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PB-TRE-dCas9-VPR Citations (25)

Originally described in: Highly efficient Cas9-mediated transcriptional programming.
Chavez A, Scheiman J, Vora S, Pruitt BW, Tuttle M, P R Iyer E, Lin S, Kiani S, Guzman CD, Wiegand DJ, Ter-Ovanesyan D, Braff JL, Davidsohn N, Housden BE, Perrimon N, Weiss R, Aach J, Collins JJ, Church GM Nat Methods. 2015 Mar 2. doi: 10.1038/nmeth.3312. PubMed Journal

Articles Citing PB-TRE-dCas9-VPR

Articles
On-demand optogenetic activation of human stem-cell-derived neurons. Klapper SD, Sauter EJ, Swiersy A, Hyman MAE, Bamann C, Bamberg E, Busskamp V. Sci Rep. 2017 Oct 31;7(1):14450. doi: 10.1038/s41598-017-14827-6. PubMed

Associated Plasmids
Conditional gene knockout and reconstitution in human iPSCs with an inducible Cas9 system. Wu M, Liu S, Gao Y, Bai H, Machairaki V, Li G, Chen T, Cheng L. Stem Cell Res. 2018 May;29:6-14. doi: 10.1016/j.scr.2018.03.003. Epub 2018 Mar 10. PubMed

Associated Plasmids
Combined Experimental and System-Level Analyses Reveal the Complex Regulatory Network of miR-124 during Human Neurogenesis. Kutsche LK, Gysi DM, Fallmann J, Lenk K, Petri R, Swiersy A, Klapper SD, Pircs K, Khattak S, Stadler PF, Jakobsson J, Nowick K, Busskamp V. Cell Syst. 2018 Sep 28. pii: S2405-4712(18)30358-2. doi: 10.1016/j.cels.2018.08.011. PubMed

Associated Plasmids
Creation of versatile cloning platforms for transgene expression and dCas9-based epigenome editing. Haldeman JM, Conway AE, Arlotto ME, Slentz DH, Muoio DM, Becker TC, Newgard CB. Nucleic Acids Res. 2018 Dec 27. pii: 5264291. doi: 10.1093/nar/gky1286. PubMed

Associated Plasmids
The metabolic sensor PASK is a histone 3 kinase that also regulates H3K4 methylation by associating with H3K4 MLL2 methyltransferase complex. Karakkat JV, Kaimala S, Sreedharan SP, Jayaprakash P, Adeghate EA, Ansari SA, Guccione E, Mensah-Brown EPK, Starling Emerald B. Nucleic Acids Res. 2019 Nov 4;47(19):10086-10103. doi: 10.1093/nar/gkz786. PubMed
Metabolic Reprogramming Promotes Neural Crest Migration via Yap/Tead Signaling. Bhattacharya D, Azambuja AP, Simoes-Costa M. Dev Cell. 2020 Apr 20;53(2):199-211.e6. doi: 10.1016/j.devcel.2020.03.005. Epub 2020 Apr 2. PubMed
Enabling large-scale genome editing at repetitive elements by reducing DNA nicking. Smith CJ, Castanon O, Said K, Volf V, Khoshakhlagh P, Hornick A, Ferreira R, Wu CT, Guell M, Garg S, Ng AHM, Myllykallio H, Church GM. Nucleic Acids Res. 2020 May 21;48(9):5183-5195. doi: 10.1093/nar/gkaa239. PubMed

Associated Plasmids
Endogenous retroviruses drive species-specific germline transcriptomes in mammals. Sakashita A, Maezawa S, Takahashi K, Alavattam KG, Yukawa M, Hu YC, Kojima S, Parrish NF, Barski A, Pavlicev M, Namekawa SH. Nat Struct Mol Biol. 2020 Oct;27(10):967-977. doi: 10.1038/s41594-020-0487-4. Epub 2020 Sep 7. PubMed
A comprehensive library of human transcription factors for cell fate engineering. Ng AHM, Khoshakhlagh P, Rojo Arias JE, Pasquini G, Wang K, Swiersy A, Shipman SL, Appleton E, Kiaee K, Kohman RE, Vernet A, Dysart M, Leeper K, Saylor W, Huang JY, Graveline A, Taipale J, Hill DE, Vidal M, Melero-Martin JM, Busskamp V, Church GM. Nat Biotechnol. 2021 Apr;39(4):510-519. doi: 10.1038/s41587-020-0742-6. Epub 2020 Nov 30. PubMed

Associated Plasmids
The dystonia gene THAP1 controls DNA double-strand break repair choice. Shinoda K, Zong D, Callen E, Wu W, Dumitrache LC, Belinky F, Chari R, Wong N, Ishikawa M, Stanlie A, Multhaupt-Buell T, Sharma N, Ozelius L, Ehrlich M, McKinnon PJ, Nussenzweig A. Mol Cell. 2021 Jun 17;81(12):2611-2624.e10. doi: 10.1016/j.molcel.2021.03.034. Epub 2021 Apr 14. PubMed
Cognate restriction of transposition by piggyBac-like proteins. Beckermann TM, Luo W, Wilson CM, Veach RA, Wilson MH. Nucleic Acids Res. 2021 Aug 20;49(14):8135-8144. doi: 10.1093/nar/gkab578. PubMed
CTCF is a barrier for 2C-like reprogramming. Olbrich T, Vega-Sendino M, Tillo D, Wu W, Zolnerowich N, Pavani R, Tran AD, Domingo CN, Franco M, Markiewicz-Potoczny M, Pegoraro G, FitzGerald PC, Kruhlak MJ, Lazzerini-Denchi E, Nora EP, Nussenzweig A, Ruiz S. Nat Commun. 2021 Aug 11;12(1):4856. doi: 10.1038/s41467-021-25072-x. PubMed
The ETS transcription factor ERF controls the exit from the naive pluripotent state in a MAPK-dependent manner. Vega-Sendino M, Olbrich T, Tillo D, Tran AD, Domingo CN, Franco M, FitzGerald PC, Kruhlak MJ, Ruiz S. Sci Adv. 2021 Oct;7(40):eabg8306. doi: 10.1126/sciadv.abg8306. Epub 2021 Oct 1. PubMed
Systematical analysis reveals a strong cancer relevance of CREB1-regulated genes. Zheng T, Huang J, Xiang X, Li S, Yu J, Qu K, Xu Z, Han P, Dong Z, Liu Y, Xu F, Yang H, Jaattela M, Luo Y, Liu B. Cancer Cell Int. 2021 Oct 12;21(1):530. doi: 10.1186/s12935-021-02224-z. PubMed
Spatial organization of transcribed eukaryotic genes. Leidescher S, Ribisel J, Ullrich S, Feodorova Y, Hildebrand E, Galitsyna A, Bultmann S, Link S, Thanisch K, Mulholland C, Dekker J, Leonhardt H, Mirny L, Solovei I. Nat Cell Biol. 2022 Mar;24(3):327-339. doi: 10.1038/s41556-022-00847-6. Epub 2022 Feb 17. PubMed
DNA methylation-independent long-term epigenetic silencing with dCRISPR/Cas9 fusion proteins. Ding L, Schmitt LT, Brux M, Surun D, Augsburg M, Lansing F, Mircetic J, Theis M, Buchholz F. Life Sci Alliance. 2022 Mar 14;5(6). pii: 5/6/e202101321. doi: 10.26508/lsa.202101321. Print 2022 Jun. PubMed

Associated Plasmids
A Whole-Genome CRISPR Screen Identifies AHR Loss as a Mechanism of Resistance to a PARP7 Inhibitor. Chen H, Diolaiti ME, O'Leary PC, Rojc A, Krogan NJ, Kim M, Ashworth A. Mol Cancer Ther. 2022 Jul 5;21(7):1076-1089. doi: 10.1158/1535-7163.MCT-21-0841. PubMed
Transplanted human cones incorporate and function in a murine cone degeneration model. Gasparini SJ, Tessmer K, Reh M, Wieneke S, Carido M, Volkner M, Borsch O, Swiersy A, Zuzic M, Goureau O, Kurth T, Busskamp V, Zeck G, Karl MO, Ader M. J Clin Invest. 2022 Apr 28. pii: 154619. doi: 10.1172/JCI154619. PubMed

Associated Plasmids
XPF activates break-induced telomere synthesis. Guh CY, Shen HJ, Chen LW, Chiu PC, Liao IH, Lo CC, Chen Y, Hsieh YH, Chang TC, Yen CP, Chen YY, Chen TW, Chen LY, Wu CS, Egly JM, Chu HC. Nat Commun. 2022 Oct 2;13(1):5781. doi: 10.1038/s41467-022-33428-0. PubMed
Enhancement of Vivid-based photo-activatable Gal4 transcription factor in mammalian cells. Nagasaki SC, Fukuda TD, Yamada M, Suzuki YI, Kakutani R, Guy AT, Imayoshi I. Cell Struct Funct. 2023 Feb 8;48(1):31-47. doi: 10.1247/csf.22074. Epub 2022 Dec 16. PubMed
Epigenetic and transcriptional regulations prime cell fate before division during human pluripotent stem cell differentiation. Madrigal P, Deng S, Feng Y, Militi S, Goh KJ, Nibhani R, Grandy R, Osnato A, Ortmann D, Brown S, Pauklin S. Nat Commun. 2023 Jan 25;14(1):405. doi: 10.1038/s41467-023-36116-9. PubMed
SELENOP modifies sporadic colorectal carcinogenesis and WNT signaling activity through LRP5/6 interactions. Pilat JM, Brown RE, Chen Z, Berle NJ, Othon AP, Washington MK, Anant SA, Kurokawa S, Ng VH, Thompson JJ, Jacobse J, Goettel JA, Lee E, Choksi YA, Lau KS, Short SP, Williams CS. J Clin Invest. 2023 Jul 3;133(13):e165988. doi: 10.1172/JCI165988. PubMed
macroH2A2 antagonizes epigenetic programs of stemness in glioblastoma. Nikolic A, Maule F, Bobyn A, Ellestad K, Paik S, Marhon SA, Mehdipour P, Lun X, Chen HM, Mallard C, Hay AJ, Johnston MJ, Gafuik CJ, Zemp FJ, Shen Y, Ninkovic N, Osz K, Labit E, Berger ND, Brownsey DK, Kelly JJ, Biernaskie J, Dirks PB, Derksen DJ, Jones SJM, Senger DL, Chan JA, Mahoney DJ, De Carvalho DD, Gallo M. Nat Commun. 2023 May 27;14(1):3062. doi: 10.1038/s41467-023-38919-2. PubMed
ESX1 gene as a potential candidate responsible for male infertility in nonobstructive azoospermia. Malcher A, Graczyk Z, Bauer H, Stokowy T, Berman A, Smolibowski M, Blaszczyk D, Jedrzejczak P, Yatsenko AN, Kurpisz M. Sci Rep. 2023 Oct 2;13(1):16563. doi: 10.1038/s41598-023-43854-9. PubMed
The pRb/RBL2-E2F1/4-GCN5 axis regulates cancer stem cell formation and G0 phase entry/exit by paracrine mechanisms. Chang CH, Liu F, Militi S, Hester S, Nibhani R, Deng S, Dunford J, Rendek A, Soonawalla Z, Fischer R, Oppermann U, Pauklin S. Nat Commun. 2024 Apr 27;15(1):3580. doi: 10.1038/s41467-024-47680-z. PubMed

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