pLKO5.sgRNA.EFS.GFP Citations (57)
Originally described in: Generation of mouse models of myeloid malignancy with combinatorial genetic lesions using CRISPR-Cas9 genome editing.Heckl D, Kowalczyk MS, Yudovich D, Belizaire R, Puram RV, McConkey ME, Thielke A, Aster JC, Regev A, Ebert BL Nat Biotechnol. 2014 Jun 22. doi: 10.1038/nbt.2951. PubMed Journal
Articles Citing pLKO5.sgRNA.EFS.GFP
| Articles |
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| Targeted Gene Activation Using RNA-Guided Nucleases. Brown A, Woods WS, Perez-Pinera P. Methods Mol Biol. 2017;1468:235-50. doi: 10.1007/978-1-4939-4035-6_16. PubMed |
| The CRISPR/Cas9 system efficiently reverts the tumorigenic ability of BCR/ABL in vitro and in a xenograft model of chronic myeloid leukemia. Garcia-Tunon I, Hernandez-Sanchez M, Ordonez JL, Alonso-Perez V, Alamo-Quijada M, Benito R, Guerrero C, Hernandez-Rivas JM, Sanchez-Martin M. Oncotarget. 2017 Apr 18;8(16):26027-26040. doi: 10.18632/oncotarget.15215. PubMed |
Locus-specific histone deacetylation using a synthetic CRISPR-Cas9-based HDAC.
Kwon DY, Zhao YT, Lamonica JM, Zhou Z.
Nat Commun. 2017 May 12;8:15315. doi: 10.1038/ncomms15315.
PubMed
Associated Plasmids |
| A B Cell Regulome Links Notch to Downstream Oncogenic Pathways in Small B Cell Lymphomas. Ryan RJH, Petrovic J, Rausch DM, Zhou Y, Lareau CA, Kluk MJ, Christie AL, Lee WY, Tarjan DR, Guo B, Donohue LKH, Gillespie SM, Nardi V, Hochberg EP, Blacklow SC, Weinstock DM, Faryabi RB, Bernstein BE, Aster JC, Pear WS. Cell Rep. 2017 Oct 17;21(3):784-797. doi: 10.1016/j.celrep.2017.09.066. PubMed |
| Aberrant Activation of a Gastrointestinal Transcriptional Circuit in Prostate Cancer Mediates Castration Resistance. Shukla S, Cyrta J, Murphy DA, Walczak EG, Ran L, Agrawal P, Xie Y, Chen Y, Wang S, Zhan Y, Li D, Wong EWP, Sboner A, Beltran H, Mosquera JM, Sher J, Cao Z, Wongvipat J, Koche RP, Gopalan A, Zheng D, Rubin MA, Scher HI, Chi P, Chen Y. Cancer Cell. 2017 Dec 11;32(6):792-806.e7. doi: 10.1016/j.ccell.2017.10.008. Epub 2017 Nov 16. PubMed |
| Ligand-Dependent Corepressor (LCoR) Is a Rexinoid-Inhibited Peroxisome Proliferator-Activated Receptor gamma-Retinoid X Receptor alpha Coactivator. Shalom-Barak T, Liersemann J, Memari B, Flechner L, Devor CE, Bernardo TM, Kim S, Matsumoto N, Friedman SL, Evans RM, White JH, Barak Y. Mol Cell Biol. 2018 Apr 16;38(9). pii: MCB.00107-17. doi: 10.1128/MCB.00107-17. Print 2018 May 1. PubMed |
| A Non-catalytic Function of SETD1A Regulates Cyclin K and the DNA Damage Response. Hoshii T, Cifani P, Feng Z, Huang CH, Koche R, Chen CW, Delaney CD, Lowe SW, Kentsis A, Armstrong SA. Cell. 2018 Feb 22;172(5):1007-1021.e17. doi: 10.1016/j.cell.2018.01.032. PubMed |
| The SS18-SSX Oncoprotein Hijacks KDM2B-PRC1.1 to Drive Synovial Sarcoma. Banito A, Li X, Laporte AN, Roe JS, Sanchez-Vega F, Huang CH, Dancsok AR, Hatzi K, Chen CC, Tschaharganeh DF, Chandwani R, Tasdemir N, Jones KB, Capecchi MR, Vakoc CR, Schultz N, Ladanyi M, Nielsen TO, Lowe SW. Cancer Cell. 2018 Mar 12;33(3):527-541.e8. doi: 10.1016/j.ccell.2018.01.018. Epub 2018 Mar 1. PubMed |
| Targetable vulnerabilities in T- and NK-cell lymphomas identified through preclinical models. Ng SY, Yoshida N, Christie AL, Ghandi M, Dharia NV, Dempster J, Murakami M, Shigemori K, Morrow SN, Van Scoyk A, Cordero NA, Stevenson KE, Puligandla M, Haas B, Lo C, Meyers R, Gao G, Cherniack A, Louissaint A Jr, Nardi V, Thorner AR, Long H, Qiu X, Morgan EA, Dorfman DM, Fiore D, Jang J, Epstein AL, Dogan A, Zhang Y, Horwitz SM, Jacobsen ED, Santiago S, Ren JG, Guerlavais V, Annis DA, Aivado M, Saleh MN, Mehta A, Tsherniak A, Root D, Vazquez F, Hahn WC, Inghirami G, Aster JC, Weinstock DM, Koch R. Nat Commun. 2018 May 22;9(1):2024. doi: 10.1038/s41467-018-04356-9. PubMed |
| Drug-based perturbation screen uncovers synergistic drug combinations in Burkitt lymphoma. Tomska K, Kurilov R, Lee KS, Hullein J, Lukas M, Sellner L, Walther T, Wagner L, Oles M, Brors B, Huber W, Zenz T. Sci Rep. 2018 Aug 13;8(1):12046. doi: 10.1038/s41598-018-30509-3. PubMed |
| CCR2 Chemokine Receptors Enhance Growth and Cell-Cycle Progression of Breast Cancer Cells through SRC and PKC Activation. Yao M, Fang W, Smart C, Hu Q, Huang S, Alvarez N, Fields P, Cheng N. Mol Cancer Res. 2019 Feb;17(2):604-617. doi: 10.1158/1541-7786.MCR-18-0750. Epub 2018 Nov 16. PubMed |
| Histone demethylase LSD1 is required for germinal center formation and BCL6-driven lymphomagenesis. Hatzi K, Geng H, Doane AS, Meydan C, LaRiviere R, Cardenas M, Duy C, Shen H, Vidal MNC, Baslan T, Mohammad HP, Kruger RG, Shaknovich R, Haberman AM, Inghirami G, Lowe SW, Melnick AM. Nat Immunol. 2019 Jan;20(1):86-96. doi: 10.1038/s41590-018-0273-1. Epub 2018 Dec 10. PubMed |
| The splicing factor RBM25 controls MYC activity in acute myeloid leukemia. Ge Y, Schuster MB, Pundhir S, Rapin N, Bagger FO, Sidiropoulos N, Hashem N, Porse BT. Nat Commun. 2019 Jan 11;10(1):172. doi: 10.1038/s41467-018-08076-y. PubMed |
| PiggyBac transposon tools for recessive screening identify B-cell lymphoma drivers in mice. Weber J, de la Rosa J, Grove CS, Schick M, Rad L, Baranov O, Strong A, Pfaus A, Friedrich MJ, Engleitner T, Lersch R, Ollinger R, Grau M, Menendez IG, Martella M, Kohlhofer U, Banerjee R, Turchaninova MA, Scherger A, Hoffman GJ, Hess J, Kuhn LB, Ammon T, Kim J, Schneider G, Unger K, Zimber-Strobl U, Heikenwalder M, Schmidt-Supprian M, Yang F, Saur D, Liu P, Steiger K, Chudakov DM, Lenz G, Quintanilla-Martinez L, Keller U, Vassiliou GS, Cadinanos J, Bradley A, Rad R. Nat Commun. 2019 Mar 29;10(1):1415. doi: 10.1038/s41467-019-09180-3. PubMed |
| Functional methylome analysis of human diabetic kidney disease. Park J, Guan Y, Sheng X, Gluck C, Seasock MJ, Hakimi AA, Qiu C, Pullman J, Verma A, Li H, Palmer M, Susztak K. JCI Insight. 2019 Jun 6;4(11). pii: 128886. doi: 10.1172/jci.insight.128886. eCollection 2019 Jun 6. PubMed |
| Neurotrophic factor GDNF regulates intestinal barrier function in inflammatory bowel disease. Meir M, Burkard N, Ungewiss H, Diefenbacher M, Flemming S, Kannapin F, Germer CT, Schweinlin M, Metzger M, Waschke J, Schlegel N. J Clin Invest. 2019 Jun 17;130:2824-2840. doi: 10.1172/JCI120261. eCollection 2019 Jun 17. PubMed |
| FOXA1 mutations alter pioneering activity, differentiation and prostate cancer phenotypes. Adams EJ, Karthaus WR, Hoover E, Liu D, Gruet A, Zhang Z, Cho H, DiLoreto R, Chhangawala S, Liu Y, Watson PA, Davicioni E, Sboner A, Barbieri CE, Bose R, Leslie CS, Sawyers CL. Nature. 2019 Jul;571(7765):408-412. doi: 10.1038/s41586-019-1318-9. Epub 2019 Jun 26. PubMed |
| Unique and Shared Epigenetic Programs of the CREBBP and EP300 Acetyltransferases in Germinal Center B Cells Reveal Targetable Dependencies in Lymphoma. Meyer SN, Scuoppo C, Vlasevska S, Bal E, Holmes AB, Holloman M, Garcia-Ibanez L, Nataraj S, Duval R, Vantrimpont T, Basso K, Brooks N, Dalla-Favera R, Pasqualucci L. Immunity. 2019 Sep 17;51(3):535-547.e9. doi: 10.1016/j.immuni.2019.08.006. Epub 2019 Sep 10. PubMed |
| Mitochondrial Reprogramming Underlies Resistance to BCL-2 Inhibition in Lymphoid Malignancies. Guieze R, Liu VM, Rosebrock D, Jourdain AA, Hernandez-Sanchez M, Martinez Zurita A, Sun J, Ten Hacken E, Baranowski K, Thompson PA, Heo JM, Cartun Z, Aygun O, Iorgulescu JB, Zhang W, Notarangelo G, Livitz D, Li S, Davids MS, Biran A, Fernandes SM, Brown JR, Lako A, Ciantra ZB, Lawlor MA, Keskin DB, Udeshi ND, Wierda WG, Livak KJ, Letai AG, Neuberg D, Harper JW, Carr SA, Piccioni F, Ott CJ, Leshchiner I, Johannessen CM, Doench J, Mootha VK, Getz G, Wu CJ. Cancer Cell. 2019 Oct 14;36(4):369-384.e13. doi: 10.1016/j.ccell.2019.08.005. Epub 2019 Sep 19. PubMed |
| A Menin-MLL Inhibitor Induces Specific Chromatin Changes and Eradicates Disease in Models of MLL-Rearranged Leukemia. Krivtsov AV, Evans K, Gadrey JY, Eschle BK, Hatton C, Uckelmann HJ, Ross KN, Perner F, Olsen SN, Pritchard T, McDermott L, Jones CD, Jing D, Braytee A, Chacon D, Earley E, McKeever BM, Claremon D, Gifford AJ, Lee HJ, Teicher BA, Pimanda JE, Beck D, Perry JA, Smith MA, McGeehan GM, Lock RB, Armstrong SA. Cancer Cell. 2019 Dec 9;36(6):660-673.e11. doi: 10.1016/j.ccell.2019.11.001. PubMed |
| Systematic characterization of chromatin modifying enzymes identifies KDM3B as a critical regulator in castration resistant prostate cancer. Sarac H, Morova T, Pires E, McCullagh J, Kaplan A, Cingoz A, Bagci-Onder T, Onder T, Kawamura A, Lack NA. Oncogene. 2020 Mar;39(10):2187-2201. doi: 10.1038/s41388-019-1116-8. Epub 2019 Dec 10. PubMed |
| Vitamin B6 Addiction in Acute Myeloid Leukemia. Chen CC, Li B, Millman SE, Chen C, Li X, Morris JP 4th, Mayle A, Ho YJ, Loizou E, Liu H, Qin W, Shah H, Violante S, Cross JR, Lowe SW, Zhang L. Cancer Cell. 2020 Jan 13;37(1):71-84.e7. doi: 10.1016/j.ccell.2019.12.002. PubMed |
| Combined Cohesin-RUNX1 Deficiency Synergistically Perturbs Chromatin Looping and Causes Myelodysplastic Syndromes. Ochi Y, Kon A, Sakata T, Nakagawa MM, Nakazawa N, Kakuta M, Kataoka K, Koseki H, Nakayama M, Morishita D, Tsuruyama T, Saiki R, Yoda A, Okuda R, Yoshizato T, Yoshida K, Shiozawa Y, Nannya Y, Kotani S, Kogure Y, Kakiuchi N, Nishimura T, Makishima H, Malcovati L, Yokoyama A, Takeuchi K, Sugihara E, Sato TA, Sanada M, Takaori-Kondo A, Cazzola M, Kengaku M, Miyano S, Shirahige K, Suzuki HI, Ogawa S. Cancer Discov. 2020 Jun;10(6):836-853. doi: 10.1158/2159-8290.CD-19-0982. Epub 2020 Apr 5. PubMed |
| Mapping DNA interaction landscapes in psoriasis susceptibility loci highlights KLF4 as a target gene in 9q31. Ray-Jones H, Duffus K, McGovern A, Martin P, Shi C, Hankinson J, Gough O, Yarwood A, Morris AP, Adamson A, Taylor C, Ding J, Gaddi VP, Fu Y, Gaffney P, Orozco G, Warren RB, Eyre S. BMC Biol. 2020 May 4;18(1):47. doi: 10.1186/s12915-020-00779-3. PubMed |
| Analysis of chromatin organization and gene expression in T cells identifies functional genes for rheumatoid arthritis. Yang J, McGovern A, Martin P, Duffus K, Ge X, Zarrineh P, Morris AP, Adamson A, Fraser P, Rattray M, Eyre S. Nat Commun. 2020 Sep 2;11(1):4402. doi: 10.1038/s41467-020-18180-7. PubMed |
| PLA2G6 guards placental trophoblasts against ferroptotic injury. Beharier O, Tyurin VA, Goff JP, Guerrero-Santoro J, Kajiwara K, Chu T, Tyurina YY, St Croix CM, Wallace CT, Parry S, Parks WT, Kagan VE, Sadovsky Y. Proc Natl Acad Sci U S A. 2020 Nov 3;117(44):27319-27328. doi: 10.1073/pnas.2009201117. Epub 2020 Oct 21. PubMed |
| Dissecting the role of TP53 alterations in del(11q) chronic lymphocytic leukemia. Quijada-Alamo M, Perez-Carretero C, Hernandez-Sanchez M, Rodriguez-Vicente AE, Herrero AB, Hernandez-Sanchez JM, Martin-Izquierdo M, Santos-Minguez S, Del Rey M, Gonzalez T, Rubio-Martinez A, Garcia de Coca A, Davila-Valls J, Hernandez-Rivas JA, Parker H, Strefford JC, Benito R, Ordonez JL, Hernandez-Rivas JM. Clin Transl Med. 2021 Feb;11(2):e304. doi: 10.1002/ctm2.304. PubMed |
| Intestinal Epithelial Barrier Maturation by Enteric Glial Cells Is GDNF-Dependent. Meir M, Kannapin F, Diefenbacher M, Ghoreishi Y, Kollmann C, Flemming S, Germer CT, Waschke J, Leven P, Schneider R, Wehner S, Burkard N, Schlegel N. Int J Mol Sci. 2021 Feb 14;22(4). pii: ijms22041887. doi: 10.3390/ijms22041887. PubMed |
| HOXBLINC long non-coding RNA activation promotes leukemogenesis in NPM1-mutant acute myeloid leukemia. Zhu G, Luo H, Feng Y, Guryanova OA, Xu J, Chen S, Lai Q, Sharma A, Xu B, Zhao Z, Feng R, Ni H, Claxton D, Guo Y, Mesa RA, Qiu Y, Yang FC, Li W, Nimer SD, Huang S, Xu M. Nat Commun. 2021 Mar 29;12(1):1956. doi: 10.1038/s41467-021-22095-2. PubMed |
| Gene Editing in Human Induced Pluripotent Stem Cells Using Doxycycline-Inducible CRISPR-Cas9 System. Thamodaran V, Rani S, Velayudhan SR. Methods Mol Biol. 2021 Apr 9. doi: 10.1007/7651_2021_348. PubMed |
| CRISPR mediated targeting of DUX4 distal regulatory element represses DUX4 target genes dysregulated in Facioscapulohumeral muscular dystrophy. Das S, Chadwick BP. Sci Rep. 2021 Jun 15;11(1):12598. doi: 10.1038/s41598-021-92096-0. PubMed |
| CSNK1A1, KDM2A, and LTB4R2 Are New Druggable Vulnerabilities in Lung Cancer. Sauta E, Reggiani F, Torricelli F, Zanetti E, Tagliavini E, Santandrea G, Gobbi G, Strocchi S, Paci M, Damia G, Bellazzi R, Ambrosetti D, Ciarrocchi A, Sancisi V. Cancers (Basel). 2021 Jul 12;13(14). pii: cancers13143477. doi: 10.3390/cancers13143477. PubMed |
| The Cancer Therapy-Related Clonal Hematopoiesis Driver Gene Ppm1d Promotes Inflammation and Non-Ischemic Heart Failure in Mice. Yura Y, Miura-Yura E, Katanasaka Y, Min KD, Chavkin N, Polizio AH, Ogawa H, Horitani K, Doviak H, Evans MA, Sano M, Wang Y, Boroviak K, Philippos G, Domingues AF, Vassiliou G, Sano S, Walsh K. Circ Res. 2021 Sep 3;129(6):684-698. doi: 10.1161/CIRCRESAHA.121.319314. Epub 2021 Jul 28. PubMed |
| MiR-205-driven downregulation of cholesterol biosynthesis through SQLE-inhibition identifies therapeutic vulnerability in aggressive prostate cancer. Kalogirou C, Linxweiler J, Schmucker P, Snaebjornsson MT, Schmitz W, Wach S, Krebs M, Hartmann E, Puhr M, Muller A, Spahn M, Seitz AK, Frank T, Marouf H, Buchel G, Eckstein M, Kubler H, Eilers M, Saar M, Junker K, Rohrig F, Kneitz B, Rosenfeldt MT, Schulze A. Nat Commun. 2021 Aug 20;12(1):5066. doi: 10.1038/s41467-021-25325-9. PubMed |
| Sex-Biased ZRSR2 Mutations in Myeloid Malignancies Impair Plasmacytoid Dendritic Cell Activation and Apoptosis. Togami K, Chung SS, Madan V, Booth CAG, Kenyon CM, Cabal-Hierro L, Taylor J, Kim SS, Griffin GK, Ghandi M, Li J, Li YY, Angelot-Delettre F, Biichle S, Seiler M, Buonamici S, Lovitch SB, Louissaint A Jr, Morgan EA, Jardin F, Piccaluga PP, Weinstock DM, Hammerman PS, Yang H, Konopleva M, Pemmaraju N, Garnache-Ottou F, Abdel-Wahab O, Koeffler HP, Lane AA. Cancer Discov. 2022 Feb;12(2):522-541. doi: 10.1158/2159-8290.CD-20-1513. Epub 2021 Oct 6. PubMed |
| Modeling cell protrusion predicts how myosin II and actin turnover affect adhesion-based signaling. Chandra A, Butler MT, Bear JE, Haugh JM. Biophys J. 2022 Jan 4;121(1):102-118. doi: 10.1016/j.bpj.2021.11.2889. Epub 2021 Dec 1. PubMed |
| Loss of hexokinase 1 sensitizes ovarian cancer to high-dose metformin. Simcikova D, Gardas D, Hlozkova K, Hruda M, Zacek P, Rob L, Heneberg P. Cancer Metab. 2021 Dec 11;9(1):41. doi: 10.1186/s40170-021-00277-2. PubMed |
| Genetic alterations of the SUMO isopeptidase SENP6 drive lymphomagenesis and genetic instability in diffuse large B-cell lymphoma. Schick M, Zhang L, Maurer S, Maurer HC, Isaakaidis K, Schneider L, Patra U, Schunck K, Rohleder E, Hofstetter J, Baluapuri A, Scherger AK, Slotta-Huspenina J, Hettler F, Weber J, Engleitner T, Maresch R, Slawska J, Lewis R, Istvanffy R, Habringer S, Steiger K, Baiker A, Oostendorp RAJ, Miething C, Lenhof HP, Bassermann F, Chapuy B, Wirth M, Wolf E, Rad R, Muller S, Keller U. Nat Commun. 2022 Jan 12;13(1):281. doi: 10.1038/s41467-021-27704-8. PubMed |
| Identification of novel HPFH-like mutations by CRISPR base editing that elevate the expression of fetal hemoglobin. Ravi NS, Wienert B, Wyman SK, Bell HW, George A, Mahalingam G, Vu JT, Prasad K, Bandlamudi BP, Devaraju N, Rajendiran V, Syedbasha N, Pai AA, Nakamura Y, Kurita R, Narayanasamy M, Balasubramanian P, Thangavel S, Marepally S, Velayudhan SR, Srivastava A, DeWitt MA, Crossley M, Corn JE, Mohankumar KM. Elife. 2022 Feb 11;11. pii: 65421. doi: 10.7554/eLife.65421. PubMed |
| SETD2 Haploinsufficiency Enhances Germinal Center-Associated AICDA Somatic Hypermutation to Drive B-cell Lymphomagenesis. Leung W, Teater M, Durmaz C, Meydan C, Chivu AG, Chadburn A, Rice EJ, Muley A, Camarillo JM, Arivalagan J, Li Z, Flowers CR, Kelleher NL, Danko CG, Imielinski M, Dave SS, Armstrong SA, Mason CE, Melnick AM. Cancer Discov. 2022 Jul 6;12(7):1782-1803. doi: 10.1158/2159-8290.CD-21-1514. PubMed |
| IKAROS and MENIN coordinate therapeutically actionable leukemogenic gene expression in MLL-r acute myeloid leukemia. Aubrey BJ, Cutler JA, Bourgeois W, Donovan KA, Gu S, Hatton C, Perlee S, Perner F, Rahnamoun H, Theall ACP, Henrich JA, Zhu Q, Nowak RP, Kim YJ, Parvin S, Cremer A, Olsen SN, Eleuteri NA, Pikman Y, McGeehan GM, Stegmaier K, Letai A, Fischer ES, Liu XS, Armstrong SA. Nat Cancer. 2022 May;3(5):595-613. doi: 10.1038/s43018-022-00366-1. Epub 2022 May 9. PubMed |
| Integrative epigenomic and transcriptomic analysis reveals the requirement of JUNB for hematopoietic fate induction. Chen X, Wang P, Qiu H, Zhu Y, Zhang X, Zhang Y, Duan F, Ding S, Guo J, Huang Y, Na J. Nat Commun. 2022 Jun 6;13(1):3131. doi: 10.1038/s41467-022-30789-4. PubMed |
| KAP1 is a new non-genetic vulnerability of malignant pleural mesothelioma (MPM). Lorenzini E, Torricelli F, Zamponi R, Donati B, Manicardi V, Sauta E, Faria do Valle I, Reggiani F, Gugnoni M, Manzotti G, Fragliasso V, Vitale E, Piana S, Sancisi V, Ciarrocchi A. NAR Cancer. 2022 Jul 29;4(3):zcac024. doi: 10.1093/narcan/zcac024. eCollection 2022 Sep. PubMed |
| SETD1A regulates transcriptional pause release of heme biosynthesis genes in leukemia. Hoshii T, Perlee S, Kikuchi S, Rahmutulla B, Fukuyo M, Masuda T, Ohtsuki S, Soga T, Nabet B, Kaneda A. Cell Rep. 2022 Nov 29;41(9):111727. doi: 10.1016/j.celrep.2022.111727. PubMed |
| Efficient and error-free correction of sickle mutation in human erythroid cells using prime editor-2. George A, Ravi NS, Prasad K, Panigrahi L, Koikkara S, Rajendiran V, Devaraju N, Paul J, Pai AA, Nakamura Y, Kurita R, Balasubramanian P, Thangavel S, Marepally S, Velayudhan SR, Srivastava A, Mohankumar KM. Front Genome Ed. 2022 Dec 20;4:1085111. doi: 10.3389/fgeed.2022.1085111. eCollection 2022. PubMed |
| Genetic screens reveal new targetable vulnerabilities in BAP1-deficient mesothelioma. Pandey GK, Landman N, Neikes HK, Hulsman D, Lieftink C, Beijersbergen R, Kolluri KK, Janes SM, Vermeulen M, Badhai J, van Lohuizen M. Cell Rep Med. 2023 Feb 21;4(2):100915. doi: 10.1016/j.xcrm.2022.100915. Epub 2023 Jan 18. PubMed |
| The lipase cofactor CGI58 controls placental lipolysis. Guerrero-Santoro J, Morizane M, Oh SY, Mishima T, Goff JP, Bildirici I, Sadovsky E, Ouyang Y, Tyurin VA, Tyurina YY, Kagan VE, Sadovsky Y. JCI Insight. 2023 May 22;8(10):e168717. doi: 10.1172/jci.insight.168717. PubMed |
| macroH2A2 antagonizes epigenetic programs of stemness in glioblastoma. Nikolic A, Maule F, Bobyn A, Ellestad K, Paik S, Marhon SA, Mehdipour P, Lun X, Chen HM, Mallard C, Hay AJ, Johnston MJ, Gafuik CJ, Zemp FJ, Shen Y, Ninkovic N, Osz K, Labit E, Berger ND, Brownsey DK, Kelly JJ, Biernaskie J, Dirks PB, Derksen DJ, Jones SJM, Senger DL, Chan JA, Mahoney DJ, De Carvalho DD, Gallo M. Nat Commun. 2023 May 27;14(1):3062. doi: 10.1038/s41467-023-38919-2. PubMed |
| Ultraviolet radiation shapes dendritic cell leukaemia transformation in the skin. Griffin GK, Booth CAG, Togami K, Chung SS, Ssozi D, Verga JA, Bouyssou JM, Lee YS, Shanmugam V, Hornick JL, LeBoeuf NR, Morgan EA, Bernstein BE, Hovestadt V, van Galen P, Lane AA. Nature. 2023 Jun;618(7966):834-841. doi: 10.1038/s41586-023-06156-8. Epub 2023 Jun 7. PubMed |
| SF3B1 mutation and ATM deletion codrive leukemogenesis via centromeric R-loop dysregulation. Cusan M, Shen H, Zhang B, Liao A, Yang L, Jin M, Fernandez M, Iyer P, Wu Y, Hart K, Gutierrez C, Nik S, Pruett-Miller SM, Stark J, Obeng EA, Bowman TV, Wu CJ, Lin RJ, Wang L. J Clin Invest. 2023 Sep 1;133(17):e163325. doi: 10.1172/JCI163325. PubMed |
| Actionable loss of SLF2 drives B-cell lymphomagenesis and impairs the DNA damage response. Zhang L, Wirth M, Patra U, Stroh J, Isaakidis K, Rieger L, Kossatz S, Milanovic M, Zang C, Demel U, Keiten-Schmitz J, Wagner K, Steiger K, Rad R, Bassermann F, Muller S, Keller U, Schick M. EMBO Mol Med. 2023 Jul 24:e16431. doi: 10.15252/emmm.202216431. PubMed |
| A novel molecular class that recruits HDAC/MECP2 complexes to PU.1 motifs reduces neuroinflammation. Ralvenius WT, Mungenast AE, Woolf H, Huston MM, Gillingham TZ, Godin SK, Penney J, Cam HP, Gao F, Fernandez CG, Czako B, Lightfoot Y, Ray WJ, Beckmann A, Goate AM, Marcora E, Romero-Molina C, Ayata P, Schaefer A, Gjoneska E, Tsai LH. J Exp Med. 2023 Nov 6;220(11):e20222105. doi: 10.1084/jem.20222105. Epub 2023 Aug 29. PubMed |
| CRISPR-Cas9 Library Screening Identifies Novel Molecular Vulnerabilities in KMT2A-Rearranged Acute Lymphoblastic Leukemia. Schneider P, Wander P, Arentsen-Peters STCJM, Vrenken KS, Rockx-Brouwer D, Adriaanse FRS, Hoeve V, Paassen I, Drost J, Pieters R, Stam RW. Int J Mol Sci. 2023 Aug 25;24(17):13207. doi: 10.3390/ijms241713207. PubMed |
| Efficient gene editing in induced pluripotent stem cells enabled by an inducible adenine base editor with tunable expression. Nandy K, Babu D, Rani S, Joshi G, Ijee S, George A, Palani D, Premkumar C, Rajesh P, Vijayanand S, David E, Murugesan M, Velayudhan SR. Sci Rep. 2023 Dec 11;13(1):21953. doi: 10.1038/s41598-023-42174-2. PubMed |
| Tumor Cell-Associated IL-1alpha Affects Breast Cancer Progression and Metastasis in Mice through Manipulation of the Tumor Immune Microenvironment. Krishnamohan M, Kaplanov I, Maudi-Boker S, Yousef M, Machluf-Katz N, Cohen I, Elkabets M, Titus J, Bersudsky M, Apte RN, Voronov E, Braiman A. Int J Mol Sci. 2024 Apr 2;25(7):3950. doi: 10.3390/ijms25073950. PubMed |
| RNA splicing analysis deciphers developmental hierarchies and reveals therapeutic targets in adult glioma. Song X, Tiek D, Miki S, Huang T, Lu M, Goenka A, Iglesia R, Yu X, Wu R, Walker M, Zeng C, Shah H, Weng SHS, Huff A, Zhang W, Koga T, Hubert C, Horbinski CM, Furnari FB, Hu B, Cheng SY. J Clin Invest. 2024 Apr 25;134(11):e173789. doi: 10.1172/JCI173789. PubMed |
| Precise correction of a spectrum of beta-thalassemia mutations in coding and non-coding regions by base editors. Prasad K, Devaraju N, George A, Ravi NS, Paul J, Mahalingam G, Rajendiran V, Panigrahi L, Venkatesan V, Lakhotiya K, Periyasami Y, Pai AA, Nakamura Y, Kurita R, Balasubramanian P, Thangavel S, Velayudhan SR, Newby GA, Marepally S, Srivastava A, Mohankumar KM. Mol Ther Nucleic Acids. 2024 May 3;35(2):102205. doi: 10.1016/j.omtn.2024.102205. eCollection 2024 Jun 11. PubMed |
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