pX333 Citations (43)
Originally described in: In vivo engineering of oncogenic chromosomal rearrangements with the CRISPR/Cas9 system.Maddalo D, Manchado E, Concepcion CP, Bonetti C, Vidigal JA, Han YC, Ogrodowski P, Crippa A, Rekhtman N, de Stanchina E, Lowe SW, Ventura A Nature. 2014 Dec 18;516(7531):423-7. doi: 10.1038/nature13902. Epub 2014 Oct 22. PubMed Journal
Articles Citing pX333
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| A lentivirus-free inducible CRISPR-Cas9 system for efficient targeting of human genes. Bisht K, Grill S, Graniel J, Nandakumar J. Anal Biochem. 2017 Aug 1;530:40-49. doi: 10.1016/j.ab.2017.05.001. Epub 2017 May 4. PubMed |
| Creation of a Novel Humanized Dystrophic Mouse Model of Duchenne Muscular Dystrophy and Application of a CRISPR/Cas9 Gene Editing Therapy. Young CS, Mokhonova E, Quinonez M, Pyle AD, Spencer MJ. J Neuromuscul Dis. 2017;4(2):139-145. doi: 10.3233/JND-170218. PubMed |
| R-spondins can potentiate WNT signaling without LGRs. Lebensohn AM, Rohatgi R. Elife. 2018 Feb 6;7. pii: 33126. doi: 10.7554/eLife.33126. PubMed |
| Resistance Mechanisms to Targeted Therapies in ROS1(+) and ALK(+) Non-small Cell Lung Cancer. McCoach CE, Le AT, Gowan K, Jones K, Schubert L, Doak A, Estrada-Bernal A, Davies KD, Merrick DT, Bunn PA Jr, Purcell WT, Dziadziuszko R, Varella-Garcia M, Aisner DL, Camidge DR, Doebele RC. Clin Cancer Res. 2018 Jul 15;24(14):3334-3347. doi: 10.1158/1078-0432.CCR-17-2452. Epub 2018 Apr 10. PubMed |
| An Inducible DamID System for Profiling Interactions of Nuclear Lamina Protein Component Lamin B1 with Chromosomes in Mouse Cells. Kozhevnikova EN, Leshchenko AE, Pindyurin AV. Biochemistry (Mosc). 2018 May;83(5):586-594. doi: 10.1134/S0006297918050115. PubMed |
| Control of neural crest multipotency by Wnt signaling and the Lin28/let-7 axis. Bhattacharya D, Rothstein M, Azambuja AP, Simoes-Costa M. Elife. 2018 Dec 6;7. pii: 40556. doi: 10.7554/eLife.40556. PubMed |
| Pipeline for the generation of gene knockout mice using dual sgRNA CRISPR/Cas9-mediated gene editing. Ghassemi B, Shamsara M, Soleimani M, Kiani J, Rassoulzadegan M. Anal Biochem. 2019 Mar 1;568:31-40. doi: 10.1016/j.ab.2018.12.002. Epub 2018 Dec 26. PubMed |
| Targeted deletion of BCL11A gene by CRISPR-Cas9 system for fetal hemoglobin reactivation: A promising approach for gene therapy of beta thalassemia disease. Khosravi MA, Abbasalipour M, Concordet JP, Berg JV, Zeinali S, Arashkia A, Azadmanesh K, Buch T, Karimipoor M. Eur J Pharmacol. 2019 Jul 5;854:398-405. doi: 10.1016/j.ejphar.2019.04.042. Epub 2019 Apr 27. PubMed |
| Genome-scale CRISPR/Cas9 screen determines factors modulating sensitivity to ProTide NUC-1031. Sarr A, Bre J, Um IH, Chan TH, Mullen P, Harrison DJ, Reynolds PA. Sci Rep. 2019 May 21;9(1):7643. doi: 10.1038/s41598-019-44089-3. PubMed |
| A New MicroRNA Cluster Involved in the Reprogramming to a Pluripotent State. Sherstyuk VV, Davletshina GI, Vyatkin YV, Shtokalo DN, Vlasov VV, Zakian SM. Acta Naturae. 2019 Apr-Jun;11(2):92-97. doi: 10.32607/20758251-2019-11-2-92-97. PubMed |
| CRISPR-Mediated Activation of Endogenous Gene Expression in the Postnatal Heart. Schoger E, Carroll KJ, Iyer LM, McAnally JR, Tan W, Liu N, Noack C, Shomroni O, Salinas G, Gross J, Herzog N, Doroudgar S, Bassel-Duby R, Zimmermann WH, Zelarayan LC. Circ Res. 2020 Jan 3;126(1):6-24. doi: 10.1161/CIRCRESAHA.118.314522. Epub 2019 Nov 15. PubMed |
| Long Noncoding RNA DRAIC Inhibits Prostate Cancer Progression by Interacting with IKK to Inhibit NF-kappaB Activation. Saha S, Kiran M, Kuscu C, Chatrath A, Wotton D, Mayo MW, Dutta A. Cancer Res. 2020 Mar 1;80(5):950-963. doi: 10.1158/0008-5472.CAN-19-3460. Epub 2020 Jan 3. PubMed |
| Pannexin-1 mediates fluid shear stress-sensitive purinergic signaling and cyst growth in polycystic kidney disease. Verschuren EHJ, Rigalli JP, Castenmiller C, Rohrbach MU, Bindels RJM, Peters DJM, Arjona FJ, Hoenderop JGJ. FASEB J. 2020 May;34(5):6382-6398. doi: 10.1096/fj.201902901R. Epub 2020 Mar 11. PubMed |
| Role for carbohydrate response element-binding protein (ChREBP) in high glucose-mediated repression of long noncoding RNA Tug1. Long J, Galvan DL, Mise K, Kanwar YS, Li L, Poungvarin N, Overbeek PA, Chang BH, Danesh FR. J Biol Chem. 2020 May 28. pii: RA120.013228. doi: 10.1074/jbc.RA120.013228. PubMed |
| High-Resolution In Vivo Identification of miRNA Targets by Halo-Enhanced Ago2 Pull-Down. Li X, Pritykin Y, Concepcion CP, Lu Y, La Rocca G, Zhang M, King B, Cook PJ, Au YW, Popow O, Paulo JA, Otis HG, Mastroleo C, Ogrodowski P, Schreiner R, Haigis KM, Betel D, Leslie CS, Ventura A. Mol Cell. 2020 Jul 2;79(1):167-179.e11. doi: 10.1016/j.molcel.2020.05.009. Epub 2020 Jun 3. PubMed |
| Germline engineering of the chicken genome using CRISPR/Cas9 by in vivo transfection of PGCs. Challagulla A, Jenkins KA, O'Neil TE, Morris KR, Wise TG, Tizard ML, Bean AGD, Schat KA, Doran TJ. Anim Biotechnol. 2020 Jul 24:1-10. doi: 10.1080/10495398.2020.1789869. PubMed |
| Design and Testing of Vector-Producing HEK293T Cells Bearing a Genomic Deletion of the SV40 T Antigen Coding Region. Bae DH, Marino M, Iaffaldano B, Fenstermaker S, Afione S, Argaw T, McCright J, Kwilas A, Chiorini JA, Timmons AE, Reiser J. Mol Ther Methods Clin Dev. 2020 Jul 9;18:631-638. doi: 10.1016/j.omtm.2020.07.006. eCollection 2020 Sep 11. PubMed |
| Downregulation of PUMA underlies resistance to FGFR1 inhibitors in the stem cell leukemia/lymphoma syndrome. Liu Y, Cai B, Chong Y, Zhang H, Kemp CA, Lu S, Chang CS, Ren M, Cowell JK, Hu T. Cell Death Dis. 2020 Oct 20;11(10):884. doi: 10.1038/s41419-020-03098-1. PubMed |
| Palmitate-Induced IRE1-XBP1-ZEB Signaling Represses Desmoplakin Expression and Promotes Cancer Cell Migration. Nath A, Oak A, Chen KY, Li I, Splichal RC, Portis J, Foster S, Walton SP, Chan C. Mol Cancer Res. 2021 Feb;19(2):240-248. doi: 10.1158/1541-7786.MCR-19-0480. Epub 2020 Oct 26. PubMed |
| In Vivo Inhibition of Marek's Disease Virus in Transgenic Chickens Expressing Cas9 and gRNA against ICP4. Challagulla A, Jenkins KA, O'Neil TE, Shi S, Morris KR, Wise TG, Paradkar PN, Tizard ML, Doran TJ, Schat KA. Microorganisms. 2021 Jan 13;9(1). pii: microorganisms9010164. doi: 10.3390/microorganisms9010164. PubMed |
| Marker counter-selection via CRISPR/Cas9 co-targeting for efficient generation of genome edited avian cell lines and germ cells. Challagulla A, Shi S, Nair K, O'Neil TE, Morris KR, Wise TG, Cahill DM, Tizard ML, Doran TJ, Jenkins KA. Anim Biotechnol. 2021 Mar 2:1-11. doi: 10.1080/10495398.2021.1885428. PubMed |
An optimized CRISPR/Cas9 approach for precise genome editing in neurons.
Fang H, Bygrave AM, Roth RH, Johnson RC, Huganir RL.
Elife. 2021 Mar 10;10. pii: 65202. doi: 10.7554/eLife.65202.
PubMed
Associated Plasmids |
| Defining super-enhancer landscape in triple-negative breast cancer by multiomic profiling. Huang H, Hu J, Maryam A, Huang Q, Zhang Y, Ramakrishnan S, Li J, Ma H, Ma VWS, Cheuk W, So GYK, Wang W, Cho WCS, Zhang L, Chan KM, Wang X, Chin YR. Nat Commun. 2021 Apr 14;12(1):2242. doi: 10.1038/s41467-021-22445-0. PubMed |
| Role of cytoplasmic localization of maspin in promoting cell invasion in breast cancer with aggressive phenotype. Sakabe T, Wakahara M, Shiota G, Umekita Y. Sci Rep. 2021 May 31;11(1):11321. doi: 10.1038/s41598-021-90887-z. PubMed |
| ANLN Enhances Triple-Negative Breast Cancer Stemness Through TWIST1 and BMP2 and Promotes its Spheroid Growth. Maryam A, Chin YR. Front Mol Biosci. 2021 Jul 1;8:700973. doi: 10.3389/fmolb.2021.700973. eCollection 2021. PubMed |
| IFNalpha and beta Mediated JCPyV Suppression through C/EBPbeta-LIP Isoform. May D, Bellizzi A, Kassa W, Cipriaso JM, Caocci M, Wollebo HS. Viruses. 2021 Sep 26;13(10). pii: v13101937. doi: 10.3390/v13101937. PubMed |
| TCOF1 upregulation in triple-negative breast cancer promotes stemness and tumour growth and correlates with poor prognosis. Hu J, Lai Y, Huang H, Ramakrishnan S, Pan Y, Ma VWS, Cheuk W, So GYK, He Q, Geoffrey Lau C, Zhang L, Cho WCS, Chan KM, Wang X, Rebecca Chin Y. Br J Cancer. 2022 Jan;126(1):57-71. doi: 10.1038/s41416-021-01596-3. Epub 2021 Oct 30. PubMed |
| CRISPR-Cas9 Mediated Exonic Disruption for HIV-1 Elimination. Herskovitz J, Hasan M, Patel M, Blomberg WR, Cohen JD, Machhi J, Shahjin F, Mosley RL, McMillan J, Kevadiya BD, Gendelman HE. EBioMedicine. 2021 Nov;73:103678. doi: 10.1016/j.ebiom.2021.103678. Epub 2021 Nov 10. PubMed |
| CRISPR-Cas9 effectors facilitate generation of single-sex litters and sex-specific phenotypes. Douglas C, Maciulyte V, Zohren J, Snell DM, Mahadevaiah SK, Ojarikre OA, Ellis PJI, Turner JMA. Nat Commun. 2021 Dec 3;12(1):6926. doi: 10.1038/s41467-021-27227-2. PubMed |
| Restoration of DNA repair mitigates genome instability and increases productivity of Chinese hamster ovary cells. Spahn PN, Zhang X, Hu Q, Lu H, Hamaker NK, Hefzi H, Li S, Kuo CC, Huang Y, Lee JC, Davis AJ, Ly P, Lee KH, Lewis NE. Biotechnol Bioeng. 2022 Mar;119(3):963-982. doi: 10.1002/bit.28016. Epub 2022 Jan 5. PubMed |
| Microglia contribute to the postnatal development of cortical somatostatin-positive inhibitory cells and to whisker-evoked cortical activity. Gesuita L, Cavaccini A, Argunsah AO, Favuzzi E, Ibrahim LA, Stachniak TJ, De Gennaro M, Utz S, Greter M, Karayannis T. Cell Rep. 2022 Aug 16;40(7):111209. doi: 10.1016/j.celrep.2022.111209. PubMed |
| Genome characterization and CRISPR-Cas9 editing of a human neocentromere. Palazzo A, Piccolo I, Minervini CF, Purgato S, Capozzi O, D'Addabbo P, Cumbo C, Albano F, Rocchi M, Catacchio CR. Chromosoma. 2022 Aug 17. pii: 10.1007/s00412-022-00779-y. doi: 10.1007/s00412-022-00779-y. PubMed |
| Enhancing Cardiomyocyte Transcription Using In Vivo CRISPR/Cas9 Systems. Schoger E, Zelarayan LC. Methods Mol Biol. 2022;2573:53-61. doi: 10.1007/978-1-0716-2707-5_5. PubMed |
In situ cell-type-specific cell-surface proteomic profiling in mice.
Shuster SA, Li J, Chon U, Sinantha-Hu MC, Luginbuhl DJ, Udeshi ND, Carey DK, Takeo YH, Xie Q, Xu C, Mani DR, Han S, Ting AY, Carr SA, Luo L.
Neuron. 2022 Dec 7;110(23):3882-3896.e9. doi: 10.1016/j.neuron.2022.09.025. Epub 2022 Oct 10.
PubMed
Associated Plasmids |
| Chromatin context-dependent regulation and epigenetic manipulation of prime editing. Li X, Chen W, Martin BK, Calderon D, Lee C, Choi J, Chardon FM, McDiarmid T, Kim H, Lalanne JB, Nathans JF, Shendure J. bioRxiv. 2023 Apr 12:2023.04.12.536587. doi: 10.1101/2023.04.12.536587. Preprint. PubMed |
| Metabolic impact of genetic and chemical ADP/ATP carrier inhibition in renal proximal tubule epithelial cells. Hoogstraten CA, Jacobs MME, de Boer G, van de Wal MAE, Koopman WJH, Smeitink JAM, Russel FGM, Schirris TJJ. Arch Toxicol. 2023 Jul;97(7):1927-1941. doi: 10.1007/s00204-023-03510-7. Epub 2023 May 8. PubMed |
| KDM3A and KDM3B Maintain Naive Pluripotency Through the Regulation of Alternative Splicing. Dillingham CM, Cormaty H, Morgan EC, Tak AI, Esgdaille DE, Boutz PL, Sridharan R. bioRxiv [Preprint]. 2024 Jan 23:2023.05.31.543088. doi: 10.1101/2023.05.31.543088. PubMed |
| In vivo recording of suprachiasmatic nucleus dynamics reveals a dominant role of arginine vasopressin neurons in circadian pacesetting. Tsuno Y, Peng Y, Horike SI, Wang M, Matsui A, Yamagata K, Sugiyama M, Nakamura TJ, Daikoku T, Maejima T, Mieda M. PLoS Biol. 2023 Aug 29;21(8):e3002281. doi: 10.1371/journal.pbio.3002281. eCollection 2023 Aug. PubMed |
| A LIGHTFUL nanomedicine overcomes EGFR-mediated drug resistance for enhanced tyrosine-kinase-inhibitor-based hepatocellular carcinoma therapy. Yi K, Kong H, Zheng C, Zhuo C, Jin Y, Zhong Q, Mintz RL, Ju E, Wang H, Lv S, Lao YH, Tao Y, Li M. Biomaterials. 2023 Nov;302:122349. doi: 10.1016/j.biomaterials.2023.122349. Epub 2023 Oct 6. PubMed |
| Delete_Remyelination protects neurons from DLK-mediated neurodegeneration. Duncan GJ, Ingram SD, Emberley K, Hill J, Cordano C, Abdelhak A, McCane M, Jabassini N, Ananth K, Ferrara SJ, Stedelin B, Sivyer B, Aicher SA, Scanlan T, Watkins TA, Mishra A, Nelson J, Green AJ, Emery B. bioRxiv [Preprint]. 2023 Oct 12:2023.09.30.560267. doi: 10.1101/2023.09.30.560267. PubMed |
| Expression of the CIC-DUX4 fusion oncoprotein mimics human CIC-rearranged sarcoma in genetically engineered mouse models. Hendrickson PG, Oristian KM, Browne MR, Luo L, Ma Y, Cardona DM, Linardic CM, Kirsch DG. Res Sq [Preprint]. 2023 Oct 29:rs.3.rs-3487637. doi: 10.21203/rs.3.rs-3487637/v1. PubMed |
| Patient-derived response estimates from zero-passage organoids of luminal breast cancer. Przanowska RK, Labban N, Przanowski P, Hawes RB, Atkins KA, Showalter SL, Janes KA. bioRxiv [Preprint]. 2024 Mar 27:2024.03.24.586432. doi: 10.1101/2024.03.24.586432. PubMed |
| De novo and salvage purine synthesis pathways across tissues and tumors. Tran DH, Kim D, Kesavan R, Brown H, Dey T, Soflaee MH, Vu HS, Tasdogan A, Guo J, Bezwada D, Al Saad H, Cai F, Solmonson A, Rion H, Chabatya R, Merchant S, Manales NJ, Tcheuyap VT, Mulkey M, Mathews TP, Brugarolas J, Morrison SJ, Zhu H, DeBerardinis RJ, Hoxhaj G. Cell. 2024 Jul 11;187(14):3602-3618.e20. doi: 10.1016/j.cell.2024.05.011. Epub 2024 May 31. PubMed |
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