pCHAC-mt-mKeima Citations (34)

Originally described in: The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy.
Lazarou M, Sliter DA, Kane LA, Sarraf SA, Wang C, Burman JL, Sideris DP, Fogel AI, Youle RJ Nature. 2015 Aug 20;524(7565):309-14. doi: 10.1038/nature14893. Epub 2015 Aug 12. PubMed Journal

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Articles Citing pCHAC-mt-mKeima

Articles
Parkin functionally interacts with PGC-1alpha to preserve mitochondria and protect dopaminergic neurons. Zheng L, Bernard-Marissal N, Moullan N, D'Amico D, Auwerx J, Moore DJ, Knott G, Aebischer P, Schneider BL. Hum Mol Genet. 2017 Jan 4. pii: ddw418. doi: 10.1093/hmg/ddw418. PubMed
Observation of Parkin-Mediated Mitophagy in Pancreatic beta-Cells. Hoshino A, Matoba S. Methods Mol Biol. 2017 May 3. doi: 10.1007/7651_2017_39. PubMed
BNIP3L-dependent mitophagy accounts for mitochondrial clearance during 3 factors-induced somatic cell reprogramming. Xiang G, Yang L, Long Q, Chen K, Tang H, Wu Y, Liu Z, Zhou Y, Qi J, Zheng L, Liu W, Ying Z, Fan W, Shi H, Li H, Lin X, Gao M, Liu J, Bao F, Li L, Duan L, Li M, Liu X. Autophagy. 2017 Sep 2;13(9):1543-1555. doi: 10.1080/15548627.2017.1338545. Epub 2017 Jul 19. PubMed
Autophagy induced during apoptosis degrades mitochondria and inhibits type I interferon secretion. Lindqvist LM, Frank D, McArthur K, Dite TA, Lazarou M, Oakhill JS, Kile BT, Vaux DL. Cell Death Differ. 2018 Mar;25(4):784-796. doi: 10.1038/s41418-017-0017-z. Epub 2017 Dec 11. PubMed
ATM directs DNA damage responses and proteostasis via genetically separable pathways. Lee JH, Mand MR, Kao CH, Zhou Y, Ryu SW, Richards AL, Coon JJ, Paull TT. Sci Signal. 2018 Jan 9;11(512). pii: 11/512/eaan5598. doi: 10.1126/scisignal.aan5598. PubMed
Loss of the ubiquitin conjugating enzyme UBE2E3 induces cellular senescence. Plafker KS, Zyla K, Berry W, Plafker SM. Redox Biol. 2018 Jul;17:411-422. doi: 10.1016/j.redox.2018.05.008. Epub 2018 May 21. PubMed
AT 101 induces early mitochondrial dysfunction and HMOX1 (heme oxygenase 1) to trigger mitophagic cell death in glioma cells. Meyer N, Zielke S, Michaelis JB, Linder B, Warnsmann V, Rakel S, Osiewacz HD, Fulda S, Mittelbronn M, Munch C, Behrends C, Kogel D. Autophagy. 2018;14(10):1693-1709. doi: 10.1080/15548627.2018.1476812. Epub 2018 Jul 21. PubMed
The RNA-Binding Protein PUM2 Impairs Mitochondrial Dynamics and Mitophagy During Aging. D'Amico D, Mottis A, Potenza F, Sorrentino V, Li H, Romani M, Lemos V, Schoonjans K, Zamboni N, Knott G, Schneider BL, Auwerx J. Mol Cell. 2019 Feb 21;73(4):775-787.e10. doi: 10.1016/j.molcel.2018.11.034. Epub 2019 Jan 11. PubMed
Deficiency of mitophagy receptor FUNDC1 impairs mitochondrial quality and aggravates dietary-induced obesity and metabolic syndrome. Wu H, Wang Y, Li W, Chen H, Du L, Liu D, Wang X, Xu T, Liu L, Chen Q. Autophagy. 2019 Nov;15(11):1882-1898. doi: 10.1080/15548627.2019.1596482. Epub 2019 Apr 6. PubMed
Mitofusins regulate lipid metabolism to mediate the development of lung fibrosis. Chung KP, Hsu CL, Fan LC, Huang Z, Bhatia D, Chen YJ, Hisata S, Cho SJ, Nakahira K, Imamura M, Choi ME, Yu CJ, Cloonan SM, Choi AMK. Nat Commun. 2019 Jul 29;10(1):3390. doi: 10.1038/s41467-019-11327-1. PubMed
Cell Clustering Promotes a Metabolic Switch that Supports Metastatic Colonization. Labuschagne CF, Cheung EC, Blagih J, Domart MC, Vousden KH. Cell Metab. 2019 Oct 1;30(4):720-734.e5. doi: 10.1016/j.cmet.2019.07.014. Epub 2019 Aug 22. PubMed
A Sensitive and Quantitative mKeima Assay for Mitophagy via FACS. Wang C. Curr Protoc Cell Biol. 2020 Mar;86(1):e99. doi: 10.1002/cpcb.99. PubMed
Detection of mitophagy in mammalian cells, mice, and yeast. Calvelli H, Krigman J, Onishi M, Narendra DP, Sun N, Okamoto K. Methods Cell Biol. 2020;155:557-579. doi: 10.1016/bs.mcb.2019.10.006. Epub 2019 Nov 27. PubMed
BRCA1 Deficiency Impairs Mitophagy and Promotes Inflammasome Activation and Mammary Tumor Metastasis. Chen Q, Lei JH, Bao J, Wang H, Hao W, Li L, Peng C, Masuda T, Miao K, Xu J, Xu X, Deng CX. Adv Sci (Weinh). 2020 Feb 14;7(6):1903616. doi: 10.1002/advs.201903616. eCollection 2020 Mar. PubMed
An optimized procedure for quantitative analysis of mitophagy with the mtKeima system using flow cytometry. Winsor NJ, Killackey SA, Philpott DJ, Girardin SE. Biotechniques. 2020 Oct;69(4):249-256. doi: 10.2144/btn-2020-0071. Epub 2020 Aug 18. PubMed
Inhibition of proteasome reveals basal mitochondrial ubiquitination. Sulkshane P, Duek I, Ram J, Thakur A, Reis N, Ziv T, Glickman MH. J Proteomics. 2020 Oct 30;229:103949. doi: 10.1016/j.jprot.2020.103949. Epub 2020 Aug 31. PubMed
Activation of ATM kinase by ROS generated during ionophore-induced mitophagy in human T and B cell malignancies. Sarkar A, Gandhi V. Mol Cell Biochem. 2021 Jan;476(1):417-423. doi: 10.1007/s11010-020-03917-1. Epub 2020 Sep 29. PubMed
Intracellular AIBP (Apolipoprotein A-I Binding Protein) Regulates Oxidized LDL (Low-Density Lipoprotein)-Induced Mitophagy in Macrophages. Choi SH, Agatisa-Boyle C, Gonen A, Kim A, Kim J, Alekseeva E, Tsimikas S, Miller YI. Arterioscler Thromb Vasc Biol. 2021 Feb;41(2):e82-e96. doi: 10.1161/ATVBAHA.120.315485. Epub 2020 Dec 24. PubMed
Role and dynamics of vacuolar pH during cell-in-cell mediated death. Su Y, Ren H, Tang M, Zheng Y, Zhang B, Wang C, Hou X, Niu Z, Wang Z, Gao X, Gao L, Jiang H, Chen Z, Luo T, Sun Q. Cell Death Dis. 2021 Jan 22;12(1):119. doi: 10.1038/s41419-021-03396-2. PubMed
AMPK/ULK1-mediated phosphorylation of Parkin ACT domain mediates an early step in mitophagy. Hung CM, Lombardo PS, Malik N, Brun SN, Hellberg K, Van Nostrand JL, Garcia D, Baumgart J, Diffenderfer K, Asara JM, Shaw RJ. Sci Adv. 2021 Apr 7;7(15). pii: 7/15/eabg4544. doi: 10.1126/sciadv.abg4544. Print 2021 Apr. PubMed
LncRNA H19 governs mitophagy and restores mitochondrial respiration in the heart through Pink1/Parkin signaling during obesity. Wang SH, Zhu XL, Wang F, Chen SX, Chen ZT, Qiu Q, Liu WH, Wu MX, Deng BQ, Xie Y, Mai JT, Yang Y, Wang JF, Zhang HF, Chen YX. Cell Death Dis. 2021 May 28;12(6):557. doi: 10.1038/s41419-021-03821-6. PubMed
Ubiquitination and receptor-mediated mitophagy converge to eliminate oxidation-damaged mitochondria during hypoxia. Sulkshane P, Ram J, Thakur A, Reis N, Kleifeld O, Glickman MH. Redox Biol. 2021 Sep;45:102047. doi: 10.1016/j.redox.2021.102047. Epub 2021 Jun 17. PubMed
Autophagy inhibition mediated by MCOLN1/TRPML1 suppresses cancer metastasis via regulating a ROS-driven TP53/p53 pathway. Xing Y, Wei X, Liu Y, Wang MM, Sui Z, Wang X, Zhu W, Wu M, Lu C, Fei YH, Jiang Y, Zhang Y, Wang Y, Guo F, Cao JL, Qi J, Wang W. Autophagy. 2022 Aug;18(8):1932-1954. doi: 10.1080/15548627.2021.2008752. Epub 2021 Dec 8. PubMed
Systematic analysis of PINK1 variants of unknown significance shows intact mitophagy function for most variants. Ma KY, Fokkens MR, van Laar T, Verbeek DS. NPJ Parkinsons Dis. 2021 Dec 10;7(1):113. doi: 10.1038/s41531-021-00258-8. PubMed
AMPK-mTOR-Mediated Activation of Autophagy Promotes Formation of Dormant Polyploid Giant Cancer Cells. You B, Xia T, Gu M, Zhang Z, Zhang Q, Shen J, Fan Y, Yao H, Pan S, Lu Y, Cheng T, Yang Z, He X, Zhang H, Shi M, Liu D, You Y. Cancer Res. 2022 Mar 1;82(5):846-858. doi: 10.1158/0008-5472.CAN-21-2342. PubMed
TRPML1-induced autophagy inhibition triggers mitochondrial mediated apoptosis. Liu Y, Wang X, Zhu W, Sui Z, Wei X, Zhang Y, Qi J, Xing Y, Wang W. Cancer Lett. 2022 Aug 10;541:215752. doi: 10.1016/j.canlet.2022.215752. Epub 2022 May 26. PubMed
MG53 preserves mitochondrial integrity of cardiomyocytes during ischemia reperfusion-induced oxidative stress. Gumpper-Fedus K, Park KH, Ma H, Zhou X, Bian Z, Krishnamurthy K, Sermersheim M, Zhou J, Tan T, Li L, Liu J, Lin PH, Zhu H, Ma J. Redox Biol. 2022 Aug;54:102357. doi: 10.1016/j.redox.2022.102357. Epub 2022 Jun 2. PubMed
Inhibition of mTOR signaling protects human glioma cells from hypoxia-induced cell death in an autophagy-independent manner. Dive I, Klann K, Michaelis JB, Heinzen D, Steinbach JP, Munch C, Ronellenfitsch MW. Cell Death Discov. 2022 Oct 6;8(1):409. doi: 10.1038/s41420-022-01195-y. PubMed
FBXL4 suppresses mitophagy by restricting the accumulation of NIX and BNIP3 mitophagy receptors. Nguyen-Dien GT, Kozul KL, Cui Y, Townsend B, Kulkarni PG, Ooi SS, Marzio A, Carrodus N, Zuryn S, Pagano M, Parton RG, Lazarou M, Millard SS, Taylor RW, Collins BM, Jones MJ, Pagan JK. EMBO J. 2023 Jul 3;42(13):e112767. doi: 10.15252/embj.2022112767. Epub 2023 May 10. PubMed
Mitophagy restricts BAX/BAK-independent, Parkin-mediated apoptosis. Quarato G, Mari L, Barrows NJ, Yang M, Ruehl S, Chen MJ, Guy CS, Low J, Chen T, Green DR. Sci Adv. 2023 May 24;9(21):eadg8156. doi: 10.1126/sciadv.adg8156. Epub 2023 May 24. PubMed
Mitochondrial DNA Variations Modulate Alveolar Epithelial Mitochondrial Function and Oxidative Stress in Newborn Mice Exposed to Hyperoxia. Kandasamy J, Li R, Vamesu BM, Olave N, Halloran B, Jilling T, Ballinger SW, Ambalavanan N. bioRxiv. 2023 May 17:2023.05.17.541177. doi: 10.1101/2023.05.17.541177. Preprint. PubMed
Temporal landscape of mitochondrial proteostasis governed by the UPR(mt). Uoselis L, Lindblom R, Lam WK, Kung CJ, Skulsuppaisarn M, Khuu G, Nguyen TN, Rudler DL, Filipovska A, Schittenhelm RB, Lazarou M. Sci Adv. 2023 Sep 22;9(38):eadh8228. doi: 10.1126/sciadv.adh8228. Epub 2023 Sep 22. PubMed
Exposure of the inner mitochondrial membrane triggers apoptotic mitophagy. Saunders TL, Windley SP, Gervinskas G, Balka KR, Rowe C, Lane R, Tailler M, Nguyen TN, Ramm G, Lazarou M, De Nardo D, Kile BT, McArthur K. Cell Death Differ. 2024 Mar;31(3):335-347. doi: 10.1038/s41418-024-01260-2. Epub 2024 Feb 23. PubMed
Targeting the autophagy-NAD axis protects against cell death in Niemann-Pick type C1 disease models. Kataura T, Sedlackova L, Sun C, Kocak G, Wilson N, Banks P, Hayat F, Trushin S, Trushina E, Maddocks ODK, Oblong JE, Miwa S, Imoto M, Saiki S, Erskine D, Migaud ME, Sarkar S, Korolchuk VI. Cell Death Dis. 2024 May 31;15(5):382. doi: 10.1038/s41419-024-06770-y. PubMed

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