pcDNA3-FLAG-MTOR-L1460P Citations (4)

Originally described in: A diverse array of cancer-associated MTOR mutations are hyperactivating and can predict rapamycin sensitivity.
Grabiner BC, Nardi V, Birsoy K, Possemato R, Shen K, Sinha S, Jordan A, Beck AH, Sabatini DM Cancer Discov. 2014 May;4(5):554-63. doi: 10.1158/2159-8290.CD-13-0929. Epub 2014 Mar 14. PubMed Journal

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Articles Citing pcDNA3-FLAG-MTOR-L1460P

Articles
Arginase 2 Suppresses Renal Carcinoma Progression via Biosynthetic Cofactor Pyridoxal Phosphate Depletion and Increased Polyamine Toxicity. Ochocki JD, Khare S, Hess M, Ackerman D, Qiu B, Daisak JI, Worth AJ, Lin N, Lee P, Xie H, Li B, Wubbenhorst B, Maguire TG, Nathanson KL, Alwine JC, Blair IA, Nissim I, Keith B, Simon MC. Cell Metab. 2018 Jun 5;27(6):1263-1280.e6. doi: 10.1016/j.cmet.2018.04.009. Epub 2018 May 10. PubMed
mTOR-mediated cancer drug resistance suppresses autophagy and generates a druggable metabolic vulnerability. Gremke N, Polo P, Dort A, Schneikert J, Elmshauser S, Brehm C, Klingmuller U, Schmitt A, Reinhardt HC, Timofeev O, Wanzel M, Stiewe T. Nat Commun. 2020 Sep 17;11(1):4684. doi: 10.1038/s41467-020-18504-7. PubMed
Lysosomal TMEM9-LAMTOR4-controlled mTOR signaling integrity is required for mammary tumorigenesis. Zhang S, Lee SH, Nie L, Huang Y, Zou G, Jung YS, Jun S, Zhang J, Lien EM, Chen J, Park JI. Cancer Commun (Lond). 2023 Jan;43(1):159-163. doi: 10.1002/cac2.12382. Epub 2022 Nov 6. PubMed
mTORC1 upregulates B7-H3/CD276 to inhibit antitumor T cells and drive tumor immune evasion. Liu HJ, Du H, Khabibullin D, Zarei M, Wei K, Freeman GJ, Kwiatkowski DJ, Henske EP. Nat Commun. 2023 Mar 3;14(1):1214. doi: 10.1038/s41467-023-36881-7. PubMed

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