TMPRSS2 Citations (24)
Originally described in: Survey of Human Chromosome 21 Gene Expression Effects on Early Development in Danio rerio.Edie S, Zaghloul NA, Leitch CC, Klinedinst DK, Lebron J, Thole JF, McCallion AS, Katsanis N, Reeves RH G3 (Bethesda). 2018 Jul 2;8(7):2215-2223. doi: 10.1534/g3.118.200144. PubMed Journal
Articles Citing TMPRSS2
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| A replication-competent vesicular stomatitis virus for studies of SARS-CoV-2 spike-mediated cell entry and its inhibition. Dieterle ME, Haslwanter D, Bortz RH 3rd, Wirchnianski AS, Lasso G, Vergnolle O, Abbasi SA, Fels JM, Laudermilch E, Florez C, Mengotto A, Kimmel D, Malonis RJ, Georgiev G, Quiroz J, Barnhill J, Pirofski LA, Daily JP, Dye JM, Lai JR, Herbert AS, Chandran K, Jangra RK. bioRxiv. 2020 May 20. doi: 10.1101/2020.05.20.105247. PubMed |
| Genetic Screens Identify Host Factors for SARS-CoV-2 and Common Cold Coronaviruses. Wang R, Simoneau CR, Kulsuptrakul J, Bouhaddou M, Travisano KA, Hayashi JM, Carlson-Stevermer J, Zengel JR, Richards CM, Fozouni P, Oki J, Rodriguez L, Joehnk B, Walcott K, Holden K, Sil A, Carette JE, Krogan NJ, Ott M, Puschnik AS. Cell. 2021 Jan 7;184(1):106-119.e14. doi: 10.1016/j.cell.2020.12.004. Epub 2020 Dec 9. PubMed |
| Alpha-1 antitrypsin inhibits TMPRSS2 protease activity and SARS-CoV-2 infection. Wettstein L, Weil T, Conzelmann C, Muller JA, Gross R, Hirschenberger M, Seidel A, Klute S, Zech F, Prelli Bozzo C, Preising N, Fois G, Lochbaum R, Knaff PM, Mailander V, Standker L, Thal DR, Schumann C, Stenger S, Kleger A, Lochnit G, Mayer B, Ruiz-Blanco YB, Hoffmann M, Sparrer KMJ, Pohlmann S, Sanchez-Garcia E, Kirchhoff F, Frick M, Munch J. Nat Commun. 2021 Mar 19;12(1):1726. doi: 10.1038/s41467-021-21972-0. PubMed |
| The furin cleavage site in the SARS-CoV-2 spike protein is required for transmission in ferrets. Peacock TP, Goldhill DH, Zhou J, Baillon L, Frise R, Swann OC, Kugathasan R, Penn R, Brown JC, Sanchez-David RY, Braga L, Williamson MK, Hassard JA, Staller E, Hanley B, Osborn M, Giacca M, Davidson AD, Matthews DA, Barclay WS. Nat Microbiol. 2021 Jul;6(7):899-909. doi: 10.1038/s41564-021-00908-w. Epub 2021 Apr 27. PubMed |
| Clinical and in Vitro Evidence against Placenta Infection at Term by Severe Acute Respiratory Syndrome Coronavirus 2. Colson A, Depoix CL, Dessilly G, Baldin P, Danhaive O, Hubinont C, Sonveaux P, Debieve F. Am J Pathol. 2021 Sep;191(9):1610-1623. doi: 10.1016/j.ajpath.2021.05.009. Epub 2021 Jun 8. PubMed |
SARS-COV-2 spike binding to ACE2 in living cells monitored by TR-FRET.
Cecon E, Burridge M, Cao L, Carter L, Ravichandran R, Dam J, Jockers R.
Cell Chem Biol. 2021 Jul 2. pii: S2451-9456(21)00307-X. doi: 10.1016/j.chembiol.2021.06.008.
PubMed
Associated Plasmids |
| Potent Anti-SARS-CoV-2 Activity by the Natural Product Gallinamide A and Analogues via Inhibition of Cathepsin L. Ashhurst AS, Tang AH, Fajtova P, Yoon MC, Aggarwal A, Bedding MJ, Stoye A, Beretta L, Pwee D, Drelich A, Skinner D, Li L, Meek TD, McKerrow JH, Hook V, Tseng CT, Larance M, Turville S, Gerwick WH, O'Donoghue AJ, Payne RJ. J Med Chem. 2022 Feb 24;65(4):2956-2970. doi: 10.1021/acs.jmedchem.1c01494. Epub 2021 Nov 3. PubMed |
| A single intranasal dose of a live-attenuated parainfluenza virus-vectored SARS-CoV-2 vaccine is protective in hamsters. Liu X, Luongo C, Matsuoka Y, Park HS, Santos C, Yang L, Moore IN, Afroz S, Johnson RF, Lafont BAP, Martens C, Best SM, Munster VJ, Holly J, Yewdell JW, Le Nouen C, Munir S, Buchholz UJ. Proc Natl Acad Sci U S A. 2021 Dec 14;118(50):e2109744118. doi: 10.1073/pnas.2109744118. PubMed |
| A serum-stable RNA aptamer specific for SARS-CoV-2 neutralizes viral entry. Valero J, Civit L, Dupont DM, Selnihhin D, Reinert LS, Idorn M, Israels BA, Bednarz AM, Bus C, Asbach B, Peterhoff D, Pedersen FS, Birkedal V, Wagner R, Paludan SR, Kjems J. Proc Natl Acad Sci U S A. 2021 Dec 14;118(50). pii: 2112942118. doi: 10.1073/pnas.2112942118. PubMed |
| Maintenance of broad neutralizing antibodies and memory B cells 1 year post-infection is predicted by SARS-CoV-2-specific CD4+ T cell responses. Balachandran H, Phetsouphanh C, Agapiou D, Adhikari A, Rodrigo C, Hammoud M, Shrestha LB, Keoshkerian E, Gupta M, Turville S, Christ D, King C, Sasson SC, Bartlett A, Grubor-Bauk B, Rawlinson W, Aggarwal A, Stella AO, Klemm V, Mina MM, Post JJ, Hudson B, Gilroy N, Konecny P, Ahlenstiel G, Dwyer DE, Sorrell TC, Kelleher A, Tedla N, Lloyd AR, Martinello M, Bull RA. Cell Rep. 2022 Feb 8;38(6):110345. doi: 10.1016/j.celrep.2022.110345. Epub 2022 Jan 19. PubMed |
| A common TMPRSS2 variant has a protective effect against severe COVID-19. David A, Parkinson N, Peacock TP, Pairo-Castineira E, Khanna T, Cobat A, Tenesa A, Sancho-Shimizu V, Casanova JL, Abel L, Barclay WS, Baillie JK, Sternberg MJ. Curr Res Transl Med. 2022 May;70(2):103333. doi: 10.1016/j.retram.2022.103333. Epub 2022 Jan 10. PubMed |
| Construction of SARS-CoV-2 spike-pseudotyped retroviral vector inducing syncytia formation. Lee SY, Kim DW, Jung YT. Virus Genes. 2022 Jun;58(3):172-179. doi: 10.1007/s11262-022-01890-z. Epub 2022 Mar 23. PubMed |
| Optimization of SARS-CoV-2 Pseudovirion Production in Lentivirus Backbone With a Novel Liposomal System. Mahalingam G, Rachamalla HK, Arjunan P, Periyasami Y, M S, Thangavel S, Mohankumar KM, Moorthy M, Velayudhan SR, Srivastava A, Marepally S. Front Pharmacol. 2022 Mar 25;13:840727. doi: 10.3389/fphar.2022.840727. eCollection 2022. PubMed |
| Structure and activity of human TMPRSS2 protease implicated in SARS-CoV-2 activation. Fraser BJ, Beldar S, Seitova A, Hutchinson A, Mannar D, Li Y, Kwon D, Tan R, Wilson RP, Leopold K, Subramaniam S, Halabelian L, Arrowsmith CH, Benard F. Nat Chem Biol. 2022 Sep;18(9):963-971. doi: 10.1038/s41589-022-01059-7. Epub 2022 Jun 8. PubMed |
| Structure, receptor recognition, and antigenicity of the human coronavirus CCoV-HuPn-2018 spike glycoprotein. Tortorici MA, Walls AC, Joshi A, Park YJ, Eguia RT, Miranda MC, Kepl E, Dosey A, Stevens-Ayers T, Boeckh MJ, Telenti A, Lanzavecchia A, King NP, Corti D, Bloom JD, Veesler D. Cell. 2022 Jun 23;185(13):2279-2291.e17. doi: 10.1016/j.cell.2022.05.019. Epub 2022 May 27. PubMed |
| Peptidomimetic inhibitors of TMPRSS2 block SARS-CoV-2 infection in cell culture. Wettstein L, Knaff PM, Kersten C, Muller P, Weil T, Conzelmann C, Muller JA, Bruckner M, Hoffmann M, Pohlmann S, Schirmeister T, Landfester K, Munch J, Mailander V. Commun Biol. 2022 Jul 8;5(1):681. doi: 10.1038/s42003-022-03613-4. PubMed |
Expanded ACE2 dependencies of diverse SARS-like coronavirus receptor binding domains.
Roelle SM, Shukla N, Pham AT, Bruchez AM, Matreyek KA.
PLoS Biol. 2022 Jul 27;20(7):e3001738. doi: 10.1371/journal.pbio.3001738.
PubMed
Associated Plasmids |
| Development of a novel peptide to prevent entry of SARS-CoV-2 into lung and olfactory bulb cells of hACE2 expressing mice. Su P, Zhai D, Wong AHC, Liu F. Mol Brain. 2022 Aug 9;15(1):71. doi: 10.1186/s13041-022-00956-1. PubMed |
| Native and activated antithrombin inhibits TMPRSS2 activity and SARS-CoV-2 infection. Wettstein L, Immenschuh P, Weil T, Conzelmann C, Almeida-Hernandez Y, Hoffmann M, Kempf A, Nehlmeier I, Lotke R, Petersen M, Stenger S, Kirchhoff F, Sauter D, Pohlmann S, Sanchez-Garcia E, Munch J. J Med Virol. 2023 Jan;95(1):e28124. doi: 10.1002/jmv.28124. Epub 2022 Sep 16. PubMed |
| An albumin-angiotensin converting enzyme 2-based SARS-CoV-2 decoy with FcRn-driven half-life extension. Fuchs E, Rudnik-Jansen I, Dinesen A, Selnihhin D, Mandrup OA, Thiam K, Kjems J, Pedersen FS, Howard KA. Acta Biomater. 2022 Nov;153:411-418. doi: 10.1016/j.actbio.2022.09.048. Epub 2022 Sep 24. PubMed |
| Metalloprotease-Dependent S2'-Activation Promotes Cell-Cell Fusion and Syncytiation of SARS-CoV-2. Harte JV, Wakerlin SL, Lindsay AJ, McCarthy JV, Coleman-Vaughan C. Viruses. 2022 Sep 21;14(10):2094. doi: 10.3390/v14102094. PubMed |
| Identification of small molecules capable of enhancing viral membrane fusion. Garcia-Murria MJ, Gadea-Salom L, Moreno S, Rius-Salvador M, Zaragoza O, Brun A, Mingarro I, Martinez-Gil L. Virol J. 2023 May 24;20(1):99. doi: 10.1186/s12985-023-02068-1. PubMed |
| TMPRSS2 is a functional receptor for human coronavirus HKU1. Saunders N, Fernandez I, Planchais C, Michel V, Rajah MM, Baquero Salazar E, Postal J, Porrot F, Guivel-Benhassine F, Blanc C, Chauveau-Le Friec G, Martin A, Grzelak L, Oktavia RM, Meola A, Ahouzi O, Hoover-Watson H, Prot M, Delaune D, Cornelissen M, Deijs M, Meriaux V, Mouquet H, Simon-Loriere E, van der Hoek L, Lafaye P, Rey F, Buchrieser J, Schwartz O. Nature. 2023 Dec;624(7990):207-214. doi: 10.1038/s41586-023-06761-7. Epub 2023 Oct 25. PubMed |
| Impact of mutations defining SARS-CoV-2 Omicron subvariants BA.2.12.1 and BA.4/5 on Spike function and neutralization. Pastorio C, Noettger S, Nchioua R, Zech F, Sparrer KMJ, Kirchhoff F. iScience. 2023 Oct 27;26(11):108299. doi: 10.1016/j.isci.2023.108299. eCollection 2023 Nov 17. PubMed |
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