lentiCas9-EGFP Citations (40)
Originally described in: Genome-wide CRISPR screen in a mouse model of tumor growth and metastasis.Chen S, Sanjana NE, Zheng K, Shalem O, Lee K, Shi X, Scott DA, Song J, Pan JQ, Weissleder R, Lee H, Zhang F, Sharp PA Cell. 2015 Mar 12;160(6):1246-60. doi: 10.1016/j.cell.2015.02.038. Epub 2015 Mar 5. PubMed Journal
Articles Citing lentiCas9-EGFP
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| LncBRM initiates YAP1 signalling activation to drive self-renewal of liver cancer stem cells. Zhu P, Wang Y, Wu J, Huang G, Liu B, Ye B, Du Y, Gao G, Tian Y, He L, Fan Z. Nat Commun. 2016 Dec 1;7:13608. doi: 10.1038/ncomms13608. PubMed |
| Epstein-Barr virus ensures B cell survival by uniquely modulating apoptosis at early and late times after infection. Price AM, Dai J, Bazot Q, Patel L, Nikitin PA, Djavadian R, Winter PS, Salinas CA, Barry AP, Wood KC, Johannsen EC, Letai A, Allday MJ, Luftig MA. Elife. 2017 Apr 20;6. pii: e22509. doi: 10.7554/eLife.22509. PubMed |
| MLL2, Not MLL1, Plays a Major Role in Sustaining MLL-Rearranged Acute Myeloid Leukemia. Chen Y, Anastassiadis K, Kranz A, Stewart AF, Arndt K, Waskow C, Yokoyama A, Jones K, Neff T, Lee Y, Ernst P. Cancer Cell. 2017 Jun 12;31(6):755-770.e6. doi: 10.1016/j.ccell.2017.05.002. PubMed |
| Epstein-Barr Virus Induces Adhesion Receptor CD226 (DNAM-1) Expression during Primary B-Cell Transformation into Lymphoblastoid Cell Lines. Grossman L, Chang C, Dai J, Nikitin PA, Jima DD, Dave SS, Luftig MA. mSphere. 2017 Nov 29;2(6). pii: mSphere00305-17. doi: 10.1128/mSphere.00305-17. eCollection 2017 Nov-Dec. PubMed |
| Ex vivo culture of cells derived from circulating tumour cell xenograft to support small cell lung cancer research and experimental therapeutics. Lallo A, Gulati S, Schenk MW, Khandelwal G, Berglund UW, Pateras IS, Chester CPE, Pham TM, Kalderen C, Frese KK, Gorgoulis VG, Miller C, Blackhall F, Helleday T, Dive C. Br J Pharmacol. 2019 Feb;176(3):436-450. doi: 10.1111/bph.14542. Epub 2018 Dec 13. PubMed |
| A conserved enhancer regulates Il9 expression in multiple lineages. Koh B, Abdul Qayum A, Srivastava R, Fu Y, Ulrich BJ, Janga SC, Kaplan MH. Nat Commun. 2018 Nov 15;9(1):4803. doi: 10.1038/s41467-018-07202-0. PubMed |
| Efferocytosis induces a novel SLC program to promote glucose uptake and lactate release. Morioka S, Perry JSA, Raymond MH, Medina CB, Zhu Y, Zhao L, Serbulea V, Onengut-Gumuscu S, Leitinger N, Kucenas S, Rathmell JC, Makowski L, Ravichandran KS. Nature. 2018 Nov;563(7733):714-718. doi: 10.1038/s41586-018-0735-5. Epub 2018 Nov 21. PubMed |
| Environmental Control of Astrocyte Pathogenic Activities in CNS Inflammation. Wheeler MA, Jaronen M, Covacu R, Zandee SEJ, Scalisi G, Rothhammer V, Tjon EC, Chao CC, Kenison JE, Blain M, Rao VTS, Hewson P, Barroso A, Gutierrez-Vazquez C, Prat A, Antel JP, Hauser R, Quintana FJ. Cell. 2019 Jan 24;176(3):581-596.e18. doi: 10.1016/j.cell.2018.12.012. Epub 2019 Jan 17. PubMed |
| Neutrophils escort circulating tumour cells to enable cell cycle progression. Szczerba BM, Castro-Giner F, Vetter M, Krol I, Gkountela S, Landin J, Scheidmann MC, Donato C, Scherrer R, Singer J, Beisel C, Kurzeder C, Heinzelmann-Schwarz V, Rochlitz C, Weber WP, Beerenwinkel N, Aceto N. Nature. 2019 Feb;566(7745):553-557. doi: 10.1038/s41586-019-0915-y. Epub 2019 Feb 6. PubMed |
| Disruption of oncogenic liver-intestine cadherin (CDH17) drives apoptotic pancreatic cancer death. Liu X, Huang Y, Yuan H, Qi X, Manjunath Y, Avella D, Kaifi JT, Miao Y, Li M, Jiang K, Li G. Cancer Lett. 2019 Jul 10;454:204-214. doi: 10.1016/j.canlet.2019.04.022. Epub 2019 Apr 17. PubMed |
| [Small Molecular Inhibitors of DNA Double Strand Break Repair Pathways Increase the ANTI-HBV Activity of CRISPR/Cas9]. Kostyusheva AP, Kostyushev DS, Brezgin SA, Zarifyan DN, Volchkova EV, Chulanov VP. Mol Biol (Mosk). 2019 Mar-Apr;53(2):311-323. doi: 10.1134/S0026898419010075. PubMed |
| Circular RNA circRHOT1 promotes hepatocellular carcinoma progression by initiation of NR2F6 expression. Wang L, Long H, Zheng Q, Bo X, Xiao X, Li B. Mol Cancer. 2019 Jul 19;18(1):119. doi: 10.1186/s12943-019-1046-7. PubMed |
| LEDGF and HDGF2 relieve the nucleosome-induced barrier to transcription in differentiated cells. LeRoy G, Oksuz O, Descostes N, Aoi Y, Ganai RA, Kara HO, Yu JR, Lee CH, Stafford J, Shilatifard A, Reinberg D. Sci Adv. 2019 Oct 2;5(10):eaay3068. doi: 10.1126/sciadv.aay3068. eCollection 2019 Oct. PubMed |
| FLT3-ITD Activates RSK1 to Enhance Proliferation and Survival of AML Cells by Activating mTORC1 and eIF4B Cooperatively with PIM or PI3K and by Inhibiting Bad and BIM. Watanabe D, Nogami A, Okada K, Akiyama H, Umezawa Y, Miura O. Cancers (Basel). 2019 Nov 20;11(12). pii: cancers11121827. doi: 10.3390/cancers11121827. PubMed |
| MAFG-driven astrocytes promote CNS inflammation. Wheeler MA, Clark IC, Tjon EC, Li Z, Zandee SEJ, Couturier CP, Watson BR, Scalisi G, Alkwai S, Rothhammer V, Rotem A, Heyman JA, Thaploo S, Sanmarco LM, Ragoussis J, Weitz DA, Petrecca K, Moffitt JR, Becher B, Antel JP, Prat A, Quintana FJ. Nature. 2020 Feb;578(7796):593-599. doi: 10.1038/s41586-020-1999-0. Epub 2020 Feb 12. PubMed |
| STAT5 promotes accessibility and is required for BATF-mediated plasticity at the Il9 locus. Fu Y, Wang J, Panangipalli G, Ulrich BJ, Koh B, Xu C, Kharwadkar R, Chu X, Wang Y, Gao H, Wu W, Sun J, Tepper RS, Zhou B, Janga SC, Yang K, Kaplan MH. Nat Commun. 2020 Sep 28;11(1):4882. doi: 10.1038/s41467-020-18648-6. PubMed |
| In vivo CRISPR/Cas9 knockout screen: TCEAL1 silencing enhances docetaxel efficacy in prostate cancer. Rushworth LK, Harle V, Repiscak P, Clark W, Shaw R, Hall H, Bushell M, Leung HY, Patel R. Life Sci Alliance. 2020 Oct 8;3(12). pii: 3/12/e202000770. doi: 10.26508/lsa.202000770. Print 2020 Dec. PubMed |
| A Simple and Efficient Method to Generate Gene-Knockout and Transgenic Cell Lines. Liu J, Ge Y, Wang N, Wen J, Wang W, Zeng B, Chen GL. DNA Cell Biol. 2021 Feb;40(2):239-246. doi: 10.1089/dna.2020.6183. Epub 2020 Dec 31. PubMed |
| Gut-licensed IFNgamma(+) NK cells drive LAMP1(+)TRAIL(+) anti-inflammatory astrocytes. Sanmarco LM, Wheeler MA, Gutierrez-Vazquez C, Polonio CM, Linnerbauer M, Pinho-Ribeiro FA, Li Z, Giovannoni F, Batterman KV, Scalisi G, Zandee SEJ, Heck ES, Alsuwailm M, Rosene DL, Becher B, Chiu IM, Prat A, Quintana FJ. Nature. 2021 Feb;590(7846):473-479. doi: 10.1038/s41586-020-03116-4. Epub 2021 Jan 6. PubMed |
| Lineage tracing and analog recording in mammalian cells by single-site DNA writing. Loveless TB, Grotts JH, Schechter MW, Forouzmand E, Carlson CK, Agahi BS, Liang G, Ficht M, Liu B, Xie X, Liu CC. Nat Chem Biol. 2021 Jun;17(6):739-747. doi: 10.1038/s41589-021-00769-8. Epub 2021 Mar 22. PubMed |
| LMO7 as an Unrecognized Factor Promoting Pancreatic Cancer Progression and Metastasis. Liu X, Yuan H, Zhou J, Wang Q, Qi X, Bernal C, Avella D, Kaifi JT, Kimchi ET, Timothy P, Cheng K, Miao Y, Jiang K, Li G. Front Cell Dev Biol. 2021 Mar 8;9:647387. doi: 10.3389/fcell.2021.647387. eCollection 2021. PubMed |
| SARS-CoV-2 evolution in an immunocompromised host reveals shared neutralization escape mechanisms. Clark SA, Clark LE, Pan J, Coscia A, McKay LGA, Shankar S, Johnson RI, Brusic V, Choudhary MC, Regan J, Li JZ, Griffiths A, Abraham J. Cell. 2021 May 13;184(10):2605-2617.e18. doi: 10.1016/j.cell.2021.03.027. Epub 2021 Mar 16. PubMed |
| Targeting Pyruvate Kinase M2 Phosphorylation Reverses Aggressive Cancer Phenotypes. Apostolidi M, Vathiotis IA, Muthusamy V, Gaule P, Gassaway BM, Rimm DL, Rinehart J. Cancer Res. 2021 Aug 15;81(16):4346-4359. doi: 10.1158/0008-5472.CAN-20-4190. Epub 2021 Jun 21. PubMed |
| ELMO1 signaling is a promoter of osteoclast function and bone loss. Arandjelovic S, Perry JSA, Zhou M, Ceroi A, Smirnov I, Walk SF, Shankman LS, Cambre I, Onengut-Gumuscu S, Elewaut D, Conrads TP, Ravichandran KS. Nat Commun. 2021 Aug 17;12(1):4974. doi: 10.1038/s41467-021-25239-6. PubMed |
| Diverse transcriptional regulation and functional effects revealed by CRISPR/Cas9-directed epigenetic editing. Vizoso M, van Rheenen J. Oncotarget. 2021 Aug 17;12(17):1651-1662. doi: 10.18632/oncotarget.28037. eCollection 2021 Aug 17. PubMed |
| PLCG1 is required for AML1-ETO leukemia stem cell self-renewal. Schnoeder TM, Schwarzer A, Jayavelu AK, Hsu CJ, Kirkpatrick J, Dohner K, Perner F, Eifert T, Huber N, Arreba-Tutusaus P, Dolnik A, Assi SA, Nafria M, Jiang L, Dai YT, Chen Z, Chen SJ, Kellaway SG, Ptasinska A, Ng ES, Stanley EG, Elefanty AG, Buschbeck M, Bierhoff H, Brodt S, Matziolis G, Fischer KD, Hochhaus A, Chen CW, Heidenreich O, Mann M, Lane SW, Bullinger L, Ori A, von Eyss B, Bonifer C, Heidel FH. Blood. 2022 Feb 17;139(7):1080-1097. doi: 10.1182/blood.2021012778. PubMed |
| Defining the fetal origin of MLL-AF4 infant leukemia highlights specific fatty acid requirements. Symeonidou V, Jakobczyk H, Bashanfer S, Malouf C, Fotopoulou F, Kotecha RS, Anderson RA, Finch AJ, Ottersbach K. Cell Rep. 2021 Oct 26;37(4):109900. doi: 10.1016/j.celrep.2021.109900. PubMed |
| Time-controlled and muscle-specific CRISPR/Cas9-mediated deletion of CTG-repeat expansion in the DMPK gene. Cardinali B, Provenzano C, Izzo M, Voellenkle C, Battistini J, Strimpakos G, Golini E, Mandillo S, Scavizzi F, Raspa M, Perfetti A, Baci D, Lazarevic D, Garcia-Manteiga JM, Gourdon G, Martelli F, Falcone G. Mol Ther Nucleic Acids. 2021 Nov 29;27:184-199. doi: 10.1016/j.omtn.2021.11.024. eCollection 2022 Mar 8. PubMed |
| Distinct antibody clones detect PD-1 checkpoint expression and block PD-L1 interactions on live murine melanoma cells. Martins C, Silva M, Rasbach E, Singh P, Itoh Y, Williams JB, Statham E, Meurer A, Martinez DV, Brandenburg A, Heppt MV, Barthel SR, Schatton T. Sci Rep. 2022 Jul 21;12(1):12491. doi: 10.1038/s41598-022-16776-1. PubMed |
| Integrated multi-omics analyses identify key anti-viral host factors and pathways controlling SARS-CoV-2 infection. Hou J, Wei Y, Zou J, Jaffery R, Liang S, Zheng C, Chen K, Shi PY, Chen Y, Xie X, Peng W. Res Sq. 2022 Aug 15:rs.3.rs-1910932. doi: 10.21203/rs.3.rs-1910932/v1. Preprint. PubMed |
| NUDT21 limits CD19 levels through alternative mRNA polyadenylation in B cell acute lymphoblastic leukemia. Witkowski MT, Lee S, Wang E, Lee AK, Talbot A, Ma C, Tsopoulidis N, Brumbaugh J, Zhao Y, Roberts KG, Hogg SJ, Nomikou S, Ghebrechristos YE, Thandapani P, Mullighan CG, Hochedlinger K, Chen W, Abdel-Wahab O, Eyquem J, Aifantis I. Nat Immunol. 2022 Oct;23(10):1424-1432. doi: 10.1038/s41590-022-01314-y. Epub 2022 Sep 22. PubMed |
| Extensive androgen receptor enhancer heterogeneity in primary prostate cancers underlies transcriptional diversity and metastatic potential. Kneppers J, Severson TM, Siefert JC, Schol P, Joosten SEP, Yu IPL, Huang CF, Morova T, Altintas UB, Giambartolomei C, Seo JH, Baca SC, Carneiro I, Emberly E, Pasaniuc B, Jeronimo C, Henrique R, Freedman ML, Wessels LFA, Lack NA, Bergman AM, Zwart W. Nat Commun. 2022 Nov 30;13(1):7367. doi: 10.1038/s41467-022-35135-2. PubMed |
Small Molecule-Activated O-GlcNAcase for Spatiotemporal Removal of O-GlcNAc in Live Cells.
Ge Y, Lu H, Yang B, Woo CM.
ACS Chem Biol. 2023 Jan 4. doi: 10.1021/acschembio.2c00894.
PubMed
Associated Plasmids |
| Stromal cells support the survival of human primary chronic lymphocytic leukemia (CLL) cells through Lyn-driven extracellular vesicles. de Oliveira TD, Vom Stein A, Rebollido-Rios R, Lobastova L, Lettau M, Janssen O, Wagle P, Nguyen PH, Hallek M, Hansen HP. Front Med (Lausanne). 2023 Jan 13;9:1059028. doi: 10.3389/fmed.2022.1059028. eCollection 2022. PubMed |
| mGluR5 from Primary Sensory Neurons Promotes Opioid-Induced Hyperalgesia and Tolerance by Interacting with and Potentiating Synaptic NMDA Receptors. Jin D, Chen H, Zhou MH, Chen SR, Pan HL. J Neurosci. 2023 Aug 2;43(31):5593-5607. doi: 10.1523/JNEUROSCI.0601-23.2023. Epub 2023 Jul 14. PubMed |
| A genome-wide in vivo CRISPR screen identifies essential regulators of T cell migration to the CNS in a multiple sclerosis model. Kendirli A, de la Rosa C, Lammle KF, Eglseer K, Bauer IJ, Kavaka V, Winklmeier S, Zhuo L, Wichmann C, Gerdes LA, Kumpfel T, Dornmair K, Beltran E, Kerschensteiner M, Kawakami N. Nat Neurosci. 2023 Oct;26(10):1713-1725. doi: 10.1038/s41593-023-01432-2. Epub 2023 Sep 14. PubMed |
| CRISPR-Cas9-based functional interrogation of unconventional translatome reveals human cancer dependency on cryptic non-canonical open reading frames. Zheng C, Wei Y, Zhang P, Lin K, He D, Teng H, Manyam G, Zhang Z, Liu W, Lee HRL, Tang X, He W, Islam N, Jain A, Chiu Y, Cao S, Diao Y, Meyer-Gauen S, Hook M, Malovannaya A, Li W, Hu M, Wang W, Xu H, Kopetz S, Chen Y. Nat Struct Mol Biol. 2023 Dec;30(12):1878-1892. doi: 10.1038/s41594-023-01117-1. Epub 2023 Nov 6. PubMed |
| Integrated multi-omics analyses identify anti-viral host factors and pathways controlling SARS-CoV-2 infection. Hou J, Wei Y, Zou J, Jaffery R, Sun L, Liang S, Zheng N, Guerrero AM, Egan NA, Bohat R, Chen S, Zheng C, Mao X, Yi SS, Chen K, McGrail DJ, Sahni N, Shi PY, Chen Y, Xie X, Peng W. Nat Commun. 2024 Jan 2;15(1):109. doi: 10.1038/s41467-023-44175-1. PubMed |
| The astrocyte-produced growth factor HB-EGF limits autoimmune CNS pathology. Linnerbauer M, Losslein L, Vandrey O, Peter A, Han Y, Tsaktanis T, Wogram E, Needhamsen M, Kular L, Nagel L, Zissler J, Andert M, Meszaros L, Hanspach J, Zuber F, Naumann UJ, Diebold M, Wheeler MA, Beyer T, Nirschl L, Cirac A, Laun FB, Gunther C, Winkler J, Bauerle T, Jagodic M, Hemmer B, Prinz M, Quintana FJ, Rothhammer V. Nat Immunol. 2024 Mar;25(3):432-447. doi: 10.1038/s41590-024-01756-6. Epub 2024 Feb 26. PubMed |
| Integrated drug profiling and CRISPR screening identify BCR::ABL1-independent vulnerabilities in chronic myeloid leukemia. Adnan Awad S, Dufva O, Klievink J, Karjalainen E, Ianevski A, Pietarinen P, Kim D, Potdar S, Wolf M, Lotfi K, Aittokallio T, Wennerberg K, Porkka K, Mustjoki S. Cell Rep Med. 2024 May 21;5(5):101521. doi: 10.1016/j.xcrm.2024.101521. Epub 2024 Apr 22. PubMed |
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