lentiCRISPRv2 puro Citations (136)
Originally described in: A reference collection of patient-derived cell line and xenograft models of proneural, classical and mesenchymal glioblastoma.Stringer BW, Day BW, D'Souza RCJ, Jamieson PR, Ensbey KS, Bruce ZC, Lim YC, Goasdoue K, Offenhauser C, Akgul S, Allan S, Robertson T, Lucas P, Tollesson G, Campbell S, Winter C, Do H, Dobrovic A, Inglis PL, Jeffree RL, Johns TG, Boyd AW Sci Rep. 2019 Mar 20;9(1):4902. doi: 10.1038/s41598-019-41277-z. PubMed Journal
Articles Citing lentiCRISPRv2 puro
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| Mitigating SOX2-potentiated Immune Escape of Head and Neck Squamous Cell Carcinoma with a STING-inducing Nanosatellite Vaccine. Tan YS, Sansanaphongpricha K, Xie Y, Donnelly CR, Luo X, Heath BR, Zhao X, Bellile E, Hu H, Chen H, Polverini PJ, Chen Q, Young S, Carey TE, Nor JE, Ferris RL, Wolf GT, Sun D, Lei YL. Clin Cancer Res. 2018 Sep 1;24(17):4242-4255. doi: 10.1158/1078-0432.CCR-17-2807. Epub 2018 May 16. PubMed |
| Triglycerides Promote Lipid Homeostasis during Hypoxic Stress by Balancing Fatty Acid Saturation. Ackerman D, Tumanov S, Qiu B, Michalopoulou E, Spata M, Azzam A, Xie H, Simon MC, Kamphorst JJ. Cell Rep. 2018 Sep 4;24(10):2596-2605.e5. doi: 10.1016/j.celrep.2018.08.015. PubMed |
| Ginkgolide B enhances gemcitabine sensitivity in pancreatic cancer cell lines via inhibiting PAFR/NF-small ka, CyrillicB pathway. Lou C, Lu H, Ma Z, Liu C, Zhang Y. Biomed Pharmacother. 2019 Jan;109:563-572. doi: 10.1016/j.biopha.2018.10.084. Epub 2018 Nov 3. PubMed |
| Trivalent RING Assembly on Retroviral Capsids Activates TRIM5 Ubiquitination and Innate Immune Signaling. Fletcher AJ, Vaysburd M, Maslen S, Zeng J, Skehel JM, Towers GJ, James LC. Cell Host Microbe. 2018 Dec 12;24(6):761-775.e6. doi: 10.1016/j.chom.2018.10.007. Epub 2018 Nov 29. PubMed |
| Cullin5 deficiency promotes small-cell lung cancer metastasis by stabilizing integrin beta1. Zhao G, Gong L, Su D, Jin Y, Guo C, Yue M, Yao S, Qin Z, Ye Y, Tang Y, Wu Q, Zhang J, Cui B, Ding Q, Huang H, Hu L, Chen Y, Zhang P, Hu G, Chen L, Wong KK, Gao D, Ji H. J Clin Invest. 2019 Mar 1;129(3):972-987. doi: 10.1172/JCI122779. Epub 2019 Jan 28. PubMed |
| Axis inhibition protein 1 (Axin1) Deletion-Induced Hepatocarcinogenesis Requires Intact beta-Catenin but Not Notch Cascade in Mice. Qiao Y, Wang J, Karagoz E, Liang B, Song X, Shang R, Evert K, Xu M, Che L, Evert M, Calvisi DF, Tao J, Wang B, Monga SP, Chen X. Hepatology. 2019 Feb 8. doi: 10.1002/hep.30556. PubMed |
| Depletion of H3K79 methyltransferase Dot1L promotes cell invasion and cancer stem-like cell property in ovarian cancer. Wang X, Wang H, Xu B, Jiang D, Huang S, Yu H, Wu Z, Wu Q. Am J Transl Res. 2019 Feb 15;11(2):1145-1153. eCollection 2019. PubMed |
| CRISPR/Cas9-Mediated Gene Tagging: A Step-by-Step Protocol. Xiang X, Li C, Chen X, Dou H, Li Y, Zhang X, Luo Y. Methods Mol Biol. 2019;1961:255-269. doi: 10.1007/978-1-4939-9170-9_16. PubMed |
| CRISPR screening using an expanded toolkit of autophagy reporters identifies TMEM41B as a novel autophagy factor. Shoemaker CJ, Huang TQ, Weir NR, Polyakov NJ, Schultz SW, Denic V. PLoS Biol. 2019 Apr 1;17(4):e2007044. doi: 10.1371/journal.pbio.2007044. eCollection 2019 Apr. PubMed |
| USP49 negatively regulates cellular antiviral responses via deconjugating K63-linked ubiquitination of MITA. Ye L, Zhang Q, Liuyu T, Xu Z, Zhang MX, Luo MH, Zeng WB, Zhu Q, Lin D, Zhong B. PLoS Pathog. 2019 Apr 3;15(4):e1007680. doi: 10.1371/journal.ppat.1007680. eCollection 2019 Apr. PubMed |
| Deletion of miR-126a Promotes Hepatic Aging and Inflammation in a Mouse Model of Cholestasis. Yan Y, Qin D, Hu B, Zhang C, Liu S, Wu D, Huang W, Huang X, Wang L, Chen X, Zhang L. Mol Ther Nucleic Acids. 2019 Jun 7;16:494-504. doi: 10.1016/j.omtn.2019.04.002. Epub 2019 Apr 11. PubMed |
| Rare inherited missense variants of POGZ associate with autism risk and disrupt neuronal development. Zhao W, Tan J, Zhu T, Ou J, Li Y, Shen L, Wu H, Han L, Liu Y, Jia X, Bai T, Li H, Ke X, Zhao J, Zou X, Hu Z, Guo H, Xia K. J Genet Genomics. 2019 May 20;46(5):247-257. doi: 10.1016/j.jgg.2019.04.002. Epub 2019 May 18. PubMed |
| Modeling microcephaly with cerebral organoids reveals a WDR62-CEP170-KIF2A pathway promoting cilium disassembly in neural progenitors. Zhang W, Yang SL, Yang M, Herrlinger S, Shao Q, Collar JL, Fierro E, Shi Y, Liu A, Lu H, Herring BE, Guo ML, Buch S, Zhao Z, Xu J, Lu Z, Chen JF. Nat Commun. 2019 Jun 13;10(1):2612. doi: 10.1038/s41467-019-10497-2. PubMed |
| Retinol binding protein 4 mediates MEHP-induced glucometabolic abnormalities in HepG2 cells. Wang F, Chang C, Li R, Zhang Z, Jiang H, Zeng N, Li D, Chen L, Xiao Y, Chen W, Wang Q. Toxicology. 2019 Aug 1;424:152236. doi: 10.1016/j.tox.2019.06.007. Epub 2019 Jun 20. PubMed |
| Induction of t(11;14) IgH enhancer/promoter-cyclin D1 gene translocation using CRISPR/Cas9. Tsuyama N, Abe Y, Yanagi A, Yanai Y, Sugai M, Katafuchi A, Kawamura F, Kamiya K, Sakai A. Oncol Lett. 2019 Jul;18(1):275-282. doi: 10.3892/ol.2019.10303. Epub 2019 May 2. PubMed |
| Chromatin remodelling factor BAF155 protects hepatitis B virus X protein (HBx) from ubiquitin-independent proteasomal degradation. Chen H, Zhang Y, Ye S, Wu Q, Lin Y, Sheng K, Chen W, Lin X, Lin X. Emerg Microbes Infect. 2019;8(1):1393-1405. doi: 10.1080/22221751.2019.1666661. PubMed |
| Germline NPM1 mutations lead to altered rRNA 2'-O-methylation and cause dyskeratosis congenita. Nachmani D, Bothmer AH, Grisendi S, Mele A, Bothmer D, Lee JD, Monteleone E, Cheng K, Zhang Y, Bester AC, Guzzetti A, Mitchell CA, Mendez LM, Pozdnyakova O, Sportoletti P, Martelli MP, Vulliamy TJ, Safra M, Schwartz S, Luzzatto L, Bluteau O, Soulier J, Darnell RB, Falini B, Dokal I, Ito K, Clohessy JG, Pandolfi PP. Nat Genet. 2019 Oct;51(10):1518-1529. doi: 10.1038/s41588-019-0502-z. Epub 2019 Sep 30. PubMed |
| Promoter demethylation of the asparagine synthetase gene is required for ATF4-dependent adaptation to asparagine depletion. Jiang J, Srivastava S, Seim G, Pavlova NN, King B, Zou L, Zhang C, Zhong M, Feng H, Kapur R, Wek RC, Fan J, Zhang J. J Biol Chem. 2019 Dec 6;294(49):18674-18684. doi: 10.1074/jbc.RA119.010447. Epub 2019 Oct 28. PubMed |
| GLP-1 Receptor Activation Abrogates beta-Cell Dysfunction by PKA Calpha-Mediated Degradation of Thioredoxin Interacting Protein. He S, Wu W, Wan Y, Nandakumar KS, Cai X, Tang X, Liu S, Yao X. Front Pharmacol. 2019 Oct 25;10:1230. doi: 10.3389/fphar.2019.01230. eCollection 2019. PubMed |
| Hepatitis Delta Virus Alters the Autophagy Process To Promote Its Genome Replication. Khabir M, Aliche AZ, Sureau C, Blanchet M, Labonte P. J Virol. 2020 Jan 31;94(4). pii: JVI.01936-19. doi: 10.1128/JVI.01936-19. Print 2020 Jan 31. PubMed |
| Entry by multiple picornaviruses is dependent on a pathway that includes TNK2, WASL, and NCK1. Jiang H, Leung C, Tahan S, Wang D. Elife. 2019 Nov 26;8. pii: 50276. doi: 10.7554/eLife.50276. PubMed |
| HPV16 drives cancer immune escape via NLRX1-mediated degradation of STING. Luo X, Donnelly CR, Gong W, Heath BR, Hao Y, Donnelly LA, Moghbeli T, Tan YS, Lin X, Bellile E, Kansy BA, Carey TE, Brenner JC, Cheng L, Polverini PJ, Morgan MA, Wen H, Prince ME, Ferris RL, Xie Y, Young S, Wolf GT, Chen Q, Lei YL. J Clin Invest. 2020 Apr 1;130(4):1635-1652. doi: 10.1172/JCI129497. PubMed |
Spatiotemporal control of phosphatidic acid signaling with optogenetic, engineered phospholipase Ds.
Tei R, Baskin JM.
J Cell Biol. 2020 Mar 2;219(3). pii: 133675. doi: 10.1083/jcb.201907013.
PubMed
Associated Plasmids |
| Germline Mutations in FAF1 Are Associated With Hereditary Colorectal Cancer. Bonjoch L, Franch-Exposito S, Garre P, Belhadj S, Munoz J, Arnau-Collell C, Diaz-Gay M, Gratacos-Mulleras A, Raimondi G, Esteban-Jurado C, Soares de Lima Y, Herrera-Pariente C, Cuatrecasas M, Ocana T, Castells A, Fillat C, Capella G, Balaguer F, Caldes T, Valle L, Castellvi-Bel S. Gastroenterology. 2020 Jul;159(1):227-240.e7. doi: 10.1053/j.gastro.2020.03.015. Epub 2020 Mar 14. PubMed |
| A Live-Cell Screen for Altered Erk Dynamics Reveals Principles of Proliferative Control. Goglia AG, Wilson MZ, Jena SG, Silbert J, Basta LP, Devenport D, Toettcher JE. Cell Syst. 2020 Mar 25;10(3):240-253.e6. doi: 10.1016/j.cels.2020.02.005. Epub 2020 Mar 18. PubMed |
| ITGBL1 promotes cell migration and invasion through stimulating the TGF-beta signalling pathway in hepatocellular carcinoma. Huang W, Yu D, Wang M, Han Y, Lin J, Wei D, Cai J, Li B, Chen P, Zhang X. Cell Prolif. 2020 Jul;53(7):e12836. doi: 10.1111/cpr.12836. Epub 2020 Jun 14. PubMed |
| p300 promotes cell proliferation through suppressing Kaposi's sarcoma-associated herpesvirus (KSHV) reactivation in the infected B-lymphoma cells. Sun C, Guo Y, Zhou W, Xia C, Xing X, Chen J, Li X, Zhu H, Lu J. Virus Res. 2020 Sep;286:198066. doi: 10.1016/j.virusres.2020.198066. Epub 2020 Jun 15. PubMed |
| CD3xCD19 DART molecule treatment induces non-apoptotic killing and is efficient against high-risk chemotherapy and venetoclax-resistant chronic lymphocytic leukemia cells. Martens AWJ, Janssen SR, Derks IAM, Adams Iii HC, Izhak L, van Kampen R, Tonino SH, Eldering E, van der Windt GJW, Kater AP. J Immunother Cancer. 2020 Jun;8(1). pii: jitc-2019-000218. doi: 10.1136/jitc-2019-000218. PubMed |
| Loss of polycystins suppresses deciliation via the activation of the centrosomal integrity pathway. Gerakopoulos V, Ngo P, Tsiokas L. Life Sci Alliance. 2020 Jul 10;3(9). pii: 3/9/e202000750. doi: 10.26508/lsa.202000750. Print 2020 Sep. PubMed |
| NuRD subunit CHD4 regulates super-enhancer accessibility in rhabdomyosarcoma and represents a general tumor dependency. Marques JG, Gryder BE, Pavlovic B, Chung Y, Ngo QA, Frommelt F, Gstaiger M, Song Y, Benischke K, Laubscher D, Wachtel M, Khan J, Schafer BW. Elife. 2020 Aug 3;9. pii: 54993. doi: 10.7554/eLife.54993. PubMed |
| A Single Mutation in the VP1 Gene of Enterovirus 71 Enhances Viral Binding to Heparan Sulfate and Impairs Viral Pathogenicity in Mice. Ke X, Zhang Y, Liu Y, Miao Y, Zheng C, Luo D, Sun J, Hu Q, Xu Y, Wang H, Zheng Z. Viruses. 2020 Aug 13;12(8). pii: v12080883. doi: 10.3390/v12080883. PubMed |
| Essential role of autophagy in restricting poliovirus infection revealed by identification of an ATG7 defect in a poliomyelitis patient. Brinck Andersen NS, Jorgensen SE, Skipper KA, Larsen SM, Heinz J, Thomsen MM, Farahani E, Cai Y, Hait AS, Kay L, Giehm Mikkelsen J, Hogsbjerg Schleimann M, Thomsen MK, Paludan SR, Mogensen TH. Autophagy. 2021 Sep;17(9):2449-2464. doi: 10.1080/15548627.2020.1831800. Epub 2020 Oct 20. PubMed |
| TGFbetaR-SMAD3 Signaling Induces Resistance to PARP Inhibitors in the Bone Marrow Microenvironment. Le BV, Podszywalow-Bartnicka P, Maifrede S, Sullivan-Reed K, Nieborowska-Skorska M, Golovine K, Yao JC, Nejati R, Cai KQ, Caruso LB, Swatler J, Dabrowski M, Lian Z, Valent P, Paietta EM, Levine RL, Fernandez HF, Tallman MS, Litzow MR, Huang J, Challen GA, Link D, Tempera I, Wasik MA, Piwocka K, Skorski T. Cell Rep. 2020 Oct 6;33(1):108221. doi: 10.1016/j.celrep.2020.108221. PubMed |
| Novel FGFR4-Targeting Single-Domain Antibodies for Multiple Targeted Therapies against Rhabdomyosarcoma. Alijaj N, Moutel S, Gouveia ZL, Gray M, Roveri M, Dzhumashev D, Weber F, Meier G, Luciani P, Rossler JK, Schafer BW, Perez F, Bernasconi M. Cancers (Basel). 2020 Nov 10;12(11). pii: cancers12113313. doi: 10.3390/cancers12113313. PubMed |
| Stromal cells promote chemoresistance of acute myeloid leukemia cells via activation of the IL-6/STAT3/OXPHOS axis. Hou D, Wang B, You R, Wang X, Liu J, Zhan W, Chen P, Qin T, Zhang X, Huang H. Ann Transl Med. 2020 Nov;8(21):1346. doi: 10.21037/atm-20-3191. PubMed |
| PRMT1 enhances oncogenic arginine methylation of NONO in colorectal cancer. Yin XK, Wang YL, Wang F, Feng WX, Bai SM, Zhao WW, Feng LL, Wei MB, Qin CL, Wang F, Chen ZL, Yi HJ, Huang Y, Xie PY, Kim T, Wang YN, Hou JW, Li CW, Liu Q, Fan XJ, Hung MC, Wan XB. Oncogene. 2021 Feb;40(7):1375-1389. doi: 10.1038/s41388-020-01617-0. Epub 2021 Jan 8. PubMed |
| CD73 and cN-II regulate the cellular response to chemotherapeutic and hypoxic stress in lung adenocarcinoma cells. Raza MZ, Cadassou O, Dumontet C, Cros-Perrial E, Jordheim LP. Biochim Biophys Acta Gen Subj. 2021 May;1865(5):129842. doi: 10.1016/j.bbagen.2021.129842. Epub 2021 Jan 9. PubMed |
| Tetracyclines promote survival and fitness in mitochondrial disease models. Perry EA, Bennett CF, Luo C, Balsa E, Jedrychowski M, O'Malley KE, Latorre-Muro P, Ladley RP, Reda K, Wright PM, Gygi SP, Myers AG, Puigserver P. Nat Metab. 2021 Jan;3(1):33-42. doi: 10.1038/s42255-020-00334-y. Epub 2021 Jan 18. PubMed |
| Mutant p53 suppresses innate immune signaling to promote tumorigenesis. Ghosh M, Saha S, Bettke J, Nagar R, Parrales A, Iwakuma T, van der Velden AWM, Martinez LA. Cancer Cell. 2021 Apr 12;39(4):494-508.e5. doi: 10.1016/j.ccell.2021.01.003. Epub 2021 Feb 4. PubMed |
| Chromosomal translocation t(11;14) and p53 deletion induced by the CRISPR/Cas9 system in normal B cell-derived iPS cells. Azami Y, Tsuyama N, Abe Y, Sugai-Takahashi M, Kudo KI, Ota A, Sivasundaram K, Muramatsu M, Shigemura T, Sasatani M, Hashimoto Y, Saji S, Kamiya K, Hanamura I, Ikezoe T, Onodera M, Sakai A. Sci Rep. 2021 Mar 4;11(1):5216. doi: 10.1038/s41598-021-84628-5. PubMed |
| MECOM permits pancreatic acinar cell dedifferentiation avoiding cell death under stress conditions. Backx E, Wauters E, Baldan J, Van Bulck M, Michiels E, Heremans Y, De Paep DL, Kurokawa M, Goyama S, Bouwens L, Jacquemin P, Houbracken I, Rooman I. Cell Death Differ. 2021 Sep;28(9):2601-2615. doi: 10.1038/s41418-021-00771-6. Epub 2021 Mar 24. PubMed |
| Sensitivity of cells to ATR and CHK1 inhibitors requires hyperactivation of CDK2 rather than endogenous replication stress or ATM dysfunction. Ditano JP, Donahue KL, Tafe LJ, McCleery CF, Eastman A. Sci Rep. 2021 Mar 29;11(1):7077. doi: 10.1038/s41598-021-86490-x. PubMed |
| Targeted Therapy to beta3 Integrin Reduces Chemoresistance in Breast Cancer Bone Metastases. Fox GC, Su X, Davis JL, Xu Y, Kwakwa KA, Ross MH, Fontana F, Xiang J, Esser AK, Cordell E, Pagliai K, Dang HX, Sivapackiam J, Stewart SA, Maher CA, Bakewell SJ, Fitzpatrick JAJ, Sharma V, Achilefu S, Veis DJ, Lanza GM, Weilbaecher KN. Mol Cancer Ther. 2021 Jun;20(6):1183-1198. doi: 10.1158/1535-7163.MCT-20-0931. Epub 2021 Mar 30. PubMed |
| G3BP1 Inhibition Alleviates Intracellular Nucleic Acid-Induced Autoimmune Responses. Cai H, Liu X, Zhang F, Han QY, Liu ZS, Xue W, Guo ZL, Zhao JM, Sun LM, Wang N, Mao J, He K, Xia T, Chen Y, Chen L, Li AL, Zhou T, Zhang XM, Li WH, Li T. J Immunol. 2021 May 15;206(10):2453-2467. doi: 10.4049/jimmunol.2001111. Epub 2021 May 3. PubMed |
| Antibody-mediated depletion of CCR10+EphA3+ cells ameliorates fibrosis in IPF. Hohmann MS, Habiel DM, Espindola MS, Huang G, Jones I, Narayanan R, Coelho AL, Oldham JM, Noth I, Ma SF, Kurkciyan A, McQualter JL, Carraro G, Stripp B, Chen P, Jiang D, Noble PW, Parks W, Woronicz J, Yarranton G, Murray LA, Hogaboam CM. JCI Insight. 2021 Jun 8;6(11). pii: 141061. doi: 10.1172/jci.insight.141061. PubMed |
| CBFB cooperates with p53 to maintain TAp73 expression and suppress breast cancer. Malik N, Yan H, Yang HH, Ayaz G, DuBois W, Tseng YC, Kim YI, Jiang S, Liu C, Lee M, Huang J. PLoS Genet. 2021 May 4;17(5):e1009553. doi: 10.1371/journal.pgen.1009553. eCollection 2021 May. PubMed |
| Discovery of Candidate DNA Methylation Cancer Driver Genes. Pan H, Renaud L, Chaligne R, Bloehdorn J, Tausch E, Mertens D, Fink AM, Fischer K, Zhang C, Betel D, Gnirke A, Imielinski M, Moreaux J, Hallek M, Meissner A, Stilgenbauer S, Wu CJ, Elemento O, Landau DA. Cancer Discov. 2021 Sep;11(9):2266-2281. doi: 10.1158/2159-8290.CD-20-1334. Epub 2021 May 10. PubMed |
| Human ribonuclease 1 serves as a secretory ligand of ephrin A4 receptor and induces breast tumor initiation. Lee HH, Wang YN, Yang WH, Xia W, Wei Y, Chan LC, Wang YH, Jiang Z, Xu S, Yao J, Qiu Y, Hsu YH, Hwang WL, Yan M, Cha JH, Hsu JL, Shen J, Ye Y, Wu X, Hou MF, Tseng LM, Wang SC, Pan MR, Yang CH, Wang YL, Yamaguchi H, Pang D, Hortobagyi GN, Yu D, Hung MC. Nat Commun. 2021 May 13;12(1):2788. doi: 10.1038/s41467-021-23075-2. PubMed |
| Glycolipid toxicity induces osteogenic dysfunction via the TLR4/S100B pathway. Liang B, Shen X, Lan C, Lin Y, Li C, Zhong S, Yan S. Int Immunopharmacol. 2021 Aug;97:107792. doi: 10.1016/j.intimp.2021.107792. Epub 2021 May 26. PubMed |
| Mitochondrial Ca(2+) oscillation induces mitophagy initiation through the PINK1-Parkin pathway. Yu Z, Wang H, Tang W, Wang S, Tian X, Zhu Y, He H. Cell Death Dis. 2021 Jun 19;12(7):632. doi: 10.1038/s41419-021-03913-3. PubMed |
| Bromodomain-containing protein 9 is a prognostic biomarker associated with immune infiltrates and promotes tumor malignancy through activating notch signaling pathway in negative HIF-2alpha clear cell renal cell carcinoma. Lou W, Gao K, Xu C, Li Q. IUBMB Life. 2021 Nov;73(11):1334-1347. doi: 10.1002/iub.2547. Epub 2021 Aug 29. PubMed |
| Fluorescent tagging of endogenous proteins with CRISPR/Cas9 in primary mouse neural stem cells. Morrow CS, Porter TJ, Moore DL. STAR Protoc. 2021 Aug 14;2(3):100744. doi: 10.1016/j.xpro.2021.100744. eCollection 2021 Sep 17. PubMed |
| Reshaping of the androgen-driven chromatin landscape in normal prostate cells by early cancer drivers and effect on therapeutic sensitivity. Grbesa I, Augello MA, Liu D, McNally DR, Gaffney CD, Huang D, Lin K, Ivenitsky D, Goueli R, Robinson BD, Khani F, Deonarine LD, Blattner M, Elemento O, Davicioni E, Sboner A, Barbieri CE. Cell Rep. 2021 Sep 7;36(10):109625. doi: 10.1016/j.celrep.2021.109625. PubMed |
| MEF2D-NR4A1-FAM134B2-mediated reticulophagy contributes to amino acid homeostasis. Shiozaki Y, Miyazaki-Anzai S, Keenan AL, Miyazaki M. Autophagy. 2021 Sep 14:1-13. doi: 10.1080/15548627.2021.1968228. PubMed |
| INK4 Tumor Suppressor Proteins Mediate Resistance to CDK4/6 Kinase Inhibitors. Li Q, Jiang B, Guo J, Shao H, Del Priore IS, Chang Q, Kudo R, Li Z, Razavi P, Liu B, Boghossian AS, Rees MG, Ronan MM, Roth JA, Donovan KA, Palafox M, Reis-Filho JS, de Stanchina E, Fischer ES, Rosen N, Serra V, Koff A, Chodera JD, Gray NS, Chandarlapaty S. Cancer Discov. 2022 Feb;12(2):356-371. doi: 10.1158/2159-8290.CD-20-1726. Epub 2021 Sep 20. PubMed |
| Unraveling the hidden role of a uORF-encoded peptide as a kinase inhibitor of PKCs. Jayaram DR, Frost S, Argov C, Liju VB, Anto NP, Muraleedharan A, Ben-Ari A, Sinay R, Smoly I, Novoplansky O, Isakov N, Toiber D, Keasar C, Elkabets M, Yeger-Lotem E, Livneh E. Proc Natl Acad Sci U S A. 2021 Oct 5;118(40). pii: 2018899118. doi: 10.1073/pnas.2018899118. Epub 2021 Sep 30. PubMed |
| Activation of the NRF2 antioxidant program sensitizes tumors to G6PD inhibition. Ding H, Chen Z, Wu K, Huang SM, Wu WL, LeBoeuf SE, Pillai RG, Rabinowitz JD, Papagiannakopoulos T. Sci Adv. 2021 Nov 19;7(47):eabk1023. doi: 10.1126/sciadv.abk1023. Epub 2021 Nov 17. PubMed |
| Targeting the spliceosome through RBM39 degradation results in exceptional responses in high-risk neuroblastoma models. Singh S, Quarni W, Goralski M, Wan S, Jin H, Van de Velde LA, Fang J, Wu Q, Abu-Zaid A, Wang T, Singh R, Craft D, Fan Y, Confer T, Johnson M, Akers WJ, Wang R, Murray PJ, Thomas PG, Nijhawan D, Davidoff AM, Yang J. Sci Adv. 2021 Nov 19;7(47):eabj5405. doi: 10.1126/sciadv.abj5405. Epub 2021 Nov 17. PubMed |
| Glutamine deprivation triggers NAGK-dependent hexosamine salvage. Campbell S, Mesaros C, Izzo L, Affronti H, Noji M, Schaffer BE, Tsang T, Sun K, Trefely S, Kruijning S, Blenis J, Blair IA, Wellen KE. Elife. 2021 Nov 30;10. pii: 62644. doi: 10.7554/eLife.62644. PubMed |
| Extracellular cathepsin Z signals through the alpha5 integrin and augments NLRP3 inflammasome activation. Campden RI, Warren AL, Greene CJ, Chiriboga JA, Arnold CR, Aggarwal D, McKenna N, Sandall CF, MacDonald JA, Yates RM. J Biol Chem. 2022 Jan;298(1):101459. doi: 10.1016/j.jbc.2021.101459. Epub 2021 Dec 2. PubMed |
| GLP-1 Induces the Expression of FNDC5 Derivatives That Execute Lipolytic Actions. Li H, Donelan W, Wang F, Zhang P, Yang L, Ding Y, Tang D, Li S. Front Cell Dev Biol. 2021 Nov 11;9:777026. doi: 10.3389/fcell.2021.777026. eCollection 2021. PubMed |
| RB expression confers sensitivity to CDK4/6 inhibitor-mediated radiosensitization across breast cancer subtypes. Pesch AM, Hirsh NH, Michmerhuizen AR, Jungles KM, Wilder-Romans K, Chandler BC, Liu M, Lerner LM, Nino CA, Ward C, Cobain EF, Lawrence TS, Pierce LJ, Rae JM, Speers CW. JCI Insight. 2022 Feb 8;7(3). pii: 154402. doi: 10.1172/jci.insight.154402. PubMed |
| Efficient gene editing through an intronic selection marker in cells. Wang S, Li Y, Zhong L, Wu K, Zhang R, Kang T, Wu S, Wu Y. Cell Mol Life Sci. 2022 Jan 31;79(2):111. doi: 10.1007/s00018-022-04152-1. PubMed |
| Tousled-like kinase 2 targets ASF1 histone chaperones through client mimicry. Simon B, Lou HJ, Huet-Calderwood C, Shi G, Boggon TJ, Turk BE, Calderwood DA. Nat Commun. 2022 Feb 8;13(1):749. doi: 10.1038/s41467-022-28427-0. PubMed |
| The arginine methyltransferase PRMT7 promotes extravasation of monocytes resulting in tissue injury in COPD. Gunes Gunsel G, Conlon TM, Jeridi A, Kim R, Ertuz Z, Lang NJ, Ansari M, Novikova M, Jiang D, Strunz M, Gaianova M, Hollauer C, Gabriel C, Angelidis I, Doll S, Pestoni JC, Edelmann SL, Kohlhepp MS, Guillot A, Bassler K, Van Eeckhoutte HP, Kayalar O, Konyalilar N, Kanashova T, Rodius S, Ballester-Lopez C, Genes Robles CM, Smirnova N, Rehberg M, Agarwal C, Krikki I, Piavaux B, Verleden SE, Vanaudenaerde B, Konigshoff M, Dittmar G, Bracke KR, Schultze JL, Watz H, Eickelberg O, Stoeger T, Burgstaller G, Tacke F, Heissmeyer V, Rinkevich Y, Bayram H, Schiller HB, Conrad M, Schneider R, Yildirim AO. Nat Commun. 2022 Mar 14;13(1):1303. doi: 10.1038/s41467-022-28809-4. PubMed |
| Siglec Receptors Modulate Dendritic Cell Activation and Antigen Presentation to T Cells in Cancer. Wang J, Manni M, Barenwaldt A, Wieboldt R, Kirchhammer N, Ivanek R, Stanczak M, Zippelius A, Konig D, Rodrigues Manutano N, Laubli H. Front Cell Dev Biol. 2022 Mar 3;10:828916. doi: 10.3389/fcell.2022.828916. eCollection 2022. PubMed |
| Loss of Rnf31 and Vps4b sensitizes pancreatic cancer to T cell-mediated killing. Frey N, Tortola L, Egli D, Janjuha S, Rothgangl T, Marquart KF, Ampenberger F, Kopf M, Schwank G. Nat Commun. 2022 Apr 4;13(1):1804. doi: 10.1038/s41467-022-29412-3. PubMed |
| Functional Genomic Analysis of CDK4 and CDK6 Gene Dependency across Human Cancer Cell Lines. Zhang Z, Golomb L, Meyerson M. Cancer Res. 2022 Jun 6;82(11):2171-2184. doi: 10.1158/0008-5472.CAN-21-2428. PubMed |
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