pAAV/D377Y-mPCSK9 Citations (25)

Originally described in: Induction of atherosclerosis in mice and hamsters without germline genetic engineering.
Bjorklund MM, Hollensen AK, Hagensen MK, Dagnaes-Hansen F, Christoffersen C, Mikkelsen JG, Bentzon JF Circ Res. 2014 May 23;114(11):1684-9. doi: 10.1161/CIRCRESAHA.114.302937. Epub 2014 Mar 27. PubMed Journal

---

Articles Citing pAAV/D377Y-mPCSK9

Articles
Accelerated atherosclerosis development in C57Bl6 mice by overexpressing AAV-mediated PCSK9 and partial carotid ligation. Kumar S, Kang DW, Rezvan A, Jo H. Lab Invest. 2017 Aug;97(8):935-945. doi: 10.1038/labinvest.2017.47. Epub 2017 May 15. PubMed
Dynamin-Related Protein 1 Inhibition Attenuates Cardiovascular Calcification in the Presence of Oxidative Stress. Rogers MA, Maldonado N, Hutcheson JD, Goettsch C, Goto S, Yamada I, Faits T, Sesaki H, Aikawa M, Aikawa E. Circ Res. 2017 Jul 21;121(3):220-233. doi: 10.1161/CIRCRESAHA.116.310293. Epub 2017 Jun 12. PubMed
Absence of Nicotinamide Nucleotide Transhydrogenase in C57BL/6J Mice Exacerbates Experimental Atherosclerosis. Vozenilek AE, Vetkoetter M, Green JM, Shen X, Traylor JG, Klein RL, Orr AW, Woolard MD, Krzywanski DM. J Vasc Res. 2018;55(2):98-110. doi: 10.1159/000486337. Epub 2018 Feb 16. PubMed
Gene Transfer Induced Hypercholesterolemia in Amyloid Mice. Grames MS, Dayton RD, Lu X, Schilke RM, Alexander JS, Orr AW, Barmada SJ, Woolard MD, Klein RL. J Alzheimers Dis. 2018;65(4):1079-1086. doi: 10.3233/JAD-180494. PubMed
AAV8-mediated overexpression of mPCSK9 in liver differs between male and female mice. Vozenilek AE, Blackburn CMR, Schilke RM, Chandran S, Castore R, Klein RL, Woolard MD. Atherosclerosis. 2018 Nov;278:66-72. doi: 10.1016/j.atherosclerosis.2018.09.005. Epub 2018 Sep 8. PubMed
Increased lymphocyte activation and atherosclerosis in CD47-deficient mice. Engelbertsen D, Autio A, Verwilligen RAF, Depuydt MAC, Newton G, Rattik S, Levinsohn E, Saggu G, Jarolim P, Wang H, Velazquez F, Lichtman AH, Luscinskas FW. Sci Rep. 2019 Jul 23;9(1):10608. doi: 10.1038/s41598-019-46942-x. PubMed
Deletion of NoxO1 limits atherosclerosis development in female mice. Buchmann GK, Schurmann C, Warwick T, Schulz MH, Spaeth M, Muller OJ, Schroder K, Jo H, Weissmann N, Brandes RP. Redox Biol. 2020 Oct;37:101713. doi: 10.1016/j.redox.2020.101713. Epub 2020 Sep 4. PubMed
Endothelial-Specific Overexpression of Histone Deacetylase 2 Protects Mice against Endothelial Dysfunction and Atherosclerosis. Hori D, Nomura Y, Nakano M, Han M, Bhatta A, Chen K, Akiyoshi K, Pandey D. Cell Physiol Biochem. 2020 Sep 26;54(5):947-958. doi: 10.33594/000000280. PubMed
Disturbed flow-induced Gs-mediated signaling protects against endothelial inflammation and atherosclerosis. Nakayama A, Albarran-Juarez J, Liang G, Roquid KA, Iring A, Tonack S, Chen M, Muller OJ, Weinstein LS, Offermanns S. JCI Insight. 2020 Dec 3;5(23). pii: 140485. doi: 10.1172/jci.insight.140485. PubMed
Hepatocyte ATF3 protects against atherosclerosis by regulating HDL and bile acid metabolism. Xu Y, Li Y, Jadhav K, Pan X, Zhu Y, Hu S, Chen S, Chen L, Tang Y, Wang HH, Yang L, Wang DQ, Yin L, Zhang Y. Nat Metab. 2021 Jan;3(1):59-74. doi: 10.1038/s42255-020-00331-1. Epub 2021 Jan 18. PubMed
Multiple cell types contribute to the atherosclerotic lesion fibrous cap by PDGFRbeta and bioenergetic mechanisms. Newman AAC, Serbulea V, Baylis RA, Shankman LS, Bradley X, Alencar GF, Owsiany K, Deaton RA, Karnewar S, Shamsuzzaman S, Salamon A, Reddy MS, Guo L, Finn A, Virmani R, Cherepanova OA, Owens GK. Nat Metab. 2021 Feb;3(2):166-181. doi: 10.1038/s42255-020-00338-8. Epub 2021 Feb 22. PubMed
Impact of PCSK9 on CTRP9-Induced Metabolic Effects in Adult Rat Cardiomyocytes. Rohrbach S, Li L, Novoyatleva T, Niemann B, Knapp F, Molenda N, Schulz R. Front Physiol. 2021 Feb 11;12:593862. doi: 10.3389/fphys.2021.593862. eCollection 2021. PubMed
Adeno-Associated Virus-Mediated Gain-of-Function mPCSK9 Expression in the Mouse Induces Hypercholesterolemia, Monocytosis, Neutrophilia, and a Hypercoagulative State. Louloudis G, Ambrosini S, Paneni F, Camici GG, Benke D, Klohs J. Front Cardiovasc Med. 2021 Sep 22;8:718741. doi: 10.3389/fcvm.2021.718741. eCollection 2021. PubMed
Differential importance of endothelial and hematopoietic cell GLP-1Rs for cardiometabolic versus hepatic actions of semaglutide. McLean BA, Wong CK, Kaur KD, Seeley RJ, Drucker DJ. JCI Insight. 2021 Nov 22;6(22). pii: 153732. doi: 10.1172/jci.insight.153732. PubMed
B lymphocyte-derived acetylcholine limits steady-state and emergency hematopoiesis. Schloss MJ, Hulsmans M, Rohde D, Lee IH, Severe N, Foy BH, Pulous FE, Zhang S, Kokkaliaris KD, Frodermann V, Courties G, Yang C, Iwamoto Y, Knudsen AS, McAlpine CS, Yamazoe M, Schmidt SP, Wojtkiewicz GR, Masson GS, Gustafsson K, Capen D, Brown D, Higgins JM, Scadden DT, Libby P, Swirski FK, Naxerova K, Nahrendorf M. Nat Immunol. 2022 Apr;23(4):605-618. doi: 10.1038/s41590-022-01165-7. Epub 2022 Mar 28. PubMed
AFM-based nanoindentation indicates an impaired cortical stiffness in the AAV-PCSK9(DY) atherosclerosis mouse model. Achner L, Klersy T, Fels B, Reinberger T, Schmidt CX, Gross N, Hille S, Muller OJ, Aherrahrou Z, Kusche-Vihrog K, Raasch W. Pflugers Arch. 2022 Sep;474(9):993-1002. doi: 10.1007/s00424-022-02710-x. Epub 2022 Jun 1. PubMed
The AAV-PCSK9 murine model of atherosclerosis and metabolic dysfunction. Keeter WC, Carter NM, Nadler JL, Galkina EV. Eur Heart J Open. 2022 Apr 20;2(3):oeac028. doi: 10.1093/ehjopen/oeac028. eCollection 2022 May. PubMed
Genetic disruption of the Gipr in Apoe(-/-) mice promotes atherosclerosis. Pujadas G, Baggio LL, Kaur KD, McLean BA, Cao X, Drucker DJ. Mol Metab. 2022 Nov;65:101586. doi: 10.1016/j.molmet.2022.101586. Epub 2022 Aug 31. PubMed
Smooth muscle-derived adventitial progenitor cells promote key cell type transitions controlling plaque stability in atherosclerosis in a Klf4-dependent manner. Dubner AM, Lu S, Jolly AJ, Strand KA, Mutryn MF, Hinthorn T, Noble T, Nemenoff RA, Moulton KS, Majesky MW, Weiser-Evans MC. bioRxiv. 2023 Jul 19:2023.07.18.549539. doi: 10.1101/2023.07.18.549539. Preprint. PubMed
DNMT1 mediates the disturbed flow-induced endothelial to mesenchymal transition through disrupting beta-alanine and carnosine homeostasis. Zhao J, Zhao C, Yang F, Jiang Z, Zhu J, Yao W, Pang W, Zhou J. Theranostics. 2023 Aug 6;13(13):4392-4411. doi: 10.7150/thno.84427. eCollection 2023. PubMed
Single-cell transcriptomics reveals subtype-specific molecular profiles in Nrf2-deficient macrophages from murine atherosclerotic aortas. Sarad K, Stefanska M, Kraszewska I, Szade K, Sluimer JC, Blyszczuk P, Dulak J, Jazwa-Kusior A. Front Immunol. 2023 Oct 27;14:1249379. doi: 10.3389/fimmu.2023.1249379. eCollection 2023. PubMed
Smooth muscle-derived adventitial progenitor cells direct atherosclerotic plaque composition complexity in a Klf4-dependent manner. Dubner AM, Lu S, Jolly AJ, Strand KA, Mutryn MF, Hinthorn T, Noble T, Nemenoff RA, Moulton KS, Majesky MW, Weiser-Evans MC. JCI Insight. 2023 Nov 22;8(22):e174639. doi: 10.1172/jci.insight.174639. PubMed
E-cigarette exposure causes early pro-atherogenic changes in an inducible murine model of atherosclerosis. Alakhtar B, Guilbert C, Subramaniam N, Caruana V, Makhani K, Baglole CJ, Mann KK. Front Toxicol. 2023 Dec 18;5:1244596. doi: 10.3389/ftox.2023.1244596. eCollection 2023. PubMed
Incidence of microvascular dysfunction is increased in hyperlipidemic mice, reducing cerebral blood flow and impairing remote memory. Hernandez Torres LD, Rezende F, Peschke E, Will O, Hovener JB, Spiecker F, Ozorhan U, Lampe J, Stolting I, Aherrahrou Z, Kunne C, Kusche-Vihrog K, Matschl U, Hille S, Brandes RP, Schwaninger M, Muller OJ, Raasch W. Front Endocrinol (Lausanne). 2024 Feb 26;15:1338458. doi: 10.3389/fendo.2024.1338458. eCollection 2024. PubMed
Multifaceted roles of Meg3 in cellular senescence and atherosclerosis. Cheng X, Shihabudeen Haider Ali MS, Baki VB, Moran M, Su H, Sun X. Atherosclerosis. 2024 May;392:117506. doi: 10.1016/j.atherosclerosis.2024.117506. Epub 2024 Mar 8. PubMed

If you have published an article using this material, please email us at to have your article added to this page.