Lenti-dCas9-KRAB-blast Citations (57)
Originally described in: Multiplexed Engineering and Analysis of Combinatorial Enhancer Activity in Single Cells.Xie S, Duan J, Li B, Zhou P, Hon GC Mol Cell. 2017 Apr 20;66(2):285-299.e5. doi: 10.1016/j.molcel.2017.03.007. Epub 2017 Apr 13. PubMed Journal
Articles Citing Lenti-dCas9-KRAB-blast
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| Risk SNP-Mediated Promoter-Enhancer Switching Drives Prostate Cancer through lncRNA PCAT19. Hua JT, Ahmed M, Guo H, Zhang Y, Chen S, Soares F, Lu J, Zhou S, Wang M, Li H, Larson NB, McDonnell SK, Patel PS, Liang Y, Yao CQ, van der Kwast T, Lupien M, Feng FY, Zoubeidi A, Tsao MS, Thibodeau SN, Boutros PC, He HH. Cell. 2018 Jul 26;174(3):564-575.e18. doi: 10.1016/j.cell.2018.06.014. Epub 2018 Jul 19. PubMed |
| Enhancer Domains in Gastrointestinal Stromal Tumor Regulate KIT Expression and Are Targetable by BET Bromodomain Inhibition. Hemming ML, Lawlor MA, Andersen JL, Hagan T, Chipashvili O, Scott TG, Raut CP, Sicinska E, Armstrong SA, Demetri GD, Bradner JE. Cancer Res. 2019 Mar 1;79(5):994-1009. doi: 10.1158/0008-5472.CAN-18-1888. Epub 2019 Jan 10. PubMed |
| Experimental and Computational Approaches for Single-Cell Enhancer Perturbation Assay. Xie S, Hon GC. Methods Mol Biol. 2019;1935:203-221. doi: 10.1007/978-1-4939-9057-3_14. PubMed |
| Mapping cis-regulatory chromatin contacts in neural cells links neuropsychiatric disorder risk variants to target genes. Song M, Yang X, Ren X, Maliskova L, Li B, Jones IR, Wang C, Jacob F, Wu K, Traglia M, Tam TW, Jamieson K, Lu SY, Ming GL, Li Y, Yao J, Weiss LA, Dixon JR, Judge LM, Conklin BR, Song H, Gan L, Shen Y. Nat Genet. 2019 Aug;51(8):1252-1262. doi: 10.1038/s41588-019-0472-1. Epub 2019 Jul 31. PubMed |
| Allele-specific NKX2-5 binding underlies multiple genetic associations with human electrocardiographic traits. Benaglio P, D'Antonio-Chronowska A, Ma W, Yang F, Young Greenwald WW, Donovan MKR, DeBoever C, Li H, Drees F, Singhal S, Matsui H, van Setten J, Sotoodehnia N, Gaulton KJ, Smith EN, D'Antonio M, Rosenfeld MG, Frazer KA. Nat Genet. 2019 Oct;51(10):1506-1517. doi: 10.1038/s41588-019-0499-3. Epub 2019 Sep 30. PubMed |
| Global Analysis of Enhancer Targets Reveals Convergent Enhancer-Driven Regulatory Modules. Xie S, Armendariz D, Zhou P, Duan J, Hon GC. Cell Rep. 2019 Nov 26;29(9):2570-2578.e5. doi: 10.1016/j.celrep.2019.10.073. PubMed |
| Noncoding mutations target cis-regulatory elements of the FOXA1 plexus in prostate cancer. Zhou S, Hawley JR, Soares F, Grillo G, Teng M, Madani Tonekaboni SA, Hua JT, Kron KJ, Mazrooei P, Ahmed M, Arlidge C, Yun HY, Livingstone J, Huang V, Yamaguchi TN, Espiritu SMG, Zhu Y, Severson TM, Murison A, Cameron S, Zwart W, van der Kwast T, Pugh TJ, Fraser M, Boutros PC, Bristow RG, He HH, Lupien M. Nat Commun. 2020 Jan 23;11(1):441. doi: 10.1038/s41467-020-14318-9. PubMed |
| Proteomic Profiling of the ECM of Xenograft Breast Cancer Metastases in Different Organs Reveals Distinct Metastatic Niches. Hebert JD, Myers SA, Naba A, Abbruzzese G, Lamar JM, Carr SA, Hynes RO. Cancer Res. 2020 Apr 1;80(7):1475-1485. doi: 10.1158/0008-5472.CAN-19-2961. Epub 2020 Feb 4. PubMed |
| Squamous trans-differentiation of pancreatic cancer cells promotes stromal inflammation. Somerville TD, Biffi G, Dassler-Plenker J, Hur SK, He XY, Vance KE, Miyabayashi K, Xu Y, Maia-Silva D, Klingbeil O, Demerdash OE, Preall JB, Hollingsworth MA, Egeblad M, Tuveson DA, Vakoc CR. Elife. 2020 Apr 24;9. pii: 53381. doi: 10.7554/eLife.53381. PubMed |
| LINC00261 Is Differentially Expressed in Pancreatic Cancer Subtypes and Regulates a Pro-Epithelial Cell Identity. Dorn A, Glass M, Neu CT, Heydel B, Huttelmaier S, Gutschner T, Haemmerle M. Cancers (Basel). 2020 May 13;12(5). pii: cancers12051227. doi: 10.3390/cancers12051227. PubMed |
| Cell-type-specific 3D epigenomes in the developing human cortex. Song M, Pebworth MP, Yang X, Abnousi A, Fan C, Wen J, Rosen JD, Choudhary MNK, Cui X, Jones IR, Bergenholtz S, Eze UC, Juric I, Li B, Maliskova L, Lee J, Liu W, Pollen AA, Li Y, Wang T, Hu M, Kriegstein AR, Shen Y. Nature. 2020 Nov;587(7835):644-649. doi: 10.1038/s41586-020-2825-4. Epub 2020 Oct 14. PubMed |
| CRISPRi enables isoform-specific loss-of-function screens and identification of gastric cancer-specific isoform dependencies. Davies R, Liu L, Taotao S, Tuano N, Chaturvedi R, Huang KK, Itman C, Mandoli A, Qamra A, Hu C, Powell D, Daly RJ, Tan P, Rosenbluh J. Genome Biol. 2021 Jan 26;22(1):47. doi: 10.1186/s13059-021-02266-6. PubMed |
| CRISPRi screens reveal a DNA methylation-mediated 3D genome dependent causal mechanism in prostate cancer. Ahmed M, Soares F, Xia JH, Yang Y, Li J, Guo H, Su P, Tian Y, Lee HJ, Wang M, Akhtar N, Houlahan KE, Bosch A, Zhou S, Mazrooei P, Hua JT, Chen S, Petricca J, Zeng Y, Davies A, Fraser M, Quigley DA, Feng FY, Boutros PC, Lupien M, Zoubeidi A, Wang L, Walsh MJ, Wang T, Ren S, Wei GH, He HH. Nat Commun. 2021 Mar 19;12(1):1781. doi: 10.1038/s41467-021-21867-0. PubMed |
| STING enhances cell death through regulation of reactive oxygen species and DNA damage. Hayman TJ, Baro M, MacNeil T, Phoomak C, Aung TN, Cui W, Leach K, Iyer R, Challa S, Sandoval-Schaefer T, Burtness BA, Rimm DL, Contessa JN. Nat Commun. 2021 Apr 19;12(1):2327. doi: 10.1038/s41467-021-22572-8. PubMed |
| Functional mapping of androgen receptor enhancer activity. Huang CF, Lingadahalli S, Morova T, Ozturan D, Hu E, Yu IPL, Linder S, Hoogstraat M, Stelloo S, Sar F, van der Poel H, Altintas UB, Saffarzadeh M, Le Bihan S, McConeghy B, Gokbayrak B, Feng FY, Gleave ME, Bergman AM, Collins C, Hach F, Zwart W, Emberly E, Lack NA. Genome Biol. 2021 May 11;22(1):149. doi: 10.1186/s13059-021-02339-6. PubMed |
| Enhancer release and retargeting activates disease-susceptibility genes. Oh S, Shao J, Mitra J, Xiong F, D'Antonio M, Wang R, Garcia-Bassets I, Ma Q, Zhu X, Lee JH, Nair SJ, Yang F, Ohgi K, Frazer KA, Zhang ZD, Li W, Rosenfeld MG. Nature. 2021 Jul;595(7869):735-740. doi: 10.1038/s41586-021-03577-1. Epub 2021 May 26. PubMed |
| Establishment of two homozygous CRISPR interference (CRISPRi) knock-in human induced pluripotent stem cell (hiPSC) lines for titratable endogenous gene repression. Schoger E, Zimmermann WH, Cyganek L, Zelarayan LC. Stem Cell Res. 2021 Aug;55:102473. doi: 10.1016/j.scr.2021.102473. Epub 2021 Jul 27. PubMed |
| Paralogous synthetic lethality underlies genetic dependencies of the cancer-mutated gene STAG2. Bailey ML, Tieu D, Habsid A, Tong AHY, Chan K, Moffat J, Hieter P. Life Sci Alliance. 2021 Aug 30;4(11). pii: 4/11/e202101083. doi: 10.26508/lsa.202101083. Print 2021 Nov. PubMed |
| Novel regulators of PrPC biosynthesis revealed by genome-wide RNA interference. Heinzer D, Avar M, Pease DP, Dhingra A, Yin JA, Schaper E, Dogancay B, Emmenegger M, Spinelli A, Maggi K, Chincisan A, Mead S, Hornemann S, Heutink P, Aguzzi A. PLoS Pathog. 2021 Oct 27;17(10):e1010013. doi: 10.1371/journal.ppat.1010013. eCollection 2021 Oct. PubMed |
| H3K27ac HiChIP in prostate cell lines identifies risk genes for prostate cancer susceptibility. Giambartolomei C, Seo JH, Schwarz T, Freund MK, Johnson RD, Spisak S, Baca SC, Gusev A, Mancuso N, Pasaniuc B, Freedman ML. Am J Hum Genet. 2021 Dec 2;108(12):2284-2300. doi: 10.1016/j.ajhg.2021.11.007. Epub 2021 Nov 24. PubMed |
| MNX1-HNF1B Axis Is Indispensable for Intraductal Papillary Mucinous Neoplasm Lineages. Kato H, Tateishi K, Fujiwara H, Nakatsuka T, Yamamoto K, Kudo Y, Hayakawa Y, Nakagawa H, Tanaka Y, Ijichi H, Otsuka M, Iwadate D, Oyama H, Kanai S, Noguchi K, Suzuki T, Sato T, Hakuta R, Ishigaki K, Saito K, Saito T, Takahara N, Kishikawa T, Hamada T, Takahashi R, Miyabayashi K, Mizuno S, Kogure H, Nakai Y, Hirata Y, Toyoda A, Ichikawa K, Qu W, Morishita S, Arita J, Tanaka M, Ushiku T, Hasegawa K, Fujishiro M, Koike K. Gastroenterology. 2022 Apr;162(4):1272-1287.e16. doi: 10.1053/j.gastro.2021.12.254. Epub 2021 Dec 22. PubMed |
| Computational identification of clonal cells in single-cell CRISPR screens. Wang Y, Xie S, Armendariz D, Hon GC. BMC Genomics. 2022 Feb 15;23(1):135. doi: 10.1186/s12864-022-08359-1. PubMed |
| The histone demethylase PHF8 regulates TGFbeta signaling and promotes melanoma metastasis. Moubarak RS, de Pablos-Aragoneses A, Ortiz-Barahona V, Gong Y, Gowen M, Dolgalev I, Shadaloey SAA, Argibay D, Karz A, Von Itter R, Vega-Saenz de Miera EC, Sokolova E, Darvishian F, Tsirigos A, Osman I, Hernando E. Sci Adv. 2022 Feb 18;8(7):eabi7127. doi: 10.1126/sciadv.abi7127. Epub 2022 Feb 18. PubMed |
| Enhancer RNA Transcription Is Essential for a Novel CSF1 Enhancer in Triple-Negative Breast Cancer. Lewis MW, Wisniewska K, King CM, Li S, Coffey A, Kelly MR, Regner MJ, Franco HL. Cancers (Basel). 2022 Apr 6;14(7). pii: cancers14071852. doi: 10.3390/cancers14071852. PubMed |
| Analysis of estrogen-regulated enhancer RNAs identifies a functional motif required for enhancer assembly and gene expression. Hou TY, Kraus WL. Cell Rep. 2022 Jun 14;39(11):110944. doi: 10.1016/j.celrep.2022.110944. PubMed |
| Inhibition of a Chromatin and Transcription Modulator, SLTM, Increases HIV-1 Reactivation Identified by a CRISPR Inhibition Screen. Pedersen SF, Collora JA, Kim RN, Yang K, Razmi A, Catalano AA, Yeh YJ, Mounzer K, Tebas P, Montaner LJ, Ho YC. J Virol. 2022 Jul 13;96(13):e0057722. doi: 10.1128/jvi.00577-22. Epub 2022 Jun 22. PubMed |
| A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer. Kelly MR, Wisniewska K, Regner MJ, Lewis MW, Perreault AA, Davis ES, Phanstiel DH, Parker JS, Franco HL. Nat Commun. 2022 Jul 22;13(1):4247. doi: 10.1038/s41467-022-31919-8. PubMed |
| Epigenetic activation of the FLT3 gene by ZNF384 fusion confers a therapeutic susceptibility in acute lymphoblastic leukemia. Zhao X, Wang P, Diedrich JD, Smart B, Reyes N, Yoshimura S, Zhang J, Yang W, Barnett K, Xu B, Li Z, Huang X, Yu J, Crews K, Yeoh AEJ, Konopleva M, Wei CL, Pui CH, Savic D, Yang JJ. Nat Commun. 2022 Sep 14;13(1):5401. doi: 10.1038/s41467-022-33143-w. PubMed |
| Therapeutic targeting the oncogenic driver EWSR1::FLI1 in Ewing sarcoma through inhibition of the FACT complex. Mo J, Tan K, Dong Y, Lu W, Liu F, Mei Y, Huang H, Zhao K, Lv Z, Ye Y, Tang Y. Oncogene. 2023 Jan;42(1):11-25. doi: 10.1038/s41388-022-02533-1. Epub 2022 Nov 10. PubMed |
| Whole genome sequencing identifies structural variants contributing to hematologic traits in the NHLBI TOPMed program. Wheeler MM, Stilp AM, Rao S, Halldorsson BV, Beyter D, Wen J, Mihkaylova AV, McHugh CP, Lane J, Jiang MZ, Raffield LM, Jun G, Sedlazeck FJ, Metcalf G, Yao Y, Bis JB, Chami N, de Vries PS, Desai P, Floyd JS, Gao Y, Kammers K, Kim W, Moon JY, Ratan A, Yanek LR, Almasy L, Becker LC, Blangero J, Cho MH, Curran JE, Fornage M, Kaplan RC, Lewis JP, Loos RJF, Mitchell BD, Morrison AC, Preuss M, Psaty BM, Rich SS, Rotter JI, Tang H, Tracy RP, Boerwinkle E, Abecasis GR, Blackwell TW, Smith AV, Johnson AD, Mathias RA, Nickerson DA, Conomos MP, Li Y, Thornorsteinsdottir U, Magnusson MK, Stefansson K, Pankratz ND, Bauer DE, Auer PL, Reiner AP. Nat Commun. 2022 Dec 8;13(1):7592. doi: 10.1038/s41467-022-35354-7. PubMed |
| PAX5 epigenetically orchestrates CD58 transcription and modulates blinatumomab response in acute lymphoblastic leukemia. Li Y, Moriyama T, Yoshimura S, Zhao X, Li Z, Yang X, Paietta E, Litzow MR, Konopleva M, Yu J, Inaba H, Ribeiro RC, Pui CH, Yang JJ. Sci Adv. 2022 Dec 14;8(50):eadd6403. doi: 10.1126/sciadv.add6403. Epub 2022 Dec 14. PubMed |
| SMAD9-MYCN positive feedback loop represents a unique dependency for MYCN-amplified neuroblastoma. Tan K, Mo J, Li M, Dong Y, Han Y, Sun X, Ma Y, Zhu K, Wu W, Lu L, Liu J, Zhao K, Zhang L, Tang Y, Lv Z. J Exp Clin Cancer Res. 2022 Dec 20;41(1):352. doi: 10.1186/s13046-022-02563-3. PubMed |
| ACTR5 controls CDKN2A and tumor progression in an INO80-independent manner. Xu X, Chan AKN, Li M, Liu Q, Mattson N, Pangeni Pokharel S, Chang WH, Yuan YC, Wang J, Moore RE, Pirrotte P, Wu J, Su R, Muschen M, Rosen ST, Chen J, Yang L, Chen CW. Sci Adv. 2022 Dec 23;8(51):eadc8911. doi: 10.1126/sciadv.adc8911. Epub 2022 Dec 23. PubMed |
| Integrative characterisation of secreted factors involved in intercellular communication between prostate epithelial or cancer cells and fibroblasts. Wu Y, Clark KC, Niranjan B, Chueh AC, Horvath LG, Taylor RA, Daly RJ. Mol Oncol. 2023 Mar;17(3):469-486. doi: 10.1002/1878-0261.13376. Epub 2023 Jan 27. PubMed |
| Signal-induced enhancer activation requires Ku70 to read topoisomerase1-DNA covalent complexes. Tan Y, Yao L, Gamliel A, Nair SJ, Taylor H, Ohgi K, Aggarwal AK, Rosenfeld MG. Nat Struct Mol Biol. 2023 Feb;30(2):148-158. doi: 10.1038/s41594-022-00883-8. Epub 2023 Feb 6. PubMed |
| An autoimmune pleiotropic SNP modulates IRF5 alternative promoter usage through ZBTB3-mediated chromatin looping. Wang Z, Liang Q, Qian X, Hu B, Zheng Z, Wang J, Hu Y, Bao Z, Zhao K, Zhou Y, Feng X, Yi X, Li J, Shi J, Liu Z, Hao J, Chen K, Yu Y, Sham PC, Lu W, Wang X, Song W, Li MJ. Nat Commun. 2023 Mar 3;14(1):1208. doi: 10.1038/s41467-023-36897-z. PubMed |
CRISPR screens identify gene targets at breast cancer risk loci.
Tuano NK, Beesley J, Manning M, Shi W, Perlaza-Jimenez L, Malaver-Ortega LF, Paynter JM, Black D, Civitarese A, McCue K, Hatzipantelis A, Hillman K, Kaufmann S, Sivakumaran H, Polo JM, Reddel RR, Band V, French JD, Edwards SL, Powell DR, Chenevix-Trench G, Rosenbluh J.
Genome Biol. 2023 Mar 29;24(1):59. doi: 10.1186/s13059-023-02898-w.
PubMed
Associated Plasmids |
| Long noncoding RNA Malat1 inhibits Tead3-Nfatc1-mediated osteoclastogenesis to suppress osteoporosis and bone metastasis. Zhao Y, Teng H, Deng Y, Sheldon M, Martinez C, Zhang J, Tian A, Sun Y, Nakagawa S, Yao F, Wang H, Ma L. Res Sq. 2023 Mar 20:rs.3.rs-2405644. doi: 10.21203/rs.3.rs-2405644/v1. Preprint. PubMed |
| MYC reshapes CTCF-mediated chromatin architecture in prostate cancer. Wei Z, Wang S, Xu Y, Wang W, Soares F, Ahmed M, Su P, Wang T, Orouji E, Xu X, Zeng Y, Chen S, Liu X, Jia T, Liu Z, Du L, Wang Y, Chen S, Wang C, He HH, Guo H. Nat Commun. 2023 Mar 30;14(1):1787. doi: 10.1038/s41467-023-37544-3. PubMed |
| Epigenetic Control of Translation Checkpoint and Tumor Progression via RUVBL1-EEF1A1 Axis. Li M, Yang L, Chan AKN, Pokharel SP, Liu Q, Mattson N, Xu X, Chang WH, Miyashita K, Singh P, Zhang L, Li M, Wu J, Wang J, Chen B, Chan LN, Lee J, Zhang XH, Rosen ST, Muschen M, Qi J, Chen J, Hiom K, Bishop AJR, Chen CW. Adv Sci (Weinh). 2023 Jun;10(17):e2206584. doi: 10.1002/advs.202206584. Epub 2023 Apr 19. PubMed |
| CHD-associated enhancers shape human cardiomyocyte lineage commitment. Armendariz DA, Goetsch SC, Sundarrajan A, Sivakumar S, Wang Y, Xie S, Munshi NV, Hon GC. Elife. 2023 Apr 25;12:e86206. doi: 10.7554/eLife.86206. PubMed |
| Identification of a DeltaNp63-Dependent Basal-Like A Subtype-Specific Transcribed Enhancer Program (B-STEP) in Aggressive Pancreatic Ductal Adenocarcinoma. Wang X, Kutschat AP, Aggrey-Fynn J, Hamdan FH, Graham RP, Wixom AQ, Souto Y, Ladigan-Badura S, Yonkus JA, Abdelrahman AM, Alva-Ruiz R, Gaedcke J, Strobel P, Kosinsky RL, Wegwitz F, Hermann P, Truty MJ, Siveke JT, Hahn SA, Hessmann E, Johnsen SA, Najafova Z. Mol Cancer Res. 2023 Sep 1;21(9):881-891. doi: 10.1158/1541-7786.MCR-22-0916. PubMed |
| Integration site-dependent HIV-1 promoter activity shapes host chromatin conformation. Collora JA, Ho YC. Genome Res. 2023 Jun;33(6):891-906. doi: 10.1101/gr.277698.123. Epub 2023 Jun 9. PubMed |
| Inhibition of a new AXL isoform (AXL3) induces apoptosis of mantle cell lymphoma cells. Gelebart P, Gjerstad ME, Benjaminsen S, Han J, Karlsen I, Mayoral Safont M, Leitch C, Fandalyuk Z, Popa M, Helgeland L, Papp B, Baran-Marszak F, McCormack E. Blood. 2023 Jun 20:blood.2022015581. doi: 10.1182/blood.2022015581. PubMed |
| Coding and non-coding elements comprise a regulatory network controlling transcription in Kaposi's sarcoma-associated herpesvirus. Morgens DW, Gulyas L, Souza AS, Glaunsinger BA. bioRxiv. 2023 Jul 8:2023.07.08.548212. doi: 10.1101/2023.07.08.548212. Preprint. PubMed |
Crosstalk between RNA m(6)A and DNA methylation regulates transposable element chromatin activation and cell fate in human pluripotent stem cells.
Sun T, Xu Y, Xiang Y, Ou J, Soderblom EJ, Diao Y.
Nat Genet. 2023 Aug;55(8):1324-1335. doi: 10.1038/s41588-023-01452-5. Epub 2023 Jul 20.
PubMed
Associated Plasmids |
| Transposable Elements Are Co-opted as Oncogenic Regulatory Elements by Lineage-Specific Transcription Factors in Prostate Cancer. Grillo G, Keshavarzian T, Linder S, Arlidge C, Mout L, Nand A, Teng M, Qamra A, Zhou S, Kron KJ, Murison A, Hawley JR, Fraser M, van der Kwast TH, Raj GV, He HH, Zwart W, Lupien M. Cancer Discov. 2023 Nov 1;13(11):2470-2487. doi: 10.1158/2159-8290.CD-23-0331. PubMed |
| An enhancer RNA recruits MLL1 to regulate transcription of Myb. Kim J, Diaz LF, Miller MJ, Leadem B, Krivega I, Dean A. bioRxiv [Preprint]. 2023 Oct 12:2023.09.26.559528. doi: 10.1101/2023.09.26.559528. PubMed |
| Enhancer regulatory networks globally connect non-coding breast cancer loci to cancer genes. Wang Y, Armendariz D, Wang L, Zhao H, Xie S, Hon GC. bioRxiv [Preprint]. 2023 Nov 20:2023.11.20.567880. doi: 10.1101/2023.11.20.567880. PubMed |
| Decoding the Epigenetics and Chromatin Loop Dynamics of Androgen Receptor-Mediated Transcription. Lack N, Altintas UB, Seo JH, Giambartolomei C, Ozturan D, Fortunato B, Nelson G, Goldman S, Adelman K, Hach F, Freedman M. Res Sq [Preprint]. 2024 Feb 2:rs.3.rs-3854707. doi: 10.21203/rs.3.rs-3854707/v1. PubMed |
| A whole-genome CRISPR screen identifies the spindle accessory checkpoint as a locus of nab-paclitaxel resistance in pancreatic cancer cells. Mondal P, Alyateem G, Mitchell AV, Gottesman MM. bioRxiv [Preprint]. 2024 Feb 15:2024.02.15.580539. doi: 10.1101/2024.02.15.580539. PubMed |
| Long noncoding RNA Malat1 protects against osteoporosis and bone metastasis. Zhao Y, Ning J, Teng H, Deng Y, Sheldon M, Shi L, Martinez C, Zhang J, Tian A, Sun Y, Nakagawa S, Yao F, Wang H, Ma L. Nat Commun. 2024 Mar 16;15(1):2384. doi: 10.1038/s41467-024-46602-3. PubMed |
| Recurrent mutations in tumor suppressor FBXW7 bypass Wnt/beta-catenin addiction in cancer. Zhong Z, Virshup DM. Sci Adv. 2024 Apr 5;10(14):eadk1031. doi: 10.1126/sciadv.adk1031. Epub 2024 Apr 3. PubMed |
| Human long noncoding RNA, VILMIR, is induced by major respiratory viral infections and modulates the host interferon response. John K, Huntress I, Smith E, Chou H, Tollison TS, Covarrubias S, Crisci E, Carpenter S, Peng X. bioRxiv [Preprint]. 2024 Mar 29:2024.03.25.586578. doi: 10.1101/2024.03.25.586578. PubMed |
| CRISPRi screens identify the lncRNA, LOUP, as a multifunctional locus regulating macrophage differentiation and inflammatory signaling. Halasz H, Malekos E, Covarrubias S, Yitiz S, Montano C, Sudek L, Katzman S, Liu SJ, Horlbeck MA, Namvar L, Weissman JS, Carpenter S. Proc Natl Acad Sci U S A. 2024 May 28;121(22):e2322524121. doi: 10.1073/pnas.2322524121. Epub 2024 May 23. PubMed |
| Defining cis-regulatory elements and transcription factors that control human cortical interneuron development. Chapman G, Determan J, Jetter H, Kaushik K, Prakasam R, Kroll KL. iScience. 2024 May 11;27(6):109967. doi: 10.1016/j.isci.2024.109967. eCollection 2024 Jun 21. PubMed |
| Pure estrogen receptor antagonists potentiate capecitabine activity in ESR1-mutant breast cancer. Grinshpun A, Russo D, Ma W, Verma A, Hermida-Prado F, Sherman S, Gaglia G, Kabraji S, Kirkner G, Hughes ME, Lin NU, Sandusky Z, Nardone A, Guarducci C, Nguyen QD, Santagata S, Nagy Z, Jeselsohn R. NPJ Breast Cancer. 2024 Jun 8;10(1):42. doi: 10.1038/s41523-024-00647-1. PubMed |
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