pSpCas9n(BB)-2A-Puro (PX462) Citations (64)
Originally described in: Genome engineering using the CRISPR-Cas9 system.Ran FA, Hsu PD, Wright J, Agarwala V, Scott DA, Zhang F Nat Protoc. 2013 Nov;8(11):2281-308. doi: 10.1038/nprot.2013.143. Epub 2013 Oct 24. PubMed Journal
Articles Citing pSpCas9n(BB)-2A-Puro (PX462)
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| Genome editing using Cas9 nickases. Trevino AE, Zhang F. Methods Enzymol. 2014;546:161-74. doi: 10.1016/B978-0-12-801185-0.00008-8. PubMed |
| SWI/SNF chromatin-remodeling complexes function in noncoding RNA-dependent assembly of nuclear bodies. Kawaguchi T, Tanigawa A, Naganuma T, Ohkawa Y, Souquere S, Pierron G, Hirose T. Proc Natl Acad Sci U S A. 2015 Apr 7;112(14):4304-9. doi: 10.1073/pnas.1423819112. Epub 2015 Mar 23. PubMed |
| Splicing of many human genes involves sites embedded within introns. Kelly S, Georgomanolis T, Zirkel A, Diermeier S, O'Reilly D, Murphy S, Langst G, Cook PR, Papantonis A. Nucleic Acids Res. 2015 May 19;43(9):4721-32. doi: 10.1093/nar/gkv386. Epub 2015 Apr 20. PubMed |
| CRISPR-mediated genotypic and phenotypic correction of a chronic granulomatous disease mutation in human iPS cells. Flynn R, Grundmann A, Renz P, Hanseler W, James WS, Cowley SA, Moore MD. Exp Hematol. 2015 Oct;43(10):838-848.e3. doi: 10.1016/j.exphem.2015.06.002. Epub 2015 Jun 19. PubMed |
| PICH promotes sister chromatid disjunction and co-operates with topoisomerase II in mitosis. Nielsen CF, Huttner D, Bizard AH, Hirano S, Li TN, Palmai-Pallag T, Bjerregaard VA, Liu Y, Nigg EA, Wang LH, Hickson ID. Nat Commun. 2015 Dec 8;6:8962. doi: 10.1038/ncomms9962. PubMed |
Metabolism. AMP-activated protein kinase mediates mitochondrial fission in response to energy stress.
Toyama EQ, Herzig S, Courchet J, Lewis TL Jr, Loson OC, Hellberg K, Young NP, Chen H, Polleux F, Chan DC, Shaw RJ.
Science. 2016 Jan 15;351(6270):275-81. doi: 10.1126/science.aab4138.
PubMed
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| Inactivating ARID1A Tumor Suppressor Enhances TERT Transcription and Maintains Telomere Length in Cancer Cells. Suryo Rahmanto Y, Jung JG, Wu RC, Kobayashi Y, Heaphy CM, Meeker AK, Wang TL, Shih IeM. J Biol Chem. 2016 Apr 29;291(18):9690-9. doi: 10.1074/jbc.M115.707612. Epub 2016 Mar 7. PubMed |
Repurposing the CRISPR-Cas9 system for targeted DNA methylation.
Vojta A, Dobrinic P, Tadic V, Bockor L, Korac P, Julg B, Klasic M, Zoldos V.
Nucleic Acids Res. 2016 Mar 11. pii: gkw159.
PubMed
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| Phosphorylation of OPTN by TBK1 enhances its binding to Ub chains and promotes selective autophagy of damaged mitochondria. Richter B, Sliter DA, Herhaus L, Stolz A, Wang C, Beli P, Zaffagnini G, Wild P, Martens S, Wagner SA, Youle RJ, Dikic I. Proc Natl Acad Sci U S A. 2016 Apr 12;113(15):4039-44. doi: 10.1073/pnas.1523926113. Epub 2016 Mar 30. PubMed |
| Serine racemase is involved in d-aspartate biosynthesis. Ito T, Hayashida M, Kobayashi S, Muto N, Hayashi A, Yoshimura T, Mori H. J Biochem. 2016 Dec;160(6):345-353. Epub 2016 Jul 7. PubMed |
| Inhibition of acetyl-CoA carboxylase suppresses fatty acid synthesis and tumor growth of non-small-cell lung cancer in preclinical models. Svensson RU, Parker SJ, Eichner LJ, Kolar MJ, Wallace M, Brun SN, Lombardo PS, Van Nostrand JL, Hutchins A, Vera L, Gerken L, Greenwood J, Bhat S, Harriman G, Westlin WF, Harwood HJ Jr, Saghatelian A, Kapeller R, Metallo CM, Shaw RJ. Nat Med. 2016 Oct;22(10):1108-1119. doi: 10.1038/nm.4181. Epub 2016 Sep 19. PubMed |
| StarD7 Protein Deficiency Adversely Affects the Phosphatidylcholine Composition, Respiratory Activity, and Cristae Structure of Mitochondria. Horibata Y, Ando H, Zhang P, Vergnes L, Aoyama C, Itoh M, Reue K, Sugimoto H. J Biol Chem. 2016 Nov 25;291(48):24880-24891. Epub 2016 Sep 30. PubMed |
| Recognition of enzymes lacking bound cofactor by protein quality control. Martinez-Limon A, Alriquet M, Lang WH, Calloni G, Wittig I, Vabulas RM. Proc Natl Acad Sci U S A. 2016 Oct 25;113(43):12156-12161. Epub 2016 Oct 12. PubMed |
| An iPSC-derived vascular model of Marfan syndrome identifies key mediators of smooth muscle cell death. Granata A, Serrano F, Bernard WG, McNamara M, Low L, Sastry P, Sinha S. Nat Genet. 2017 Jan;49(1):97-109. doi: 10.1038/ng.3723. Epub 2016 Nov 28. PubMed |
| The nature and nurture of cell heterogeneity: accounting for macrophage gene-environment interactions with single-cell RNA-Seq. Wills QF, Mellado-Gomez E, Nolan R, Warner D, Sharma E, Broxholme J, Wright B, Lockstone H, James W, Lynch M, Gonzales M, West J, Leyrat A, Padilla-Parra S, Filippi S, Holmes C, Moore MD, Bowden R. BMC Genomics. 2017 Jan 7;18(1):53. doi: 10.1186/s12864-016-3445-0. PubMed |
| XPF knockout via CRISPR/Cas9 reveals that ERCC1 is retained in the cytoplasm without its heterodimer partner XPF. Lehmann J, Seebode C, Smolorz S, Schubert S, Emmert S. Cell Mol Life Sci. 2017 Jun;74(11):2081-2094. doi: 10.1007/s00018-017-2455-7. Epub 2017 Jan 27. PubMed |
| Recapitulating and Correcting Marfan Syndrome in a Cellular Model. Park JW, Yan L, Stoddard C, Wang X, Yue Z, Crandall L, Robinson T, Chang Y, Denton K, Li E, Jiang B, Zhang Z, Martins-Taylor K, Yee SP, Nie H, Gu F, Si W, Xie T, Yue L, Xu RH. Int J Biol Sci. 2017 Apr 10;13(5):588-603. doi: 10.7150/ijbs.19517. eCollection 2017. PubMed |
| The cellular ceramide transport protein CERT promotes Chlamydia psittaci infection and controls bacterial sphingolipid uptake. Koch-Edelmann S, Banhart S, Saied EM, Rose L, Aeberhard L, Laue M, Doellinger J, Arenz C, Heuer D. Cell Microbiol. 2017 May 19. doi: 10.1111/cmi.12752. PubMed |
UBASH3A Mediates Risk for Type 1 Diabetes Through Inhibition of T-Cell Receptor-Induced NF-kappaB Signaling.
Ge Y, Paisie TK, Newman JRB, McIntyre LM, Concannon P.
Diabetes. 2017 Jul;66(7):2033-2043. doi: 10.2337/db16-1023. Epub 2017 Jun 12.
PubMed
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A Single-Chain Photoswitchable CRISPR-Cas9 Architecture for Light-Inducible Gene Editing and Transcription.
Zhou XX, Zou X, Chung HK, Gao Y, Liu Y, Qi LS, Lin MZ.
ACS Chem Biol. 2017 Sep 29. doi: 10.1021/acschembio.7b00603.
PubMed
Associated Plasmids |
| Human SHMT inhibitors reveal defective glycine import as a targetable metabolic vulnerability of diffuse large B-cell lymphoma. Ducker GS, Ghergurovich JM, Mainolfi N, Suri V, Jeong SK, Hsin-Jung Li S, Friedman A, Manfredi MG, Gitai Z, Kim H, Rabinowitz JD. Proc Natl Acad Sci U S A. 2017 Oct 24;114(43):11404-11409. doi: 10.1073/pnas.1706617114. Epub 2017 Oct 9. PubMed |
| CHIP as a membrane-shuttling proteostasis sensor. Kopp Y, Lang WH, Schuster TB, Martinez-Limon A, Hofbauer HF, Ernst R, Calloni G, Vabulas RM. Elife. 2017 Nov 1;6. doi: 10.7554/eLife.29388. PubMed |
| A tyrosine kinase-STAT5-miR21-PDCD4 regulatory axis in chronic and acute myeloid leukemia cells. Espadinha AS, Prouzet-Mauleon V, Claverol S, Lagarde V, Bonneu M, Mahon FX, Cardinaud B. Oncotarget. 2017 Jul 12;8(44):76174-76188. doi: 10.18632/oncotarget.19192. eCollection 2017 Sep 29. PubMed |
| The exon 38-containing ARHGEF11 splice isoform is differentially expressed and is required for migration and growth in invasive breast cancer cells. Itoh M, Radisky DC, Hashiguchi M, Sugimoto H. Oncotarget. 2017 Sep 18;8(54):92157-92170. doi: 10.18632/oncotarget.20985. eCollection 2017 Nov 3. PubMed |
| Transmission of integrin beta7 transmembrane domain topology enables gut lymphoid tissue development. Sun H, Lagarrigue F, Gingras AR, Fan Z, Ley K, Ginsberg MH. J Cell Biol. 2018 Apr 2;217(4):1453-1465. doi: 10.1083/jcb.201707055. Epub 2018 Mar 13. PubMed |
| Inhibition of ovarian tumor cell invasiveness by targeting SYK in the tyrosine kinase signaling pathway. Yu Y, Suryo Rahmanto Y, Lee MH, Wu PH, Phillip JM, Huang CH, Vitolo MI, Gaillard S, Martin SS, Wirtz D, Shih IM, Wang TL. Oncogene. 2018 Jul;37(28):3778-3789. doi: 10.1038/s41388-018-0241-0. Epub 2018 Apr 11. PubMed |
RNase H2, mutated in Aicardi-Goutieres syndrome, promotes LINE-1 retrotransposition.
Benitez-Guijarro M, Lopez-Ruiz C, Tarnauskaite Z, Murina O, Mian Mohammad M, Williams TC, Fluteau A, Sanchez L, Vilar-Astasio R, Garcia-Canadas M, Cano D, Kempen MH, Sanchez-Pozo A, Heras SR, Jackson AP, Reijns MA, Garcia-Perez JL.
EMBO J. 2018 Aug 1;37(15). pii: embj.201798506. doi: 10.15252/embj.201798506. Epub 2018 Jun 29.
PubMed
Associated Plasmids |
| Remodeling of the Acetylproteome by SIRT3 Manipulation Fails to Affect Insulin Secretion or beta Cell Metabolism in the Absence of Overnutrition. Peterson BS, Campbell JE, Ilkayeva O, Grimsrud PA, Hirschey MD, Newgard CB. Cell Rep. 2018 Jul 3;24(1):209-223.e6. doi: 10.1016/j.celrep.2018.05.088. PubMed |
| CRISPR screens identify genomic ribonucleotides as a source of PARP-trapping lesions. Zimmermann M, Murina O, Reijns MAM, Agathanggelou A, Challis R, Tarnauskaite Z, Muir M, Fluteau A, Aregger M, McEwan A, Yuan W, Clarke M, Lambros MB, Paneesha S, Moss P, Chandrashekhar M, Angers S, Moffat J, Brunton VG, Hart T, de Bono J, Stankovic T, Jackson AP, Durocher D. Nature. 2018 Jul;559(7713):285-289. doi: 10.1038/s41586-018-0291-z. Epub 2018 Jul 4. PubMed |
| A new genetic tool to improve immune-compromised mouse models: Derivation and CRISPR/Cas9-mediated targeting of NRG embryonic stem cell lines. Martin Gonzalez J, Baudet A, Abelechian S, Bonderup K, d'Altri T, Porse B, Brakebusch C, Juliusson G, Cammenga J. Genesis. 2018 Sep;56(9):e23238. doi: 10.1002/dvg.23238. PubMed |
| Lipase maturation factor 1 affects redox homeostasis in the endoplasmic reticulum. Roberts BS, Babilonia-Rosa MA, Broadwell LJ, Wu MJ, Neher SB. EMBO J. 2018 Oct 1;37(19). pii: embj.201797379. doi: 10.15252/embj.201797379. Epub 2018 Aug 1. PubMed |
| RIPK1 is a critical modulator of both tonic and TLR-responsive inflammatory and cell death pathways in human macrophage differentiation. Buchrieser J, Oliva-Martin MJ, Moore MD, Long JCD, Cowley SA, Perez-Simon JA, James W, Venero JL. Cell Death Dis. 2018 Sep 24;9(10):973. doi: 10.1038/s41419-018-1053-4. PubMed |
| The Implication of Early Chromatin Changes in X Chromosome Inactivation. Zylicz JJ, Bousard A, Zumer K, Dossin F, Mohammad E, da Rocha ST, Schwalb B, Syx L, Dingli F, Loew D, Cramer P, Heard E. Cell. 2019 Jan 10;176(1-2):182-197.e23. doi: 10.1016/j.cell.2018.11.041. Epub 2018 Dec 27. PubMed |
| CRISPR-Cas9 genome editing induces megabase-scale chromosomal truncations. Cullot G, Boutin J, Toutain J, Prat F, Pennamen P, Rooryck C, Teichmann M, Rousseau E, Lamrissi-Garcia I, Guyonnet-Duperat V, Bibeyran A, Lalanne M, Prouzet-Mauleon V, Turcq B, Ged C, Blouin JM, Richard E, Dabernat S, Moreau-Gaudry F, Bedel A. Nat Commun. 2019 Mar 8;10(1):1136. doi: 10.1038/s41467-019-09006-2. PubMed |
| Identification of on-target mutagenesis during correction of a beta-thalassemia splice mutation in iPS cells with optimised CRISPR/Cas9-double nickase reveals potential safety concerns. Alateeq S, Ovchinnikov D, Tracey T, Whitworth D, Al-Rubaish A, Al-Ali A, Wolvetang E. APL Bioeng. 2018 Dec 3;2(4):046103. doi: 10.1063/1.5048625. eCollection 2018 Dec. PubMed |
| RB1 Deletion in Retinoblastoma Protein Pathway-Disrupted Cells Results in DNA Damage and Cancer Progression. Marshall AE, Roes MV, Passos DT, DeWeerd MC, Chaikovsky AC, Sage J, Howlett CJ, Dick FA. Mol Cell Biol. 2019 Jul 29;39(16). pii: MCB.00105-19. doi: 10.1128/MCB.00105-19. Print 2019 Aug 15. PubMed |
| FAK activity sustains intrinsic and acquired ovarian cancer resistance to platinum chemotherapy. Diaz Osterman CJ, Ozmadenci D, Kleinschmidt EG, Taylor KN, Barrie AM, Jiang S, Bean LM, Sulzmaier FJ, Jean C, Tancioni I, Anderson K, Uryu S, Cordasco EA, Li J, Chen XL, Fu G, Ojalill M, Rappu P, Heino J, Mark AM, Xu G, Fisch KM, Kolev VN, Weaver DT, Pachter JA, Gyorffy B, McHale MT, Connolly DC, Molinolo A, Stupack DG, Schlaepfer DD. Elife. 2019 Sep 3;8. pii: 47327. doi: 10.7554/eLife.47327. PubMed |
| Spleen tyrosine kinase activity regulates epidermal growth factor receptor signaling pathway in ovarian cancer. Yu Y, Suryo Rahmanto Y, Shen YA, Ardighieri L, Davidson B, Gaillard S, Ayhan A, Shi X, Xuan J, Wang TL, Shih IM. EBioMedicine. 2019 Sep;47:184-194. doi: 10.1016/j.ebiom.2019.08.055. Epub 2019 Sep 3. PubMed |
| A causal role for TRESK loss of function in migraine mechanisms. Pettingill P, Weir GA, Wei T, Wu Y, Flower G, Lalic T, Handel A, Duggal G, Chintawar S, Cheung J, Arunasalam K, Couper E, Haupt LM, Griffiths LR, Bassett A, Cowley SA, Cader MZ. Brain. 2019 Dec 1;142(12):3852-3867. doi: 10.1093/brain/awz342. PubMed |
| Nucleoplasmic Reticulum Formation in Human Endometrial Cells is Steroid Hormone Responsive and Recruits Nascent Components. Pytowski L, Drozdz MM, Jiang H, Hernandez Z, Kumar K, Knott E, Vaux DJ. Int J Mol Sci. 2019 Nov 20;20(23). pii: ijms20235839. doi: 10.3390/ijms20235839. PubMed |
| Hydroxysteroid sulfotransferase 2B1 affects gastric epithelial function and carcinogenesis induced by a carcinogenic agent. Hong W, Guo F, Yang M, Xu D, Zhuang Z, Niu B, Bai Q, Li X. Lipids Health Dis. 2019 Nov 22;18(1):203. doi: 10.1186/s12944-019-1149-6. PubMed |
| The ASXL1-G643W variant accelerates the development of CEBPA mutant acute myeloid leukemia. D'Altri T, Wilhelmson AS, Schuster MB, Wenzel A, Kalvisa A, Pundhir S, Hansen AM, Porse BT. Haematologica. 2020 May 7. pii: haematol.2019.235150. doi: 10.3324/haematol.2019.235150. PubMed |
| Generation and characterization of HLA-universal platelets derived from induced pluripotent stem cells. Norbnop P, Ingrungruanglert P, Israsena N, Suphapeetiporn K, Shotelersuk V. Sci Rep. 2020 May 21;10(1):8472. doi: 10.1038/s41598-020-65577-x. PubMed |
| Inactivation of Arid1a in the endometrium is associated with endometrioid tumorigenesis through transcriptional reprogramming. Suryo Rahmanto Y, Shen W, Shi X, Chen X, Yu Y, Yu ZC, Miyamoto T, Lee MH, Singh V, Asaka R, Shimberg G, Vitolo MI, Martin SS, Wirtz D, Drapkin R, Xuan J, Wang TL, Shih IM. Nat Commun. 2020 Jun 1;11(1):2717. doi: 10.1038/s41467-020-16416-0. PubMed |
| CAM-Delam: an in vivo approach to visualize and quantify the delamination and invasion capacity of human cancer cells. Palaniappan TK, Slekiene L, Jonasson AK, Gilthorpe J, Gunhaga L. Sci Rep. 2020 Jun 26;10(1):10472. doi: 10.1038/s41598-020-67492-7. PubMed |
| Iron chelation rescues hemolytic anemia and skin photosensitivity in congenital erythropoietic porphyria. Blouin JM, Ged C, Lalanne M, Lamrissi-Garcia I, Morice-Picard F, Costet P, Daher R, Moreau-Gaudry F, Bedel A, Puy H, Gouya L, Karim Z, Richard E. Blood. 2020 Jul 17. pii: 461423. doi: 10.1182/blood.2020006037. PubMed |
| Defining endogenous TACC3-chTOG-clathrin-GTSE1 interactions at the mitotic spindle using induced relocalization. Ryan EL, Shelford J, Massam-Wu T, Bayliss R, Royle SJ. J Cell Sci. 2021 Feb 1;134(3). pii: jcs.255794. doi: 10.1242/jcs.255794. PubMed |
| Cancer-associated exportin-6 upregulation inhibits the transcriptionally repressive and anticancer effects of nuclear profilin-1. Zhu C, Kim SJ, Mooradian A, Wang F, Li Z, Holohan S, Collins PL, Wang K, Guo Z, Hoog J, Ma CX, Oltz EM, Held JM, Shao J. Cell Rep. 2021 Feb 16;34(7):108749. doi: 10.1016/j.celrep.2021.108749. PubMed |
| Reconstructing single-cell karyotype alterations in colorectal cancer identifies punctuated and gradual diversification patterns. Bollen Y, Stelloo E, van Leenen P, van den Bos M, Ponsioen B, Lu B, van Roosmalen MJ, Bolhaqueiro ACF, Kimberley C, Mossner M, Cross WCH, Besselink NJM, van der Roest B, Boymans S, Oost KC, de Vries SG, Rehmann H, Cuppen E, Lens SMA, Kops GJPL, Kloosterman WP, Terstappen LWMM, Barnes CP, Sottoriva A, Graham TA, Snippert HJG. Nat Genet. 2021 Aug;53(8):1187-1195. doi: 10.1038/s41588-021-00891-2. Epub 2021 Jul 1. PubMed |
| Genetic screens identify a context-specific PI3K/p27Kip1 node driving extrahepatic biliary cancer. Falcomata C, Barthel S, Ulrich A, Diersch S, Veltkamp C, Rad L, Boniolo F, Solar M, Steiger K, Seidler B, Zukowska M, Madej J, Wang M, Ollinger R, Maresch R, Barenboim M, Eser S, Tschurtschenthaler M, Mehrabi A, Roessler S, Goeppert B, Kind A, Schnieke A, Robles MS, Bradley A, Schmid RM, Schmidt-Supprian M, Reichert M, Weichert W, Sansom OJ, Morton JP, Rad R, Schneider G, Saur D. Cancer Discov. 2021 Jul 19. pii: 2159-8290.CD-21-0209. doi: 10.1158/2159-8290.CD-21-0209. PubMed |
| Targeting the Highly Expressed microRNA miR-146b with CRISPR/Cas9n Gene Editing System in Thyroid Cancer. Santa-Inez DC, Fuziwara CS, Saito KC, Kimura ET. Int J Mol Sci. 2021 Jul 27;22(15). pii: ijms22157992. doi: 10.3390/ijms22157992. PubMed |
| Interleukin-32 regulates downstream molecules and promotes the invasion of pancreatic cancer cells. Takagi K, Shimomura A, Imura J, Mori H, Noguchi A, Tanaka S, Minamisaka T, Nishida T, Hatta H, Nakajima T. Oncol Lett. 2022 Jan;23(1):14. doi: 10.3892/ol.2021.13132. Epub 2021 Nov 11. PubMed |
Efficient and error-free fluorescent gene tagging in human organoids without double-strand DNA cleavage.
Bollen Y, Hageman JH, van Leenen P, Derks LLM, Ponsioen B, Buissant des Amorie JR, Verlaan-Klink I, van den Bos M, Terstappen LWMM, van Boxtel R, Snippert HJG.
PLoS Biol. 2022 Jan 28;20(1):e3001527. doi: 10.1371/journal.pbio.3001527.
PubMed
Associated Plasmids |
| Persistent DNA damage associated with ATM kinase deficiency promotes microglial dysfunction. Bourseguin J, Cheng W, Talbot E, Hardy L, Lai J, Jeffries AM, Lodato MA, Lee EA, Khoronenkova SV. Nucleic Acids Res. 2022 Mar 21;50(5):2700-2718. doi: 10.1093/nar/gkac104. PubMed |
| The nuclear receptor ERR cooperates with the cardiogenic factor GATA4 to orchestrate cardiomyocyte maturation. Sakamoto T, Batmanov K, Wan S, Guo Y, Lai L, Vega RB, Kelly DP. Nat Commun. 2022 Apr 13;13(1):1991. doi: 10.1038/s41467-022-29733-3. PubMed |
| Seamless Gene Correction in the Human Cystic Fibrosis Transmembrane Conductance Regulator Locus by Vector Replacement and Vector Insertion Events. Suzuki S, Chosa K, Barilla C, Yao M, Zuffardi O, Kai H, Shuto T, Suico MA, Kan YW, Sargent RG, Gruenert DC. Front Genome Ed. 2022 Apr 6;4:843885. doi: 10.3389/fgeed.2022.843885. eCollection 2022. PubMed |
| The Unusual Cosubstrate Specificity of NQO2: Conservation Throughout the Amniotes and Implications for Cellular Function. Islam F, Leung KK, Walker MD, Al Massri S, Shilton BH. Front Pharmacol. 2022 Apr 20;13:838500. doi: 10.3389/fphar.2022.838500. eCollection 2022. PubMed |
| Cholesterol sulfate alleviates ulcerative colitis by promoting cholesterol biosynthesis in colonic epithelial cells. Xu D, Ma R, Ju Y, Song X, Niu B, Hong W, Wang R, Yang Q, Zhao Z, Zhang Y, Zheng Y, Bai Q, Lv M, Sun N, Li X. Nat Commun. 2022 Jul 30;13(1):4428. doi: 10.1038/s41467-022-32158-7. PubMed |
A general chemical principle for creating closure-stabilizing integrin inhibitors.
Lin FY, Li J, Xie Y, Zhu J, Huong Nguyen TT, Zhang Y, Zhu J, Springer TA.
Cell. 2022 Sep 15;185(19):3533-3550.e27. doi: 10.1016/j.cell.2022.08.008.
PubMed
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| Induction of lysosomal and mitochondrial biogenesis by AMPK phosphorylation of FNIP1. Malik N, Ferreira BI, Hollstein PE, Curtis SD, Trefts E, Weiser Novak S, Yu J, Gilson R, Hellberg K, Fang L, Sheridan A, Hah N, Shadel GS, Manor U, Shaw RJ. Science. 2023 Apr 21;380(6642):eabj5559. doi: 10.1126/science.abj5559. Epub 2023 Apr 21. PubMed |
| Cell type-specific labeling of newly synthesized proteins by puromycin inactivation. Cabrera-Cabrera F, Tull H, Capuana R, Kasvandik S, Timmusk T, Koppel I. J Biol Chem. 2023 Sep;299(9):105129. doi: 10.1016/j.jbc.2023.105129. Epub 2023 Aug 4. PubMed |
| Differentiation and Characterization of Cystic Fibrosis Transmembrane Conductance Regulator Knockout Human Pluripotent Stem Cells into Salivary Gland Epithelial Progenitors. Yan S, Zhang Y, Zhang S, Wei S. Int J Stem Cells. 2023 Nov 30;16(4):394-405. doi: 10.15283/ijsc23036. Epub 2023 Sep 6. PubMed |
| A porcine kidney-derived clonal cell line with clear genetic annotation is highly susceptible to African swine fever virus. Cao H, Zhang M, Liao Z, Li D, He X, Ma H, Li P, Yu X, Peng G, Xie S, He Q, Li W. Vet Res. 2024 Apr 4;55(1):42. doi: 10.1186/s13567-024-01300-2. PubMed |
Ligand binding initiates single-molecule integrin conformational activation.
Li J, Jo MH, Yan J, Hall T, Lee J, Lopez-Sanchez U, Yan S, Ha T, Springer TA.
Cell. 2024 May 14:S0092-8674(24)00475-6. doi: 10.1016/j.cell.2024.04.049.
PubMed
Associated Plasmids |
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