N, Rehberg M, Agarwal C, Krikki I, Piavaux B, Verleden SE, Vanaudenaerde B, Konigshoff M, Dittmar G, Bracke KR, Schultze JL, Watz H, Eickelberg O, Stoeger T, Burgstaller G, Tacke F, Heissmeyer V, Rinkevich Y, Bayram H, Schiller HB, Conrad M, Schneider R, Yildirim AO. Nat Commun. 2022 Mar 14;13(1):1303. doi: 10.1038/s41467-022-28809-4. PubMed |
| The synthetic triterpenoids CDDO-TFEA and CDDO-Me, but not CDDO, promote nuclear exclusion of BACH1 impairing its activity. Casares L, Moreno R, Ali KX, Higgins M, Dayalan Naidu S, Neill G, Cassin L, Kiib AE, Svenningsen EB, Minassi A, Honda T, Poulsen TB, Wiel C, Sayin VI, Dinkova-Kostova AT, Olagnier D, de la Vega L. Redox Biol. 2022 May;51:102291. doi: 10.1016/j.redox.2022.102291. Epub 2022 Mar 17. PubMed |
| The nuclear receptor ERR cooperates with the cardiogenic factor GATA4 to orchestrate cardiomyocyte maturation. Sakamoto T, Batmanov K, Wan S, Guo Y, Lai L, Vega RB, Kelly DP. Nat Commun. 2022 Apr 13;13(1):1991. doi: 10.1038/s41467-022-29733-3. PubMed |
Optimal LentiCRISPR-Based System for Sequential CRISPR/Cas9 Screens.
Hutcheson RL, Hayes M, Sugden B.
ACS Synth Biol. 2022 Jun 29. doi: 10.1021/acssynbio.2c00152.
PubMed
Associated Plasmids |
| STAT and Janus kinase targeting by human herpesvirus 8 interferon regulatory factor in the suppression of type-I interferon signaling. Xiang Q, Yang Z, Nicholas J. PLoS Pathog. 2022 Jul 1;18(7):e1010676. doi: 10.1371/journal.ppat.1010676. eCollection 2022 Jul. PubMed |
| A non-canonical vitamin K cycle is a potent ferroptosis suppressor. Mishima E, Ito J, Wu Z, Nakamura T, Wahida A, Doll S, Tonnus W, Nepachalovich P, Eggenhofer E, Aldrovandi M, Henkelmann B, Yamada KI, Wanninger J, Zilka O, Sato E, Feederle R, Hass D, Maida A, Mourao ASD, Linkermann A, Geissler EK, Nakagawa K, Abe T, Fedorova M, Proneth B, Pratt DA, Conrad M. Nature. 2022 Aug;608(7924):778-783. doi: 10.1038/s41586-022-05022-3. Epub 2022 Aug 3. PubMed |
| TROP2 Represents a Negative Prognostic Factor in Colorectal Adenocarcinoma and Its Expression Is Associated with Features of Epithelial-Mesenchymal Transition and Invasiveness. Svec J, Stastna M, Janeckova L, Hrckulak D, Vojtechova M, Onhajzer J, Kriz V, Galuskova K, Sloncova E, Kubovciak J, Pfeiferova L, Hrudka J, Matej R, Waldauf P, Havluj L, Kolar M, Korinek V. Cancers (Basel). 2022 Aug 26;14(17):4137. doi: 10.3390/cancers14174137. PubMed |
| Liquid-liquid phase separation facilitates the biogenesis of secretory storage granules. Parchure A, Tian M, Stalder D, Boyer CK, Bearrows SC, Rohli KE, Zhang J, Rivera-Molina F, Ramazanov BR, Mahata SK, Wang Y, Stephens SB, Gershlick DC, von Blume J. J Cell Biol. 2022 Dec 5;221(12):e202206132. doi: 10.1083/jcb.202206132. Epub 2022 Sep 29. PubMed |
| A local tumor microenvironment acquired super-enhancer induces an oncogenic driver in colorectal carcinoma. Zhou RW, Xu J, Martin TC, Zachem AL, He J, Ozturk S, Demircioglu D, Bansal A, Trotta AP, Giotti B, Gryder B, Shen Y, Wu X, Carcamo S, Bosch K, Hopkins B, Tsankov A, Steinhagen R, Jones DR, Asara J, Chipuk JE, Brody R, Itzkowitz S, Chio IIC, Hasson D, Bernstein E, Parsons RE. Nat Commun. 2022 Oct 17;13(1):6041. doi: 10.1038/s41467-022-33377-8. PubMed |
| Targeting RNA Exonuclease XRN1 Potentiates Efficacy of Cancer Immunotherapy. Ran XB, Ding LW, Sun QY, Yang H, Said JW, Zhentang L, Madan V, Dakle P, Xiao JF, Loh X, Li Y, Xu L, Xiang XQ, Wang LZ, Goh BC, Lin DC, Chng WJ, Tan SY, Jha S, Koeffler HP. Cancer Res. 2023 Mar 15;83(6):922-938. doi: 10.1158/0008-5472.CAN-21-3052. PubMed |
| Cullin-5 deficiency orchestrates the tumor microenvironment to promote mammary tumor development through CREB1-CCL2 signaling. Chen S, Shao F, Zeng J, Guo S, Wang L, Sun H, Lei JH, Lyu X, Gao S, Chen Q, Miao K, Xu X, Deng CX. Sci Adv. 2023 Jan 20;9(3):eabq1395. doi: 10.1126/sciadv.abq1395. Epub 2023 Jan 20. PubMed |
| Induction of lysosomal and mitochondrial biogenesis by AMPK phosphorylation of FNIP1. Malik N, Ferreira BI, Hollstein PE, Curtis SD, Trefts E, Weiser Novak S, Yu J, Gilson R, Hellberg K, Fang L, Sheridan A, Hah N, Shadel GS, Manor U, Shaw RJ. Science. 2023 Apr 21;380(6642):eabj5559. doi: 10.1126/science.abj5559. Epub 2023 Apr 21. PubMed |
| A tissue injury sensing and repair pathway distinct from host pathogen defense. Liu S, Hur YH, Cai X, Cong Q, Yang Y, Xu C, Bilate AM, Gonzales KAU, Parigi SM, Cowley CJ, Hurwitz B, Luo JD, Tseng T, Gur-Cohen S, Sribour M, Omelchenko T, Levorse J, Pasolli HA, Thompson CB, Mucida D, Fuchs E. Cell. 2023 May 11;186(10):2127-2143.e22. doi: 10.1016/j.cell.2023.03.031. Epub 2023 Apr 24. PubMed |
| A genome-wide screen in macrophages identifies PTEN as required for myeloid restriction of Listeria monocytogenes infection. Glover RC, Schwardt NH, Leano SE, Sanchez ME, Thomason MK, Olive AJ, Reniere ML. PLoS Pathog. 2023 May 22;19(5):e1011058. doi: 10.1371/journal.ppat.1011058. eCollection 2023 May. PubMed |
| Phase separation of FSP1 promotes ferroptosis. Nakamura T, Hipp C, Santos Dias Mourao A, Borggrafe J, Aldrovandi M, Henkelmann B, Wanninger J, Mishima E, Lytton E, Emler D, Proneth B, Sattler M, Conrad M. Nature. 2023 Jul;619(7969):371-377. doi: 10.1038/s41586-023-06255-6. Epub 2023 Jun 28. PubMed |
| DHODH inhibitors sensitize to ferroptosis by FSP1 inhibition. Mishima E, Nakamura T, Zheng J, Zhang W, Mourao ASD, Sennhenn P, Conrad M. Nature. 2023 Jul;619(7968):E9-E18. doi: 10.1038/s41586-023-06269-0. Epub 2023 Jul 5. PubMed |
| LRP8-mediated selenocysteine uptake is a targetable vulnerability in MYCN-amplified neuroblastoma. Alborzinia H, Chen Z, Yildiz U, Freitas FP, Vogel FCE, Varga JP, Batani J, Bartenhagen C, Schmitz W, Buchel G, Michalke B, Zheng J, Meierjohann S, Girardi E, Espinet E, Florez AF, Dos Santos AF, Aroua N, Cheytan T, Haenlin J, Schlicker L, Xavier da Silva TN, Przybylla A, Zeisberger P, Superti-Furga G, Eilers M, Conrad M, Fabiano M, Schweizer U, Fischer M, Schulze A, Trumpp A, Friedmann Angeli JP. EMBO Mol Med. 2023 Aug 7;15(8):e18014. doi: 10.15252/emmm.202318014. Epub 2023 Jul 12. PubMed |
| LY6E is a pan-coronavirus restriction factor in the respiratory tract. Mar KB, Wells AI, Caballero Van Dyke MC, Lopez AH, Eitson JL, Fan W, Hanners NW, Evers BM, Shelton JM, Schoggins JW. Nat Microbiol. 2023 Aug;8(8):1587-1599. doi: 10.1038/s41564-023-01431-w. Epub 2023 Jul 13. PubMed |
| MYC is a clinically significant driver of mTOR inhibitor resistance in breast cancer. Bhin J, Yemelyanenko J, Chao X, Klarenbeek S, Opdam M, Malka Y, Hoekman L, Kruger D, Bleijerveld O, Brambillasca CS, Sprengers J, Siteur B, Annunziato S, van Haren MJ, Martin NI, van de Ven M, Peters D, Agami R, Linn SC, Boven E, Altelaar M, Jonkers J, Zingg D, Wessels LFA. J Exp Med. 2023 Nov 6;220(11):e20211743. doi: 10.1084/jem.20211743. Epub 2023 Aug 29. PubMed |
| Direct and biologically significant interactions of human herpesvirus 8 interferon regulatory factor 1 with STAT3 and Janus kinase TYK2. Yang Z, Xiang Q, Nicholas J. PLoS Pathog. 2023 Nov 20;19(11):e1011806. doi: 10.1371/journal.ppat.1011806. eCollection 2023 Nov. PubMed |
BioE3 identifies specific substrates of ubiquitin E3 ligases.
Barroso-Gomila O, Merino-Cacho L, Muratore V, Perez C, Taibi V, Maspero E, Azkargorta M, Iloro I, Trulsson F, Vertegaal ACO, Mayor U, Elortza F, Polo S, Barrio R, Sutherland JD.
Nat Commun. 2023 Nov 23;14(1):7656. doi: 10.1038/s41467-023-43326-8.
PubMed
Associated Plasmids |
| BLM helicase unwinds lagging strand substrates to assemble the ALT telomere damage response. Jiang H, Zhang T, Kaur H, Shi T, Krishnan A, Kwon Y, Sung P, Greenberg RA. Mol Cell. 2024 May 2;84(9):1684-1698.e9. doi: 10.1016/j.molcel.2024.03.011. Epub 2024 Apr 8. PubMed |
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