lentiMPH v2 Citations (49)
Originally described in: Genome-scale CRISPR-Cas9 knockout and transcriptional activation screening.Joung J, Konermann S, Gootenberg JS, Abudayyeh OO, Platt RJ, Brigham MD, Sanjana NE, Zhang F Nat Protoc. 2017 Apr;12(4):828-863. doi: 10.1038/nprot.2017.016. Epub 2017 Mar 23. PubMed Journal
Articles Citing lentiMPH v2
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| A transcribed enhancer dictates mesendoderm specification in pluripotency. Alexanian M, Maric D, Jenkinson SP, Mina M, Friedman CE, Ting CC, Micheletti R, Plaisance I, Nemir M, Maison D, Kernen J, Pezzuto I, Villeneuve D, Burdet F, Ibberson M, Leib SL, Palpant NJ, Hernandez N, Ounzain S, Pedrazzini T. Nat Commun. 2017 Nov 27;8(1):1806. doi: 10.1038/s41467-017-01804-w. PubMed |
| An Integrated Genome-wide CRISPRa Approach to Functionalize lncRNAs in Drug Resistance. Bester AC, Lee JD, Chavez A, Lee YR, Nachmani D, Vora S, Victor J, Sauvageau M, Monteleone E, Rinn JL, Provero P, Church GM, Clohessy JG, Pandolfi PP. Cell. 2018 Apr 19;173(3):649-664.e20. doi: 10.1016/j.cell.2018.03.052. PubMed |
| Risk SNP-Mediated Promoter-Enhancer Switching Drives Prostate Cancer through lncRNA PCAT19. Hua JT, Ahmed M, Guo H, Zhang Y, Chen S, Soares F, Lu J, Zhou S, Wang M, Li H, Larson NB, McDonnell SK, Patel PS, Liang Y, Yao CQ, van der Kwast T, Lupien M, Feng FY, Zoubeidi A, Tsao MS, Thibodeau SN, Boutros PC, He HH. Cell. 2018 Jul 26;174(3):564-575.e18. doi: 10.1016/j.cell.2018.06.014. Epub 2018 Jul 19. PubMed |
| Intrinsic Xenobiotic Resistance of the Intestinal Stem Cell Niche. Chee YC, Pahnke J, Bunte R, Adsool VA, Madan B, Virshup DM. Dev Cell. 2018 Sep 24;46(6):681-695.e5. doi: 10.1016/j.devcel.2018.07.023. Epub 2018 Aug 23. PubMed |
| A CRISPR Activation Screen Identifies Genes That Protect against Zika Virus Infection. Dukhovny A, Lamkiewicz K, Chen Q, Fricke M, Jabrane-Ferrat N, Marz M, Jung JU, Sklan EH. J Virol. 2019 Jul 30;93(16). pii: JVI.00211-19. doi: 10.1128/JVI.00211-19. Print 2019 Aug 15. PubMed |
| BACH1 Stabilization by Antioxidants Stimulates Lung Cancer Metastasis. Wiel C, Le Gal K, Ibrahim MX, Jahangir CA, Kashif M, Yao H, Ziegler DV, Xu X, Ghosh T, Mondal T, Kanduri C, Lindahl P, Sayin VI, Bergo MO. Cell. 2019 Jul 11;178(2):330-345.e22. doi: 10.1016/j.cell.2019.06.005. Epub 2019 Jun 27. PubMed |
| Genome-scale CRISPR activation screening identifies a role of ELAVL2-CDKN1A axis in paclitaxel resistance in esophageal squamous cell carcinoma. Zhao WS, Yan WP, Chen DB, Dai L, Yang YB, Kang XZ, Fu H, Chen P, Deng KJ, Wang XY, Xie XW, Chen HS, Chen KN. Am J Cancer Res. 2019 Jun 1;9(6):1183-1200. eCollection 2019. PubMed |
| RIPK3 upregulation confers robust proliferation and collateral cystine-dependence on breast cancer recurrence. Lin CC, Mabe NW, Lin YT, Yang WH, Tang X, Hong L, Sun T, Force J, Marks JR, Yao TP, Alvarez JV, Chi JT. Cell Death Differ. 2020 Jul;27(7):2234-2247. doi: 10.1038/s41418-020-0499-y. Epub 2020 Jan 27. PubMed |
| Genome-scale CRISPR activation screening identifies a role of LRP8 in Sorafenib resistance in Hepatocellular carcinoma. Cai J, Chen J, Wu T, Cheng Z, Tian Y, Pu C, Shi W, Suo X, Wu X, Zhang K. Biochem Biophys Res Commun. 2020 Jun 11;526(4):1170-1176. doi: 10.1016/j.bbrc.2020.04.040. Epub 2020 Apr 18. PubMed |
| CRISPR screening identifies M1AP as a new MYC regulator with a promoter-reporter system. Yamamoto A, Kurata M, Onishi I, Sugita K, Matsumura M, Ishibashi S, Ikeda M, Yamamoto K, Kitagawa M. PeerJ. 2020 May 6;8:e9046. doi: 10.7717/peerj.9046. eCollection 2020. PubMed |
| ZKSCAN3 counteracts cellular senescence by stabilizing heterochromatin. Hu H, Ji Q, Song M, Ren J, Liu Z, Wang Z, Liu X, Yan K, Hu J, Jing Y, Wang S, Zhang W, Liu GH, Qu J. Nucleic Acids Res. 2020 Jun 19;48(11):6001-6018. doi: 10.1093/nar/gkaa425. PubMed |
Direct-seq: programmed gRNA scaffold for streamlined scRNA-seq in CRISPR screen.
Song Q, Ni K, Liu M, Li Y, Wang L, Wang Y, Liu Y, Yu Z, Qi Y, Lu Z, Ma L.
Genome Biol. 2020 Jun 8;21(1):136. doi: 10.1186/s13059-020-02044-w.
PubMed
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| Human myotube formation is determined by MyoD-Myomixer/Myomaker axis. Zhang H, Wen J, Bigot A, Chen J, Shang R, Mouly V, Bi P. Sci Adv. 2020 Dec 18;6(51):eabc4062. doi: 10.1126/sciadv.abc4062. Print 2020 Dec. PubMed |
Efficient Immune Cell Genome Engineering with Enhanced CRISPR Editing Tools.
Chan W, Gottschalk RA, Yao Y, Pomerantz JL, Germain RN.
Immunohorizons. 2021 Feb 23;5(2):117-132. doi: 10.4049/immunohorizons.2000082.
PubMed
Associated Plasmids |
Proteasomal degradation of the tumour suppressor FBW7 requires branched ubiquitylation by TRIP12.
Khan OM, Almagro J, Nelson JK, Horswell S, Encheva V, Keyan KS, Clurman BE, Snijders AP, Behrens A.
Nat Commun. 2021 Apr 6;12(1):2043. doi: 10.1038/s41467-021-22319-5.
PubMed
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| Silencing of LINE-1 retrotransposons is a selective dependency of myeloid leukemia. Gu Z, Liu Y, Zhang Y, Cao H, Lyu J, Wang X, Wylie A, Newkirk SJ, Jones AE, Lee M Jr, Botten GA, Deng M, Dickerson KE, Zhang CC, An W, Abrams JM, Xu J. Nat Genet. 2021 May;53(5):672-682. doi: 10.1038/s41588-021-00829-8. Epub 2021 Apr 8. PubMed |
| In vivo genome-wide CRISPR screen reveals breast cancer vulnerabilities and synergistic mTOR/Hippo targeted combination therapy. Dai M, Yan G, Wang N, Daliah G, Edick AM, Poulet S, Boudreault J, Ali S, Burgos SA, Lebrun JJ. Nat Commun. 2021 May 24;12(1):3055. doi: 10.1038/s41467-021-23316-4. PubMed |
| Genome-wide CRISPR/Cas9 screening identifies CARHSP1 responsible for radiation resistance in glioblastoma. Zhu GD, Yu J, Sun ZY, Chen Y, Zheng HM, Lin ML, Ou-Yang S, Liu GL, Zhang JW, Shao FM. Cell Death Dis. 2021 Jul 21;12(8):724. doi: 10.1038/s41419-021-04000-3. PubMed |
Targeted regulation of transcription in primary cells using CRISPRa and CRISPRi.
Jensen TI, Mikkelsen NS, Gao Z, Fosselteder J, Pabst G, Axelgaard E, Laustsen A, Konig S, Reinisch A, Bak RO.
Genome Res. 2021 Nov;31(11):2120-2130. doi: 10.1101/gr.275607.121. Epub 2021 Aug 18.
PubMed
Associated Plasmids |
| A CRISPR knockout screen reveals new regulators of canonical Wnt signaling. Evron T, Caspi M, Kazelnik M, Shor-Nareznoy Y, Armoza-Eilat S, Kariv R, Manber Z, Elkon R, Sklan EH, Rosin-Arbesfeld R. Oncogenesis. 2021 Sep 22;10(9):63. doi: 10.1038/s41389-021-00354-7. PubMed |
| TCOF1 upregulation in triple-negative breast cancer promotes stemness and tumour growth and correlates with poor prognosis. Hu J, Lai Y, Huang H, Ramakrishnan S, Pan Y, Ma VWS, Cheuk W, So GYK, He Q, Geoffrey Lau C, Zhang L, Cho WCS, Chan KM, Wang X, Rebecca Chin Y. Br J Cancer. 2022 Jan;126(1):57-71. doi: 10.1038/s41416-021-01596-3. Epub 2021 Oct 30. PubMed |
| SEC23A rescues SEC23B-deficient congenital dyserythropoietic anemia type II. King R, Lin Z, Balbin-Cuesta G, Myers G, Friedman A, Zhu G, McGee B, Saunders TL, Kurita R, Nakamura Y, Engel JD, Reddy P, Khoriaty R. Sci Adv. 2021 Nov 26;7(48):eabj5293. doi: 10.1126/sciadv.abj5293. Epub 2021 Nov 24. PubMed |
| A genome-wide CRISPR activation screen reveals Hexokinase 1 as a critical factor in promoting resistance to multi-kinase inhibitors in hepatocellular carcinoma cells. Sofer S, Lamkiewicz K, Armoza Eilat S, Partouche S, Marz M, Moskovits N, Stemmer SM, Shlomai A, Sklan EH. FASEB J. 2022 Mar;36(3):e22191. doi: 10.1096/fj.202101507RR. PubMed |
| CRISPR activation screen identifies BCL-2 proteins and B3GNT2 as drivers of cancer resistance to T cell-mediated cytotoxicity. Joung J, Kirchgatterer PC, Singh A, Cho JH, Nety SP, Larson RC, Macrae RK, Deasy R, Tseng YY, Maus MV, Zhang F. Nat Commun. 2022 Mar 25;13(1):1606. doi: 10.1038/s41467-022-29205-8. PubMed |
| Transcription Factor 4 loss-of-function is associated with deficits in progenitor proliferation and cortical neuron content. Papes F, Camargo AP, de Souza JS, Carvalho VMA, Szeto RA, LaMontagne E, Teixeira JR, Avansini SH, Sanchez-Sanchez SM, Nakahara TS, Santo CN, Wu W, Yao H, Araujo BMP, Velho PENF, Haddad GG, Muotri AR. Nat Commun. 2022 May 2;13(1):2387. doi: 10.1038/s41467-022-29942-w. PubMed |
| The risk variant rs11836367 contributes to breast cancer onset and metastasis by attenuating Wnt signaling via regulating NTN4 expression. Yang H, Ting X, Geng YH, Xie Y, Nierenberg JL, Huo YF, Zhou YT, Huang Y, Yu YQ, Yu XY, Li XF, Ziv E, Zhang H, Fang WG, Shen Y, Tian XX. Sci Adv. 2022 Jun 10;8(23):eabn3509. doi: 10.1126/sciadv.abn3509. Epub 2022 Jun 10. PubMed |
| CRISPR activation screen identifies TGFbeta-associated PEG10 as a crucial tumor suppressor in Ewing sarcoma. Saratov V, Ngo QA, Pedot G, Sidorov S, Wachtel M, Niggli FK, Schafer BW. Sci Rep. 2022 Jun 23;12(1):10671. doi: 10.1038/s41598-022-12659-7. PubMed |
Comparative analysis of dCas9-VP64 variants and multiplexed guide RNAs mediating CRISPR activation.
Omachi K, Miner JH.
PLoS One. 2022 Jun 28;17(6):e0270008. doi: 10.1371/journal.pone.0270008. eCollection 2022.
PubMed
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| 3D Chromatin Organization Involving MEIS1 Factor in the cis-Regulatory Landscape of GJB2. Le Nabec A, Blotas C, Briset A, Collobert M, Ferec C, Moisan S. Int J Mol Sci. 2022 Jun 23;23(13). pii: ijms23136964. doi: 10.3390/ijms23136964. PubMed |
| Therapeutic targeting of ATR in alveolar rhabdomyosarcoma. Dorado Garcia H, Pusch F, Bei Y, von Stebut J, Ibanez G, Guillan K, Imami K, Gurgen D, Rolff J, Helmsauer K, Meyer-Liesener S, Timme N, Bardinet V, Chamorro Gonzalez R, MacArthur IC, Chen CY, Schulz J, Wengner AM, Furth C, Lala B, Eggert A, Seifert G, Hundsoerfer P, Kirchner M, Mertins P, Selbach M, Lissat A, Dubois F, Horst D, Schulte JH, Spuler S, You D, Dela Cruz F, Kung AL, Haase K, DiVirgilio M, Scheer M, Ortiz MV, Henssen AG. Nat Commun. 2022 Jul 25;13(1):4297. doi: 10.1038/s41467-022-32023-7. PubMed |
| Efficient Identification of the MYC Regulator with the Use of the CRISPR Library and Context-Matched Database Screenings. Tanaka Y, Kambayashi H, Yamamoto A, Onishi I, Sugita K, Matsumura M, Ishibashi S, Ikeda M, Yamamoto K, Kitagawa M, Kurata M. Int J Mol Sci. 2022 Jul 13;23(14):7723. doi: 10.3390/ijms23147723. PubMed |
| Modest increase of KIF11 expression exposes fragilities in the mitotic spindle, causing chromosomal instability. Dale KL, Armond JW, Hynds RE, Vladimirou E. J Cell Sci. 2022 Sep 1;135(17):jcs260031. doi: 10.1242/jcs.260031. Epub 2022 Aug 30. PubMed |
Gain-of-function genetic screens in human cells identify SLC transporters overcoming environmental nutrient restrictions.
Rebsamen M, Girardi E, Sedlyarov V, Scorzoni S, Papakostas K, Vollert M, Konecka J, Guertl B, Klavins K, Wiedmer T, Superti-Furga G.
Life Sci Alliance. 2022 Sep 16;5(11):e202201404. doi: 10.26508/lsa.202201404. Print 2022 Nov.
PubMed
Associated Plasmids |
| Identification of the Factor That Leads Human Mesenchymal Stem Cell Lines into Decellularized Bone. Koyanagi A, Onishi I, Muraoka K, Sato I, Sato S, Kimura T, Kishida A, Yamamoto K, Kitagawa M, Kurata M. Bioengineering (Basel). 2022 Sep 21;9(10):490. doi: 10.3390/bioengineering9100490. PubMed |
| Identification of NRAS Downstream Genes with CRISPR Activation Screening. Tatsumi A, Hirakochi H, Inoue S, Tanaka Y, Furuno H, Ikeda M, Ishibashi S, Taguchi T, Yamamoto K, Onishi I, Sachs Z, Largaespada DA, Kitagawa M, Kurata M. Biology (Basel). 2022 Oct 23;11(11):1551. doi: 10.3390/biology11111551. PubMed |
| Genome-wide gain-of-function screening characterized lncRNA regulators for tumor immune response. Wang Y, Zhao Y, Guo W, Yadav GS, Bhaskarla C, Wang Z, Wang X, Li S, Wang Y, Chen Y, Pattarayan D, Xie W, Li S, Lu B, Kammula US, Zhang M, Yang D. Sci Adv. 2022 Dec 9;8(49):eadd0005. doi: 10.1126/sciadv.add0005. Epub 2022 Dec 7. PubMed |
| Multimodal CRISPR perturbations of GWAS loci associated with coronary artery disease in vascular endothelial cells. Wunnemann F, Fotsing Tadjo T, Beaudoin M, Lalonde S, Lo KS, Kleinstiver BP, Lettre G. PLoS Genet. 2023 Mar 16;19(3):e1010680. doi: 10.1371/journal.pgen.1010680. eCollection 2023 Mar. PubMed |
| Single-cell transcriptomic atlas of mouse cochlear aging. Sun G, Zheng Y, Fu X, Zhang W, Ren J, Ma S, Sun S, He X, Wang Q, Ji Z, Cheng F, Yan K, Liu Z, Belmonte JCI, Qu J, Wang S, Chai R, Liu GH. Protein Cell. 2023 Apr 13;14(3):180-201. doi: 10.1093/procel/pwac058. PubMed |
| Deep sampling of gRNA in the human genome and deep-learning-informed prediction of gRNA activities. Zhang H, Yan J, Lu Z, Zhou Y, Zhang Q, Cui T, Li Y, Chen H, Ma L. Cell Discov. 2023 May 16;9(1):48. doi: 10.1038/s41421-023-00549-9. PubMed |
| Transcriptomic and functional analysis of ANGPTL4 overexpression in pancreatic cancer nominates targets that reverse chemoresistance. Gordon ER, Wright CA, James M, Cooper SJ. BMC Cancer. 2023 Jun 8;23(1):524. doi: 10.1186/s12885-023-11010-1. PubMed |
| Integration site-dependent HIV-1 promoter activity shapes host chromatin conformation. Collora JA, Ho YC. Genome Res. 2023 Jun;33(6):891-906. doi: 10.1101/gr.277698.123. Epub 2023 Jun 9. PubMed |
| Reducing oxidative protein folding alleviates senescence by minimizing ER-to-nucleus H(2) O(2) release. Cheng F, Ji Q, Wang L, Wang CC, Liu GH, Wang L. EMBO Rep. 2023 Aug 3;24(8):e56439. doi: 10.15252/embr.202256439. Epub 2023 Jun 12. PubMed |
| Small Extracellular Vesicle-Derived vWF Induces a Positive Feedback Loop between Tumor and Endothelial Cells to Promote Angiogenesis and Metastasis in Hepatocellular Carcinoma. Wong SWK, Tey SK, Mao X, Fung HL, Xiao ZJ, Wong DKH, Mak LY, Yuen MF, Ng IO, Yun JP, Gao Y, Yam JWP. Adv Sci (Weinh). 2023 Sep;10(26):e2302677. doi: 10.1002/advs.202302677. Epub 2023 Jun 30. PubMed |
| LRP8-mediated selenocysteine uptake is a targetable vulnerability in MYCN-amplified neuroblastoma. Alborzinia H, Chen Z, Yildiz U, Freitas FP, Vogel FCE, Varga JP, Batani J, Bartenhagen C, Schmitz W, Buchel G, Michalke B, Zheng J, Meierjohann S, Girardi E, Espinet E, Florez AF, Dos Santos AF, Aroua N, Cheytan T, Haenlin J, Schlicker L, Xavier da Silva TN, Przybylla A, Zeisberger P, Superti-Furga G, Eilers M, Conrad M, Fabiano M, Schweizer U, Fischer M, Schulze A, Trumpp A, Friedmann Angeli JP. EMBO Mol Med. 2023 Aug 7;15(8):e18014. doi: 10.15252/emmm.202318014. Epub 2023 Jul 12. PubMed |
| Reovirus infection of tumor cells reduces the expression of NKG2D ligands, leading to impaired NK-cell cytotoxicity and functionality. Khaleafi R, Zeleznjak J, Cordela S, Drucker S, Rovis TL, Jonjic S, Bar-On Y. Front Immunol. 2023 Sep 11;14:1231782. doi: 10.3389/fimmu.2023.1231782. eCollection 2023. PubMed |
| Combined in vitro/in vivo genome-wide CRISPR screens in triple negative breast cancer identify cancer stemness regulators in paclitaxel resistance. Yan G, Dai M, Poulet S, Wang N, Boudreault J, Daliah G, Ali S, Lebrun JJ. Oncogenesis. 2023 Nov 6;12(1):51. doi: 10.1038/s41389-023-00497-9. PubMed |
| CPT1A induction following epigenetic perturbation promotes MAVS palmitoylation and activation to potentiate antitumor immunity. Zhang G, Jiang P, Tang W, Wang Y, Qiu F, An J, Zheng Y, Wu D, Zhou J, Neculai D, Shi Y, Sheng W. Mol Cell. 2023 Dec 7;83(23):4370-4385.e9. doi: 10.1016/j.molcel.2023.10.043. Epub 2023 Nov 27. PubMed |
| Surplus fatty acid synthesis increases oxidative stress in adipocytes and lnduces lipodystrophy. Weng L, Tang WS, Wang X, Gong Y, Liu C, Hong NN, Tao Y, Li KZ, Liu SN, Jiang W, Li Y, Yao K, Chen L, Huang H, Zhao YZ, Hu ZP, Lu Y, Ye H, Du X, Zhou H, Li P, Zhao TJ. Nat Commun. 2024 Jan 2;15(1):133. doi: 10.1038/s41467-023-44393-7. PubMed |
| The sirtuin-associated human senescence program converges on the activation of placenta-specific gene PAPPA. Bi S, Jiang X, Ji Q, Wang Z, Ren J, Wang S, Yu Y, Wang R, Liu Z, Liu J, Hu J, Sun G, Wu Z, Diao Z, Li J, Sun L, Izpisua Belmonte JC, Zhang W, Liu GH, Qu J. Dev Cell. 2024 Apr 22;59(8):991-1009.e12. doi: 10.1016/j.devcel.2024.02.008. Epub 2024 Mar 13. PubMed |
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