pL-CRISPR.EFS.GFP Citations (77)
Originally described in: Generation of mouse models of myeloid malignancy with combinatorial genetic lesions using CRISPR-Cas9 genome editing.Heckl D, Kowalczyk MS, Yudovich D, Belizaire R, Puram RV, McConkey ME, Thielke A, Aster JC, Regev A, Ebert BL Nat Biotechnol. 2014 Jun 22. doi: 10.1038/nbt.2951. PubMed Journal
Articles Citing pL-CRISPR.EFS.GFP
| Articles |
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| Non-coding recurrent mutations in chronic lymphocytic leukaemia. Puente XS, Bea S, Valdes-Mas R, Villamor N, Gutierrez-Abril J, Martin-Subero JI, Munar M, Rubio-Perez C, Jares P, Aymerich M, Baumann T, Beekman R, Belver L, Carrio A, Castellano G, Clot G, Colado E, Colomer D, Costa D, Delgado J, Enjuanes A, Estivill X, Ferrando AA, Gelpi JL, Gonzalez B, Gonzalez S, Gonzalez M, Gut M, Hernandez-Rivas JM, Lopez-Guerra M, Martin-Garcia D, Navarro A, Nicolas P, Orozco M, Payer AR, Pinyol M, Pisano DG, Puente DA, Queiros AC, Quesada V, Romeo-Casabona CM, Royo C, Royo R, Rozman M, Russinol N, Salaverria I, Stamatopoulos K, Stunnenberg HG, Tamborero D, Terol MJ, Valencia A, Lopez-Bigas N, Torrents D, Gut I, Lopez-Guillermo A, Lopez-Otin C, Campo E. Nature. 2015 Oct 22;526(7574):519-24. doi: 10.1038/nature14666. Epub 2015 Jul 22. PubMed |
| Metabolic reprogramming induces resistance to anti-NOTCH1 therapies in T cell acute lymphoblastic leukemia. Herranz D, Ambesi-Impiombato A, Sudderth J, Sanchez-Martin M, Belver L, Tosello V, Xu L, Wendorff AA, Castillo M, Haydu JE, Marquez J, Mates JM, Kung AL, Rayport S, Cordon-Cardo C, DeBerardinis RJ, Ferrando AA. Nat Med. 2015 Oct;21(10):1182-9. doi: 10.1038/nm.3955. Epub 2015 Sep 21. PubMed |
| Alpharetroviral self-inactivating vectors produced by a superinfection-resistant stable packaging cell line allow genetic modification of primary human T lymphocytes. Labenski V, Suerth JD, Barczak E, Heckl D, Levy C, Bernadin O, Charpentier E, Williams DA, Fehse B, Verhoeyen E, Schambach A. Biomaterials. 2016 Aug;97:97-109. doi: 10.1016/j.biomaterials.2016.04.019. Epub 2016 Apr 26. PubMed |
| Single Amino Acid Substitution N659D in HIV-2 Envelope Glycoprotein (Env) Impairs Viral Release and Hampers BST-2 Antagonism. Dufrasne FE, Lombard C, Goubau P, Ruelle J. Viruses. 2016 Oct 14;8(10). pii: E285. PubMed |
| Chromosome conformation elucidates regulatory relationships in developing human brain. Won H, de la Torre-Ubieta L, Stein JL, Parikshak NN, Huang J, Opland CK, Gandal MJ, Sutton GJ, Hormozdiari F, Lu D, Lee C, Eskin E, Voineagu I, Ernst J, Geschwind DH. Nature. 2016 Oct 27;538(7626):523-527. doi: 10.1038/nature19847. Epub 2016 Oct 19. PubMed |
| In vivo genome editing and organoid transplantation models of colorectal cancer and metastasis. Roper J, Tammela T, Cetinbas NM, Akkad A, Roghanian A, Rickelt S, Almeqdadi M, Wu K, Oberli MA, Sanchez-Rivera F, Park YK, Liang X, Eng G, Taylor MS, Azimi R, Kedrin D, Neupane R, Beyaz S, Sicinska ET, Suarez Y, Yoo J, Chen L, Zukerberg L, Katajisto P, Deshpande V, Bass AJ, Tsichlis PN, Lees J, Langer R, Hynes RO, Chen J, Bhutkar A, Jacks T, Yilmaz OH. Nat Biotechnol. 2017 May 1. doi: 10.1038/nbt.3836. PubMed |
| Suppressors and activators of JAK-STAT signaling at diagnosis and relapse of acute lymphoblastic leukemia in Down syndrome. Schwartzman O, Savino AM, Gombert M, Palmi C, Cario G, Schrappe M, Eckert C, von Stackelberg A, Huang JY, Hameiri-Grossman M, Avigad S, Te Kronnie G, Geron I, Birger Y, Rein A, Zarfati G, Fischer U, Mukamel Z, Stanulla M, Biondi A, Cazzaniga G, Vetere A, Wagner BK, Chen Z, Chen SJ, Tanay A, Borkhardt A, Izraeli S. Proc Natl Acad Sci U S A. 2017 May 16;114(20):E4030-E4039. doi: 10.1073/pnas.1702489114. Epub 2017 May 1. PubMed |
Genome-wide siRNA screen identifies UNC50 as a regulator of Shiga toxin 2 trafficking.
Selyunin AS, Iles LR, Bartholomeusz G, Mukhopadhyay S.
J Cell Biol. 2017 Oct 2;216(10):3249-3262. doi: 10.1083/jcb.201704015. Epub 2017 Sep 7.
PubMed
Associated Plasmids |
| miR-130a Deregulates PTEN and Stimulates Tumor Growth. Wei H, Cui R, Bahr J, Zanesi N, Luo Z, Meng W, Liang G, Croce CM. Cancer Res. 2017 Nov 15;77(22):6168-6178. doi: 10.1158/0008-5472.CAN-17-0530. Epub 2017 Sep 21. PubMed |
| Multiplex CRISPR/Cas9-Based Genome Editing in Human Hematopoietic Stem Cells Models Clonal Hematopoiesis and Myeloid Neoplasia. Tothova Z, Krill-Burger JM, Popova KD, Landers CC, Sievers QL, Yudovich D, Belizaire R, Aster JC, Morgan EA, Tsherniak A, Ebert BL. Cell Stem Cell. 2017 Oct 5;21(4):547-555.e8. doi: 10.1016/j.stem.2017.07.015. PubMed |
| SETD2 alterations impair DNA damage recognition and lead to resistance to chemotherapy in leukemia. Mar BG, Chu SH, Kahn JD, Krivtsov AV, Koche R, Castellano CA, Kotlier JL, Zon RL, McConkey ME, Chabon J, Chappell R, Grauman PV, Hsieh JJ, Armstrong SA, Ebert BL. Blood. 2017 Dec 14;130(24):2631-2641. doi: 10.1182/blood-2017-03-775569. Epub 2017 Oct 10. PubMed |
| The Dynamic Landscape of Open Chromatin during Human Cortical Neurogenesis. de la Torre-Ubieta L, Stein JL, Won H, Opland CK, Liang D, Lu D, Geschwind DH. Cell. 2018 Jan 11;172(1-2):289-304.e18. doi: 10.1016/j.cell.2017.12.014. Epub 2018 Jan 4. PubMed |
| Binding of NUFIP2 to Roquin promotes recognition and regulation of ICOS mRNA. Rehage N, Davydova E, Conrad C, Behrens G, Maiser A, Stehklein JE, Brenner S, Klein J, Jeridi A, Hoffmann A, Lee E, Dianzani U, Willemsen R, Feederle R, Reiche K, Hackermuller J, Leonhardt H, Sharma S, Niessing D, Heissmeyer V. Nat Commun. 2018 Jan 19;9(1):299. doi: 10.1038/s41467-017-02582-1. PubMed |
| Knockdown of Human AMPK Using the CRISPR/Cas9 Genome-Editing System. Grenier A, Sujobert P, Olivier S, Guermouche H, Mondesir J, Kosmider O, Viollet B, Tamburini J. Methods Mol Biol. 2018;1732:171-194. doi: 10.1007/978-1-4939-7598-3_11. PubMed |
| SETDB2 Links E2A-PBX1 to Cell-Cycle Dysregulation in Acute Leukemia through CDKN2C Repression. Lin CH, Wong SH, Kurzer JH, Schneidawind C, Wei MC, Duque-Afonso J, Jeong J, Feng X, Cleary ML. Cell Rep. 2018 Apr 24;23(4):1166-1177. doi: 10.1016/j.celrep.2018.03.124. PubMed |
| PTPN12/PTP-PEST Regulates Phosphorylation-Dependent Ubiquitination and Stability of Focal Adhesion Substrates in Invasive Glioblastoma Cells. Chen Z, Morales JE, Guerrero PA, Sun H, McCarty JH. Cancer Res. 2018 Jul 15;78(14):3809-3822. doi: 10.1158/0008-5472.CAN-18-0085. Epub 2018 May 9. PubMed |
| Specific targeting of point mutations in EGFR L858R-positive lung cancer by CRISPR/Cas9. Cheung AH, Chow C, Zhang J, Zhou Y, Huang T, Ng KC, Or TC, Yao YY, Dong Y, Fung JM, Xiong L, Chan AK, Lung WR, Kang W, To KF. Lab Invest. 2018 Jul;98(7):968-976. doi: 10.1038/s41374-018-0056-1. Epub 2018 May 10. PubMed |
| Curative Ex Vivo Hepatocyte-Directed Gene Editing in a Mouse Model of Hereditary Tyrosinemia Type 1. VanLith C, Guthman R, Nicolas CT, Allen K, Du Z, Joo DJ, Nyberg SL, Lillegard JB, Hickey RD. Hum Gene Ther. 2018 Nov;29(11):1315-1326. doi: 10.1089/hum.2017.252. Epub 2018 Jun 22. PubMed |
| VE-cadherin promotes vasculogenic mimicry by modulating kaiso-dependent gene expression. Delgado-Bellido D, Fernandez-Cortes M, Rodriguez MI, Serrano-Saenz S, Carracedo A, Garcia-Diaz A, Oliver FJ. Cell Death Differ. 2019 Jan;26(2):348-361. doi: 10.1038/s41418-018-0125-4. Epub 2018 May 21. PubMed |
| STK3 is a therapeutic target for a subset of acute myeloid leukemias. Camgoz A, Paszkowski-Rogacz M, Satpathy S, Wermke M, Hamann MV, von Bonin M, Choudhary C, Knapp S, Buchholz F. Oncotarget. 2018 May 22;9(39):25458-25473. doi: 10.18632/oncotarget.25238. eCollection 2018 May 22. PubMed |
| Fumarate hydratase inactivation in hereditary leiomyomatosis and renal cell cancer is synthetic lethal with ferroptosis induction. Kerins MJ, Milligan J, Wohlschlegel JA, Ooi A. Cancer Sci. 2018 Sep;109(9):2757-2766. doi: 10.1111/cas.13701. Epub 2018 Jul 20. PubMed |
| PPM1D-truncating mutations confer resistance to chemotherapy and sensitivity to PPM1D inhibition in hematopoietic cells. Kahn JD, Miller PG, Silver AJ, Sellar RS, Bhatt S, Gibson C, McConkey M, Adams D, Mar B, Mertins P, Fereshetian S, Krug K, Zhu H, Letai A, Carr SA, Doench J, Jaiswal S, Ebert BL. Blood. 2018 Sep 13;132(11):1095-1105. doi: 10.1182/blood-2018-05-850339. Epub 2018 Jun 28. PubMed |
| Structure and Mechanisms of NT5C2 Mutations Driving Thiopurine Resistance in Relapsed Lymphoblastic Leukemia. Dieck CL, Tzoneva G, Forouhar F, Carpenter Z, Ambesi-Impiombato A, Sanchez-Martin M, Kirschner-Schwabe R, Lew S, Seetharaman J, Tong L, Ferrando AA. Cancer Cell. 2018 Jul 9;34(1):136-147.e6. doi: 10.1016/j.ccell.2018.06.003. PubMed |
| CCR2 Chemokine Receptors Enhance Growth and Cell-Cycle Progression of Breast Cancer Cells through SRC and PKC Activation. Yao M, Fang W, Smart C, Hu Q, Huang S, Alvarez N, Fields P, Cheng N. Mol Cancer Res. 2019 Feb;17(2):604-617. doi: 10.1158/1541-7786.MCR-18-0750. Epub 2018 Nov 16. PubMed |
| Neuron-Specific Gene 2 (NSG2) Encodes an AMPA Receptor Interacting Protein That Modulates Excitatory Neurotransmission. Chander P, Kennedy MJ, Winckler B, Weick JP. eNeuro. 2019 Jan 24;6(1). pii: eN-NWR-0292-18. doi: 10.1523/ENEURO.0292-18.2018. eCollection 2019 Jan-Feb. PubMed |
| Integrated Phosphoproteome and Transcriptome Analysis Reveals Chlamydia-Induced Epithelial-to-Mesenchymal Transition in Host Cells. Zadora PK, Chumduri C, Imami K, Berger H, Mi Y, Selbach M, Meyer TF, Gurumurthy RK. Cell Rep. 2019 Jan 29;26(5):1286-1302.e8. doi: 10.1016/j.celrep.2019.01.006. PubMed |
| CRISPR/Cas9 as a tool to dissect cancer mutations. Sayed S, Paszkowski-Rogacz M, Schmitt LT, Buchholz F. Methods. 2019 Jul 15;164-165:36-48. doi: 10.1016/j.ymeth.2019.05.007. Epub 2019 May 10. PubMed |
| PTEN interacts with the transcription machinery on chromatin and regulates RNA polymerase II-mediated transcription. Steinbach N, Hasson D, Mathur D, Stratikopoulos EE, Sachidanandam R, Bernstein E, Parsons RE. Nucleic Acids Res. 2019 Jun 20;47(11):5573-5586. doi: 10.1093/nar/gkz272. PubMed |
| Spatial Chromosome Folding and Active Transcription Drive DNA Fragility and Formation of Oncogenic MLL Translocations. Gothe HJ, Bouwman BAM, Gusmao EG, Piccinno R, Petrosino G, Sayols S, Drechsel O, Minneker V, Josipovic N, Mizi A, Nielsen CF, Wagner EM, Takeda S, Sasanuma H, Hudson DF, Kindler T, Baranello L, Papantonis A, Crosetto N, Roukos V. Mol Cell. 2019 Jul 25;75(2):267-283.e12. doi: 10.1016/j.molcel.2019.05.015. Epub 2019 Jun 12. PubMed |
| Neuronally Enriched RUFY3 Is Required for Caspase-Mediated Axon Degeneration. Hertz NT, Adams EL, Weber RA, Shen RJ, O'Rourke MK, Simon DJ, Zebroski H, Olsen O, Morgan CW, Mileur TR, Hitchcock AM, Sinnott Armstrong NA, Wainberg M, Bassik MC, Molina H, Wells JA, Tessier-Lavigne M. Neuron. 2019 Aug 7;103(3):412-422.e4. doi: 10.1016/j.neuron.2019.05.030. Epub 2019 Jun 17. PubMed |
| Circadian gene PER1 senses progesterone signal during human endometrial decidualization. Zhang Y, Meng N, Bao H, Jiang Y, Yang N, Wu K, Wu J, Wang H, Kong S, Zhang Y. J Endocrinol. 2019 Sep 1. pii: JOE-19-0284.R2. doi: 10.1530/JOE-19-0284. PubMed |
| AMPK Activation Promotes Tight Junction Assembly in Intestinal Epithelial Caco-2 Cells. Olivier S, Leclerc J, Grenier A, Foretz M, Tamburini J, Viollet B. Int J Mol Sci. 2019 Oct 18;20(20). pii: ijms20205171. doi: 10.3390/ijms20205171. PubMed |
| Functional impact of the long non-coding RNA MEG3 deletion by CRISPR/Cas9 in the human triple negative metastatic Hs578T cancer cell line. Deocesano-Pereira C, Machado RAC, De Jesus-Ferreira HC, Marchini T, Pereira TF, Carreira ACO, Sogayar MC. Oncol Lett. 2019 Dec;18(6):5941-5951. doi: 10.3892/ol.2019.10969. Epub 2019 Oct 8. PubMed |
| Frequent mutations that converge on the NFKBIZ pathway in ulcerative colitis. Kakiuchi N, Yoshida K, Uchino M, Kihara T, Akaki K, Inoue Y, Kawada K, Nagayama S, Yokoyama A, Yamamoto S, Matsuura M, Horimatsu T, Hirano T, Goto N, Takeuchi Y, Ochi Y, Shiozawa Y, Kogure Y, Watatani Y, Fujii Y, Kim SK, Kon A, Kataoka K, Yoshizato T, Nakagawa MM, Yoda A, Nanya Y, Makishima H, Shiraishi Y, Chiba K, Tanaka H, Sanada M, Sugihara E, Sato TA, Maruyama T, Miyoshi H, Taketo MM, Oishi J, Inagaki R, Ueda Y, Okamoto S, Okajima H, Sakai Y, Sakurai T, Haga H, Hirota S, Ikeuchi H, Nakase H, Marusawa H, Chiba T, Takeuchi O, Miyano S, Seno H, Ogawa S. Nature. 2020 Jan;577(7789):260-265. doi: 10.1038/s41586-019-1856-1. Epub 2019 Dec 18. PubMed |
An improved strategy for CRISPR/Cas9 gene knockout and subsequent wildtype and mutant gene rescue.
Jin J, Xu Y, Huo L, Ma L, Scott AW, Pizzi MP, Li Y, Wang Y, Yao X, Song S, Ajani JA.
PLoS One. 2020 Feb 13;15(2):e0228910. doi: 10.1371/journal.pone.0228910. eCollection 2020.
PubMed
Associated Plasmids |
| Alteration of CTCF-associated chromatin neighborhood inhibits TAL1-driven oncogenic transcription program and leukemogenesis. Li Y, Liao Z, Luo H, Benyoucef A, Kang Y, Lai Q, Dovat S, Miller B, Chepelev I, Li Y, Zhao K, Brand M, Huang S. Nucleic Acids Res. 2020 Apr 6;48(6):3119-3133. doi: 10.1093/nar/gkaa098. PubMed |
| MYC Regulation of D2HGDH and L2HGDH Influences the Epigenome and Epitranscriptome. Qiu Z, Lin AP, Jiang S, Elkashef SM, Myers J, Srikantan S, Sasi B, Cao JZ, Godley LA, Rakheja D, Lyu Y, Zheng S, Madesh M, Shiio Y, Dahia PLM, Aguiar RCT. Cell Chem Biol. 2020 May 21;27(5):538-550.e7. doi: 10.1016/j.chembiol.2020.02.002. Epub 2020 Feb 25. PubMed |
| Endothelial Phosphatase VE-PTP Participates in Vasculogenic Mimicry by Preventing Autophagic Degradation of VE-Cadherin. Delgado-Bellido D, Bueno-Galera C, Lopez-Jimenez L, Garcia-Diaz A, Oliver FJ. Front Oncol. 2020 Jan 24;10:18. doi: 10.3389/fonc.2020.00018. eCollection 2020. PubMed |
| Follistatin is a novel therapeutic target and biomarker in FLT3/ITD acute myeloid leukemia. He BL, Yang N, Man CH, Ng NK, Cher CY, Leung HC, Kan LL, Cheng BY, Lam SS, Wang ML, Zhang CX, Kwok H, Cheng G, Sharma R, Ma AC, So CW, Kwong YL, Leung AY. EMBO Mol Med. 2020 Apr 7;12(4):e10895. doi: 10.15252/emmm.201910895. Epub 2020 Mar 5. PubMed |
| Role of RB1 in human embryonic stem cell-derived retinal organoids. Zheng C, Schneider JW, Hsieh J. Dev Biol. 2020 Jun 15;462(2):197-207. doi: 10.1016/j.ydbio.2020.03.011. Epub 2020 Mar 19. PubMed |
| AMOTL1 enhances YAP1 stability and promotes YAP1-driven gastric oncogenesis. Zhou Y, Zhang J, Li H, Huang T, Wong CC, Wu F, Wu M, Weng N, Liu L, Cheng ASL, Yu J, Wong N, Lo KW, Tang PMK, Kang W, To KF. Oncogene. 2020 May;39(22):4375-4389. doi: 10.1038/s41388-020-1293-5. Epub 2020 Apr 20. PubMed |
| Amyloid Precursor Protein (APP) Controls the Expression of the Transcriptional Activator Neuronal PAS Domain Protein 4 (NPAS4) and Synaptic GABA Release. Opsomer R, Contino S, Perrin F, Gualdani R, Tasiaux B, Doyen P, Vergouts M, Vrancx C, Doshina A, Pierrot N, Octave JN, Gailly P, Stanga S, Kienlen-Campard P. eNeuro. 2020 May 28;7(3):ENEURO.0322-19.2020. doi: 10.1523/ENEURO.0322-19.2020. Print 2020 May/Jun. PubMed |
| LINC00261 Is Differentially Expressed in Pancreatic Cancer Subtypes and Regulates a Pro-Epithelial Cell Identity. Dorn A, Glass M, Neu CT, Heydel B, Huttelmaier S, Gutschner T, Haemmerle M. Cancers (Basel). 2020 May 13;12(5). pii: cancers12051227. doi: 10.3390/cancers12051227. PubMed |
| CRISPR Gene Editing of Murine Blood Stem and Progenitor Cells Induces MLL-AF9 Chromosomal Translocation and MLL-AF9 Leukaemogenesis. Sarrou E, Richmond L, Carmody RJ, Gibson B, Keeshan K. Int J Mol Sci. 2020 Jun 15;21(12). pii: ijms21124266. doi: 10.3390/ijms21124266. PubMed |
| Gamma-Delta CAR-T Cells Show CAR-Directed and Independent Activity Against Leukemia. Rozenbaum M, Meir A, Aharony Y, Itzhaki O, Schachter J, Bank I, Jacoby E, Besser MJ. Front Immunol. 2020 Jul 2;11:1347. doi: 10.3389/fimmu.2020.01347. eCollection 2020. PubMed |
| Easy and robust electrotransfection protocol for efficient ectopic gene expression and genome editing in human B cells. Canoy RJ, Andre F, Shmakova A, Wiels J, Lipinski M, Vassetzky Y, Germini D. Gene Ther. 2020 Sep 30. pii: 10.1038/s41434-020-00194-x. doi: 10.1038/s41434-020-00194-x. PubMed |
| MLLT6 maintains PD-L1 expression and mediates tumor immune resistance. Sreevalsan S, Doring M, Paszkowski-Rogacz M, Brux M, Blanck C, Meyer M, Momburg F, Buchholz F, Theis M. EMBO Rep. 2020 Dec 3;21(12):e50155. doi: 10.15252/embr.202050155. Epub 2020 Oct 15. PubMed |
| Decoding myofibroblast origins in human kidney fibrosis. Kuppe C, Ibrahim MM, Kranz J, Zhang X, Ziegler S, Perales-Paton J, Jansen J, Reimer KC, Smith JR, Dobie R, Wilson-Kanamori JR, Halder M, Xu Y, Kabgani N, Kaesler N, Klaus M, Gernhold L, Puelles VG, Huber TB, Boor P, Menzel S, Hoogenboezem RM, Bindels EMJ, Steffens J, Floege J, Schneider RK, Saez-Rodriguez J, Henderson NC, Kramann R. Nature. 2021 Jan;589(7841):281-286. doi: 10.1038/s41586-020-2941-1. Epub 2020 Nov 11. PubMed |
| NOP10 predicts lung cancer prognosis and its associated small nucleolar RNAs drive proliferation and migration. Cui C, Liu Y, Gerloff D, Rohde C, Pauli C, Kohn M, Misiak D, Oellerich T, Schwartz S, Schmidt LH, Wiewrodt R, Marra A, Hillejan L, Bartel F, Wickenhauser C, Huttelmaier S, Gollner S, Zhou F, Edemir B, Muller-Tidow C. Oncogene. 2021 Feb;40(5):909-921. doi: 10.1038/s41388-020-01570-y. Epub 2020 Dec 7. PubMed |
| The CXCL12gamma chemokine immobilized by heparan sulfate on stromal niche cells controls adhesion and mediates drug resistance in multiple myeloma. Ren Z, Lantermans H, Kuil A, Kraan W, Arenzana-Seisdedos F, Kersten MJ, Spaargaren M, Pals ST. J Hematol Oncol. 2021 Jan 12;14(1):11. doi: 10.1186/s13045-021-01031-3. PubMed |
| Gasdermin D mediates the maturation and release of IL-1alpha downstream of inflammasomes. Tsuchiya K, Hosojima S, Hara H, Kushiyama H, Mahib MR, Kinoshita T, Suda T. Cell Rep. 2021 Mar 23;34(12):108887. doi: 10.1016/j.celrep.2021.108887. PubMed |
| SynNotch CAR circuits enhance solid tumor recognition and promote persistent antitumor activity in mouse models. Hyrenius-Wittsten A, Su Y, Park M, Garcia JM, Alavi J, Perry N, Montgomery G, Liu B, Roybal KT. Sci Transl Med. 2021 Apr 28;13(591). pii: 13/591/eabd8836. doi: 10.1126/scitranslmed.abd8836. PubMed |
| Tanshinones induce tumor cell apoptosis via directly targeting FHIT. Zhou X, Pan Y, Wang Y, Wang B, Yan Y, Qu Y, Ke X. Sci Rep. 2021 Jun 9;11(1):12217. doi: 10.1038/s41598-021-91708-z. PubMed |
| CD33-directed immunotherapy with third-generation chimeric antigen receptor T cells and gemtuzumab ozogamicin in intact and CD33-edited acute myeloid leukemia and hematopoietic stem and progenitor cells. Liu Y, Wang S, Schubert ML, Lauk A, Yao H, Blank MF, Cui C, Janssen M, Schmidt C, Gollner S, Kleist C, Zhou F, Rahfeld JU, Sauer T, Schmitt M, Muller-Tidow C. Int J Cancer. 2022 Apr 1;150(7):1141-1155. doi: 10.1002/ijc.33865. Epub 2021 Nov 23. PubMed |
| Small Molecule Palmatine Targeting Musashi-2 in Colorectal Cancer. Zhang X, Su K, Liu Y, Zhu D, Pan Y, Ke X, Qu Y. Front Pharmacol. 2022 Jan 27;12:793449. doi: 10.3389/fphar.2021.793449. eCollection 2021. PubMed |
| HOTTIP-dependent R-loop formation regulates CTCF boundary activity and TAD integrity in leukemia. Luo H, Zhu G, Eshelman MA, Fung TK, Lai Q, Wang F, Zeisig BB, Lesperance J, Ma X, Chen S, Cesari N, Cogle C, Chen B, Xu B, Yang FC, So CWE, Qiu Y, Xu M, Huang S. Mol Cell. 2022 Feb 17;82(4):833-851.e11. doi: 10.1016/j.molcel.2022.01.014. PubMed |
| SOX4 facilitates PGR protein stability and FOXO1 expression conducive for human endometrial decidualization. Huang P, Deng W, Bao H, Lin Z, Liu M, Wu J, Zhou X, Qiao M, Yang Y, Cai H, Rao F, Chen J, Chen D, Lu J, Wang H, Qin A, Kong S. Elife. 2022 Mar 4;11:e72073. doi: 10.7554/eLife.72073. PubMed |
| Transiently expressed CRISPR/Cas9 induces wild-type dystrophin in vitro in DMD patient myoblasts carrying duplications. Pini V, Mariot V, Dumonceaux J, Counsell J, O'Neill HC, Farmer S, Conti F, Muntoni F. Sci Rep. 2022 Mar 8;12(1):3756. doi: 10.1038/s41598-022-07671-w. PubMed |
| RNAi-Mediated Screen of Primary AML Cells Nominates MDM4 as a Therapeutic Target in NK-AML with DNMT3A Mutations. Sidorova OA, Sayed S, Paszkowski-Rogacz M, Seifert M, Camgoz A, Roeder I, Bornhauser M, Thiede C, Buchholz F. Cells. 2022 Mar 2;11(5). pii: cells11050854. doi: 10.3390/cells11050854. PubMed |
| Genome Engineering of Hematopoietic Stem Cells Using CRISPR/Cas9 System. Devaraju N, Rajendiran V, Ravi NS, Mohankumar KM. Methods Mol Biol. 2022;2429:307-331. doi: 10.1007/978-1-0716-1979-7_20. PubMed |
| Using CRISPR-Cas9 to Dissect Cancer Mutations in Cell Lines. Sayed S, Surun D, Mircetic J, Sidorova OA, Buchholz F. Methods Mol Biol. 2022;2508:235-260. doi: 10.1007/978-1-0716-2376-3_18. PubMed |
| Efficient Correction of Oncogenic KRAS and TP53 Mutations through CRISPR Base Editing. Sayed S, Sidorova OA, Hennig A, Augsburg M, Cortes Vesga CP, Abohawya M, Schmitt LT, Surun D, Stange DE, Mircetic J, Buchholz F. Cancer Res. 2022 Sep 2;82(17):3002-3015. doi: 10.1158/0008-5472.CAN-21-2519. PubMed |
| Eltrombopag binds SDC4 directly and enhances MAPK signaling and macropinocytosis in cancer cells. Cui C, Pan Y, Zhang C, Zhu D, Xuan Y, Hao P, Ke X, Zhou X, Qu Y. Am J Cancer Res. 2022 Jun 15;12(6):2697-2710. eCollection 2022. PubMed |
| Pharmacologic Inhibition of NT5C2 Reverses Genetic and Nongenetic Drivers of 6-MP Resistance in Acute Lymphoblastic Leukemia. Reglero C, Dieck CL, Zask A, Forouhar F, Laurent AP, Lin WW, Albero R, Miller HI, Ma C, Gastier-Foster JM, Loh ML, Tong L, Stockwell BR, Palomero T, Ferrando AA. Cancer Discov. 2022 Nov 2;12(11):2646-2665. doi: 10.1158/2159-8290.CD-22-0010. PubMed |
| Protein tyrosine kinase 2b inhibition reverts niche-associated resistance to tyrosine kinase inhibitors in AML. Allert C, Waclawiczek A, Zimmermann SMN, Gollner S, Heid D, Janssen M, Renders S, Rohde C, Bauer M, Bruckmann M, Zinz R, Pauli C, Besenbeck B, Wickenhauser C, Trumpp A, Krijgsveld J, Muller-Tidow C, Blank MF. Leukemia. 2022 Oct;36(10):2418-2429. doi: 10.1038/s41375-022-01687-x. Epub 2022 Sep 2. PubMed |
| CRISPR/Cas9 ribonucleoprotein (RNP) complex enables higher viability of transfected cells in genome editing of acute myeloid cells. Cheng Q, Xia J, Wang K, Zhang Y, Chen Y, Zhong Q, Wang X, Wu Q. Ann Transl Med. 2022 Aug;10(16):862. doi: 10.21037/atm-22-3279. PubMed |
| Reversal of IKZF1-induced glucocorticoid resistance by dual targeting of AKT and ERK signaling pathways. Butler M, Vervoort BMT, van Ingen Schenau DS, Jongeneel L, van der Zwet JCG, Marke R, Meijerink JPP, Scheijen B, van der Meer LT, van Leeuwen FN. Front Oncol. 2022 Sep 2;12:905665. doi: 10.3389/fonc.2022.905665. eCollection 2022. PubMed |
| CD47 cross-dressing by extracellular vesicles expressing CD47 inhibits phagocytosis without transmitting cell death signals. Li Y, Wu Y, Federzoni EA, Wang X, Dharmawan A, Hu X, Wang H, Hawley RJ, Stevens S, Sykes M, Yang YG. Elife. 2022 Dec 1;11:e73677. doi: 10.7554/eLife.73677. PubMed |
| Tumorigenic role of Musashi-2 in aggressive mantle cell lymphoma. Sureda-Gomez M, Balsas P, Rodriguez ML, Nadeu F, De Bolos A, Eguileor A, Kulis M, Castellano G, Lopez C, Gine E, Demajo S, Jares P, Martin-Subero JI, Bea S, Campo E, Amador V. Leukemia. 2023 Feb;37(2):408-421. doi: 10.1038/s41375-022-01776-x. Epub 2022 Dec 12. PubMed |
| Diosgenin enhances liposome-enabled nucleic acid delivery and CRISPR/Cas9-mediated gene editing by modulating endocytic pathways. Lohchania B, Christopher AC, Arjunan P, Mahalingam G, Kathirvelu D, Prasannan A, Venkatesan V, Taneja P, Km MK, Thangavel S, Marepally S. Front Bioeng Biotechnol. 2023 Jan 9;10:1031049. doi: 10.3389/fbioe.2022.1031049. eCollection 2022. PubMed |
| The oncogenic human B-cell lymphoma MYD88 L265P mutation genocopies activation by phosphorylation at the Toll/interleukin-1 receptor (TIR) domain. Minderman M, Lantermans H, van der Zwaan C, Hoogendijk AJ, van den Biggelaar M, Kersten MJ, Spaargaren M, Pals ST. Blood Cancer J. 2023 Aug 18;13(1):125. doi: 10.1038/s41408-023-00896-6. PubMed |
| A branching model of lineage differentiation underpinning the neurogenic potential of enteric glia. Laddach A, Chng SH, Lasrado R, Progatzky F, Shapiro M, Erickson A, Sampedro Castaneda M, Artemov AV, Bon-Frauches AC, Amaniti EM, Kleinjung J, Boeing S, Ultanir S, Adameyko I, Pachnis V. Nat Commun. 2023 Sep 22;14(1):5904. doi: 10.1038/s41467-023-41492-3. PubMed |
| Specificity of cancer-related chromosomal translocations is linked to proximity after the DNA double-strand break and subsequent selection. Canoy RJ, Shmakova A, Karpukhina A, Lomov N, Tiukacheva E, Kozhevnikova Y, Andre F, Germini D, Vassetzky Y. NAR Cancer. 2023 Sep 23;5(3):zcad049. doi: 10.1093/narcan/zcad049. eCollection 2023 Sep. PubMed |
| Evidence of a synthetic lethality interaction between SETDB1 histone methyltransferase and CHD4 chromatin remodeling protein in a triple negative breast cancer cell line. Moraes-Almeida MS, Sogayar MC, Demasi MAA. Braz J Med Biol Res. 2023 Nov 13;56:e12854. doi: 10.1590/1414-431X2023e12854. eCollection 2023. PubMed |
| Integrative functional genomic analyses identify genetic variants influencing skin pigmentation in Africans. Feng Y, Xie N, Inoue F, Fan S, Saskin J, Zhang C, Zhang F, Hansen MEB, Nyambo T, Mpoloka SW, Mokone GG, Fokunang C, Belay G, Njamnshi AK, Marks MS, Oancea E, Ahituv N, Tishkoff SA. Nat Genet. 2024 Feb;56(2):258-272. doi: 10.1038/s41588-023-01626-1. Epub 2024 Jan 10. PubMed |
| Efficient deletion of microRNAs using CRISPR/Cas9 with dual guide RNAs. Ijee S, Chambayil K, Chaudhury AD, Bagchi A, Modak K, Das S, Benjamin ESB, Rani S, Paul DZ, Nath A, Roy D, Palani D, Priyanka S, Ravichandran R, Kumary BK, Sivamani Y, S V, Babu D, Nakamura Y, Thamodaran V, Balasubramanian P, Velayudhan SR. Front Mol Biosci. 2024 Apr 2;10:1295507. doi: 10.3389/fmolb.2023.1295507. eCollection 2023. PubMed |
| Metabolic signature and response to glutamine deprivation are independent of p53 status in B cell malignancies. Montironi C, Chen Z, Derks IAM, Cretenet G, Krap EA, Eldering E, Simon-Molas H. iScience. 2024 Mar 28;27(5):109640. doi: 10.1016/j.isci.2024.109640. eCollection 2024 May 17. PubMed |
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