Lenti‐Cas9‐2A‐Blast Citations (43)
Originally described in: High-Resolution CRISPR Screens Reveal Fitness Genes and Genotype-Specific Cancer Liabilities.Hart T, Chandrashekhar M, Aregger M, Steinhart Z, Brown KR, MacLeod G, Mis M, Zimmermann M, Fradet-Turcotte A, Sun S, Mero P, Dirks P, Sidhu S, Roth FP, Rissland OS, Durocher D, Angers S, Moffat J Cell. 2015 Dec 3;163(6):1515-26. doi: 10.1016/j.cell.2015.11.015. Epub 2015 Nov 25. PubMed Journal
Articles Citing Lenti‐Cas9‐2A‐Blast
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| Genome-wide CRISPR screens reveal a Wnt-FZD5 signaling circuit as a druggable vulnerability of RNF43-mutant pancreatic tumors. Steinhart Z, Pavlovic Z, Chandrashekhar M, Hart T, Wang X, Zhang X, Robitaille M, Brown KR, Jaksani S, Overmeer R, Boj SF, Adams J, Pan J, Clevers H, Sidhu S, Moffat J, Angers S. Nat Med. 2017 Jan;23(1):60-68. doi: 10.1038/nm.4219. Epub 2016 Nov 21. PubMed |
| A Pan-Cancer Analysis of Enhancer Expression in Nearly 9000 Patient Samples. Chen H, Li C, Peng X, Zhou Z, Weinstein JN, Liang H. Cell. 2018 Apr 5;173(2):386-399.e12. doi: 10.1016/j.cell.2018.03.027. PubMed |
| Gastrointestinal stromal tumor enhancers support a transcription factor network predictive of clinical outcome. Hemming ML, Lawlor MA, Zeid R, Lesluyes T, Fletcher JA, Raut CP, Sicinska ET, Chibon F, Armstrong SA, Demetri GD, Bradner JE. Proc Natl Acad Sci U S A. 2018 Jun 19;115(25):E5746-E5755. doi: 10.1073/pnas.1802079115. Epub 2018 Jun 4. PubMed |
| Endothelial AMP-Activated Kinase alpha1 Phosphorylates eNOS on Thr495 and Decreases Endothelial NO Formation. Zippel N, Loot AE, Stingl H, Randriamboavonjy V, Fleming I, Fisslthaler B. Int J Mol Sci. 2018 Sep 13;19(9). pii: ijms19092753. doi: 10.3390/ijms19092753. PubMed |
| Enhancer Architecture and Essential Core Regulatory Circuitry of Chronic Lymphocytic Leukemia. Ott CJ, Federation AJ, Schwartz LS, Kasar S, Klitgaard JL, Lenci R, Li Q, Lawlor M, Fernandes SM, Souza A, Polaski D, Gadi D, Freedman ML, Brown JR, Bradner JE. Cancer Cell. 2018 Dec 10;34(6):982-995.e7. doi: 10.1016/j.ccell.2018.11.001. Epub 2018 Nov 29. PubMed |
| Functional genomic characterization of a synthetic anti-HER3 antibody reveals a role for ubiquitination by RNF41 in the anti-proliferative response. Turowec JP, Lau EWT, Wang X, Brown KR, Fellouse FA, Jawanda KK, Pan J, Moffat J, Sidhu SS. J Biol Chem. 2019 Jan 25;294(4):1396-1409. doi: 10.1074/jbc.RA118.004420. Epub 2018 Dec 6. PubMed |
| Enhancer Domains in Gastrointestinal Stromal Tumor Regulate KIT Expression and Are Targetable by BET Bromodomain Inhibition. Hemming ML, Lawlor MA, Andersen JL, Hagan T, Chipashvili O, Scott TG, Raut CP, Sicinska E, Armstrong SA, Demetri GD, Bradner JE. Cancer Res. 2019 Mar 1;79(5):994-1009. doi: 10.1158/0008-5472.CAN-18-1888. Epub 2019 Jan 10. PubMed |
| Orthologous CRISPR/Cas9 systems for specific and efficient degradation of covalently closed circular DNA of hepatitis B virus. Kostyushev D, Brezgin S, Kostyusheva A, Zarifyan D, Goptar I, Chulanov V. Cell Mol Life Sci. 2019 May;76(9):1779-1794. doi: 10.1007/s00018-019-03021-8. Epub 2019 Jan 23. PubMed |
| FOXD3 Suppresses Tumor-Initiating Features in Lung Cancer via Transcriptional Repression of WDR5. Xu W, Li J, Li L, Hou T, Cai X, Liu T, Yang X, Wei H, Jiang C, Xiao J. Stem Cells. 2019 May;37(5):582-592. doi: 10.1002/stem.2984. Epub 2019 Mar 12. PubMed |
| Suppressing the NHEJ pathway by DNA-PKcs inhibitor NU7026 prevents degradation of HBV cccDNA cleaved by CRISPR/Cas9. Kostyushev D, Kostyusheva A, Brezgin S, Zarifyan D, Utkina A, Goptar I, Chulanov V. Sci Rep. 2019 Feb 12;9(1):1847. doi: 10.1038/s41598-019-38526-6. PubMed |
| The Mitochondrial Transacylase, Tafazzin, Regulates for AML Stemness by Modulating Intracellular Levels of Phospholipids. Seneviratne AK, Xu M, Henao JJA, Fajardo VA, Hao Z, Voisin V, Xu GW, Hurren R, Kim S, MacLean N, Wang X, Gronda M, Jeyaraju D, Jitkova Y, Ketela T, Mullokandov M, Sharon D, Thomas G, Chouinard-Watkins R, Hawley JR, Schafer C, Yau HL, Khuchua Z, Aman A, Al-Awar R, Gross A, Claypool SM, Bazinet RP, Lupien M, Chan S, De Carvalho DD, Minden MD, Bader GD, Stark KD, LeBlanc P, Schimmer AD. Cell Stem Cell. 2019 Apr 4;24(4):621-636.e16. doi: 10.1016/j.stem.2019.02.020. Epub 2019 Mar 28. PubMed |
| Genome-Wide CRISPR-Cas9 Screens Expose Genetic Vulnerabilities and Mechanisms of Temozolomide Sensitivity in Glioblastoma Stem Cells. MacLeod G, Bozek DA, Rajakulendran N, Monteiro V, Ahmadi M, Steinhart Z, Kushida MM, Yu H, Coutinho FJ, Cavalli FMG, Restall I, Hao X, Hart T, Luchman HA, Weiss S, Dirks PB, Angers S. Cell Rep. 2019 Apr 16;27(3):971-986.e9. doi: 10.1016/j.celrep.2019.03.047. PubMed |
| Genome-wide target interactome profiling reveals a novel EEF1A1 epigenetic pathway for oncogenic lncRNA MALAT1 in breast cancer. Li X, Chen N, Zhou L, Wang C, Wen X, Jia L, Cui J, Hoffman AR, Hu JF, Li W. Am J Cancer Res. 2019 Apr 1;9(4):714-729. eCollection 2019. PubMed |
| The KDM5A/RBP2 histone demethylase represses NOTCH signaling to sustain neuroendocrine differentiation and promote small cell lung cancer tumorigenesis. Oser MG, Sabet AH, Gao W, Chakraborty AA, Schinzel AC, Jennings RB, Fonseca R, Bonal DM, Booker MA, Flaifel A, Novak JS, Christensen CL, Zhang H, Herbert ZT, Tolstorukov MY, Buss EJ, Wong KK, Bronson RT, Nguyen QD, Signoretti S, Kaelin WG Jr. Genes Dev. 2019 Dec 1;33(23-24):1718-1738. doi: 10.1101/gad.328336.119. Epub 2019 Nov 14. PubMed |
| Translational reprogramming marks adaptation to asparagine restriction in cancer. Pathria G, Lee JS, Hasnis E, Tandoc K, Scott DA, Verma S, Feng Y, Larue L, Sahu AD, Topisirovic I, Ruppin E, Ronai ZA. Nat Cell Biol. 2019 Dec;21(12):1590-1603. doi: 10.1038/s41556-019-0415-1. Epub 2019 Nov 18. PubMed |
| gscreend: modelling asymmetric count ratios in CRISPR screens to decrease experiment size and improve phenotype detection. Imkeller K, Ambrosi G, Boutros M, Huber W. Genome Biol. 2020 Mar 2;21(1):53. doi: 10.1186/s13059-020-1939-1. PubMed |
| Pan-cancer multi-omics analysis and orthogonal experimental assessment of epigenetic driver genes. Halaburkova A, Cahais V, Novoloaca A, Araujo MGDS, Khoueiry R, Ghantous A, Herceg Z. Genome Res. 2020 Oct;30(10):1517-1532. doi: 10.1101/gr.268292.120. Epub 2020 Sep 22. PubMed |
| Orally bioavailable CDK9/2 inhibitor shows mechanism-based therapeutic potential in MYCN-driven neuroblastoma. Poon E, Liang T, Jamin Y, Walz S, Kwok C, Hakkert A, Barker K, Urban Z, Thway K, Zeid R, Hallsworth A, Box G, Ebus ME, Licciardello MP, Sbirkov Y, Lazaro G, Calton E, Costa BM, Valenti M, De Haven Brandon A, Webber H, Tardif N, Almeida GS, Christova R, Boysen G, Richards MW, Barone G, Ford A, Bayliss R, Clarke PA, De Bono J, Gray NS, Blagg J, Robinson SP, Eccles SA, Zheleva D, Bradner JE, Molenaar J, Vivanco I, Eilers M, Workman P, Lin CY, Chesler L. J Clin Invest. 2020 Nov 2;130(11):5875-5892. doi: 10.1172/JCI134132. PubMed |
| Genome-scale CRISPR screening at high sensitivity with an empirically designed sgRNA library. Henkel L, Rauscher B, Schmitt B, Winter J, Boutros M. BMC Biol. 2020 Nov 23;18(1):174. doi: 10.1186/s12915-020-00905-1. PubMed |
| HAND1 and BARX1 Act as Transcriptional and Anatomic Determinants of Malignancy in Gastrointestinal Stromal Tumor. Hemming ML, Coy S, Lin JR, Andersen JL, Przybyl J, Mazzola E, Abdelhamid Ahmed AH, van de Rijn M, Sorger PK, Armstrong SA, Demetri GD, Santagata S. Clin Cancer Res. 2021 Mar 15;27(6):1706-1719. doi: 10.1158/1078-0432.CCR-20-3538. Epub 2021 Jan 15. PubMed |
| A genome-wide CRISPR/Cas9 screen in acute myeloid leukemia cells identifies regulators of TAK-243 sensitivity. Barghout SH, Aman A, Nouri K, Blatman Z, Arevalo K, Thomas GE, MacLean N, Hurren R, Ketela T, Saini M, Abohawya M, Kiyota T, Al-Awar R, Schimmer AD. JCI Insight. 2021 Mar 8;6(5). pii: 141518. doi: 10.1172/jci.insight.141518. PubMed |
| Acquired cancer cell resistance to T cell bispecific antibodies and CAR T targeting HER2 through JAK2 down-modulation. Arenas EJ, Martinez-Sabadell A, Rius Ruiz I, Roman Alonso M, Escorihuela M, Luque A, Fajardo CA, Gros A, Klein C, Arribas J. Nat Commun. 2021 Feb 23;12(1):1237. doi: 10.1038/s41467-021-21445-4. PubMed |
| Small tandem DNA duplications result from CST-guided Pol alpha-primase action at DNA break termini. Schimmel J, Munoz-Subirana N, Kool H, van Schendel R, Tijsterman M. Nat Commun. 2021 Aug 10;12(1):4843. doi: 10.1038/s41467-021-25154-w. PubMed |
| Unexpected gene activation following CRISPR-Cas9-mediated genome editing. Manjon AG, Linder S, Teunissen H, Friskes A, Zwart W, de Wit E, Medema RH. EMBO Rep. 2022 Feb 3;23(2):e53902. doi: 10.15252/embr.202153902. Epub 2021 Dec 20. PubMed |
| Valine tRNA levels and availability regulate complex I assembly in leukaemia. Thandapani P, Kloetgen A, Witkowski MT, Glytsou C, Lee AK, Wang E, Wang J, LeBoeuf SE, Avrampou K, Papagiannakopoulos T, Tsirigos A, Aifantis I. Nature. 2022 Jan;601(7893):428-433. doi: 10.1038/s41586-021-04244-1. Epub 2021 Dec 22. PubMed |
| Systematic identification of genomic elements that regulate FCGR2A expression and harbor variants linked with autoimmune disease. Dahlqvist J, Fulco CP, Ray JP, Liechti T, de Boer CG, Lieb DJ, Eisenhaure TM, Engreitz JM, Roederer M, Hacohen N. Hum Mol Genet. 2021 Dec 31. pii: 6490623. doi: 10.1093/hmg/ddab372. PubMed |
| MOZ and Menin-MLL Complexes Are Complementary Regulators of Chromatin Association and Transcriptional Output in Gastrointestinal Stromal Tumor. Hemming ML, Benson MR, Loycano MA, Anderson JA, Andersen JL, Taddei ML, Krivtsov AV, Aubrey BJ, Cutler JA, Hatton C, Sicinska E, Armstrong SA. Cancer Discov. 2022 Jul 6;12(7):1804-1823. doi: 10.1158/2159-8290.CD-21-0646. PubMed |
| Immortalised Cas9-expressing Cell lines for Gene interrogation. Malaver-Ortega LF, Rosenbluh J. Methods Mol Biol. 2022;2495:91-97. doi: 10.1007/978-1-0716-2301-5_5. PubMed |
| Metabolic balance in colorectal cancer is maintained by optimal Wnt signaling levels. Imkeller K, Ambrosi G, Klemm N, Claveras Cabezudo A, Henkel L, Huber W, Boutros M. Mol Syst Biol. 2022 Aug;18(8):e10874. doi: 10.15252/msb.202110874. PubMed |
| NUDT21 limits CD19 levels through alternative mRNA polyadenylation in B cell acute lymphoblastic leukemia. Witkowski MT, Lee S, Wang E, Lee AK, Talbot A, Ma C, Tsopoulidis N, Brumbaugh J, Zhao Y, Roberts KG, Hogg SJ, Nomikou S, Ghebrechristos YE, Thandapani P, Mullighan CG, Hochedlinger K, Chen W, Abdel-Wahab O, Eyquem J, Aifantis I. Nat Immunol. 2022 Oct;23(10):1424-1432. doi: 10.1038/s41590-022-01314-y. Epub 2022 Sep 22. PubMed |
| Lineage-coupled clonal capture identifies clonal evolution mechanisms and vulnerabilities of BRAF(V600E) inhibition resistance in melanoma. Zhang ZY, Ding Y, Ezhilarasan R, Lhakhang T, Wang Q, Yang J, Modrek AS, Zhang H, Tsirigos A, Futreal A, Draetta GF, Verhaak RGW, Sulman EP. Cell Discov. 2022 Oct 6;8(1):102. doi: 10.1038/s41421-022-00462-7. PubMed |
| Development of a robust and convenient dual-reporter high-throughput screening assay for SARS-CoV-2 antiviral drug discovery. Chiu W, Schepers J, Francken T, Vangeel L, Abbasi K, Jochmans D, De Jonghe S, Thibaut HJ, Thiel V, Neyts J, Laporte M, Leyssen P. Antiviral Res. 2023 Feb;210:105506. doi: 10.1016/j.antiviral.2022.105506. Epub 2022 Dec 21. PubMed |
| Excessive transcription-replication conflicts are a vulnerability of BRCA1-mutant cancers. Patel PS, Algouneh A, Krishnan R, Reynolds JJ, Nixon KCJ, Hao J, Lee J, Feng Y, Fozil C, Stanic M, Yerlici T, Su P, Soares F, Liedtke E, Prive G, Baider GD, Pujana MA, Mekhail K, He HH, Hakem A, Stewart GS, Hakem R. Nucleic Acids Res. 2023 May 22;51(9):4341-4362. doi: 10.1093/nar/gkad172. PubMed |
| Thymidine nucleotide metabolism controls human telomere length. Mannherz W, Agarwal S. Nat Genet. 2023 Apr;55(4):568-580. doi: 10.1038/s41588-023-01339-5. Epub 2023 Mar 23. PubMed |
CRISPR screens identify gene targets at breast cancer risk loci.
Tuano NK, Beesley J, Manning M, Shi W, Perlaza-Jimenez L, Malaver-Ortega LF, Paynter JM, Black D, Civitarese A, McCue K, Hatzipantelis A, Hillman K, Kaufmann S, Sivakumaran H, Polo JM, Reddel RR, Band V, French JD, Edwards SL, Powell DR, Chenevix-Trench G, Rosenbluh J.
Genome Biol. 2023 Mar 29;24(1):59. doi: 10.1186/s13059-023-02898-w.
PubMed
Associated Plasmids |
| Mitophagy Promotes Resistance to BH3 Mimetics in Acute Myeloid Leukemia. Glytsou C, Chen X, Zacharioudakis E, Al-Santli W, Zhou H, Nadorp B, Lee S, Lasry A, Sun Z, Papaioannou D, Cammer M, Wang K, Zal T, Zal MA, Carter BZ, Ishizawa J, Tibes R, Tsirigos A, Andreeff M, Gavathiotis E, Aifantis I. Cancer Discov. 2023 Jul 7;13(7):1656-1677. doi: 10.1158/2159-8290.CD-22-0601. PubMed |
| A bioengineered immunocompetent human leukemia chip for preclinical screening of CAR T cell immunotherapy. Chen W, Ma C, Wang H, Liu L, Tong J, Witkowski M, Aifantis I, Ghassemi S. Res Sq. 2023 Apr 21:rs.3.rs-2762929. doi: 10.21203/rs.3.rs-2762929/v1. Preprint. PubMed |
| Transient and tunable CRISPRa regulation of APOBEC/AID genes for targeting hepatitis B virus. Kostyushev D, Brezgin S, Kostyusheva A, Ponomareva N, Bayurova E, Zakirova N, Kondrashova A, Goptar I, Nikiforova A, Sudina A, Babin Y, Gordeychuk I, Lukashev A, Zamyatnin AA Jr, Ivanov A, Chulanov V. Mol Ther Nucleic Acids. 2023 Apr 20;32:478-493. doi: 10.1016/j.omtn.2023.04.016. eCollection 2023 Jun 13. PubMed |
| ARID1A deficiency promotes progression and potentiates therapeutic antitumour immunity in hepatitis B virus-related hepatocellular carcinoma. Xing T, Li L, Rao X, Zhao J, Chen Y, Ju G, Xu Y, Gao X, Dong G, Xia X, Guan Y, Zhang L, Wen Z, Liang J. BMC Gastroenterol. 2024 Jan 2;24(1):11. doi: 10.1186/s12876-023-03059-w. PubMed |
| Higher-order protein assembly controls kinetochore formation. Sissoko GB, Tarasovetc EV, Marescal O, Grishchuk EL, Cheeseman IM. Nat Cell Biol. 2024 Jan;26(1):45-56. doi: 10.1038/s41556-023-01313-7. Epub 2024 Jan 2. PubMed |
| Molecular density-accelerated binding-site maturation underlies CENP-T-dependent kinetochore assembly. Tarasovetc EV, Sissoko GB, Mukhina AS, Maiorov A, Ataullakhanov FI, Cheeseman IM, Grishchuk EL. bioRxiv [Preprint]. 2024 Feb 26:2024.02.25.581584. doi: 10.1101/2024.02.25.581584. PubMed |
| The SPATA5-SPATA5L1 ATPase complex directs replisome proteostasis to ensure genome integrity. Krishnamoorthy V, Foglizzo M, Dilley RL, Wu A, Datta A, Dutta P, Campbell LJ, Degtjarik O, Musgrove LJ, Calabrese AN, Zeqiraj E, Greenberg RA. Cell. 2024 Apr 25;187(9):2250-2268.e31. doi: 10.1016/j.cell.2024.03.002. Epub 2024 Mar 29. PubMed |
| G6PD and ACSL3 are synthetic lethal partners of NF2 in Schwann cells. Kyrkou A, Valla R, Zhang Y, Ambrosi G, Laier S, Muller-Decker K, Boutros M, Teleman AA. Nat Commun. 2024 Jun 15;15(1):5115. doi: 10.1038/s41467-024-49298-7. PubMed |
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