pLKO5.sgRNA.EFS.tRFP Citations (33)
Originally described in: Generation of mouse models of myeloid malignancy with combinatorial genetic lesions using CRISPR-Cas9 genome editing.Heckl D, Kowalczyk MS, Yudovich D, Belizaire R, Puram RV, McConkey ME, Thielke A, Aster JC, Regev A, Ebert BL Nat Biotechnol. 2014 Jun 22. doi: 10.1038/nbt.2951. PubMed Journal
Articles Citing pLKO5.sgRNA.EFS.tRFP
| Articles |
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| A B Cell Regulome Links Notch to Downstream Oncogenic Pathways in Small B Cell Lymphomas. Ryan RJH, Petrovic J, Rausch DM, Zhou Y, Lareau CA, Kluk MJ, Christie AL, Lee WY, Tarjan DR, Guo B, Donohue LKH, Gillespie SM, Nardi V, Hochberg EP, Blacklow SC, Weinstock DM, Faryabi RB, Bernstein BE, Aster JC, Pear WS. Cell Rep. 2017 Oct 17;21(3):784-797. doi: 10.1016/j.celrep.2017.09.066. PubMed |
| Participation of integrin beta3 in osteoblast differentiation induced by titanium with nano or microtopography. Lopes HB, Freitas GP, Elias CN, Tye C, Stein JL, Stein GS, Lian JB, Rosa AL, Beloti MM. J Biomed Mater Res A. 2019 Jun;107(6):1303-1313. doi: 10.1002/jbm.a.36643. Epub 2019 Feb 23. PubMed |
| Unique and Shared Epigenetic Programs of the CREBBP and EP300 Acetyltransferases in Germinal Center B Cells Reveal Targetable Dependencies in Lymphoma. Meyer SN, Scuoppo C, Vlasevska S, Bal E, Holmes AB, Holloman M, Garcia-Ibanez L, Nataraj S, Duval R, Vantrimpont T, Basso K, Brooks N, Dalla-Favera R, Pasqualucci L. Immunity. 2019 Sep 17;51(3):535-547.e9. doi: 10.1016/j.immuni.2019.08.006. Epub 2019 Sep 10. PubMed |
| A primate-specific retroviral enhancer wires the XACT lncRNA into the core pluripotency network in humans. Casanova M, Moscatelli M, Chauviere LE, Huret C, Samson J, Liyakat Ali TM, Rosspopoff O, Rougeulle C. Nat Commun. 2019 Dec 11;10(1):5652. doi: 10.1038/s41467-019-13551-1. PubMed |
| Alteration of CTCF-associated chromatin neighborhood inhibits TAL1-driven oncogenic transcription program and leukemogenesis. Li Y, Liao Z, Luo H, Benyoucef A, Kang Y, Lai Q, Dovat S, Miller B, Chepelev I, Li Y, Zhao K, Brand M, Huang S. Nucleic Acids Res. 2020 Apr 6;48(6):3119-3133. doi: 10.1093/nar/gkaa098. PubMed |
| Loss of CHD1 Promotes Heterogeneous Mechanisms of Resistance to AR-Targeted Therapy via Chromatin Dysregulation. Zhang Z, Zhou C, Li X, Barnes SD, Deng S, Hoover E, Chen CC, Lee YS, Zhang Y, Wang C, Metang LA, Wu C, Tirado CR, Johnson NA, Wongvipat J, Navrazhina K, Cao Z, Choi D, Huang CH, Linton E, Chen X, Liang Y, Mason CE, de Stanchina E, Abida W, Lujambio A, Li S, Lowe SW, Mendell JT, Malladi VS, Sawyers CL, Mu P. Cancer Cell. 2020 Apr 13;37(4):584-598.e11. doi: 10.1016/j.ccell.2020.03.001. Epub 2020 Mar 26. PubMed |
| Combined Cohesin-RUNX1 Deficiency Synergistically Perturbs Chromatin Looping and Causes Myelodysplastic Syndromes. Ochi Y, Kon A, Sakata T, Nakagawa MM, Nakazawa N, Kakuta M, Kataoka K, Koseki H, Nakayama M, Morishita D, Tsuruyama T, Saiki R, Yoda A, Okuda R, Yoshizato T, Yoshida K, Shiozawa Y, Nannya Y, Kotani S, Kogure Y, Kakiuchi N, Nishimura T, Makishima H, Malcovati L, Yokoyama A, Takeuchi K, Sugihara E, Sato TA, Sanada M, Takaori-Kondo A, Cazzola M, Kengaku M, Miyano S, Shirahige K, Suzuki HI, Ogawa S. Cancer Discov. 2020 Jun;10(6):836-853. doi: 10.1158/2159-8290.CD-19-0982. Epub 2020 Apr 5. PubMed |
| Computational inference of cancer-specific vulnerabilities in clinical samples. Jang K, Park MJ, Park JS, Hwangbo H, Sung MK, Kim S, Jung J, Lee JW, Ahn SH, Chang S, Choi JK. Genome Biol. 2020 Jun 29;21(1):155. doi: 10.1186/s13059-020-02077-1. PubMed |
| High throughput single-cell detection of multiplex CRISPR-edited gene modifications. Ten Hacken E, Clement K, Li S, Hernandez-Sanchez M, Redd R, Wang S, Ruff D, Gruber M, Baranowski K, Jacob J, Flynn J, Jones KW, Neuberg D, Livak KJ, Pinello L, Wu CJ. Genome Biol. 2020 Oct 20;21(1):266. doi: 10.1186/s13059-020-02174-1. PubMed |
Targeted brachyury degradation disrupts a highly specific autoregulatory program controlling chordoma cell identity.
Sheppard HE, Dall'Agnese A, Park WD, Shamim MH, Dubrulle J, Johnson HL, Stossi F, Cogswell P, Sommer J, Levy J, Sharifnia T, Wawer MJ, Nabet B, Gray NS, Clemons PA, Schreiber SL, Workman P, Young RA, Lin CY.
Cell Rep Med. 2021 Jan 19;2(1):100188. doi: 10.1016/j.xcrm.2020.100188. eCollection 2021 Jan 19.
PubMed
Associated Plasmids |
| Dissecting the role of TP53 alterations in del(11q) chronic lymphocytic leukemia. Quijada-Alamo M, Perez-Carretero C, Hernandez-Sanchez M, Rodriguez-Vicente AE, Herrero AB, Hernandez-Sanchez JM, Martin-Izquierdo M, Santos-Minguez S, Del Rey M, Gonzalez T, Rubio-Martinez A, Garcia de Coca A, Davila-Valls J, Hernandez-Rivas JA, Parker H, Strefford JC, Benito R, Ordonez JL, Hernandez-Rivas JM. Clin Transl Med. 2021 Feb;11(2):e304. doi: 10.1002/ctm2.304. PubMed |
| CRISPRi screens reveal a DNA methylation-mediated 3D genome dependent causal mechanism in prostate cancer. Ahmed M, Soares F, Xia JH, Yang Y, Li J, Guo H, Su P, Tian Y, Lee HJ, Wang M, Akhtar N, Houlahan KE, Bosch A, Zhou S, Mazrooei P, Hua JT, Chen S, Petricca J, Zeng Y, Davies A, Fraser M, Quigley DA, Feng FY, Boutros PC, Lupien M, Zoubeidi A, Wang L, Walsh MJ, Wang T, Ren S, Wei GH, He HH. Nat Commun. 2021 Mar 19;12(1):1781. doi: 10.1038/s41467-021-21867-0. PubMed |
| Focused CRISPR-Cas9 genetic screening reveals USO1 as a vulnerability in B-cell acute lymphoblastic leukemia. Jaiswal AK, Truong H, Tran TM, Lin TL, Casero D, Alberti MO, Rao DS. Sci Rep. 2021 Jun 23;11(1):13158. doi: 10.1038/s41598-021-92448-w. PubMed |
| The Cancer Therapy-Related Clonal Hematopoiesis Driver Gene Ppm1d Promotes Inflammation and Non-Ischemic Heart Failure in Mice. Yura Y, Miura-Yura E, Katanasaka Y, Min KD, Chavkin N, Polizio AH, Ogawa H, Horitani K, Doviak H, Evans MA, Sano M, Wang Y, Boroviak K, Philippos G, Domingues AF, Vassiliou G, Sano S, Walsh K. Circ Res. 2021 Sep 3;129(6):684-698. doi: 10.1161/CIRCRESAHA.121.319314. Epub 2021 Jul 28. PubMed |
| Sex-Biased ZRSR2 Mutations in Myeloid Malignancies Impair Plasmacytoid Dendritic Cell Activation and Apoptosis. Togami K, Chung SS, Madan V, Booth CAG, Kenyon CM, Cabal-Hierro L, Taylor J, Kim SS, Griffin GK, Ghandi M, Li J, Li YY, Angelot-Delettre F, Biichle S, Seiler M, Buonamici S, Lovitch SB, Louissaint A Jr, Morgan EA, Jardin F, Piccaluga PP, Weinstock DM, Hammerman PS, Yang H, Konopleva M, Pemmaraju N, Garnache-Ottou F, Abdel-Wahab O, Koeffler HP, Lane AA. Cancer Discov. 2022 Feb;12(2):522-541. doi: 10.1158/2159-8290.CD-20-1513. Epub 2021 Oct 6. PubMed |
| Deciphering intratumoral heterogeneity using integrated clonal tracking and single-cell transcriptome analyses. Contreras-Trujillo H, Eerdeng J, Akre S, Jiang D, Contreras J, Gala B, Vergel-Rodriguez MC, Lee Y, Jorapur A, Andreasian A, Harton L, Bramlett CS, Nogalska A, Xiao G, Lee JW, Chan LN, Muschen M, Merchant AA, Lu R. Nat Commun. 2021 Nov 11;12(1):6522. doi: 10.1038/s41467-021-26771-1. PubMed |
| Human alveolar type 2 epithelium transdifferentiates into metaplastic KRT5(+) basal cells. Kathiriya JJ, Wang C, Zhou M, Brumwell A, Cassandras M, Le Saux CJ, Cohen M, Alysandratos KD, Wang B, Wolters P, Matthay M, Kotton DN, Chapman HA, Peng T. Nat Cell Biol. 2022 Jan;24(1):10-23. doi: 10.1038/s41556-021-00809-4. Epub 2021 Dec 30. PubMed |
| Mutant Kras co-opts a proto-oncogenic enhancer network in inflammation-induced metaplastic progenitor cells to initiate pancreatic cancer. Li Y, He Y, Peng J, Su Z, Li Z, Zhang B, Ma J, Zhuo M, Zou D, Liu X, Liu X, Wang W, Huang D, Xu M, Wang J, Deng H, Xue J, Xie W, Lan X, Chen M, Zhao Y, Wu W, David CJ. Nat Cancer. 2021 Jan;2(1):49-65. doi: 10.1038/s43018-020-00134-z. Epub 2020 Nov 2. PubMed |
| Identification of novel HPFH-like mutations by CRISPR base editing that elevate the expression of fetal hemoglobin. Ravi NS, Wienert B, Wyman SK, Bell HW, George A, Mahalingam G, Vu JT, Prasad K, Bandlamudi BP, Devaraju N, Rajendiran V, Syedbasha N, Pai AA, Nakamura Y, Kurita R, Narayanasamy M, Balasubramanian P, Thangavel S, Marepally S, Velayudhan SR, Srivastava A, DeWitt MA, Crossley M, Corn JE, Mohankumar KM. Elife. 2022 Feb 11;11. pii: 65421. doi: 10.7554/eLife.65421. PubMed |
| Promoting antibody-dependent cellular phagocytosis for effective macrophage-based cancer immunotherapy. Cao X, Chen J, Li B, Dang J, Zhang W, Zhong X, Wang C, Raoof M, Sun Z, Yu J, Fakih MG, Feng M. Sci Adv. 2022 Mar 18;8(11):eabl9171. doi: 10.1126/sciadv.abl9171. Epub 2022 Mar 18. PubMed |
| Inert Pepper aptamer-mediated endogenous mRNA recognition and imaging in living cells. Wang Q, Xiao F, Su H, Liu H, Xu J, Tang H, Qin S, Fang Z, Lu Z, Wu J, Weng X, Zhou X. Nucleic Acids Res. 2022 Aug 12;50(14):e84. doi: 10.1093/nar/gkac368. PubMed |
| RUNX1 Inhibition Using Lipid Nanoparticle-Mediated Silencing RNA Delivery as an Effective Treatment for Acute Leukemias. Iida K, Tsuchiya A, Tamura M, Yamamoto K, Kawata S, Ishihara-Sugano M, Kato M, Kitamura T, Goyama S. Exp Hematol. 2022 Aug-Sep;112-113:1-8. doi: 10.1016/j.exphem.2022.05.001. Epub 2022 May 26. PubMed |
| Modulating the Excitability of Olfactory Output Neurons Affects Whole-Body Metabolism. Kolling LJ, Tatti R, Lowry T, Loeven AM, Fadool JM, Fadool DA. J Neurosci. 2022 Jul 27;42(30):5966-5990. doi: 10.1523/JNEUROSCI.0190-22.2022. Epub 2022 Jun 16. PubMed |
| Antibody-mediated blockade for galectin-3 binding protein in tumor secretome abrogates PDAC metastasis. Choi YS, Kim MJ, Choi EA, Kim S, Lee EJ, Park MJ, Kim MJ, Kim YW, Ahn HS, Jung JY, Jang G, Kim Y, Kim H, Kim K, Kim JY, Hong SM, Kim SC, Chang S. Proc Natl Acad Sci U S A. 2022 Jul 26;119(30):e2119048119. doi: 10.1073/pnas.2119048119. Epub 2022 Jul 18. PubMed |
| Ectopic JAK-STAT activation enables the transition to a stem-like and multilineage state conferring AR-targeted therapy resistance. Deng S, Wang C, Wang Y, Xu Y, Li X, Johnson NA, Mukherji A, Lo UG, Xu L, Gonzalez J, Metang LA, Ye J, Tirado CR, Rodarte K, Zhou Y, Xie Z, Arana C, Annamalai V, Liu X, Vander Griend DJ, Strand D, Hsieh JT, Li B, Raj G, Wang T, Mu P. Nat Cancer. 2022 Sep;3(9):1071-1087. doi: 10.1038/s43018-022-00431-9. Epub 2022 Sep 5. PubMed |
| Reversal of IKZF1-induced glucocorticoid resistance by dual targeting of AKT and ERK signaling pathways. Butler M, Vervoort BMT, van Ingen Schenau DS, Jongeneel L, van der Zwet JCG, Marke R, Meijerink JPP, Scheijen B, van der Meer LT, van Leeuwen FN. Front Oncol. 2022 Sep 2;12:905665. doi: 10.3389/fonc.2022.905665. eCollection 2022. PubMed |
| Targeting cell cycle and apoptosis to overcome chemotherapy resistance in acute myeloid leukemia. Ling VY, Straube J, Godfrey W, Haldar R, Janardhanan Y, Cooper L, Bruedigam C, Cooper E, Tavakoli Shirazi P, Jacquelin S, Tey SK, Baell J, Huang F, Jin J, Zhao Y, Bullinger L, Bywater MJ, Lane SW. Leukemia. 2023 Jan;37(1):143-153. doi: 10.1038/s41375-022-01755-2. Epub 2022 Nov 18. PubMed |
| Efficient and error-free correction of sickle mutation in human erythroid cells using prime editor-2. George A, Ravi NS, Prasad K, Panigrahi L, Koikkara S, Rajendiran V, Devaraju N, Paul J, Pai AA, Nakamura Y, Kurita R, Balasubramanian P, Thangavel S, Marepally S, Velayudhan SR, Srivastava A, Mohankumar KM. Front Genome Ed. 2022 Dec 20;4:1085111. doi: 10.3389/fgeed.2022.1085111. eCollection 2022. PubMed |
| Species-specific regulation of XIST by the JPX/FTX orthologs. Rosspopoff O, Cazottes E, Huret C, Loda A, Collier AJ, Casanova M, Rugg-Gunn PJ, Heard E, Ouimette JF, Rougeulle C. Nucleic Acids Res. 2023 Mar 21;51(5):2177-2194. doi: 10.1093/nar/gkad029. PubMed |
| A lncRNA identifies Irf8 enhancer element in negative feedback control of dendritic cell differentiation. Xu H, Li Z, Kuo CC, Gotz K, Look T, de Toledo MAS, Sere K, Costa IG, Zenke M. Elife. 2023 Mar 14;12:e83342. doi: 10.7554/eLife.83342. PubMed |
| RNA binding protein IGF2BP1 synergizes with ETV6-RUNX1 to drive oncogenic signaling in B-cell Acute Lymphoblastic Leukemia. Sharma G, Tran TM, Bansal I, Beg MS, Bhardwaj R, Bassi J, Tan Y, Jaiswal AK, Tso C, Jain A, Singh J, Chattopadhyay P, Singh A, Chopra A, Bakhshi S, Casero D, Rao DS, Palanichamy JK. J Exp Clin Cancer Res. 2023 Sep 5;42(1):231. doi: 10.1186/s13046-023-02810-1. PubMed |
Genome-scale pan-cancer interrogation of lncRNA dependencies using CasRx.
Montero JJ, Trozzo R, Sugden M, Ollinger R, Belka A, Zhigalova E, Waetzig P, Engleitner T, Schmidt-Supprian M, Saur D, Rad R.
Nat Methods. 2024 Feb 26. doi: 10.1038/s41592-024-02190-0.
PubMed
Associated Plasmids |
| Precise correction of a spectrum of beta-thalassemia mutations in coding and non-coding regions by base editors. Prasad K, Devaraju N, George A, Ravi NS, Paul J, Mahalingam G, Rajendiran V, Panigrahi L, Venkatesan V, Lakhotiya K, Periyasami Y, Pai AA, Nakamura Y, Kurita R, Balasubramanian P, Thangavel S, Velayudhan SR, Newby GA, Marepally S, Srivastava A, Mohankumar KM. Mol Ther Nucleic Acids. 2024 May 3;35(2):102205. doi: 10.1016/j.omtn.2024.102205. eCollection 2024 Jun 11. PubMed |
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