pLX_311-KRAB-dCas9 Citations (16)
Originally described in: Complementary information derived from CRISPR Cas9 mediated gene deletion and suppression.Rosenbluh J, Xu H, Harrington W, Gill S, Wang X, Vazquez F, Root DE, Tsherniak A, Hahn WC Nat Commun. 2017 May 23;8:15403. doi: 10.1038/ncomms15403. PubMed Journal
Articles Citing pLX_311-KRAB-dCas9
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| Modulating Gene Expression in Epstein-Barr Virus (EBV)-Positive B Cell Lines with CRISPRa and CRISPRi. Wang LW, Trudeau SJ, Wang C, Gerdt C, Jiang S, Zhao B, Gewurz BE. Curr Protoc Mol Biol. 2018 Jan 16;121:31.13.1-31.13.18. doi: 10.1002/cpmb.50. PubMed |
Optimized libraries for CRISPR-Cas9 genetic screens with multiple modalities.
Sanson KR, Hanna RE, Hegde M, Donovan KF, Strand C, Sullender ME, Vaimberg EW, Goodale A, Root DE, Piccioni F, Doench JG.
Nat Commun. 2018 Dec 21;9(1):5416. doi: 10.1038/s41467-018-07901-8.
PubMed
Associated Plasmids
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| Identification of functional regulatory elements in the human genome using pooled CRISPR screens. Borys SM, Younger ST. BMC Genomics. 2020 Jan 31;21(1):107. doi: 10.1186/s12864-020-6497-0. PubMed |
| Identification of BLNK and BTK as mediators of rituximab-induced programmed cell death by CRISPR screens in GCB-subtype diffuse large B-cell lymphoma. Thomsen EA, Rovsing AB, Anderson MV, Due H, Huang J, Luo Y, Dybkaer K, Mikkelsen JG. Mol Oncol. 2020 Jun 25. doi: 10.1002/1878-0261.12753. PubMed |
| Selective Modulation of a Pan-Essential Protein as a Therapeutic Strategy in Cancer. Malone CF, Dharia NV, Kugener G, Forman AB, Rothberg MV, Abdusamad M, Gonzalez A, Kuljanin M, Robichaud AL, Conway AS, Dempster JM, Paolella BR, Dumont N, Hovestadt V, Mancias JD, Younger ST, Root DE, Golub TR, Vazquez F, Stegmaier K. Cancer Discov. 2021 Sep;11(9):2282-2299. doi: 10.1158/2159-8290.CD-20-1213. Epub 2021 Apr 21. PubMed |
| Transcription factor-mediated intestinal metaplasia and the role of a shadow enhancer. Singh H, Seruggia D, Madha S, Saxena M, Nagaraja AK, Wu Z, Zhou J, Huebner AJ, Maglieri A, Wezenbeek J, Hochedlinger K, Orkin SH, Bass AJ, Hornick JL, Shivdasani RA. Genes Dev. 2022 Jan 1;36(1-2):38-52. doi: 10.1101/gad.348983.121. Epub 2021 Dec 30. PubMed |
| Synergistic action of WDR5 and HDM2 inhibitors in SMARCB1-deficient cancer cells. Florian AC, Woodley CM, Wang J, Grieb BC, Slota MJ, Guerrazzi K, Hsu CY, Matlock BK, Flaherty DK, Lorey SL, Fesik SW, Howard GC, Liu Q, Weissmiller AM, Tansey WP. NAR Cancer. 2022 Mar 3;4(1):zcac007. doi: 10.1093/narcan/zcac007. eCollection 2022 Mar. PubMed |
| Claudin-5 binder enhances focused ultrasound-mediated opening in an in vitro blood-brain barrier model. Chen L, Sutharsan R, Lee JL, Cruz E, Asnicar B, Palliyaguru T, Wasielewska JM, Gaudin A, Song J, Leinenga G, Gotz J. Theranostics. 2022 Jan 31;12(5):1952-1970. doi: 10.7150/thno.65539. eCollection 2022. PubMed |
| Massively parallel identification of functionally consequential noncoding genetic variants in undiagnosed rare disease patients. McQuerry JA, Mclaird M, Hartin SN, Means JC, Johnston J, Pastinen T, Younger ST. Sci Rep. 2022 May 9;12(1):7576. doi: 10.1038/s41598-022-11589-8. PubMed |
| CRISPRi screening reveals regulators of tau pathology shared between exosomal and vesicle-free tau. Polanco JC, Akimov Y, Fernandes A, Briner A, Hand GR, van Roijen M, Balistreri G, Gotz J. Life Sci Alliance. 2022 Oct 31;6(1):e202201689. doi: 10.26508/lsa.202201689. Print 2023 Jan. PubMed |
| Extensive androgen receptor enhancer heterogeneity in primary prostate cancers underlies transcriptional diversity and metastatic potential. Kneppers J, Severson TM, Siefert JC, Schol P, Joosten SEP, Yu IPL, Huang CF, Morova T, Altintas UB, Giambartolomei C, Seo JH, Baca SC, Carneiro I, Emberly E, Pasaniuc B, Jeronimo C, Henrique R, Freedman ML, Wessels LFA, Lack NA, Bergman AM, Zwart W. Nat Commun. 2022 Nov 30;13(1):7367. doi: 10.1038/s41467-022-35135-2. PubMed |
| Optimized whole-genome CRISPR interference screens identify ARID1A-dependent growth regulators in human induced pluripotent stem cells. Usluer S, Hallast P, Crepaldi L, Zhou Y, Urgo K, Dincer C, Su J, Noell G, Alasoo K, El Garwany O, Gerety SS, Newman B, Dovey OM, Parts L. Stem Cell Reports. 2023 May 9;18(5):1061-1074. doi: 10.1016/j.stemcr.2023.03.008. Epub 2023 Apr 6. PubMed |
| The human Y and inactive X chromosomes similarly modulate autosomal gene expression. San Roman AK, Skaletsky H, Godfrey AK, Bokil NV, Teitz L, Singh I, Blanton LV, Bellott DW, Pyntikova T, Lange J, Koutseva N, Hughes JF, Brown L, Phou S, Buscetta A, Kruszka P, Banks N, Dutra A, Pak E, Lasutschinkow PC, Keen C, Davis SM, Lin AE, Tartaglia NR, Samango-Sprouse C, Muenke M, Page DC. bioRxiv. 2023 Jun 7:2023.06.05.543763. doi: 10.1101/2023.06.05.543763. Preprint. PubMed |
| Combinatorial CRISPR screens and lectin microarrays identify novel glycosylation regulators. Tsui CK, Twells N, Doan E, Brooks J, Kulepa A, Webster B, Mahal LK, Dillin A. bioRxiv [Preprint]. 2023 Oct 24:2023.10.23.563662. doi: 10.1101/2023.10.23.563662. PubMed |
| The Parkinson's disease risk gene cathepsin B promotes fibrillar alpha-synuclein clearance, lysosomal function and glucocerebrosidase activity in dopaminergic neurons. Jones-Tabah J, He K, Senkevich K, Karpilovsky N, Deyab G, Cousineau Y, Nikanorova D, Goldsmith T, Del Cid Pellitero E, Chen CX, Luo W, You Z, Abdian N, Pietrantonio I, Goiran T, Ahmad J, Ruskey JA, Asayesh F, Spiegelman D, Waters C, Monchi O, Dauvilliers Y, Dupre N, Miliukhina I, Timofeeva A, Emelyanov A, Pchelina S, Greenbaum L, Hassin-Baer S, Alcalay RN, Milnerwood A, Durcan TM, Gan-Or Z, Fon EA. bioRxiv [Preprint]. 2023 Nov 15:2023.11.11.566693. doi: 10.1101/2023.11.11.566693. PubMed |
| The Parkinson's disease risk gene cathepsin B promotes fibrillar alpha-synuclein clearance, lysosomal function and glucocerebrosidase activity in dopaminergic neurons. Jones-Tabah J, He K, Senkevich K, Karpilovsky N, Deyab G, Cousineau Y, Nikanorova D, Goldsmith T, Del-Cid Pellitero E, Chen CX, Luo W, You Z, Abdian N, Pietrantonio I, Goiran T, Ahmad J, Ruskey JA, Asayesh F, Spiegelman D, Waters C, Monchi O, Dauvilliers Y, Dupre N, Miliukhina I, Timofeeva A, Emelyanov A, Pchelina S, Greenbaum L, HassinBaer S, Alcalay RN, Milnerwood A, Durcan TM, Gan-Or Z, Fon EA. Res Sq [Preprint]. 2024 Mar 19:rs.3.rs-3979098. doi: 10.21203/rs.3.rs-3979098/v1. PubMed |
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