AAVS1-TALEN-R Citations (37)
Originally described in: An iCRISPR Platform for Rapid, Multiplexable, and Inducible Genome Editing in Human Pluripotent Stem Cells.Gonzalez F, Zhu Z, Shi ZD, Lelli K, Verma N, Li QV, Huangfu D Cell Stem Cell. 2014 Jun 11. pii: S1934-5909(14)00205-7. doi: 10.1016/j.stem.2014.05.018. PubMed Journal
Articles Citing AAVS1-TALEN-R
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| A platform for functional assessment of large variant libraries in mammalian cells. Matreyek KA, Stephany JJ, Fowler DM. Nucleic Acids Res. 2017 Mar 15. doi: 10.1093/nar/gkx183. PubMed |
| Nanoporous Immunoprotective Device for Stem-Cell-Derived beta-Cell Replacement Therapy. Chang R, Faleo G, Russ HA, Parent AV, Elledge SK, Bernards DA, Allen JL, Villanueva K, Hebrok M, Tang Q, Desai TA. ACS Nano. 2017 Aug 22;11(8):7747-7757. doi: 10.1021/acsnano.7b01239. Epub 2017 Aug 7. PubMed |
| Mitigating Ischemic Injury of Stem Cell-Derived Insulin-Producing Cells after Transplant. Faleo G, Russ HA, Wisel S, Parent AV, Nguyen V, Nair GG, Freise JE, Villanueva KE, Szot GL, Hebrok M, Tang Q. Stem Cell Reports. 2017 Sep 12;9(3):807-819. doi: 10.1016/j.stemcr.2017.07.012. Epub 2017 Aug 10. PubMed |
| Inducible CRISPR genome editing platform in naive human embryonic stem cells reveals JARID2 function in self-renewal. Ferreccio A, Mathieu J, Detraux D, Somasundaram L, Cavanaugh C, Sopher B, Fischer K, Bello T, M Hussein A, Levy S, Cook S, Sidhu SB, Artoni F, Palpant NJ, Reinecke H, Wang Y, Paddison P, Murry C, Jayadev S, Ware C, Ruohola-Baker H. Cell Cycle. 2018;17(5):535-549. doi: 10.1080/15384101.2018.1442621. Epub 2018 Apr 5. PubMed |
| Folliculin regulates mTORC1/2 and WNT pathways in early human pluripotency. Mathieu J, Detraux D, Kuppers D, Wang Y, Cavanaugh C, Sidhu S, Levy S, Robitaille AM, Ferreccio A, Bottorff T, McAlister A, Somasundaram L, Artoni F, Battle S, Hawkins RD, Moon RT, Ware CB, Paddison PJ, Ruohola-Baker H. Nat Commun. 2019 Feb 7;10(1):632. doi: 10.1038/s41467-018-08020-0. PubMed |
| hESC-Derived Thalamic Organoids Form Reciprocal Projections When Fused with Cortical Organoids. Xiang Y, Tanaka Y, Cakir B, Patterson B, Kim KY, Sun P, Kang YJ, Zhong M, Liu X, Patra P, Lee SH, Weissman SM, Park IH. Cell Stem Cell. 2019 Mar 7;24(3):487-497.e7. doi: 10.1016/j.stem.2018.12.015. Epub 2019 Feb 21. PubMed |
| Cortical branched actin determines cell cycle progression. Molinie N, Rubtsova SN, Fokin A, Visweshwaran SP, Rocques N, Polesskaya A, Schnitzler A, Vacher S, Denisov EV, Tashireva LA, Perelmuter VM, Cherdyntseva NV, Bieche I, Gautreau AM. Cell Res. 2019 Jun;29(6):432-445. doi: 10.1038/s41422-019-0160-9. Epub 2019 Apr 10. PubMed |
A multiplexed gRNA piggyBac transposon system facilitates efficient induction of CRISPRi and CRISPRa in human pluripotent stem cells.
Hazelbaker DZ, Beccard A, Angelini G, Mazzucato P, Messana A, Lam D, Eggan K, Barrett LE.
Sci Rep. 2020 Jan 20;10(1):635. doi: 10.1038/s41598-020-57500-1.
PubMed
Associated Plasmids |
Mitochondrial stress is relayed to the cytosol by an OMA1-DELE1-HRI pathway.
Guo X, Aviles G, Liu Y, Tian R, Unger BA, Lin YT, Wiita AP, Xu K, Correia MA, Kampmann M.
Nature. 2020 Mar;579(7799):427-432. doi: 10.1038/s41586-020-2078-2. Epub 2020 Mar 4.
PubMed
Associated Plasmids |
| Loss of the transcription factor MAFB limits beta-cell derivation from human PSCs. Russell R, Carnese PP, Hennings TG, Walker EM, Russ HA, Liu JS, Giacometti S, Stein R, Hebrok M. Nat Commun. 2020 Jun 2;11(1):2742. doi: 10.1038/s41467-020-16550-9. PubMed |
| OSMR controls glioma stem cell respiration and confers resistance of glioblastoma to ionizing radiation. Sharanek A, Burban A, Laaper M, Heckel E, Joyal JS, Soleimani VD, Jahani-Asl A. Nat Commun. 2020 Aug 17;11(1):4116. doi: 10.1038/s41467-020-17885-z. PubMed |
| p53 directly represses human LINE1 transposons. Tiwari B, Jones AE, Caillet CJ, Das S, Royer SK, Abrams JM. Genes Dev. 2020 Nov 1;34(21-22):1439-1451. doi: 10.1101/gad.343186.120. Epub 2020 Oct 15. PubMed |
| The Arp1/11 minifilament of dynactin primes the endosomal Arp2/3 complex. Fokin AI, David V, Oguievetskaia K, Derivery E, Stone CE, Cao L, Rocques N, Molinie N, Henriot V, Aumont-Nicaise M, Hinckelmann MV, Saudou F, Le Clainche C, Carter AP, Romet-Lemonne G, Gautreau AM. Sci Adv. 2021 Jan 13;7(3). pii: 7/3/eabd5956. doi: 10.1126/sciadv.abd5956. Print 2021 Jan. PubMed |
| Generation of two gene edited iPSC-lines carrying a DOX-inducible NGN2 expression cassette with and without GFP in the AAVS1 locus. Schmid B, Holst B, Poulsen U, Jorring I, Clausen C, Rasmussen M, Mau-Holzmann UA, Steeg R, Nuthall H, Ebneth A, Cabrera-Socorro A. Stem Cell Res. 2021 Apr;52:102240. doi: 10.1016/j.scr.2021.102240. Epub 2021 Feb 11. PubMed |
| MAPRE2 mutations result in altered human cranial neural crest migration, underlying craniofacial malformations in CSC-KT syndrome. Thues C, Valadas JS, Deaulmerie L, Geens A, Chouhan AK, Duran-Romana R, Schymkowitz J, Rousseau F, Bartusel M, Rehimi R, Rada-Iglesias A, Verstreken P, Van Esch H. Sci Rep. 2021 Mar 2;11(1):4976. doi: 10.1038/s41598-021-83771-3. PubMed |
| KRAS(G12C) Can Either Promote or Impair Cap-Dependent Translation in Two Different Lung Adenocarcinoma Cell Lines. Kyriakopoulos G, Katopodi V, Skeparnias I, Kaliatsi EG, Grafanaki K, Stathopoulos C. Int J Mol Sci. 2021 Feb 23;22(4). pii: ijms22042222. doi: 10.3390/ijms22042222. PubMed |
| Protocol for genome-scale CRISPR screening in engineered lineage reporter hPSCs to study cell fate determination. Zhou Z, Ma L, Zhang X. STAR Protoc. 2021 May 20;2(2):100548. doi: 10.1016/j.xpro.2021.100548. eCollection 2021 Jun 18. PubMed |
| Selective deletion of human leukocyte antigens protects stem cell-derived islets from immune rejection. Parent AV, Faleo G, Chavez J, Saxton M, Berrios DI, Kerper NR, Tang Q, Hebrok M. Cell Rep. 2021 Aug 17;36(7):109538. doi: 10.1016/j.celrep.2021.109538. PubMed |
| Allele-Specific Gene Editing Rescues Pathology in a Human Model of Charcot-Marie-Tooth Disease Type 2E. Feliciano CM, Wu K, Watry HL, Marley CBE, Ramadoss GN, Ghanim HY, Liu AZ, Zholudeva LV, McDevitt TC, Saporta MA, Conklin BR, Judge LM. Front Cell Dev Biol. 2021 Aug 16;9:723023. doi: 10.3389/fcell.2021.723023. eCollection 2021. PubMed |
| Establishment of a human induced pluripotent stem cell neuronal model for identification of modulators of A53T alpha-synuclein levels and aggregation. Vajhoj C, Schmid B, Alik A, Melki R, Fog K, Holst B, Stummann TC. PLoS One. 2021 Dec 21;16(12):e0261536. doi: 10.1371/journal.pone.0261536. eCollection 2021. PubMed |
| Comprehensive analysis of prime editing outcomes in human embryonic stem cells. Habib O, Habib G, Hwang GH, Bae S. Nucleic Acids Res. 2022 Jan 25;50(2):1187-1197. doi: 10.1093/nar/gkab1295. PubMed |
| Endogenous formaldehyde scavenges cellular glutathione resulting in redox disruption and cytotoxicity. Umansky C, Morellato AE, Rieckher M, Scheidegger MA, Martinefski MR, Fernandez GA, Pak O, Kolesnikova K, Reingruber H, Bollini M, Crossan GP, Sommer N, Monge ME, Schumacher B, Pontel LB. Nat Commun. 2022 Feb 8;13(1):745. doi: 10.1038/s41467-022-28242-7. PubMed |
| dCas9 fusion to computer-designed PRC2 inhibitor reveals functional TATA box in distal promoter region. Levy S, Somasundaram L, Raj IX, Ic-Mex D, Phal A, Schmidt S, Ng WI, Mar D, Decarreau J, Moss N, Alghadeer A, Honkanen H, Sarthy J, Vitanza A, Hawkins RD, Mathieu J, Wang Y, Baker D, Bomsztyk K, Ruohola-Baker H. Cell Rep. 2022 Mar 1;38(9):110457. doi: 10.1016/j.celrep.2022.110457. PubMed |
CRISPR interference interrogation of COPD GWAS genes reveals the functional significance of desmoplakin in iPSC-derived alveolar epithelial cells.
Werder RB, Liu T, Abo KM, Lindstrom-Vautrin J, Villacorta-Martin C, Huang J, Hinds A, Boyer N, Bullitt E, Liesa M, Silverman EK, Kotton DN, Cho MH, Zhou X, Wilson AA.
Sci Adv. 2022 Jul 15;8(28):eabo6566. doi: 10.1126/sciadv.abo6566. Epub 2022 Jul 13.
PubMed
Associated Plasmids |
CRISPRi screens in human iPSC-derived astrocytes elucidate regulators of distinct inflammatory reactive states.
Leng K, Rose IVL, Kim H, Xia W, Romero-Fernandez W, Rooney B, Koontz M, Li E, Ao Y, Wang S, Krawczyk M, Tcw J, Goate A, Zhang Y, Ullian EM, Sofroniew MV, Fancy SPJ, Schrag MS, Lippmann ES, Kampmann M.
Nat Neurosci. 2022 Nov;25(11):1528-1542. doi: 10.1038/s41593-022-01180-9. Epub 2022 Oct 27.
PubMed
Associated Plasmids |
| High-content synaptic phenotyping in human cellular models reveals a role for BET proteins in synapse assembly. Berryer MH, Rizki G, Nathanson A, Klein JA, Trendafilova D, Susco SG, Lam D, Messana A, Holton KM, Karhohs KW, Cimini BA, Pfaff K, Carpenter AE, Rubin LL, Barrett LE. Elife. 2023 Apr 21;12:e80168. doi: 10.7554/eLife.80168. PubMed |
In Vivo Delivery of Therapeutic Molecules by Transplantation of Genome-Edited Induced Pluripotent Stem Cells.
Nakajima I, Tsukimura T, Ono T, Shiga T, Shitara H, Togawa T, Sakuraba H, Miyaoka Y.
Cell Transplant. 2023 Jan-Dec;32:9636897231173734. doi: 10.1177/09636897231173734.
PubMed
Associated Plasmids |
| CRISPRi Gene Modulation and All-Optical Electrophysiology in Post-Differentiated Human iPSC-Cardiomyocytes. Han JL, Heinson YW, Chua CJ, Liu W, Entcheva E. bioRxiv. 2023 May 9:2023.05.07.539756. doi: 10.1101/2023.05.07.539756. Preprint. PubMed |
| PPP2R1A regulates migration persistence through the NHSL1-containing WAVE Shell Complex. Wang Y, Chiappetta G, Guerois R, Liu Y, Romero S, Boesch DJ, Krause M, Dessalles CA, Babataheri A, Barakat AI, Chen B, Vinh J, Polesskaya A, Gautreau AM. Nat Commun. 2023 Jun 15;14(1):3541. doi: 10.1038/s41467-023-39276-w. PubMed |
| Early Alzheimer's disease pathology in human cortex is associated with a transient phase of distinct cell states. Gazestani V, Kamath T, Nadaf NM, Burris SJ, Rooney B, Junkkari A, Vanderburg C, Rauramaa T, Therrien M, Tegtmeyer M, Herukka SK, Abdulraouf A, Marsh S, Malm T, Hiltunen M, Nehme R, Stevens B, Leinonen V, Macosko EZ. bioRxiv. 2023 Jun 5:2023.06.03.543569. doi: 10.1101/2023.06.03.543569. Preprint. PubMed |
| Neuronal lineage tracing from progenitors in human cortical organoids reveals novel mechanisms of human neuronal production, diversity, and disease. Bury LAD, Fu S, Wynshaw-Boris A. bioRxiv. 2023 Jun 17:2023.06.17.545314. doi: 10.1101/2023.06.17.545314. Preprint. PubMed |
| Protocol for selecting single human pluripotent stem cells using a modified micropipetter. Mojica-Perez SP, Stokes K, Jaklic DC, Jahagirdar S, Uhler M, Parent JM, Niu W. STAR Protoc. 2023 Dec 15;4(4):102629. doi: 10.1016/j.xpro.2023.102629. Epub 2023 Oct 9. PubMed |
| Identifying key underlying regulatory networks and predicting targets of orphan C/D box SNORD116 snoRNAs in Prader-Willi syndrome. Gilmore RB, Liu Y, Stoddard CE, Chung MS, Carmichael GG, Cotney J. bioRxiv [Preprint]. 2023 Oct 5:2023.10.03.560773. doi: 10.1101/2023.10.03.560773. PubMed |
| Systematic Dissection of Sequence Features Affecting the Binding Specificity of a Pioneer Factor Reveals Binding Synergy Between FOXA1 and AP-1. Xu C, Kleinschmidt H, Yang J, Leith E, Johnson J, Tan S, Mahony S, Bai L. bioRxiv [Preprint]. 2023 Nov 11:2023.11.08.566246. doi: 10.1101/2023.11.08.566246. PubMed |
| CRISPRi gene modulation and all-optical electrophysiology in post-differentiated human iPSC-cardiomyocytes. Han JL, Heinson YW, Chua CJ, Liu W, Entcheva E. Commun Biol. 2023 Dec 7;6(1):1236. doi: 10.1038/s42003-023-05627-y. PubMed |
| OptoDyCE-plate as an affordable high throughput imager for all optical cardiac electrophysiology. Heinson YW, Han JL, Entcheva E. J Mol Cell Cardiol Plus. 2023 Dec;6:100054. doi: 10.1016/j.jmccpl.2023.100054. Epub 2023 Nov 9. PubMed |
| Circular RNA as a source of neoantigens for cancer vaccines. Ren Y, Manoharan T, Liu B, Cheng CZM, En Siew B, Cheong WK, Lee KY, Tan IJ, Lieske B, Tan KK, Chia G. J Immunother Cancer. 2024 Mar 19;12(3):e008402. doi: 10.1136/jitc-2023-008402. PubMed |
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