pLX-sgRNA Citations (71)
Originally described in: Genetic screens in human cells using the CRISPR-Cas9 system.Wang T, Wei JJ, Sabatini DM, Lander ES Science. 2014 Jan 3;343(6166):80-4. doi: 10.1126/science.1246981. Epub 2013 Dec 12. PubMed Journal
Articles Citing pLX-sgRNA
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| Efficient Gene Disruption in Cultured Primary Human Endothelial Cells by CRISPR/Cas9. Abrahimi P, Chang WG, Kluger MS, Qyang Y, Tellides G, Saltzman WM, Pober JS. Circ Res. 2015 Jul 3;117(2):121-8. doi: 10.1161/CIRCRESAHA.117.306290. Epub 2015 May 4. PubMed |
| The C-terminal Domain (CTD) of Human DNA Glycosylase NEIL1 Is Required for Forming BERosome Repair Complex with DNA Replication Proteins at the Replicating Genome: Dominant Negative Function of CTD. Hegde PM, Dutta A, Sengupta S, Mitra J, Adhikari S, Tomkinson AE, Li GM, Boldogh I, Hazra TK, Mitra S, Hegde ML. J Biol Chem. 2015 Jul 1. pii: jbc.M115.642918. PubMed |
| The antitumor toxin CD437 is a direct inhibitor of DNA polymerase alpha. Han T, Goralski M, Capota E, Padrick SB, Kim J, Xie Y, Nijhawan D. Nat Chem Biol. 2016 Jul;12(7):511-5. doi: 10.1038/nchembio.2082. Epub 2016 May 16. PubMed |
| Focal Adhesion Kinase regulates the DNA damage response and its inhibition radiosensitizes mutant KRAS lung cancer. Tang KJ, Constanzo J, Venkateswaran N, Melegari M, Ilcheva M, Morales JC, Skoulidis F, Heymach JV, Boothman DA, Scaglioni PP. Clin Cancer Res. 2016 May 24. pii: clincanres.2603.2015. PubMed |
| Generation of porcine fetal fibroblasts expressing the tetracycline-inducible Cas9 gene by somatic cell nuclear transfer. Liu G, Liu K, Wei H, Li L, Zhang S. Mol Med Rep. 2016 Sep;14(3):2527-33. doi: 10.3892/mmr.2016.5530. Epub 2016 Jul 19. PubMed |
| A PGC1alpha-mediated transcriptional axis suppresses melanoma metastasis. Luo C, Lim JH, Lee Y, Granter SR, Thomas A, Vazquez F, Widlund HR, Puigserver P. Nature. 2016 Sep 15;537(7620):422-426. doi: 10.1038/nature19347. Epub 2016 Aug 31. PubMed |
Targeted AID-mediated mutagenesis (TAM) enables efficient genomic diversification in mammalian cells.
Ma Y, Zhang J, Yin W, Zhang Z, Song Y, Chang X.
Nat Methods. 2016 Dec;13(12):1029-1035. doi: 10.1038/nmeth.4027. Epub 2016 Oct 10.
PubMed
Associated Plasmids |
| Systematic Analysis of Known and Candidate Lysine Demethylases in the Regulation of Myoblast Differentiation. Munehira Y, Yang Z, Gozani O. J Mol Biol. 2016 Oct 11. pii: S0022-2836(16)30419-3. doi: 10.1016/j.jmb.2016.10.004. PubMed |
| A pH- and ionic strength-dependent conformational change in the neck region regulates DNGR-1 function in dendritic cells. Hanc P, Schulz O, Fischbach H, Martin SR, Kjaer S, Reis E Sousa C. EMBO J. 2016 Nov 15;35(22):2484-2497. Epub 2016 Oct 17. PubMed |
| PAR1 Scaffolds TGFbetaRII to Downregulate TGF-beta Signaling and Activate ESC Differentiation to Endothelial Cells. Gong H, An S, Sassmann A, Liu M, Mastej V, Mittal M, Zhang W, Hong Z, Offermanns S, Rehman J, Malik AB. Stem Cell Reports. 2016 Dec 13;7(6):1050-1058. doi: 10.1016/j.stemcr.2016.10.006. Epub 2016 Nov 17. PubMed |
| A High-Throughput Strategy for Dissecting Mammalian Genetic Interactions. Stockman VB, Ghamsari L, Lasso G, Honig B, Shapira SD, Wang HH. PLoS One. 2016 Dec 9;11(12):e0167617. doi: 10.1371/journal.pone.0167617. eCollection 2016. PubMed |
| Context-dependent role for chromatin remodeling component PBRM1/BAF180 in clear cell renal cell carcinoma. Murakami A, Wang L, Kalhorn S, Schraml P, Rathmell WK, Tan AC, Nemenoff R, Stenmark K, Jiang BH, Reyland ME, Heasley L, Hu CJ. Oncogenesis. 2017 Jan 16;6(1):e287. doi: 10.1038/oncsis.2016.89. PubMed |
| Method for Dual Viral Vector Mediated CRISPR-Cas9 Gene Disruption in Primary Human Endothelial Cells. Gong H, Liu M, Klomp J, Merrill BJ, Rehman J, Malik AB. Sci Rep. 2017 Feb 15;7:42127. doi: 10.1038/srep42127. PubMed |
| Application of CRISPR/Cas9 to Autophagy Research. O'Prey J, Sakamaki J, Baudot AD, New M, Van Acker T, Tooze SA, Long JS, Ryan KM. Methods Enzymol. 2017;588:79-108. doi: 10.1016/bs.mie.2016.09.076. Epub 2016 Dec 1. PubMed |
| CRISPR-Cas9 system-driven site-specific selection pressure on Herpes simplex virus genomes. Li Z, Bi Y, Xiao H, Sun L, Ren Y, Li Y, Chen C, Cun W. Virus Res. 2017 Mar 6. pii: S0168-1702(16)30694-3. doi: 10.1016/j.virusres.2017.03.010. PubMed |
| Atg2A/B deficiency switches cytoprotective autophagy to non-canonical caspase-8 activation and apoptosis. Tang Z, Takahashi Y, Chen C, Liu Y, He H, Tsotakos N, Serfass JM, Gebru MT, Chen H, Young MM, Wang HG. Cell Death Differ. 2017 Dec;24(12):2127-2138. doi: 10.1038/cdd.2017.133. Epub 2017 Aug 11. PubMed |
| MTG16 is a tumor suppressor in colitis-associated carcinoma. McDonough EM, Barrett CW, Parang B, Mittal MK, Smith JJ, Bradley AM, Choksi YA, Coburn LA, Short SP, Thompson JJ, Zhang B, Poindexter SV, Fischer MA, Chen X, Li J, Revetta FL, Naik R, Washington MK, Rosen MJ, Hiebert SW, Wilson KT, Williams CS. JCI Insight. 2017 Aug 17;2(16). pii: 78210. doi: 10.1172/jci.insight.78210. PubMed |
| Smac mimetics and oncolytic viruses synergize in driving anticancer T-cell responses through complementary mechanisms. Kim DS, Dastidar H, Zhang C, Zemp FJ, Lau K, Ernst M, Rakic A, Sikdar S, Rajwani J, Naumenko V, Balce DR, Ewanchuk BW, Tailor P, Yates RM, Jenne C, Gafuik C, Mahoney DJ. Nat Commun. 2017 Aug 24;8(1):344. doi: 10.1038/s41467-017-00324-x. PubMed |
| miR-130a Deregulates PTEN and Stimulates Tumor Growth. Wei H, Cui R, Bahr J, Zanesi N, Luo Z, Meng W, Liang G, Croce CM. Cancer Res. 2017 Nov 15;77(22):6168-6178. doi: 10.1158/0008-5472.CAN-17-0530. Epub 2017 Sep 21. PubMed |
| CRISPR-Cas9-mediated functional dissection of 3'-UTRs. Zhao W, Siegel D, Biton A, Tonqueze OL, Zaitlen N, Ahituv N, Erle DJ. Nucleic Acids Res. 2017 Oct 13;45(18):10800-10810. doi: 10.1093/nar/gkx675. PubMed |
MicroRNA-focused CRISPR-Cas9 Library Screen Reveals Fitness-Associated miRNAs.
Kurata JS, Lin RJ.
RNA. 2018 May 2. pii: rna.066282.118. doi: 10.1261/rna.066282.118.
PubMed
Associated Plasmids |
| The Listeriolysin O PEST-like Sequence Co-opts AP-2-Mediated Endocytosis to Prevent Plasma Membrane Damage during Listeria Infection. Chen C, Nguyen BN, Mitchell G, Margolis SR, Ma D, Portnoy DA. Cell Host Microbe. 2018 Jun 13;23(6):786-795.e5. doi: 10.1016/j.chom.2018.05.006. PubMed |
| Epigenetic silencing of tumor suppressor Par-4 promotes chemoresistance in recurrent breast cancer. Mabe NW, Fox DB, Lupo R, Decker AE, Phelps SN, Thompson JW, Alvarez JV. J Clin Invest. 2018 Oct 1;128(10):4413-4428. doi: 10.1172/JCI99481. Epub 2018 Aug 27. PubMed |
| Function of HNRNPC in breast cancer cells by controlling the dsRNA-induced interferon response. Wu Y, Zhao W, Liu Y, Tan X, Li X, Zou Q, Xiao Z, Xu H, Wang Y, Yang X. EMBO J. 2018 Dec 3;37(23). pii: embj.201899017. doi: 10.15252/embj.201899017. Epub 2018 Aug 29. PubMed |
| SHQ1 regulation of RNA splicing is required for T-lymphoblastic leukemia cell survival. Su H, Hu J, Huang L, Yang Y, Thenoz M, Kuchmiy A, Hu Y, Li P, Feng H, Zhou Y, Taghon T, Van Vlierberghe P, Qing G, Chen Z, Liu H. Nat Commun. 2018 Oct 15;9(1):4281. doi: 10.1038/s41467-018-06523-4. PubMed |
| Role of Mitochondria in Ferroptosis. Gao M, Yi J, Zhu J, Minikes AM, Monian P, Thompson CB, Jiang X. Mol Cell. 2019 Jan 17;73(2):354-363.e3. doi: 10.1016/j.molcel.2018.10.042. Epub 2018 Dec 20. PubMed |
| Uncoupling protein 2 reprograms the tumor microenvironment to support the anti-tumor immune cycle. Cheng WC, Tsui YC, Ragusa S, Koelzer VH, Mina M, Franco F, Laubli H, Tschumi B, Speiser D, Romero P, Zippelius A, Petrova TV, Mertz K, Ciriello G, Ho PC. Nat Immunol. 2019 Feb;20(2):206-217. doi: 10.1038/s41590-018-0290-0. Epub 2019 Jan 21. PubMed |
| Overcoming BET Inhibitor Resistance in Malignant Peripheral Nerve Sheath Tumors. Cooper JM, Patel AJ, Chen Z, Liao CP, Chen K, Mo J, Wang Y, Le LQ. Clin Cancer Res. 2019 Jun 1;25(11):3404-3416. doi: 10.1158/1078-0432.CCR-18-2437. Epub 2019 Feb 22. PubMed |
| DNA Polymerase alpha is essential for intracellular amplification of hepatitis B virus covalently closed circular DNA. Tang L, Sheraz M, McGrane M, Chang J, Guo JT. PLoS Pathog. 2019 Apr 26;15(4):e1007742. doi: 10.1371/journal.ppat.1007742. eCollection 2019 Apr. PubMed |
| Sox17 is required for endothelial regeneration following inflammation-induced vascular injury. Liu M, Zhang L, Marsboom G, Jambusaria A, Xiong S, Toth PT, Benevolenskaya EV, Rehman J, Malik AB. Nat Commun. 2019 May 9;10(1):2126. doi: 10.1038/s41467-019-10134-y. PubMed |
| [Small Molecular Inhibitors of DNA Double Strand Break Repair Pathways Increase the ANTI-HBV Activity of CRISPR/Cas9]. Kostyusheva AP, Kostyushev DS, Brezgin SA, Zarifyan DN, Volchkova EV, Chulanov VP. Mol Biol (Mosk). 2019 Mar-Apr;53(2):311-323. doi: 10.1134/S0026898419010075. PubMed |
| Artemisinin compounds sensitize cancer cells to ferroptosis by regulating iron homeostasis. Chen GQ, Benthani FA, Wu J, Liang D, Bian ZX, Jiang X. Cell Death Differ. 2019 May 21. pii: 10.1038/s41418-019-0352-3. doi: 10.1038/s41418-019-0352-3. PubMed |
| Intercellular interaction dictates cancer cell ferroptosis via NF2-YAP signalling. Wu J, Minikes AM, Gao M, Bian H, Li Y, Stockwell BR, Chen ZN, Jiang X. Nature. 2019 Aug;572(7769):402-406. doi: 10.1038/s41586-019-1426-6. Epub 2019 Jul 24. PubMed |
| Progenitor-derived human endothelial cells evade alloimmunity by CRISPR/Cas9-mediated complete ablation of MHC expression. Merola J, Reschke M, Pierce RW, Qin L, Spindler S, Baltazar T, Manes TD, Lopez-Giraldez F, Li G, Bracaglia LG, Xie C, Kirkiles-Smith N, Saltzman WM, Tietjen GT, Tellides G, Pober JS. JCI Insight. 2019 Oct 17;4(20). pii: 129739. doi: 10.1172/jci.insight.129739. PubMed |
| Aberrant activation of RPB1 is critical for cell overgrowth in acute myeloid leukemia. Yu Q, Xu Y, Zhuang H, Wu Z, Zhang L, Li J, Yang L, Wu B, Wang P, Zhang X, Gan X, Liang Y, Zheng S, Yu X, Gu Y, Xu R. Exp Cell Res. 2019 Nov 15;384(2):111653. doi: 10.1016/j.yexcr.2019.111653. Epub 2019 Sep 28. PubMed |
| Endosomal signalling via exosome surface TGFbeta-1. Shelke GV, Yin Y, Jang SC, Lasser C, Wennmalm S, Hoffmann HJ, Li L, Gho YS, Nilsson JA, Lotvall J. J Extracell Vesicles. 2019 Sep 20;8(1):1650458. doi: 10.1080/20013078.2019.1650458. eCollection 2019. PubMed |
| IRG1 and Inducible Nitric Oxide Synthase Act Redundantly with Other Interferon-Gamma-Induced Factors To Restrict Intracellular Replication of Legionella pneumophila. Price JV, Russo D, Ji DX, Chavez RA, DiPeso L, Lee AY, Coers J, Vance RE. mBio. 2019 Nov 12;10(6). pii: mBio.02629-19. doi: 10.1128/mBio.02629-19. PubMed |
| Effective CRISPR interference of an endogenous gene via a single transgene in mice. MacLeod RS, Cawley KM, Gubrij I, Nookaew I, Onal M, O'Brien CA. Sci Rep. 2019 Nov 21;9(1):17312. doi: 10.1038/s41598-019-53611-6. PubMed |
| West Nile virus capsid protein inhibits autophagy by AMP-activated protein kinase degradation in neurological disease development. Kobayashi S, Yoshii K, Phongphaew W, Muto M, Hirano M, Orba Y, Sawa H, Kariwa H. PLoS Pathog. 2020 Jan 23;16(1):e1008238. doi: 10.1371/journal.ppat.1008238. eCollection 2020 Jan. PubMed |
| Electron transport chain activity is a predictor and target for venetoclax sensitivity in multiple myeloma. Bajpai R, Sharma A, Achreja A, Edgar CL, Wei C, Siddiqa AA, Gupta VA, Matulis SM, McBrayer SK, Mittal A, Rupji M, Barwick BG, Lonial S, Nooka AK, Boise LH, Nagrath D, Shanmugam M. Nat Commun. 2020 Mar 6;11(1):1228. doi: 10.1038/s41467-020-15051-z. PubMed |
| Interleukin-10 contributes to PGE2 signalling through upregulation of EP4 via SHIP1 and STAT3. Samiea A, Yoon JSJ, Cheung ST, Chamberlain TC, Mui AL. PLoS One. 2020 Apr 2;15(4):e0230427. doi: 10.1371/journal.pone.0230427. eCollection 2020. PubMed |
| Interleukin-10 control of pre-miR155 maturation involves CELF2. Yoon JSJ, Wu MK, Zhu TH, Zhao H, Cheung ST, Chamberlain TC, Mui AL. PLoS One. 2020 Apr 23;15(4):e0231639. doi: 10.1371/journal.pone.0231639. eCollection 2020. PubMed |
| CAMKIIgamma is a targetable driver of multiple myeloma through CaMKIIgamma/ Stat3 axis. Yang L, Wu B, Wu Z, Xu Y, Wang P, Li M, Xu R, Liang Y. Aging (Albany NY). 2020 Jul 13;12(13):13668-13683. doi: 10.18632/aging.103490. Epub 2020 Jul 13. PubMed |
| The c-Rel-c-Myc axis controls metabolism and proliferation of human T leukemia cells. Li X, Luo G, Li T, Sun H, Wang W, Eiler E, Goldsmith JR, Chen YH. Mol Immunol. 2020 Sep;125:115-122. doi: 10.1016/j.molimm.2020.06.029. Epub 2020 Jul 10. PubMed |
| PPT1 inhibition enhances the antitumor activity of anti-PD-1 antibody in melanoma. Sharma G, Ojha R, Noguera-Ortega E, Rebecca VW, Attanasio J, Liu S, Piao S, Lee JJ, Nicastri MC, Harper SL, Ronghe A, Jain V, Winkler JD, Speicher DW, Mastio J, Gimotty PA, Xu X, Wherry EJ, Gabrilovich DI, Amaravadi RK. JCI Insight. 2020 Sep 3;5(17). pii: 133225. doi: 10.1172/jci.insight.133225. PubMed |
| Knockout of the Transducin-Like Enhancer of Split 6 Gene Affects the Proliferation and Cell Cycle Process of Mouse Spermatogonia. Feng M, Bai Y, Chen Y, Wang K. Int J Mol Sci. 2020 Aug 13;21(16). pii: ijms21165827. doi: 10.3390/ijms21165827. PubMed |
| Kaposi's Sarcoma-Associated Herpesvirus Drives a Super-Enhancer-Mediated Survival Gene Expression Program in Primary Effusion Lymphoma. Manzano M, Gunther T, Ju H, Nicholas J, Bartom ET, Grundhoff A, Gottwein E. mBio. 2020 Aug 25;11(4). pii: mBio.01457-20. doi: 10.1128/mBio.01457-20. PubMed |
| Suppression of non-homologous end joining does not rescue DNA repair defects in Fanconi anemia patient cells. Thongthip S, Conti BA, Lach FP, Smogorzewska A. Cell Cycle. 2020 Oct;19(19):2553-2561. doi: 10.1080/15384101.2020.1810394. Epub 2020 Aug 30. PubMed |
| CRISPR/Cas9 genome-wide loss-of-function screening identifies druggable cellular factors involved in sunitinib resistance in renal cell carcinoma. Makhov P, Sohn JA, Serebriiskii IG, Fazliyeva R, Khazak V, Boumber Y, Uzzo RG, Kolenko VM. Br J Cancer. 2020 Dec;123(12):1749-1756. doi: 10.1038/s41416-020-01087-x. Epub 2020 Sep 24. PubMed |
| Generation and validation of versatile inducible CRISPRi embryonic stem cell and mouse model. Li R, Xia X, Wang X, Sun X, Dai Z, Huo D, Zheng H, Xiong H, He A, Wu X. PLoS Biol. 2020 Nov 30;18(11):e3000749. doi: 10.1371/journal.pbio.3000749. eCollection 2020 Nov. PubMed |
| c-Rel Is a Myeloid Checkpoint for Cancer Immunotherapy. Li T, Li X, Zamani A, Wang W, Lee CN, Li M, Luo G, Eiler E, Sun H, Ghosh S, Jin J, Murali R, Ruan Q, Shi W, Chen YH. Nat Cancer. 2020 May;1(5):507-517. doi: 10.1038/s43018-020-0061-3. Epub 2020 May 18. PubMed |
| Support of BCP-ALL-cells by autologous bone marrow Th-cells involves induction of AID expression but not widespread AID off-target mutagenesis. Traxel S, Lehmann J, Richard S, Sidorov S, Niggli F, Berger C, Nadal D, Burgler S. Cancer Immunol Immunother. 2021 Jan 28. pii: 10.1007/s00262-020-02835-x. doi: 10.1007/s00262-020-02835-x. PubMed |
| Bioinformatics and Functional Analyses Implicate Potential Roles for EOGT and L-fringe in Pancreatic Cancers. Barua R, Mizuno K, Tashima Y, Ogawa M, Takeuchi H, Taguchi A, Okajima T. Molecules. 2021 Feb 7;26(4). pii: molecules26040882. doi: 10.3390/molecules26040882. PubMed |
| LKB1/STK11 Is a Tumor Suppressor in the Progression of Myeloproliferative Neoplasms. Marinaccio C, Suraneni P, Celik H, Volk A, Wen QJ, Ling T, Bulic M, Lasho T, Koche RP, Famulare CA, Farnoud N, Stein B, Schieber M, Gurbuxani S, Root DE, Younger ST, Hoffman R, Gangat N, Ntziachristos P, Chandel NS, Levine RL, Rampal RK, Challen GA, Tefferi A, Crispino JD. Cancer Discov. 2021 Jun;11(6):1398-1410. doi: 10.1158/2159-8290.CD-20-1353. Epub 2021 Feb 12. PubMed |
| Venetoclax sensitivity in multiple myeloma is associated with B-cell gene expression. Gupta VA, Barwick BG, Matulis SM, Shirasaki R, Jaye DL, Keats JJ, Oberlton B, Joseph NS, Hofmeister CC, Heffner LT, Dhodapkar MV, Nooka AK, Lonial S, Mitsiades CS, Kaufman JL, Boise LH. Blood. 2021 Jul 1;137(26):3604-3615. doi: 10.1182/blood.2020007899. PubMed |
| Disruption of the MSL complex inhibits tumour maintenance by exacerbating chromosomal instability. Monserrat J, Morales Torres C, Richardson L, Wilson TS, Patel H, Domart MC, Horswell S, Song OR, Jiang M, Crawford M, Bui M, Dalal Y, Scaffidi P. Nat Cell Biol. 2021 Apr;23(4):401-412. doi: 10.1038/s41556-021-00657-2. Epub 2021 Apr 9. PubMed |
| ABHD17 regulation of plasma membrane palmitoylation and N-Ras-dependent cancer growth. Remsberg JR, Suciu RM, Zambetti NA, Hanigan TW, Firestone AJ, Inguva A, Long A, Ngo N, Lum KM, Henry CL, Richardson SK, Predovic M, Huang B, Dix MM, Howell AR, Niphakis MJ, Shannon K, Cravatt BF. Nat Chem Biol. 2021 Aug;17(8):856-864. doi: 10.1038/s41589-021-00785-8. Epub 2021 Apr 29. PubMed |
| TEC kinase stabilizes PLK4 to promote liver cancer metastasis. Yeung SF, Zhou Y, Zou W, Chan WL, Ching YP. Cancer Lett. 2022 Jan 1;524:70-81. doi: 10.1016/j.canlet.2021.08.038. Epub 2021 Oct 9. PubMed |
| Supraphysiologic Testosterone Induces Ferroptosis and Activates Immune Pathways through Nucleophagy in Prostate Cancer. Kumar R, Mendonca J, Owoyemi O, Boyapati K, Thomas N, Kanacharoen S, Coffey M, Topiwala D, Gomes C, Ozbek B, Jones T, Rosen M, Dong L, Wiens S, Brennen WN, Isaacs JT, De Marzo AM, Markowski MC, Antonarakis ES, Qian DZ, Pienta KJ, Pardoll DM, Carducci MA, Denmeade SR, Kachhap SK. Cancer Res. 2021 Dec 1;81(23):5948-5962. doi: 10.1158/0008-5472.CAN-20-3607. Epub 2021 Oct 13. PubMed |
| CpG island reconfiguration for the establishment and synchronization of polycomb functions upon exit from naive pluripotency. Huo D, Yu Z, Li R, Gong M, Sidoli S, Lu X, Hou Y, Dai Z, Kong Y, Liu G, Jensen ON, Xie W, Helin K, Xiong C, Li G, Zhang Y, Wu X. Mol Cell. 2022 Mar 17;82(6):1169-1185.e7. doi: 10.1016/j.molcel.2022.01.027. Epub 2022 Feb 23. PubMed |
| PDZ Proteins SCRIB and DLG1 Regulate Myeloma Cell Surface CD86 Expression, Growth, and Survival. Moser-Katz T, Gavile CM, Barwick BG, Lee KP, Boise LH. Mol Cancer Res. 2022 Jul 6;20(7):1122-1136. doi: 10.1158/1541-7786.MCR-21-0681. PubMed |
| Histone methyltransferase Dot1L recruits O-GlcNAc transferase to target chromatin sites to regulate histone O-GlcNAcylation. Xu B, Zhang C, Jiang A, Zhang X, Liang F, Wang X, Li D, Liu C, Liu X, Xia J, Li Y, Wang Y, Yang Z, Chen J, Zhou Y, Chen L, Sun H. J Biol Chem. 2022 Jul;298(7):102115. doi: 10.1016/j.jbc.2022.102115. Epub 2022 Jun 9. PubMed |
| Targeted genomic translocations and inversions generated using a paired prime editing strategy. Kweon J, Hwang HY, Ryu H, Jang AH, Kim D, Kim Y. Mol Ther. 2023 Jan 4;31(1):249-259. doi: 10.1016/j.ymthe.2022.09.008. Epub 2022 Sep 15. PubMed |
| Autophagy inhibition signals through senescence to promote tumor suppression. Peng N, Kang HH, Feng Y, Minikes AM, Jiang X. Autophagy. 2022 Dec 15:1-17. doi: 10.1080/15548627.2022.2155794. PubMed |
| HER2-driven breast cancer suppression by the JNK signaling pathway. Itah Z, Chaudhry S, Raju Ponny S, Aydemir O, Lee A, Cavanagh-Kyros J, Tournier C, Muller WJ, Davis RJ. Proc Natl Acad Sci U S A. 2023 Jan 24;120(4):e2218373120. doi: 10.1073/pnas.2218373120. Epub 2023 Jan 19. PubMed |
| Transient and tunable CRISPRa regulation of APOBEC/AID genes for targeting hepatitis B virus. Kostyushev D, Brezgin S, Kostyusheva A, Ponomareva N, Bayurova E, Zakirova N, Kondrashova A, Goptar I, Nikiforova A, Sudina A, Babin Y, Gordeychuk I, Lukashev A, Zamyatnin AA Jr, Ivanov A, Chulanov V. Mol Ther Nucleic Acids. 2023 Apr 20;32:478-493. doi: 10.1016/j.omtn.2023.04.016. eCollection 2023 Jun 13. PubMed |
| A target discovery pipeline identified ILT3 as a target for immunotherapy of multiple myeloma. Di Meo F, Iyer A, Akama K, Cheng R, Yu C, Cesarano A, Kurihara N, Tenshin H, Aljoufi A, Marino S, Soni RK, Roda J, Sissons J, Vu LP, Guzman M, Huang K, Laskowski T, Broxmeyer HE, Roodman DG, Perna F. Cell Rep Med. 2023 Jul 18;4(7):101110. doi: 10.1016/j.xcrm.2023.101110. PubMed |
| Matriptase-dependent epidermal pre-neoplasm in zebrafish embryos caused by a combination of hypotonic stress and epithelial polarity defects. Hatzold J, Nett V, Brantsch S, Zhang JL, Armistead J, Wessendorf H, Stephens R, Humbert PO, Iden S, Hammerschmidt M. PLoS Genet. 2023 Aug 11;19(8):e1010873. doi: 10.1371/journal.pgen.1010873. eCollection 2023 Aug. PubMed |
| The Fanconi anemia core complex promotes CtIP-dependent end-resection to drive homologous recombination at DNA double-strand breaks. van de Kooij B, van der Wal FJ, Rother MB, Creixell P, Stout M, Wiegant W, Joughin BA, Vornberger J, van Vugt MATM, Altmeyer M, Yaffe MB, van Attikum H. bioRxiv [Preprint]. 2023 Sep 6:2023.09.05.556391. doi: 10.1101/2023.09.05.556391. PubMed |
| The cancer testes antigen, HORMAD1, limits genomic instability in cancer cells by protecting stalled replication forks. Herrera LR, Johnson RA, McGlynn K, Gibbs ZA, Davis AJ, Whitehurst AW. J Biol Chem. 2023 Nov;299(11):105348. doi: 10.1016/j.jbc.2023.105348. Epub 2023 Oct 12. PubMed |
| Active growth signaling promotes senescence and cancer cell sensitivity to CDK7 inhibition. Wilson GA, Vuina K, Sava G, Huard C, Meneguello L, Coulombe-Huntington J, Bertomeu T, Maizels RJ, Lauring J, Kriston-Vizi J, Tyers M, Ali S, Bertoli C, de Bruin RAM. Mol Cell. 2023 Nov 16;83(22):4078-4092.e6. doi: 10.1016/j.molcel.2023.10.017. Epub 2023 Nov 16. PubMed |
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