FUCas9Cherry Citations (34)
Originally described in: An inducible lentiviral guide RNA platform enables the identification of tumor-essential genes and tumor-promoting mutations in vivo.Aubrey BJ, Kelly GL, Kueh AJ, Brennan MS, O'Connor L, Milla L, Wilcox S, Tai L, Strasser A, Herold MJ Cell Rep. 2015 Mar 3;10(8):1422-32. doi: 10.1016/j.celrep.2015.02.002. Epub 2015 Feb 26. PubMed Journal
Articles Citing FUCas9Cherry
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| Spatial cycles mediated by UNC119 solubilisation maintain Src family kinases plasma membrane localisation. Konitsiotis AD, Rossmannek L, Stanoev A, Schmick M, Bastiaens PIH. Nat Commun. 2017 Jul 24;8(1):114. doi: 10.1038/s41467-017-00116-3. PubMed |
| Regulation of perforin activation and pre-synaptic toxicity through C-terminal glycosylation. House IG, House CM, Brennan AJ, Gilan O, Dawson MA, Whisstock JC, Law RH, Trapani JA, Voskoboinik I. EMBO Rep. 2017 Oct;18(10):1775-1785. doi: 10.15252/embr.201744351. Epub 2017 Aug 14. PubMed |
| Generation of Genetic Knockouts in Myeloid Cell Lines Using a Lentiviral CRISPR/Cas9 System. Baker PJ, Masters SL. Methods Mol Biol. 2018;1714:41-55. doi: 10.1007/978-1-4939-7519-8_3. PubMed |
| MARCH1-mediated ubiquitination of MHC II impacts the MHC I antigen presentation pathway. Wilson KR, Liu H, Healey G, Vuong V, Ishido S, Herold MJ, Villadangos JA, Mintern JD. PLoS One. 2018 Jul 12;13(7):e0200540. doi: 10.1371/journal.pone.0200540. eCollection 2018. PubMed |
| Loss of GRHL3 leads to TARC/CCL17-mediated keratinocyte proliferation in the epidermis. Goldie SJ, Cottle DL, Tan FH, Roslan S, Srivastava S, Brady R, Partridge DD, Auden A, Smyth IM, Jane SM, Dworkin S, Darido C. Cell Death Dis. 2018 Oct 19;9(11):1072. doi: 10.1038/s41419-018-0901-6. PubMed |
| Bcor loss perturbs myeloid differentiation and promotes leukaemogenesis. Kelly MJ, So J, Rogers AJ, Gregory G, Li J, Zethoven M, Gearhart MD, Bardwell VJ, Johnstone RW, Vervoort SJ, Kats LM. Nat Commun. 2019 Mar 22;10(1):1347. doi: 10.1038/s41467-019-09250-6. PubMed |
| Targeting enhancer switching overcomes non-genetic drug resistance in acute myeloid leukaemia. Bell CC, Fennell KA, Chan YC, Rambow F, Yeung MM, Vassiliadis D, Lara L, Yeh P, Martelotto LG, Rogiers A, Kremer BE, Barbash O, Mohammad HP, Johanson TM, Burr ML, Dhar A, Karpinich N, Tian L, Tyler DS, MacPherson L, Shi J, Pinnawala N, Yew Fong C, Papenfuss AT, Grimmond SM, Dawson SJ, Allan RS, Kruger RG, Vakoc CR, Goode DL, Naik SH, Gilan O, Lam EYN, Marine JC, Prinjha RK, Dawson MA. Nat Commun. 2019 Jun 20;10(1):2723. doi: 10.1038/s41467-019-10652-9. PubMed |
| Combinatorial ixazomib and belinostat therapy induces NFE2L2-dependent apoptosis in Hodgkin and T-cell lymphoma. Passero FC Jr, Ravi D, McDonald JT, Beheshti A, David KA, Evens AM. Br J Haematol. 2020 Jan;188(2):295-308. doi: 10.1111/bjh.16160. Epub 2019 Aug 26. PubMed |
| An Evolutionarily Conserved Function of Polycomb Silences the MHC Class I Antigen Presentation Pathway and Enables Immune Evasion in Cancer. Burr ML, Sparbier CE, Chan KL, Chan YC, Kersbergen A, Lam EYN, Azidis-Yates E, Vassiliadis D, Bell CC, Gilan O, Jackson S, Tan L, Wong SQ, Hollizeck S, Michalak EM, Siddle HV, McCabe MT, Prinjha RK, Guerra GR, Solomon BJ, Sandhu S, Dawson SJ, Beavis PA, Tothill RW, Cullinane C, Lehner PJ, Sutherland KD, Dawson MA. Cancer Cell. 2019 Oct 14;36(4):385-401.e8. doi: 10.1016/j.ccell.2019.08.008. Epub 2019 Sep 26. PubMed |
| Non-coding somatic mutations converge on the PAX8 pathway in ovarian cancer. Corona RI, Seo JH, Lin X, Hazelett DJ, Reddy J, Fonseca MAS, Abassi F, Lin YG, Mhawech-Fauceglia PY, Shah SP, Huntsman DG, Gusev A, Karlan BY, Berman BP, Freedman ML, Gayther SA, Lawrenson K. Nat Commun. 2020 Apr 24;11(1):2020. doi: 10.1038/s41467-020-15951-0. PubMed |
| Autophagy alleviates amiodarone-induced hepatotoxicity. Wandrer F, Frangez Z, Liebig S, John K, Vondran F, Wedemeyer H, Veltmann C, Pfeffer TJ, Shibolet O, Schulze-Osthoff K, Simon HU, Bantel H. Arch Toxicol. 2020 Jul 10. pii: 10.1007/s00204-020-02837-9. doi: 10.1007/s00204-020-02837-9. PubMed |
| Influenza A virus infection-induced macroautophagy facilitates MHC class II-restricted endogenous presentation of an immunodominant viral epitope. Deng J, Lu C, Liu C, Oveissi S, Fairlie WD, Lee EF, Bilsel P, Puthalakath H, Chen W. FEBS J. 2021 May;288(10):3164-3185. doi: 10.1111/febs.15654. Epub 2020 Dec 18. PubMed |
| ANLN Enhances Triple-Negative Breast Cancer Stemness Through TWIST1 and BMP2 and Promotes its Spheroid Growth. Maryam A, Chin YR. Front Mol Biosci. 2021 Jul 1;8:700973. doi: 10.3389/fmolb.2021.700973. eCollection 2021. PubMed |
| TCOF1 upregulation in triple-negative breast cancer promotes stemness and tumour growth and correlates with poor prognosis. Hu J, Lai Y, Huang H, Ramakrishnan S, Pan Y, Ma VWS, Cheuk W, So GYK, He Q, Geoffrey Lau C, Zhang L, Cho WCS, Chan KM, Wang X, Rebecca Chin Y. Br J Cancer. 2022 Jan;126(1):57-71. doi: 10.1038/s41416-021-01596-3. Epub 2021 Oct 30. PubMed |
| Protein kinase R is an innate immune sensor of proteotoxic stress via accumulation of cytoplasmic IL-24. Davidson S, Yu CH, Steiner A, Ebstein F, Baker PJ, Jarur-Chamy V, Hrovat Schaale K, Laohamonthonkul P, Kong K, Calleja DJ, Harapas CR, Balka KR, Mitchell J, Jackson JT, Geoghegan ND, Moghaddas F, Rogers KL, Mayer-Barber KD, De Jesus AA, De Nardo D, Kile BT, Sadler AJ, Poli MC, Kruger E, Goldbach Mansky R, Masters SL. Sci Immunol. 2022 Feb 11;7(68):eabi6763. doi: 10.1126/sciimmunol.abi6763. Epub 2022 Feb 11. PubMed |
| Loss of METTL3 attenuates blastic plasmacytoid dendritic cell neoplasm response to PRMT5 inhibition via IFN signaling. Rethnam M, Tan DQ, Tan SH, Li J, Yokomori R, Li Y, Yang H, Sanda T, Suda T. Blood Adv. 2022 Sep 27;6(18):5330-5344. doi: 10.1182/bloodadvances.2021006306. PubMed |
| Deficiency in coatomer complex I causes aberrant activation of STING signalling. Steiner A, Hrovat-Schaale K, Prigione I, Yu CH, Laohamonthonkul P, Harapas CR, Low RRJ, De Nardo D, Dagley LF, Mlodzianoski MJ, Rogers KL, Zillinger T, Hartmann G, Gantier MP, Gattorno M, Geyer M, Volpi S, Davidson S, Masters SL. Nat Commun. 2022 Apr 28;13(1):2321. doi: 10.1038/s41467-022-29946-6. PubMed |
| Inhibition of pyrimidine biosynthesis targets protein translation in acute myeloid leukemia. So J, Lewis AC, Smith LK, Stanley K, Franich R, Yoannidis D, Pijpers L, Dominguez P, Hogg SJ, Vervoort SJ, Brown FC, Johnstone RW, McDonald G, Ulanet DB, Murtie J, Gruber E, Kats LM. EMBO Mol Med. 2022 Jul 7;14(7):e15203. doi: 10.15252/emmm.202115203. Epub 2022 May 6. PubMed |
| Eprenetapopt triggers ferroptosis, inhibits NFS1 cysteine desulfurase, and synergizes with serine and glycine dietary restriction. Fujihara KM, Zhang BZ, Jackson TD, Ogunkola MO, Nijagal B, Milne JV, Sallman DA, Ang CS, Nikolic I, Kearney CJ, Hogg SJ, Cabalag CS, Sutton VR, Watt S, Fujihara AT, Trapani JA, Simpson KJ, Stojanovski D, Leimkuhler S, Haupt S, Phillips WA, Clemons NJ. Sci Adv. 2022 Sep 16;8(37):eabm9427. doi: 10.1126/sciadv.abm9427. Epub 2022 Sep 14. PubMed |
| A specialized tyrosine-based endocytosis signal in MR1 controls antigen presentation to MAIT cells. Lim HJ, Wubben JM, Garcia CP, Cruz-Gomez S, Deng J, Mak JYW, Hachani A, Anderson RJ, Painter GF, Goyette J, Amarasinghe SL, Ritchie ME, Roquilly A, Fairlie DP, Gaus K, Rossjohn J, Villadangos JA, McWilliam HEG. J Cell Biol. 2022 Dec 5;221(12):e202110125. doi: 10.1083/jcb.202110125. Epub 2022 Sep 21. PubMed |
| Hedgehog-interacting protein acts in the habenula to regulate nicotine intake. Caligiuri SPB, Howe WM, Wills L, Smith ACW, Lei Y, Bali P, Heyer MP, Moen JK, Ables JL, Elayouby KS, Williams M, Fillinger C, Oketokoun Z, Lehmann VE, DiFeliceantonio AG, Johnson PM, Beaumont K, Sebra RP, Ibanez-Tallon I, Kenny PJ. Proc Natl Acad Sci U S A. 2022 Nov 15;119(46):e2209870119. doi: 10.1073/pnas.2209870119. Epub 2022 Nov 8. PubMed |
| A Myb enhancer-guided analysis of basophil and mast cell differentiation. Matsumura T, Totani H, Gunji Y, Fukuda M, Yokomori R, Deng J, Rethnam M, Yang C, Tan TK, Karasawa T, Kario K, Takahashi M, Osato M, Sanda T, Suda T. Nat Commun. 2022 Nov 18;13(1):7064. doi: 10.1038/s41467-022-34906-1. PubMed |
| Targeting Menin disrupts the KMT2A/B and polycomb balance to paradoxically activate bivalent genes. Sparbier CE, Gillespie A, Gomez J, Kumari N, Motazedian A, Chan KL, Bell CC, Gilan O, Chan YC, Popp S, Gough DJ, Eckersley-Maslin MA, Dawson SJ, Lehner PJ, Sutherland KD, Ernst P, McGeehan GM, Lam EYN, Burr ML, Dawson MA. Nat Cell Biol. 2023 Feb;25(2):258-272. doi: 10.1038/s41556-022-01056-x. Epub 2023 Jan 12. PubMed |
| Lymphoma cells lacking pro-apoptotic BAX are highly resistant to BH3-mimetics targeting pro-survival MCL-1 but retain sensitivity to conventional DNA-damaging drugs. Diepstraten ST, Young S, La Marca JE, Wang Z, Kluck RM, Strasser A, Kelly GL. Cell Death Differ. 2023 Apr;30(4):1005-1017. doi: 10.1038/s41418-023-01117-0. Epub 2023 Feb 8. PubMed |
| Anti-apoptotic protein BCL-XL as a therapeutic vulnerability in gastric cancer. Wei Y, Zhang L, Wang C, Li Z, Luo M, Xie G, Yang X, Li M, Ren S, Zhao D, Gao R, Gong JN. Animal Model Exp Med. 2023 Jun;6(3):245-254. doi: 10.1002/ame2.12330. Epub 2023 Jun 4. PubMed |
| CaMKK2 is not involved in contraction-stimulated AMPK activation and glucose uptake in skeletal muscle. Negoita F, Addinsall AB, Hellberg K, Bringas CF, Hafen PS, Sermersheim TJ, Agerholm M, Lewis CTA, Ahwazi D, Ling NXY, Larsen JK, Deshmukh AS, Hossain MA, Oakhill JS, Ochala J, Brault JJ, Sankar U, Drewry DH, Scott JW, Witczak CA, Sakamoto K. Mol Metab. 2023 Sep;75:101761. doi: 10.1016/j.molmet.2023.101761. Epub 2023 Jun 26. PubMed |
| Gain of chromosome 21 increases the propensity for P2RY8::CRLF2 acute lymphoblastic leukemia via increased HMGN1 expression. Page EC, Heatley SL, Rehn J, Thomas PQ, Yeung DT, White DL. Front Oncol. 2023 Jul 6;13:1177871. doi: 10.3389/fonc.2023.1177871. eCollection 2023. PubMed |
| KCNQ potassium channels modulate Wnt activity in gastro-oesophageal adenocarcinomas. Shorthouse D, Zhuang L, Rahrmann EP, Kosmidou C, Wickham Rahrmann K, Hall M, Greenwood B, Devonshire G, Gilbertson RJ, Fitzgerald RC, Hall BA. Life Sci Alliance. 2023 Sep 25;6(12):e202302124. doi: 10.26508/lsa.202302124. Print 2023 Dec. PubMed |
| A genome-wide CRISPR/Cas9 screen identifies DNA-PK as a sensitiser to (177)Lutetium-DOTA-octreotate radionuclide therapy. Waldeck K, Van Zuylekom J, Cullinane C, Gulati T, Simpson KJ, Tothill RW, Blyth B, Hicks RJ. Theranostics. 2023 Aug 28;13(14):4745-4761. doi: 10.7150/thno.84628. eCollection 2023. PubMed |
| A p53 score derived from TP53 CRISPR/Cas9 HMCLs predicts survival and reveals major role of BAX in BH3 mimetics response. Durand R, Descamps G, Dousset C, Bellanger C, Maiga S, Alberge JB, Derrien J, Cruard J, Minvielle S, Lilli NL, Godon C, Le Bris Y, Tessoulin B, Amiot M, Gomez-Bougie P, Touzeau C, Moreau P, Chiron D, Moreau-Aubry A, Pellat-Deceunynck C. Blood. 2023 Dec 14:blood.2023021581. doi: 10.1182/blood.2023021581. PubMed |
| The cholesterol biosynthesis enzyme FAXDC2 couples Wnt/beta-catenin to RTK/MAPK signaling. Madan B, Wadia SR, Patnaik S, Harmston N, Tan E, Tan IBH, Nes WD, Petretto E, Virshup DM. J Clin Invest. 2024 Jan 23;134(6):e171222. doi: 10.1172/JCI171222. PubMed |
| Recurrent mutations in tumor suppressor FBXW7 bypass Wnt/beta-catenin addiction in cancer. Zhong Z, Virshup DM. Sci Adv. 2024 Apr 5;10(14):eadk1031. doi: 10.1126/sciadv.adk1031. Epub 2024 Apr 3. PubMed |
| Putting the STING back into BH3-mimetic drugs for TP53-mutant blood cancers. Diepstraten ST, Yuan Y, La Marca JE, Young S, Chang C, Whelan L, Ross AM, Fischer KC, Pomilio G, Morris R, Georgiou A, Litalien V, Brown FC, Roberts AW, Strasser A, Wei AH, Kelly GL. Cancer Cell. 2024 May 13;42(5):850-868.e9. doi: 10.1016/j.ccell.2024.04.004. Epub 2024 Apr 25. PubMed |
| Multiomics analysis identifies oxidative phosphorylation as a cancer vulnerability arising from myristoylation inhibition. Beauchamp E, Gamma JM, Cromwell CR, Moussa EW, Pain R, Kostiuk MA, Acevedo-Morantes C, Iyer A, Yap M, Vincent KM, Postovit LM, Julien O, Hubbard BP, Mackey JR, Berthiaume LG. J Transl Med. 2024 May 7;22(1):431. doi: 10.1186/s12967-024-05150-6. PubMed |
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