lentiCRISPR v2-Blast Citations (80)
Originally described in: CRISPR/Cas9-based system for loss-of-function screeningHabashy et al Unpublished
Articles Citing lentiCRISPR v2-Blast
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| Interferon regulatory factor 8 regulates caspase-1 expression to facilitate Epstein-Barr virus reactivation in response to B cell receptor stimulation and chemical induction. Lv DW, Zhang K, Li R. PLoS Pathog. 2018 Jan 22;14(1):e1006868. doi: 10.1371/journal.ppat.1006868. eCollection 2018 Jan. PubMed |
| KREMEN1 Is a Host Entry Receptor for a Major Group of Enteroviruses. Staring J, van den Hengel LG, Raaben M, Blomen VA, Carette JE, Brummelkamp TR. Cell Host Microbe. 2018 May 9;23(5):636-643.e5. doi: 10.1016/j.chom.2018.03.019. Epub 2018 Apr 19. PubMed |
| Protein kinase CK2 modulation of pyruvate kinase M isoforms augments the Warburg effect in cancer cells. Yang KM, Kim K. J Cell Biochem. 2018 Nov;119(10):8501-8510. doi: 10.1002/jcb.27078. Epub 2018 Jul 17. PubMed |
| Genome-scale CRISPR-Cas9 screen identifies druggable dependencies in TP53 wild-type Ewing sarcoma. Stolte B, Iniguez AB, Dharia NV, Robichaud AL, Conway AS, Morgan AM, Alexe G, Schauer NJ, Liu X, Bird GH, Tsherniak A, Vazquez F, Buhrlage SJ, Walensky LD, Stegmaier K. J Exp Med. 2018 Aug 6;215(8):2137-2155. doi: 10.1084/jem.20171066. Epub 2018 Jul 25. PubMed |
| Cicero Predicts cis-Regulatory DNA Interactions from Single-Cell Chromatin Accessibility Data. Pliner HA, Packer JS, McFaline-Figueroa JL, Cusanovich DA, Daza RM, Aghamirzaie D, Srivatsan S, Qiu X, Jackson D, Minkina A, Adey AC, Steemers FJ, Shendure J, Trapnell C. Mol Cell. 2018 Sep 6;71(5):858-871.e8. doi: 10.1016/j.molcel.2018.06.044. Epub 2018 Aug 2. PubMed |
| GSK3 suppression upregulates beta-catenin and c-Myc to abrogate KRas-dependent tumors. Kazi A, Xiang S, Yang H, Delitto D, Trevino J, Jiang RHY, Ayaz M, Lawrence HR, Kennedy P, Sebti SM. Nat Commun. 2018 Dec 4;9(1):5154. doi: 10.1038/s41467-018-07644-6. PubMed |
| Loss of Sirtuin 1 Alters the Secretome of Breast Cancer Cells by Impairing Lysosomal Integrity. Latifkar A, Ling L, Hingorani A, Johansen E, Clement A, Zhang X, Hartman J, Fischbach C, Lin H, Cerione RA, Antonyak MA. Dev Cell. 2019 May 6;49(3):393-408.e7. doi: 10.1016/j.devcel.2019.03.011. Epub 2019 Apr 11. PubMed |
| Physical Principles of Membrane Shape Regulation by the Glycocalyx. Shurer CR, Kuo JC, Roberts LM, Gandhi JG, Colville MJ, Enoki TA, Pan H, Su J, Noble JM, Hollander MJ, O'Donnell JP, Yin R, Pedram K, Mockl L, Kourkoutis LF, Moerner WE, Bertozzi CR, Feigenson GW, Reesink HL, Paszek MJ. Cell. 2019 Jun 13;177(7):1757-1770.e21. doi: 10.1016/j.cell.2019.04.017. Epub 2019 May 2. PubMed |
| EMSY expression affects multiple components of the skin barrier with relevance to atopic dermatitis. Elias MS, Wright SC, Remenyi J, Abbott JC, Bray SE, Cole C, Edwards S, Gierlinski M, Glok M, McGrath JA, Nicholson WV, Paternoster L, Prescott AR, Have ST, Whitfield PD, Lamond AI, Brown SJ. J Allergy Clin Immunol. 2019 May 31. pii: S0091-6749(19)30741-9. doi: 10.1016/j.jaci.2019.05.024. PubMed |
| Sulfated glycosaminoglycans and low-density lipoprotein receptor contribute to Clostridium difficile toxin A entry into cells. Tao L, Tian S, Zhang J, Liu Z, Robinson-McCarthy L, Miyashita SI, Breault DT, Gerhard R, Oottamasathien S, Whelan SPJ, Dong M. Nat Microbiol. 2019 Oct;4(10):1760-1769. doi: 10.1038/s41564-019-0464-z. Epub 2019 Jun 3. PubMed |
| A real-time, click chemistry imaging approach reveals stimulus-specific subcellular locations of phospholipase D activity. Liang D, Wu K, Tei R, Bumpus TW, Ye J, Baskin JM. Proc Natl Acad Sci U S A. 2019 Jul 30;116(31):15453-15462. doi: 10.1073/pnas.1903949116. Epub 2019 Jul 16. PubMed |
| A PRMT5-RNF168-SMURF2 Axis Controls H2AX Proteostasis. Du C, Hansen LJ, Singh SX, Wang F, Sun R, Moure CJ, Roso K, Greer PK, Yan H, He Y. Cell Rep. 2019 Sep 17;28(12):3199-3211.e5. doi: 10.1016/j.celrep.2019.08.031. PubMed |
| Identification of FUBP1 as a Long Tail Cancer Driver and Widespread Regulator of Tumor Suppressor and Oncogene Alternative Splicing. Elman JS, Ni TK, Mengwasser KE, Jin D, Wronski A, Elledge SJ, Kuperwasser C. Cell Rep. 2019 Sep 24;28(13):3435-3449.e5. doi: 10.1016/j.celrep.2019.08.060. PubMed |
| PGC1alpha Suppresses Prostate Cancer Cell Invasion through ERRalpha Transcriptional Control. Valcarcel-Jimenez L, Macchia A, Crosas-Molist E, Schaub-Clerigue A, Camacho L, Martin-Martin N, Cicogna P, Viera-Bardon C, Fernandez-Ruiz S, Rodriguez-Hernandez I, Hermanova I, Astobiza I, Cortazar AR, Corres-Mendizabal J, Gomez-Munoz A, Sanz-Moreno V, Torrano V, Carracedo A. Cancer Res. 2019 Dec 15;79(24):6153-6165. doi: 10.1158/0008-5472.CAN-19-1231. Epub 2019 Oct 8. PubMed |
| Noncoding mutations target cis-regulatory elements of the FOXA1 plexus in prostate cancer. Zhou S, Hawley JR, Soares F, Grillo G, Teng M, Madani Tonekaboni SA, Hua JT, Kron KJ, Mazrooei P, Ahmed M, Arlidge C, Yun HY, Livingstone J, Huang V, Yamaguchi TN, Espiritu SMG, Zhu Y, Severson TM, Murison A, Cameron S, Zwart W, van der Kwast T, Pugh TJ, Fraser M, Boutros PC, Bristow RG, He HH, Lupien M. Nat Commun. 2020 Jan 23;11(1):441. doi: 10.1038/s41467-020-14318-9. PubMed |
| Lipin-2 degradation elicits a proinflammatory gene signature in macrophages. Watahiki A, Shimizu K, Hoshikawa S, Chiba M, Kitamura H, Egusa H, Fukumoto S, Inuzuka H. Biochem Biophys Res Commun. 2020 Apr 2;524(2):477-483. doi: 10.1016/j.bbrc.2020.01.119. Epub 2020 Jan 31. PubMed |
| Using iRFP Genetic Labeling Technology to Track Tumorogenesis of Transplanted CRISPR/Cas9-Edited iPSC in Skeletal Muscle. Jin Y, Shen Y, Weintraub NL, Tang Y. Methods Mol Biol. 2020;2126:73-83. doi: 10.1007/978-1-0716-0364-2_7. PubMed |
| Copper is an essential regulator of the autophagic kinases ULK1/2 to drive lung adenocarcinoma. Tsang T, Posimo JM, Gudiel AA, Cicchini M, Feldser DM, Brady DC. Nat Cell Biol. 2020 Apr;22(4):412-424. doi: 10.1038/s41556-020-0481-4. Epub 2020 Mar 16. PubMed |
| Effective restoration of dystrophin expression in iPSC (Mdx)-derived muscle progenitor cells using the CRISPR/Cas9 system and homology-directed repair technology. Jin Y, Shen Y, Su X, Weintraub NL, Tang Y. Comput Struct Biotechnol J. 2020 Mar 25;18:765-773. doi: 10.1016/j.csbj.2020.03.012. eCollection 2020. PubMed |
| Mitochondrial Respiratory Defect Enhances Hepatoma Cell Invasiveness via STAT3/NFE2L1/STX12 Axis. Lee YK, Kwon SM, Lee EB, Kim GH, Min S, Hong SM, Wang HJ, Lee DM, Choi KS, Park TJ, Yoon G. Cancers (Basel). 2020 Sep 15;12(9). pii: cancers12092632. doi: 10.3390/cancers12092632. PubMed |
| Rapid and direct control of target protein levels with VHL-recruiting dTAG molecules. Nabet B, Ferguson FM, Seong BKA, Kuljanin M, Leggett AL, Mohardt ML, Robichaud A, Conway AS, Buckley DL, Mancias JD, Bradner JE, Stegmaier K, Gray NS. Nat Commun. 2020 Sep 18;11(1):4687. doi: 10.1038/s41467-020-18377-w. PubMed |
Functional interrogation of HOXA9 regulome in MLLr leukemia via reporter-based CRISPR/Cas9 screen.
Zhang H, Zhang Y, Zhou X, Wright S, Hyle J, Zhao L, An J, Zhao X, Shao Y, Xu B, Lee HM, Chen T, Zhou Y, Chen X, Lu R, Li C.
Elife. 2020 Oct 1;9. pii: 57858. doi: 10.7554/eLife.57858.
PubMed
Associated Plasmids |
| Activation of Clustered IFNgamma Target Genes Drives Cohesin-Controlled Transcriptional Memory. Siwek W, Tehrani SSH, Mata JF, Jansen LET. Mol Cell. 2020 Nov 5;80(3):396-409.e6. doi: 10.1016/j.molcel.2020.10.005. Epub 2020 Oct 26. PubMed |
| CD73 and cN-II regulate the cellular response to chemotherapeutic and hypoxic stress in lung adenocarcinoma cells. Raza MZ, Cadassou O, Dumontet C, Cros-Perrial E, Jordheim LP. Biochim Biophys Acta Gen Subj. 2021 May;1865(5):129842. doi: 10.1016/j.bbagen.2021.129842. Epub 2021 Jan 9. PubMed |
| Targeted immunotherapy for HER2-low breast cancer with 17p loss. Li Y, Sun Y, Kulke M, Hechler T, Van der Jeught K, Dong T, He B, Miller KD, Radovich M, Schneider BP, Pahl A, Zhang X, Lu X. Sci Transl Med. 2021 Feb 10;13(580). pii: 13/580/eabc6894. doi: 10.1126/scitranslmed.abc6894. PubMed |
| Warburg Effect Is a Cancer Immune Evasion Mechanism Against Macrophage Immunosurveillance. Chen J, Cao X, Li B, Zhao Z, Chen S, Lai SWT, Muend SA, Nossa GK, Wang L, Guo W, Ye J, Lee PP, Feng M. Front Immunol. 2021 Feb 2;11:621757. doi: 10.3389/fimmu.2020.621757. eCollection 2020. PubMed |
| Role of Clathrin Light Chains in Regulating Invadopodia Formation. Mukenhirn M, Muraca F, Bucher D, Asberger E, Cappio Barazzone E, Cavalcanti-Adam EA, Boulant S. Cells. 2021 Feb 20;10(2). pii: cells10020451. doi: 10.3390/cells10020451. PubMed |
| Genome wide CRISPR screening reveals a role for sialylation in the tumorigenesis and chemoresistance of acute myeloid leukemia cells. Lee DH, Kang SH, Choi DS, Ko M, Choi E, Ahn H, Min H, Oh SJ, Lee MS, Park Y, Jin HS. Cancer Lett. 2021 Jul 10;510:37-47. doi: 10.1016/j.canlet.2021.04.006. Epub 2021 Apr 16. PubMed |
| ARHGEF26 enhances Salmonella invasion and inflammation in cells and mice. Bourgeois JS, Wang L, Rabino AF, Everitt J, Alvarez MI, Awadia S, Wittchen ES, Garcia-Mata R, Ko DC. PLoS Pathog. 2021 Jul 9;17(7):e1009713. doi: 10.1371/journal.ppat.1009713. eCollection 2021 Jul. PubMed |
| Generation of microRNA-378a-deficient hiPSC as a novel tool to study its role in human cardiomyocytes. Martyniak A, Andrysiak K, Motais B, Coste S, Podkalicka P, Ferdek P, Stepniewski J, Dulak J. J Mol Cell Cardiol. 2021 Jul 28;160:128-141. doi: 10.1016/j.yjmcc.2021.07.007. PubMed |
| GRB2 enforces homology-directed repair initiation by MRE11. Ye Z, Xu S, Shi Y, Bacolla A, Syed A, Moiani D, Tsai CL, Shen Q, Peng G, Leonard PG, Jones DE, Wang B, Tainer JA, Ahmed Z. Sci Adv. 2021 Aug 4;7(32). pii: 7/32/eabe9254. doi: 10.1126/sciadv.abe9254. Print 2021 Aug. PubMed |
| Caspases Switch off the m(6)A RNA Modification Pathway to Foster the Replication of a Ubiquitous Human Tumor Virus. Zhang K, Zhang Y, Maharjan Y, Sugiokto FG, Wan J, Li R. mBio. 2021 Aug 31;12(4):e0170621. doi: 10.1128/mBio.01706-21. Epub 2021 Aug 24. PubMed |
| TRIM15 and CYLD regulate ERK activation via lysine-63-linked polyubiquitination. Zhu G, Herlyn M, Yang X. Nat Cell Biol. 2021 Sep;23(9):978-991. doi: 10.1038/s41556-021-00732-8. Epub 2021 Sep 8. PubMed |
| Derivation of human pluripotent stem cell line via CRISPR/Cas9 mediated deletion of exon 3 LAMA2 gene (DMBi001-A-1). Jelinkova S, Martyniak A, Dulak J, Stepniewski J. Stem Cell Res. 2021 Oct;56:102529. doi: 10.1016/j.scr.2021.102529. Epub 2021 Sep 2. PubMed |
| Cooperative methylation of human tRNA3Lys at positions A58 and U54 drives the early and late steps of HIV-1 replication. Fukuda H, Chujo T, Wei FY, Shi SL, Hirayama M, Kaitsuka T, Yamamoto T, Oshiumi H, Tomizawa K. Nucleic Acids Res. 2021 Nov 18;49(20):11855-11867. doi: 10.1093/nar/gkab879. PubMed |
| The SETDB1-TRIM28 Complex Suppresses Antitumor Immunity. Lin J, Guo D, Liu H, Zhou W, Wang C, Muller I, Kossenkov AV, Drapkin R, Bitler BG, Helin K, Zhang R. Cancer Immunol Res. 2021 Dec;9(12):1413-1424. doi: 10.1158/2326-6066.CIR-21-0754. PubMed |
| Systematic decomposition of sequence determinants governing CRISPR/Cas9 specificity. Fu R, He W, Dou J, Villarreal OD, Bedford E, Wang H, Hou C, Zhang L, Wang Y, Ma D, Chen Y, Gao X, Depken M, Xu H. Nat Commun. 2022 Jan 25;13(1):474. doi: 10.1038/s41467-022-28028-x. PubMed |
| Acetate Improves the Killing of Streptococcus pneumoniae by Alveolar Macrophages via NLRP3 Inflammasome and Glycolysis-HIF-1alpha Axis. Machado MG, Patente TA, Rouille Y, Heumel S, Melo EM, Deruyter L, Pourcet B, Sencio V, Teixeira MM, Trottein F. Front Immunol. 2022 Jan 20;13:773261. doi: 10.3389/fimmu.2022.773261. eCollection 2022. PubMed |
| Confined migration promotes cancer metastasis through resistance to anoikis and increased invasiveness. Fanfone D, Wu Z, Mammi J, Berthenet K, Neves D, Weber K, Halaburkova A, Virard F, Bunel F, Jamard C, Hernandez-Vargas H, Tait SWG, Hennino A, Ichim G. Elife. 2022 Mar 8;11. pii: 73150. doi: 10.7554/eLife.73150. PubMed |
| Metformin Combining PD-1 Inhibitor Enhanced Anti-Tumor Efficacy in STK11 Mutant Lung Cancer Through AXIN-1-Dependent Inhibition of STING Ubiquitination. Wang Z, Lu C, Zhang K, Lin C, Wu F, Tang X, Wu D, Dou Y, Han R, Wang Y, Hou C, Ouyang Q, Feng M, He Y, Li L. Front Mol Biosci. 2022 Feb 23;9:780200. doi: 10.3389/fmolb.2022.780200. eCollection 2022. PubMed |
| Functional Genomic Analysis of CDK4 and CDK6 Gene Dependency across Human Cancer Cell Lines. Zhang Z, Golomb L, Meyerson M. Cancer Res. 2022 Jun 6;82(11):2171-2184. doi: 10.1158/0008-5472.CAN-21-2428. PubMed |
| Antithetic effect of interferon-alpha on cell-free and cell-to-cell HIV-1 infection. Kumata R, Iwanami S, Mar KB, Kakizoe Y, Misawa N, Nakaoka S, Koyanagi Y, Perelson AS, Schoggins JW, Iwami S, Sato K. PLoS Comput Biol. 2022 Apr 25;18(4):e1010053. doi: 10.1371/journal.pcbi.1010053. eCollection 2022 Apr. PubMed |
| Regulation of chromatin accessibility by the histone chaperone CAF-1 sustains lineage fidelity. Franklin R, Guo Y, He S, Chen M, Ji F, Zhou X, Frankhouser D, Do BT, Chiem C, Jang M, Blanco MA, Vander Heiden MG, Rockne RC, Ninova M, Sykes DB, Hochedlinger K, Lu R, Sadreyev RI, Murn J, Volk A, Cheloufi S. Nat Commun. 2022 Apr 29;13(1):2350. doi: 10.1038/s41467-022-29730-6. PubMed |
| A nucleation barrier spring-loads the CBM signalosome for binary activation. Rodriguez Gama A, Miller T, Lange JJ, Unruh JR, Halfmann R. Elife. 2022 Jun 21;11:e79826. doi: 10.7554/eLife.79826. PubMed |
| Recruitment of the CoREST transcription repressor complexes by Nerve Growth factor IB-like receptor (Nurr1/NR4A2) mediates silencing of HIV in microglial cells. Ye F, Alvarez-Carbonell D, Nguyen K, Leskov K, Garcia-Mesa Y, Sreeram S, Valadkhan S, Karn J. PLoS Pathog. 2022 Jul 7;18(7):e1010110. doi: 10.1371/journal.ppat.1010110. eCollection 2022 Jul. PubMed |
Structure-function analysis of the SHOC2-MRAS-PP1C holophosphatase complex.
Kwon JJ, Hajian B, Bian Y, Young LC, Amor AJ, Fuller JR, Fraley CV, Sykes AM, So J, Pan J, Baker L, Lee SJ, Wheeler DB, Mayhew DL, Persky NS, Yang X, Root DE, Barsotti AM, Stamford AW, Perry CK, Burgin A, McCormick F, Lemke CT, Hahn WC, Aguirre AJ.
Nature. 2022 Jul 13. pii: 10.1038/s41586-022-04928-2. doi: 10.1038/s41586-022-04928-2.
PubMed
Associated Plasmids |
| The Mutational Landscape of Cancer's Vulnerability to Ionizing Radiation. Gopal P, Yard BD, Petty A, Lal JC, Bera TK, Hoang TQ, Buhimschi AD, Abazeed ME. Clin Cancer Res. 2022 Dec 15;28(24):5343-5358. doi: 10.1158/1078-0432.CCR-22-1914. PubMed |
| Epigenetic silencing by the SMC5/6 complex mediates HIV-1 latency. Irwan ID, Bogerd HP, Cullen BR. Nat Microbiol. 2022 Dec;7(12):2101-2113. doi: 10.1038/s41564-022-01264-z. Epub 2022 Nov 14. PubMed |
| KMT2D deficiency drives lung squamous cell carcinoma and hypersensitivity to RTK-RAS inhibition. Pan Y, Han H, Hu H, Wang H, Song Y, Hao Y, Tong X, Patel AS, Misirlioglu S, Tang S, Huang HY, Geng K, Chen T, Karatza A, Sherman F, Labbe KE, Yang F, Chafitz A, Peng C, Guo C, Moreira AL, Velcheti V, Lau SCM, Sui P, Chen H, Diehl JA, Rustgi AK, Bass AJ, Poirier JT, Zhang X, Ji H, Zhang H, Wong KK. Cancer Cell. 2023 Jan 9;41(1):88-105.e8. doi: 10.1016/j.ccell.2022.11.015. Epub 2022 Dec 15. PubMed |
| The HAPSTR2 retrogene buffers stress signaling and resilience in mammals. Amici DR, Cingoz H, Alasady MJ, Alhayek S, Phoumyvong CM, Sahni N, Yi SS, Mendillo ML. Nat Commun. 2023 Jan 11;14(1):152. doi: 10.1038/s41467-022-35697-1. PubMed |
| The ETS transcription factor ETV6 constrains the transcriptional activity of EWS-FLI to promote Ewing sarcoma. Lu DY, Ellegast JM, Ross KN, Malone CF, Lin S, Mabe NW, Dharia NV, Meyer A, Conway A, Su AH, Selich-Anderson J, Taslim C, Byrum AK, Seong BKA, Adane B, Gray NS, Rivera MN, Lessnick SL, Stegmaier K. Nat Cell Biol. 2023 Feb;25(2):285-297. doi: 10.1038/s41556-022-01059-8. Epub 2023 Jan 19. PubMed |
| Retrospective identification of intrinsic factors that mark pluripotency potential in rare somatic cells. Jain N, Goyal Y, Dunagin MC, Cote CJ, Mellis IA, Emert B, Jiang CL, Dardani IP, Reffsin S, Raj A. bioRxiv. 2023 Feb 10:2023.02.10.527870. doi: 10.1101/2023.02.10.527870. Preprint. PubMed |
| Genome-Scale CRISPR Screening Reveals Host Factors Required for Ribosome Formation and Viral Replication. Ohlson MB, Eitson JL, Wells AI, Kumar A, Jang S, Ni C, Xing C, Buszczak M, Schoggins JW. mBio. 2023 Apr 25;14(2):e0012723. doi: 10.1128/mbio.00127-23. Epub 2023 Feb 21. PubMed |
| A neurodevelopmental epigenetic programme mediated by SMARCD3-DAB1-Reelin signalling is hijacked to promote medulloblastoma metastasis. Zou H, Poore B, Brown EE, Qian J, Xie B, Asimakidou E, Razskazovskiy V, Ayrapetian D, Sharma V, Xia S, Liu F, Chen A, Guan Y, Li Z, Wanggou S, Saulnier O, Ly M, Fellows-Mayle W, Xi G, Tomita T, Resnick AC, Mack SC, Raabe EH, Eberhart CG, Sun D, Stronach BE, Agnihotri S, Kohanbash G, Lu S, Herrup K, Rich JN, Gittes GK, Broniscer A, Hu Z, Li X, Pollack IF, Friedlander RM, Hainer SJ, Taylor MD, Hu B. Nat Cell Biol. 2023 Mar;25(3):493-507. doi: 10.1038/s41556-023-01093-0. Epub 2023 Feb 27. PubMed |
| HPV upregulates MARCHF8 ubiquitin ligase and inhibits apoptosis by degrading the death receptors in head and neck cancer. Khalil MI, Yang C, Vu L, Chadha S, Nabors H, Welbon C, James CD, Morgan IM, Spanos WC, Pyeon D. PLoS Pathog. 2023 Mar 3;19(3):e1011171. doi: 10.1371/journal.ppat.1011171. eCollection 2023 Mar. PubMed |
| PP6 regulation of Aurora A-TPX2 limits NDC80 phosphorylation and mitotic spindle size. Sobajima T, Kowalczyk KM, Skylakakis S, Hayward D, Fulcher LJ, Neary C, Batley C, Kurlekar S, Roberts E, Gruneberg U, Barr FA. J Cell Biol. 2023 May 1;222(5):e202205117. doi: 10.1083/jcb.202205117. Epub 2023 Mar 10. PubMed |
| Protein supersaturation powers innate immune signaling. Rodriguez Gama A, Miller T, Lange JJ, Wu J, Song X, Venkatesan S, Unruh JR, Bradford D, Halfmann R. bioRxiv. 2023 Mar 21:2023.03.20.533581. doi: 10.1101/2023.03.20.533581. Preprint. PubMed |
| CDK5-PRMT1-WDR24 signaling cascade promotes mTORC1 signaling and tumor growth. Yin S, Liu L, Ball LE, Wang Y, Bedford MT, Duncan SA, Wang H, Gan W. Cell Rep. 2023 Apr 25;42(4):112316. doi: 10.1016/j.celrep.2023.112316. Epub 2023 Mar 29. PubMed |
Interrogating bromodomain inhibitor resistance in KMT2A-rearranged leukemia through combinatorial CRISPR screens.
Wright S, Hu J, Wang H, Hyle J, Zhang Y, Du G, Konopleva MY, Kornblau SM, Djekidel MN, Rosikiewicz W, Xu B, Lu R, Yang JJ, Li C.
Proc Natl Acad Sci U S A. 2023 Apr 18;120(16):e2220134120. doi: 10.1073/pnas.2220134120. Epub 2023 Apr 10.
PubMed
Associated Plasmids |
| Nicotinamide N-methyltransferase (NNMT) regulates the glucocorticoid signaling pathway during the early phase of adipogenesis. Roberti A, Tejedor JR, Diaz-Moreno I, Lopez V, Santamarina-Ojeda P, Perez RF, Urdinguio RG, Concellon C, Martinez-Chantar ML, Fernandez-Morera JL, Diaz-Quintana A, Del Amo V, Fernandez AF, Fraga MF. Sci Rep. 2023 May 22;13(1):8293. doi: 10.1038/s41598-023-34916-z. PubMed |
| CDK8 and CDK19: positive regulators of signal-induced transcription and negative regulators of Mediator complex proteins. Chen M, Li J, Zhang L, Wang L, Cheng C, Ji H, Altilia S, Ding X, Cai G, Altomare D, Shtutman M, Byrum SD, Mackintosh SG, Feoktistov A, Soshnikova N, Mogila VA, Tatarskiy V, Erokhin M, Chetverina D, Prawira A, Ni Y, Urban S, McInnes C, Broude EV, Roninson IB. Nucleic Acids Res. 2023 Aug 11;51(14):7288-7313. doi: 10.1093/nar/gkad538. PubMed |
| METTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer. Garcia-Vilchez R, Anazco-Guenkova AM, Dietmann S, Lopez J, Moron-Calvente V, D'Ambrosi S, Nombela P, Zamacola K, Mendizabal I, Garcia-Longarte S, Zabala-Letona A, Astobiza I, Fernandez S, Paniagua A, Miguel-Lopez B, Marchand V, Alonso-Lopez D, Merkel A, Garcia-Tunon I, Ugalde-Olano A, Loizaga-Iriarte A, Lacasa-Viscasillas I, Unda M, Azkargorta M, Elortza F, Barcena L, Gonzalez-Lopez M, Aransay AM, Di Domenico T, Sanchez-Martin MA, De Las Rivas J, Guil S, Motorin Y, Helm M, Pandolfi PP, Carracedo A, Blanco S. Mol Cancer. 2023 Jul 29;22(1):119. doi: 10.1186/s12943-023-01809-8. PubMed |
Global analysis of suppressor mutations that rescue human genetic defects.
Unlu B, Pons C, Ho UL, Batte A, Aloy P, van Leeuwen J.
Genome Med. 2023 Oct 12;15(1):78. doi: 10.1186/s13073-023-01232-0.
PubMed
Associated Plasmids |
| CD36 maintains lipid homeostasis via selective uptake of monounsaturated fatty acids during matrix detachment and tumor progression. Terry AR, Nogueira V, Rho H, Ramakrishnan G, Li J, Kang S, Pathmasiri KC, Bhat SA, Jiang L, Kuchay S, Cologna SM, Hay N. Cell Metab. 2023 Nov 7;35(11):2060-2076.e9. doi: 10.1016/j.cmet.2023.09.012. Epub 2023 Oct 17. PubMed |
| Copy-back viral genomes induce a cellular stress response that interferes with viral protein expression without affecting antiviral immunity. Gonzalez Aparicio LJ, Yang Y, Hackbart M, Lopez CB. PLoS Biol. 2023 Nov 20;21(11):e3002381. doi: 10.1371/journal.pbio.3002381. eCollection 2023 Nov. PubMed |
| Cell fusion upregulates PD-L1 expression for evasion from immunosurveillance. Tajima Y, Shibasaki F, Masai H. Cancer Gene Ther. 2024 Jan;31(1):158-173. doi: 10.1038/s41417-023-00693-0. Epub 2023 Nov 21. PubMed |
| The ELAVL3/MYCN positive feedback loop provides a therapeutic target for neuroendocrine prostate cancer. Ji Y, Zhang W, Shen K, Su R, Liu X, Ma Z, Liu B, Hu C, Xue Y, Xin Z, Yang Y, Li A, Jiang Z, Jing N, Zhu HH, Dong L, Zhu Y, Dong B, Pan J, Wang Q, Xue W. Nat Commun. 2023 Nov 28;14(1):7794. doi: 10.1038/s41467-023-43676-3. PubMed |
| Weakened APC/C activity at mitotic exit drives cancer vulnerability to KIF18A inhibition. Gliech CR, Yeow ZY, Tapias-Gomez D, Yang Y, Huang Z, Tijhuis AE, Spierings DC, Foijer F, Chung G, Tamayo N, Bahrami-Nejad Z, Collins P, Nguyen TT, Plata Stapper A, Hughes PE, Payton M, Holland AJ. EMBO J. 2024 Mar;43(5):666-694. doi: 10.1038/s44318-024-00031-6. Epub 2024 Jan 26. PubMed |
| Tunable DNMT1 degradation reveals DNMT1/DNMT3B synergy in DNA methylation and genome organization. Scelfo A, Barra V, Abdennur N, Spracklin G, Busato F, Salinas-Luypaert C, Bonaiti E, Velasco G, Bonhomme F, Chipont A, Tijhuis AE, Spierings DCJ, Guerin C, Arimondo P, Francastel C, Foijer F, Tost J, Mirny L, Fachinetti D. J Cell Biol. 2024 Apr 1;223(4):e202307026. doi: 10.1083/jcb.202307026. Epub 2024 Feb 20. PubMed |
NINJ1 induces plasma membrane rupture and release of damage-associated molecular pattern molecules during ferroptosis.
Ramos S, Hartenian E, Santos JC, Walch P, Broz P.
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