pdCas9-DNMT3A-EGFP Citations (21)
Originally described in: Repurposing the CRISPR-Cas9 system for targeted DNA methylation.Vojta A, Dobrinic P, Tadic V, Bockor L, Korac P, Julg B, Klasic M, Zoldos V Nucleic Acids Res. 2016 Mar 11. pii: gkw159. PubMed Journal
Articles Citing pdCas9-DNMT3A-EGFP
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Targeted DNA methylation in vivo using an engineered dCas9-MQ1 fusion protein.
Lei Y, Zhang X, Su J, Jeong M, Gundry MC, Huang YH, Zhou Y, Li W, Goodell MA.
Nat Commun. 2017 Jul 11;8:16026. doi: 10.1038/ncomms16026.
PubMed
Associated Plasmids |
Targeted DNA methylation in human cells using engineered dCas9-methyltransferases.
Xiong T, Meister GE, Workman RE, Kato NC, Spellberg MJ, Turker F, Timp W, Ostermeier M, Novina CD.
Sci Rep. 2017 Jul 27;7(1):6732. doi: 10.1038/s41598-017-06757-0.
PubMed
Associated Plasmids |
DNA epigenome editing using CRISPR-Cas SunTag-directed DNMT3A.
Huang YH, Su J, Lei Y, Brunetti L, Gundry MC, Zhang X, Jeong M, Li W, Goodell MA.
Genome Biol. 2017 Sep 18;18(1):176. doi: 10.1186/s13059-017-1306-z.
PubMed
Associated Plasmids |
| Genome-wide tracking of dCas9-methyltransferase footprints. Galonska C, Charlton J, Mattei AL, Donaghey J, Clement K, Gu H, Mohammad AW, Stamenova EK, Cacchiarelli D, Klages S, Timmermann B, Cantz T, Scholer HR, Gnirke A, Ziller MJ, Meissner A. Nat Commun. 2018 Feb 9;9(1):597. doi: 10.1038/s41467-017-02708-5. PubMed |
| Retinoid-Sensitive Epigenetic Regulation of the Hoxb Cluster Maintains Normal Hematopoiesis and Inhibits Leukemogenesis. Qian P, De Kumar B, He XC, Nolte C, Gogol M, Ahn Y, Chen S, Li Z, Xu H, Perry JM, Hu D, Tao F, Zhao M, Han Y, Hall K, Peak A, Paulson A, Zhao C, Venkatraman A, Box A, Perera A, Haug JS, Parmely T, Li H, Krumlauf R, Li L. Cell Stem Cell. 2018 May 3;22(5):740-754.e7. doi: 10.1016/j.stem.2018.04.012. PubMed |
| CRISPR-Based Targeted Epigenetic Editing Enables Gene Expression Modulation of the Silenced Beta-Galactoside Alpha-2,6-Sialyltransferase 1 in CHO Cells. Marx N, Grunwald-Gruber C, Bydlinski N, Dhiman H, Ngoc Nguyen L, Klanert G, Borth N. Biotechnol J. 2018 Oct;13(10):e1700217. doi: 10.1002/biot.201700217. Epub 2018 Jun 11. PubMed |
| Downregulation of SNCA Expression by Targeted Editing of DNA Methylation: A Potential Strategy for Precision Therapy in PD. Kantor B, Tagliafierro L, Gu J, Zamora ME, Ilich E, Grenier C, Huang ZY, Murphy S, Chiba-Falek O. Mol Ther. 2018 Nov 7;26(11):2638-2649. doi: 10.1016/j.ymthe.2018.08.019. Epub 2018 Aug 29. PubMed |
| Neurog3-Independent Methylation Is the Earliest Detectable Mark Distinguishing Pancreatic Progenitor Identity. Liu J, Banerjee A, Herring CA, Attalla J, Hu R, Xu Y, Shao Q, Simmons AJ, Dadi PK, Wang S, Jacobson DA, Liu B, Hodges E, Lau KS, Gu G. Dev Cell. 2019 Jan 7;48(1):49-63.e7. doi: 10.1016/j.devcel.2018.11.048. PubMed |
| Epigenetic therapy of novel tumour suppressor ZAR1 and its cancer biomarker function. Deutschmeyer V, Breuer J, Walesch SK, Sokol AM, Graumann J, Bartkuhn M, Boettger T, Rossbach O, Richter AM. Clin Epigenetics. 2019 Dec 4;11(1):182. doi: 10.1186/s13148-019-0774-2. PubMed |
| Locus-Specific Regulation of Xist Expression Using the CRISPR-Cas9-Based System. Deng M, Liu Z, Chen B, Cai Y, Wan Y, Wang F. DNA Cell Biol. 2020 Apr;39(4):572-578. doi: 10.1089/dna.2019.4945. Epub 2020 Feb 19. PubMed |
| Genome-wide analysis in the mouse embryo reveals the importance of DNA methylation for transcription integrity. Dahlet T, Argueso Lleida A, Al Adhami H, Dumas M, Bender A, Ngondo RP, Tanguy M, Vallet J, Auclair G, Bardet AF, Weber M. Nat Commun. 2020 Jun 19;11(1):3153. doi: 10.1038/s41467-020-16919-w. PubMed |
| Regulation of MYB by distal enhancer elements in human myeloid leukemia. Li M, Jiang P, Cheng K, Zhang Z, Lan S, Li X, Zhao L, Wang Y, Wang X, Chen J, Ji T, Han B, Zhang J. Cell Death Dis. 2021 Feb 26;12(2):223. doi: 10.1038/s41419-021-03515-z. PubMed |
| Genetic and Epigenetic Interplay Within a COLGALT2 Enhancer Associated With Osteoarthritis. Kehayova YS, Watson E, Wilkinson JM, Loughlin J, Rice SJ. Arthritis Rheumatol. 2021 Oct;73(10):1856-1865. doi: 10.1002/art.41738. Epub 2021 Aug 31. PubMed |
| Diverse transcriptional regulation and functional effects revealed by CRISPR/Cas9-directed epigenetic editing. Vizoso M, van Rheenen J. Oncotarget. 2021 Aug 17;12(17):1651-1662. doi: 10.18632/oncotarget.28037. eCollection 2021 Aug 17. PubMed |
| Age-related demethylation of the TDP-43 autoregulatory region in the human motor cortex. Koike Y, Sugai A, Hara N, Ito J, Yokoseki A, Ishihara T, Yamagishi T, Tsuboguchi S, Tada M, Ikeuchi T, Kakita A, Onodera O. Commun Biol. 2021 Sep 21;4(1):1107. doi: 10.1038/s42003-021-02621-0. PubMed |
| Genome-wide DNA hypermethylation opposes healing in patients with chronic wounds by impairing epithelial-mesenchymal transition. Singh K, Rustagi Y, Abouhashem AS, Tabasum S, Verma P, Hernandez E, Pal D, Khona DK, Mohanty SK, Kumar M, Srivastava R, Guda PR, Verma SS, Mahajan S, Killian JA, Walker LA, Ghatak S, Mathew-Steiner SS, Wanczyk KE, Liu S, Wan J, Yan P, Bundschuh R, Khanna S, Gordillo GM, Murphy MP, Roy S, Sen CK. J Clin Invest. 2022 Sep 1;132(17):e157279. doi: 10.1172/JCI157279. PubMed |
| Independent osteoarthritis risk-conferring alleles mediate the same epigenetic and transcriptional effect on a shared target gene, COLGALT2. Kehayova YS, Wilkinson JM, Rice SJ, Loughlin J. Arthritis Rheumatol. 2022 Dec 20. doi: 10.1002/art.42427. PubMed |
| Neural crest E-cadherin loss drives cleft lip/palate by epigenetic modulation via pro-inflammatory gene-environment interaction. Alvizi L, Nani D, Brito LA, Kobayashi GS, Passos-Bueno MR, Mayor R. Nat Commun. 2023 May 24;14(1):2868. doi: 10.1038/s41467-023-38526-1. PubMed |
| The dCas9-based genome editing in Plasmodium yoelii. Zhang C, Yang S, Quansah E, Zhang Z, Da W, Wang B. mSphere. 2024 Mar 26;9(3):e0009524. doi: 10.1128/msphere.00095-24. Epub 2024 Feb 27. PubMed |
| Endocrine islet beta-cell subtypes with differential function are derived from biochemically distinct embryonic endocrine islet progenitors that are regulated by maternal nutrients. Gu G, Brown M, Agan V, Nevills S, Hu R, Simmons A, Xu Y, Yang Y, Yagan M, Najam S, Dadi P, Sampson L, Magnuson M, Jacobson D, Lau K, Hodges E. Res Sq [Preprint]. 2024 Mar 7:rs.3.rs-3946483. doi: 10.21203/rs.3.rs-3946483/v1. PubMed |
| Specific isoforms of the ubiquitin ligase gene WWP2 are targets of osteoarthritis genetic risk via a differentially methylated DNA sequence. Roberts JB, Boldvig OLG, Aubourg G, Kanchenapally ST, Deehan DJ, Rice SJ, Loughlin J. Arthritis Res Ther. 2024 Apr 3;26(1):78. doi: 10.1186/s13075-024-03315-8. PubMed |
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