Flag Nprl2 pRK5 Citations (4)

Originally described in: A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1.
Bar-Peled L, Chantranupong L, Cherniack AD, Chen WW, Ottina KA, Grabiner BC, Spear ED, Carter SL, Meyerson M, Sabatini DM Science. 2013 May 31;340(6136):1100-6. doi: 10.1126/science.1232044. PubMed Journal

Articles Citing Flag Nprl2 pRK5

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Functional screening of GATOR1 complex variants reveals a role for mTORC1 deregulation in FCD and focal epilepsy. Dawson RE, Nieto Guil AF, Robertson LJ, Piltz SG, Hughes JN, Thomas PQ. Neurobiol Dis. 2020 Feb;134:104640. doi: 10.1016/j.nbd.2019.104640. Epub 2019 Oct 19. PubMed
Src regulates amino acid-mediated mTORC1 activation by disrupting GATOR1-Rag GTPase interaction. Pal R, Palmieri M, Chaudhury A, Klisch TJ, di Ronza A, Neilson JR, Rodney GG, Sardiello M. Nat Commun. 2018 Oct 19;9(1):4351. doi: 10.1038/s41467-018-06844-4. PubMed
Sestrin2 inhibits mTORC1 through modulation of GATOR complexes. Kim JS, Ro SH, Kim M, Park HW, Semple IA, Park H, Cho US, Wang W, Guan KL, Karin M, Lee JH. Sci Rep. 2015 Mar 30;5:9502. doi: 10.1038/srep09502. PubMed
Preliminary functional assessment and classification of DEPDC5 variants associated with focal epilepsy. van Kranenburg M, Hoogeveen-Westerveld M, Nellist M. Hum Mutat. 2015 Feb;36(2):200-9. doi: 10.1002/humu.22723. Epub 2014 Nov 27. PubMed

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