Stat3-C Flag pRc/CMV Citations (34)
Originally described in: Stat3 as an oncogene.Bromberg JF, Wrzeszczynska MH, Devgan G, Zhao Y, Pestell RG, Albanese C, Darnell JE Jr Cell 1999 Aug 6;98(3):295-303. PubMed Journal
Articles Citing Stat3-C Flag pRc/CMV
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| Stat3-siRNA induces Fas-mediated apoptosis in vitro and in vivo in breast cancer. Kunigal S, Lakka SS, Sodadasu PK, Estes N, Rao JS. Int J Oncol. 2009 May;34(5):1209-20. PubMed |
| Indirubin-3'-monoxime blocks vascular smooth muscle cell proliferation by inhibition of signal transducer and activator of transcription 3 signaling and reduces neointima formation in vivo. Schwaiberger AV, Heiss EH, Cabaravdic M, Oberan T, Zaujec J, Schachner D, Uhrin P, Atanasov AG, Breuss JM, Binder BR, Dirsch VM. Arterioscler Thromb Vasc Biol. 2010 Dec;30(12):2475-81. doi: 10.1161/ATVBAHA.110.212654. Epub 2010 Sep 16. PubMed |
| SPARC stimulates neuronal differentiation of medulloblastoma cells via the Notch1/STAT3 pathway. Bhoopathi P, Chetty C, Dontula R, Gujrati M, Dinh DH, Rao JS, Lakka SS. Cancer Res. 2011 Jul 15;71(14):4908-19. doi: 10.1158/0008-5472.CAN-10-3395. Epub 2011 May 25. PubMed |
| Somatic mutations activating STAT3 in human inflammatory hepatocellular adenomas. Pilati C, Amessou M, Bihl MP, Balabaud C, Nhieu JT, Paradis V, Nault JC, Izard T, Bioulac-Sage P, Couchy G, Poussin K, Zucman-Rossi J. J Exp Med. 2011 Jul 4;208(7):1359-66. doi: 10.1084/jem.20110283. Epub 2011 Jun 20. PubMed |
| SPARC expression induces cell cycle arrest via STAT3 signaling pathway in medulloblastoma cells. Chetty C, Dontula R, Ganji PN, Gujrati M, Lakka SS. Biochem Biophys Res Commun. 2012 Jan 13;417(2):874-9. doi: 10.1016/j.bbrc.2011.12.065. Epub 2011 Dec 20. PubMed |
| Inhibition of integrin alpha2beta1 ameliorates glomerular injury. Borza CM, Su Y, Chen X, Yu L, Mont S, Chetyrkin S, Voziyan P, Hudson BG, Billings PC, Jo H, Bennett JS, Degrado WF, Eckes B, Zent R, Pozzi A. J Am Soc Nephrol. 2012 Jun;23(6):1027-38. doi: 10.1681/ASN.2011040367. Epub 2012 Mar 22. PubMed |
| JAK/STAT3 pathway inhibition blocks skeletal muscle wasting downstream of IL-6 and in experimental cancer cachexia. Bonetto A, Aydogdu T, Jin X, Zhang Z, Zhan R, Puzis L, Koniaris LG, Zimmers TA. Am J Physiol Endocrinol Metab. 2012 Aug 1;303(3):E410-21. doi: 10.1152/ajpendo.00039.2012. Epub 2012 Jun 5. PubMed |
| Targeting the intrinsic inflammatory pathway: honokiol exerts proapoptotic effects through STAT3 inhibition in transformed Barrett's cells. Yu C, Zhang Q, Zhang HY, Zhang X, Huo X, Cheng E, Wang DH, Arbiser JL, Spechler SJ, Souza RF. Am J Physiol Gastrointest Liver Physiol. 2012 Sep 1;303(5):G561-9. doi: 10.1152/ajpgi.00033.2012. Epub 2012 Jun 28. PubMed |
| Notch signaling regulates tumor-induced angiogenesis in SPARC-overexpressed neuroblastoma. Gorantla B, Bhoopathi P, Chetty C, Gogineni VR, Sailaja GS, Gondi CS, Rao JS. Angiogenesis. 2013 Jan;16(1):85-100. doi: 10.1007/s10456-012-9301-1. Epub 2012 Sep 6. PubMed |
| Defining a tissue stem cell-driven Runx1/Stat3 signalling axis in epithelial cancer. Scheitz CJ, Lee TS, McDermitt DJ, Tumbar T. EMBO J. 2012 Nov 5;31(21):4124-39. doi: 10.1038/emboj.2012.270. Epub 2012 Oct 2. PubMed |
| Essential role of cooperative NF-kappaB and Stat3 recruitment to ICAM-1 intronic consensus elements in the regulation of radiation-induced invasion and migration in glioma. Kesanakurti D, Chetty C, Rajasekhar Maddirela D, Gujrati M, Rao JS. Oncogene. 2013 Oct 24;32(43):5144-55. doi: 10.1038/onc.2012.546. Epub 2012 Nov 26. PubMed |
| Transformation of human ovarian surface epithelial cells by Kruppel-like factor 8. Lu H, Wang X, Urvalek AM, Li T, Xie H, Yu L, Zhao J. Oncogene. 2014 Jan 2;33(1):10-8. doi: 10.1038/onc.2012.545. Epub 2012 Dec 10. PubMed |
| STAT3 and HIF1alpha cooperatively activate HIF1 target genes in MDA-MB-231 and RCC4 cells. Pawlus MR, Wang L, Hu CJ. Oncogene. 2014 Mar 27;33(13):1670-9. doi: 10.1038/onc.2013.115. Epub 2013 Apr 22. PubMed |
| Isoliquiritigenin, a flavonoid from licorice, blocks M2 macrophage polarization in colitis-associated tumorigenesis through downregulating PGE2 and IL-6. Zhao H, Zhang X, Chen X, Li Y, Ke Z, Tang T, Chai H, Guo AM, Chen H, Yang J. Toxicol Appl Pharmacol. 2014 Sep 15;279(3):311-21. doi: 10.1016/j.taap.2014.07.001. Epub 2014 Jul 12. PubMed |
| A noncanonical Frizzled2 pathway regulates epithelial-mesenchymal transition and metastasis. Gujral TS, Chan M, Peshkin L, Sorger PK, Kirschner MW, MacBeath G. Cell. 2014 Nov 6;159(4):844-56. doi: 10.1016/j.cell.2014.10.032. PubMed |
| Highly pathogenic avian influenza virus infection in chickens but not ducks is associated with elevated host immune and pro-inflammatory responses. Kuchipudi SV, Tellabati M, Sebastian S, Londt BZ, Jansen C, Vervelde L, Brookes SM, Brown IH, Dunham SP, Chang KC. Vet Res. 2014 Nov 28;45:118. doi: 10.1186/s13567-014-0118-3. PubMed |
| Lysyl hydroxylase 2 induces a collagen cross-link switch in tumor stroma. Chen Y, Terajima M, Yang Y, Sun L, Ahn YH, Pankova D, Puperi DS, Watanabe T, Kim MP, Blackmon SH, Rodriguez J, Liu H, Behrens C, Wistuba II, Minelli R, Scott KL, Sanchez-Adams J, Guilak F, Pati D, Thilaganathan N, Burns AR, Creighton CJ, Martinez ED, Zal T, Grande-Allen KJ, Yamauchi M, Kurie JM. J Clin Invest. 2015 Mar 2;125(3):1147-62. doi: 10.1172/JCI74725. Epub 2015 Feb 9. PubMed |
| Matrine suppresses proliferation and induces apoptosis in human cholangiocarcinoma cells through suppression of JAK2/STAT3 signaling. Yang N, Han F, Cui H, Huang J, Wang T, Zhou Y, Zhou J. Pharmacol Rep. 2015 Apr;67(2):388-93. doi: 10.1016/j.pharep.2014.10.016. Epub 2014 Nov 5. PubMed |
| Secretion-mediated STAT3 activation promotes self-renewal of glioma stem-like cells during hypoxia. Almiron Bonnin DA, Havrda MC, Lee MC, Liu H, Zhang Z, Nguyen LN, Harrington LX, Hassanpour S, Cheng C, Israel MA. Oncogene. 2018 Feb 22;37(8):1107-1118. doi: 10.1038/onc.2017.404. Epub 2017 Nov 20. PubMed |
Interleukin-6 promotes a sustained loss of endothelial barrier function via Janus kinase-mediated STAT3 phosphorylation and de novo protein synthesis.
Alsaffar H, Martino N, Garrett JP, Adam AP.
Am J Physiol Cell Physiol. 2018 Jan 10. doi: 10.1152/ajpcell.00235.2017.
PubMed
Associated Plasmids |
| Transforming growth factor beta1 suppresses proinflammatory gene program independent of its regulation on vascular smooth muscle differentiation and autophagy. Gao P, Wu W, Ye J, Lu YW, Adam AP, Singer HA, Long X. Cell Signal. 2018 Oct;50:160-170. doi: 10.1016/j.cellsig.2018.07.002. Epub 2018 Jul 11. PubMed |
| Tmub1 negatively regulates liver regeneration via inhibiting STAT3 phosphorylation. Fu H, Dong R, Zhang Y, Xu J, Liu M, Chen P. Cell Signal. 2019 Mar;55:65-72. doi: 10.1016/j.cellsig.2018.12.013. Epub 2019 Jan 2. PubMed |
| Leukemia Inhibitory Factor Represses GnRH Gene Expression via cFOS during Inflammation in Male Mice. Lainez NM, Coss D. Neuroendocrinology. 2019 Jan 10. pii: 000496754. doi: 10.1159/000496754. PubMed |
| Epithelial CD80 promotes immune surveillance of colonic preneoplastic lesions and its expression is increased by oxidative stress through STAT3 in colon cancer cells. Marchiori C, Scarpa M, Kotsafti A, Morgan S, Fassan M, Guzzardo V, Porzionato A, Angriman I, Ruffolo C, Sut S, Dall'Acqua S, Bardini R, De Caro R, Castoro C, Scarpa M, Castagliuolo I. J Exp Clin Cancer Res. 2019 May 9;38(1):190. doi: 10.1186/s13046-019-1205-0. PubMed |
KLF4 protein stability regulated by interaction with pluripotency transcription factors overrides transcriptional control.
Dhaliwal NK, Abatti LE, Mitchell JA.
Genes Dev. 2019 Jun 20. pii: gad.324319.119. doi: 10.1101/gad.324319.119.
PubMed
Associated Plasmids |
| Differentiation-inducing factor-1 suppresses cyclin D1-induced cell proliferation of MCF-7 breast cancer cells by inhibiting S6K-mediated signal transducer and activator of transcription 3 synthesis. Tetsuo F, Arioka M, Miura K, Kai M, Kubo M, Igawa K, Tomooka K, Takahashi-Yanaga F, Nishimura F, Sasaguri T. Cancer Sci. 2019 Dec;110(12):3761-3772. doi: 10.1111/cas.14204. Epub 2019 Oct 26. PubMed |
| Threonine Phosphorylation of IkappaBzeta Mediates Inhibition of Selective Proinflammatory Target Genes. Grondona P, Bucher P, Schmitt A, Schonfeld C, Streibl B, Muller A, Essmann F, Liberatori S, Mohammed S, Hennig A, Kramer D, Schulze-Osthoff K, Hailfinger S. J Invest Dermatol. 2020 Sep;140(9):1805-1814.e6. doi: 10.1016/j.jid.2019.12.036. Epub 2020 Feb 6. PubMed |
| Inhibiting the Src/STAT3 signaling pathway contributes to the anti-melanoma mechanisms of dioscin. Liu YX, Xu BW, Chen YJ, Fu XQ, Zhu PL, Bai JX, Chou JY, Yin CL, Li JK, Wang YP, Wu JY, Wu Y, Chan KK, Liang C, Yu ZL. Oncol Lett. 2020 Mar;19(3):2508-2514. doi: 10.3892/ol.2020.11315. Epub 2020 Jan 17. PubMed |
| Kruppel-like factor 4 upregulates matrix metalloproteinase 13 expression in chondrocytes via mRNA stabilization. Takeuchi Y, Tatsuta S, Kito A, Fujikawa J, Itoh S, Itoh Y, Akiyama S, Yamashiro T, Wakisaka S, Abe M. Cell Tissue Res. 2020 Jun 15. pii: 10.1007/s00441-020-03228-3. doi: 10.1007/s00441-020-03228-3. PubMed |
| The CDK4/6-EZH2 pathway is a potential therapeutic target for psoriasis. Muller A, Dickmanns A, Resch C, Schakel K, Hailfinger S, Dobbelstein M, Schulze-Osthoff K, Kramer D. J Clin Invest. 2020 Jul 23. pii: 134217. doi: 10.1172/JCI134217. PubMed |
| Hemistepsin a Induces Apoptosis of Hepatocellular Carcinoma Cells by Downregulating STAT3. Cho IJ, Kim JK, Kim EO, Park SM, Kim SC, Ki SH, Ku SK. Int J Mol Sci. 2021 Apr 29;22(9). pii: ijms22094743. doi: 10.3390/ijms22094743. PubMed |
| Macrophage IL-1beta promotes arteriogenesis by autocrine STAT3- and NF-kappaB-mediated transcription of pro-angiogenic VEGF-A. Mantsounga CS, Lee C, Neverson J, Sharma S, Healy A, Berus JM, Parry C, Ceneri NM, Lopez-Giraldez F, Chun HJ, Lu Q, Sellke F, Choudhary G, Morrison AR. Cell Rep. 2022 Feb 1;38(5):110309. doi: 10.1016/j.celrep.2022.110309. PubMed |
| A traditional prescription comprising Astragali Radix and Schisandra chinensis Fructus induces apoptosis and protective autophagy in hepatocellular carcinoma cells. Zhu PL, Li JK, Jiang XL, Zhang SQ, Zhang Z, Wang Y, Zhang Z, Chen WQ, Yung KK. J Ethnopharmacol. 2023 Aug 10;312:116548. doi: 10.1016/j.jep.2023.116548. Epub 2023 Apr 24. PubMed |
| Pharmacological inhibition of the LIF/LIFR autocrine loop reveals vulnerability of ovarian cancer cells to ferroptosis. Ebrahimi B, Viswanadhapalli S, Pratap UP, Rahul G, Yang X, Pitta Venkata P, Drel V, Santhamma B, Konda S, Li X, Sanchez ALR, Yan H, Sareddy GR, Xu Z, Singh BB, Valente PT, Chen Y, Lai Z, Rao M, Kost ER, Curiel T, Tekmal RR, Nair HB, Vadlamudi RK. NPJ Precis Oncol. 2024 May 24;8(1):118. doi: 10.1038/s41698-024-00612-y. PubMed |
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