pcDNA3-FLAG-LKB1 Citations (19)
Originally described in: The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress.Shaw RJ, Kosmatka M, Bardeesy N, Hurley RL, Witters LA, DePinho RA, Cantley LC Proc Natl Acad Sci U S A 2004 Mar 9;101(10):3329-35. Epub 2004 Feb 25. PubMed Journal
Articles Citing pcDNA3-FLAG-LKB1
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| Sestrin2 promotes LKB1-mediated AMPK activation in the ischemic heart. Morrison A, Chen L, Wang J, Zhang M, Yang H, Ma Y, Budanov A, Lee JH, Karin M, Li J. FASEB J. 2015 Feb;29(2):408-17. doi: 10.1096/fj.14-258814. Epub 2014 Nov 3. PubMed |
| A Critical SUMO1 Modification of LKB1 Regulates AMPK Activity during Energy Stress. Ritho J, Arold ST, Yeh ET. Cell Rep. 2015 Aug 4;12(5):734-42. doi: 10.1016/j.celrep.2015.07.002. Epub 2015 Jul 23. PubMed |
| Regulation of triple-negative breast cancer cell metastasis by the tumor-suppressor liver kinase B1. Rhodes LV, Tate CR, Hoang VT, Burks HE, Gilliam D, Martin EC, Elliott S, Miller DB, Buechlein A, Rusch D, Tang H, Nephew KP, Burow ME, Collins-Burow BM. Oncogenesis. 2015 Oct 5;4:e168. doi: 10.1038/oncsis.2015.27. PubMed |
| Lysosomal recruitment of TSC2 is a universal response to cellular stress. Demetriades C, Plescher M, Teleman AA. Nat Commun. 2016 Feb 12;7:10662. doi: 10.1038/ncomms10662. PubMed |
| A Sensitive NanoString-Based Assay to Score STK11 (LKB1) Pathway Disruption in Lung Adenocarcinoma. Chen L, Engel BE, Welsh EA, Yoder SJ, Brantley SG, Chen DT, Beg AA, Cao C, Kaye FJ, Haura EB, Schabath MB, Cress WD. J Thorac Oncol. 2016 Jun;11(6):838-49. doi: 10.1016/j.jtho.2016.02.009. Epub 2016 Feb 23. PubMed |
| Focal Adhesion Kinase Inhibitors in Combination with Erlotinib Demonstrate Enhanced Anti-Tumor Activity in Non-Small Cell Lung Cancer. Howe GA, Xiao B, Zhao H, Al-Zahrani KN, Hasim MS, Villeneuve J, Sekhon HS, Goss GD, Sabourin LA, Dimitroulakos J, Addison CL. PLoS One. 2016 Mar 10;11(3):e0150567. doi: 10.1371/journal.pone.0150567. eCollection 2016. PubMed |
| Mitochondrial biogenesis is required for axonal growth. Vaarmann A, Mandel M, Zeb A, Wareski P, Liiv J, Kuum M, Antsov E, Liiv M, Cagalinec M, Choubey V, Kaasik A. Development. 2016 Jun 1;143(11):1981-92. doi: 10.1242/dev.128926. Epub 2016 Apr 27. PubMed |
| Metformin Induces Osteoblastic Differentiation of Human Induced Pluripotent Stem Cell-derived Mesenchymal Stem Cells. Wang P, Ma T, Guo D, Hu K, Shu Y, Xu HHK, Schneider A. J Tissue Eng Regen Med. 2017 May 11. doi: 10.1002/term.2470. PubMed |
| Aurora-A-mediated phosphorylation of LKB1 compromises LKB1/AMPK signaling axis to facilitate NSCLC growth and migration. Zheng X, Chi J, Zhi J, Zhang H, Yue D, Zhao J, Li D, Li Y, Gao M, Guo J. Oncogene. 2018 Jan 25;37(4):502-511. doi: 10.1038/onc.2017.354. Epub 2017 Oct 2. PubMed |
| Class III phosphatidylinositol-3-OH kinase controls epithelial integrity through endosomal LKB1 regulation. O'Farrell F, Lobert VH, Sneeggen M, Jain A, Katheder NS, Wenzel EM, Schultz SW, Tan KW, Brech A, Stenmark H, Rusten TE. Nat Cell Biol. 2017 Dec;19(12):1412-1423. doi: 10.1038/ncb3631. Epub 2017 Oct 30. PubMed |
| Liver kinase B1 restoration promotes exosome secretion and motility of lung cancer cells. Zhang C, Xiao X, Chen M, Aldharee H, Chen Y, Long W. Oncol Rep. 2018 Jan;39(1):376-382. doi: 10.3892/or.2017.6085. Epub 2017 Nov 9. PubMed |
| The PLAG1-GDH1 Axis Promotes Anoikis Resistance and Tumor Metastasis through CamKK2-AMPK Signaling in LKB1-Deficient Lung Cancer. Jin L, Chun J, Pan C, Kumar A, Zhang G, Ha Y, Li D, Alesi GN, Kang Y, Zhou L, Yu WM, Magliocca KR, Khuri FR, Qu CK, Metallo C, Owonikoko TK, Kang S. Mol Cell. 2018 Jan 4;69(1):87-99.e7. doi: 10.1016/j.molcel.2017.11.025. Epub 2017 Dec 14. PubMed |
LKB1, Salt-Inducible Kinases, and MEF2C Are Linked Dependencies in Acute Myeloid Leukemia.
Tarumoto Y, Lu B, Somerville TDD, Huang YH, Milazzo JP, Wu XS, Klingbeil O, El Demerdash O, Shi J, Vakoc CR.
Mol Cell. 2018 Feb 28. pii: S1097-2765(18)30109-6. doi: 10.1016/j.molcel.2018.02.011.
PubMed
Associated Plasmids |
| Concurrent regulation of LKB1 and CaMKK2 in the activation of AMPK in castrate-resistant prostate cancer by a well-defined polyherbal mixture with anticancer properties. MacDonald AF, Bettaieb A, Donohoe DR, Alani DS, Han A, Zhao Y, Whelan J. BMC Complement Altern Med. 2018 Jun 18;18(1):188. doi: 10.1186/s12906-018-2255-0. PubMed |
| Hyaluronidase2 (Hyal2) modulates low shear stress-induced glycocalyx impairment via the LKB1/AMPK/NADPH oxidase-dependent pathway. Yang H, Zhu L, Chao Y, Gu Y, Kong X, Chen M, Ye P, Luo J, Chen S. J Cell Physiol. 2018 Dec;233(12):9701-9715. doi: 10.1002/jcp.26944. Epub 2018 Aug 5. PubMed |
| LKB1 Deficiency Renders NSCLC Cells Sensitive to ERK Inhibitors. Caiola E, Iezzi A, Tomanelli M, Bonaldi E, Scagliotti A, Colombo M, Guffanti F, Micotti E, Garassino MC, Minoli L, Scanziani E, Broggini M, Marabese M. J Thorac Oncol. 2020 Mar;15(3):360-370. doi: 10.1016/j.jtho.2019.10.009. Epub 2019 Oct 18. PubMed |
| Suppression of m6A mRNA modification by DNA hypermethylated ALKBH5 aggravates the oncological behavior of KRAS mutation/LKB1 loss lung cancer. Zhang D, Ning J, Okon I, Zheng X, Satyanarayana G, Song P, Xu S, Zou MH. Cell Death Dis. 2021 May 20;12(6):518. doi: 10.1038/s41419-021-03793-7. PubMed |
| Functional assessment of somatic STK11 variants identified in primary human non-small cell lung cancers. Donnelly LL, Hogan TC, Lenahan SM, Nandagopal G, Eaton JG, Lebeau MA, McCann CL, Sarausky HM, Hampel KJ, Armstrong JD, Cameron MP, Sidiropoulos N, Deming P, Seward DJ. Carcinogenesis. 2021 Dec 31;42(12):1428-1438. doi: 10.1093/carcin/bgab104. PubMed |
| Redefining the role of AMPK in autophagy and the energy stress response. Park JM, Lee DH, Kim DH. Nat Commun. 2023 May 24;14(1):2994. doi: 10.1038/s41467-023-38401-z. PubMed |
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