5HRE/GFP Citations (20)
Originally described in: Green fluorescent protein is a suitable reporter of tumor hypoxia despite an oxygen requirement for chromophore formation.Vordermark D, Shibata T, Brown JM Neoplasia. 2001 Nov-Dec;3(6):527-34. PubMed Journal
Articles Citing 5HRE/GFP
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A novel family of fluorescent hypoxia sensors reveal strong heterogeneity in tumor hypoxia at the cellular level.
Erapaneedi R, Belousov VV, Schafers M, Kiefer F.
EMBO J. 2016 Jan 4;35(1):102-13. doi: 10.15252/embj.201592775. Epub 2015 Nov 23.
PubMed
Associated Plasmids |
| Oxygen as a chemoattractant: confirming cellular hypoxia in paper-based invasion assays. Truong AS, Lockett MR. Analyst. 2016 Jun 21;141(12):3874-82. doi: 10.1039/c6an00630b. Epub 2016 May 3. PubMed |
| Gene delivery of hypoxia-inducible VEGF targeting collagen effectively improves cardiac function after myocardial infarction. Xia JB, Wu HY, Lai BL, Zheng L, Zhou DC, Chang ZS, Mao CZ, Liu GH, Park KS, Zhao H, Kim SK, Song GH, Cai DQ, Qi XF. Sci Rep. 2017 Oct 16;7(1):13273. doi: 10.1038/s41598-017-13547-1. PubMed |
| The hypoxic tumor microenvironment in vivo selects the cancer stem cell fate of breast cancer cells. Kim H, Lin Q, Glazer PM, Yun Z. Breast Cancer Res. 2018 Mar 6;20(1):16. doi: 10.1186/s13058-018-0944-8. PubMed |
Acid Suspends the Circadian Clock in Hypoxia through Inhibition of mTOR.
Walton ZE, Patel CH, Brooks RC, Yu Y, Ibrahim-Hashim A, Riddle M, Porcu A, Jiang T, Ecker BL, Tameire F, Koumenis C, Weeraratna AT, Welsh DK, Gillies R, Alwine JC, Zhang L, Powell JD, Dang CV.
Cell. 2018 Jun 28;174(1):72-87.e32. doi: 10.1016/j.cell.2018.05.009. Epub 2018 May 31.
PubMed
Associated Plasmids |
| Induction of HIF-1alpha by HIV-1 Infection in CD4(+) T Cells Promotes Viral Replication and Drives Extracellular Vesicle-Mediated Inflammation. Duette G, Pereyra Gerber P, Rubione J, Perez PS, Landay AL, Crowe SM, Liao Z, Witwer KW, Holgado MP, Salido J, Geffner J, Sued O, Palmer CS, Ostrowski M. MBio. 2018 Sep 11;9(5). pii: mBio.00757-18. doi: 10.1128/mBio.00757-18. PubMed |
| Evaluating natural killer cell cytotoxicity against solid tumors using a microfluidic model. Ayuso JM, Truttschel R, Gong MM, Humayun M, Virumbrales-Munoz M, Vitek R, Felder M, Gillies SD, Sondel P, Wisinski KB, Patankar M, Beebe DJ, Skala MC. Oncoimmunology. 2018 Dec 12;8(3):1553477. doi: 10.1080/2162402X.2018.1553477. eCollection 2019. PubMed |
| The focal adhesion protein kindlin-2 controls mitotic spindle assembly by inhibiting histone deacetylase 6 and maintaining alpha-tubulin acetylation. Tan HF, Tan SM. J Biol Chem. 2020 May 1;295(18):5928-5943. doi: 10.1074/jbc.RA120.012954. Epub 2020 Mar 13. PubMed |
| Isolinderalactone suppresses human glioblastoma growth and angiogenic activity in 3D microfluidic chip and in vivo mouse models. Park JH, Kim MJ, Kim WJ, Kwon KD, Ha KT, Choi BT, Lee SY, Shin HK. Cancer Lett. 2020 May 28;478:71-81. doi: 10.1016/j.canlet.2020.03.009. Epub 2020 Mar 12. PubMed |
| Generating linear oxygen gradients across 3D cell cultures with block-layered oxygen controlled chips (BLOCCs). Boyce MW, Simke WC, Kenney RM, Lockett MR. Anal Methods. 2020 Jan 7;12(1):18-24. doi: 10.1039/C9AY01690B. Epub 2019 Nov 26. PubMed |
| Microfluidic Tumor-on-a-Chip Model to Study Tumor Metabolic Vulnerability. Ayuso JM, Rehman S, Farooqui M, Virumbrales-Munoz M, Setaluri V, Skala MC, Beebe DJ. Int J Mol Sci. 2020 Nov 28;21(23). pii: ijms21239075. doi: 10.3390/ijms21239075. PubMed |
| Cell line development for continuous high cell density biomanufacturing: Exploiting hypoxia for improved productivity. Zeh N, Schlossbauer P, Raab N, Klingler F, Handrick R, Otte K. Metab Eng Commun. 2021 Jul 29;13:e00181. doi: 10.1016/j.mec.2021.e00181. eCollection 2021 Dec. PubMed |
The MEMIC is an ex vivo system to model the complexity of the tumor microenvironment.
Janska L, Anandi L, Kirchberger NC, Marinkovic ZS, Schachtner LT, Guzelsoy G, Carmona-Fontaine C.
Dis Model Mech. 2021 Aug 1;14(8). pii: 271783. doi: 10.1242/dmm.048942. Epub 2021 Aug 18.
PubMed
Associated Plasmids |
| Hypoxia and HIF-1 Trigger Marek's Disease Virus Reactivation in Lymphoma-Derived Latently Infected T Lymphocytes. Mallet C, Cochard J, Leclercq S, Trapp-Fragnet L, Chouteau P, Denesvre C. J Virol. 2022 Mar 9;96(5):e0142721. doi: 10.1128/JVI.01427-21. Epub 2021 Dec 22. PubMed |
| Exploring synthetic biology for the development of a sensor cell line for automated bioprocess control. Zeh N, Brauer M, Raab N, Handrick R, Otte K. Sci Rep. 2022 Feb 10;12(1):2268. doi: 10.1038/s41598-022-06272-x. PubMed |
| Neddylation is required for perinatal cardiac development through stimulation of metabolic maturation. Zou J, Wang W, Lu Y, Ayala J, Dong K, Zhou H, Wang J, Chen W, Weintraub NL, Zhou J, Li J, Su H. Cell Rep. 2023 Jan 31;42(1):112018. doi: 10.1016/j.celrep.2023.112018. Epub 2023 Jan 19. PubMed |
| Selecting the appropriate indirect viability assay for 3D paper-based cultures: a data-driven study. Sitte ZR, Larson TS, McIntosh JC, Sinanian M, Lockett MR. Analyst. 2023 May 16;148(10):2245-2255. doi: 10.1039/d3an00283g. PubMed |
| Quantitative intravital imaging for real-time monitoring of pancreatic tumor cell hypoxia and stroma in an orthotopic mouse model. Samuel T, Rapic S, O'Brien C, Edson M, Zhong Y, DaCosta RS. Sci Adv. 2023 Jun 9;9(23):eade8672. doi: 10.1126/sciadv.ade8672. Epub 2023 Jun 7. PubMed |
| Newly developed preclinical models reveal broad-spectrum CDK inhibitors as potent drugs for CRPC exhibiting primary resistance to enzalutamide. Matsuoka T, Sugiyama A, Miyawaki Y, Hidaka Y, Okuno Y, Sakai H, Tanaka H, Yoshikawa K, Fukui T, Mizuno K, Sumiyoshi T, Goto T, Inoue T, Akamatsu S, Kobayashi T, Nakamura E. Cancer Sci. 2024 Jan;115(1):283-297. doi: 10.1111/cas.15984. Epub 2023 Nov 3. PubMed |
| Positive selection CRISPR screens reveal a druggable pocket in an oligosaccharyltransferase required for inflammatory signaling to NF-kappaB. Lampson BL, Ramiotarez AS, Baro M, He L, Hegde M, Koduri V, Pfaff JL, Hanna RE, Kowal J, Shirole NH, He Y, Doench JG, Contessa JN, Locher KP, Kaelin WG Jr. Cell. 2024 Apr 25;187(9):2209-2223.e16. doi: 10.1016/j.cell.2024.03.022. PubMed |
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