HA Nprl3 pRK5 Citations (7)
Originally described in: A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1.Bar-Peled L, Chantranupong L, Cherniack AD, Chen WW, Ottina KA, Grabiner BC, Spear ED, Carter SL, Meyerson M, Sabatini DM Science. 2013 May 31;340(6136):1100-6. doi: 10.1126/science.1232044. PubMed Journal
Articles Citing HA Nprl3 pRK5
| Articles |
|---|
| Preliminary functional assessment and classification of DEPDC5 variants associated with focal epilepsy. van Kranenburg M, Hoogeveen-Westerveld M, Nellist M. Hum Mutat. 2015 Feb;36(2):200-9. doi: 10.1002/humu.22723. Epub 2014 Nov 27. PubMed |
| Sestrin2 inhibits mTORC1 through modulation of GATOR complexes. Kim JS, Ro SH, Kim M, Park HW, Semple IA, Park H, Cho US, Wang W, Guan KL, Karin M, Lee JH. Sci Rep. 2015 Mar 30;5:9502. doi: 10.1038/srep09502. PubMed |
Intersubunit Crosstalk in the Rag GTPase Heterodimer Enables mTORC1 to Respond Rapidly to Amino Acid Availability.
Shen K, Choe A, Sabatini DM.
Mol Cell. 2017 Oct 17. pii: S1097-2765(17)30704-9. doi: 10.1016/j.molcel.2017.09.026.
PubMed
Associated Plasmids |
| Src regulates amino acid-mediated mTORC1 activation by disrupting GATOR1-Rag GTPase interaction. Pal R, Palmieri M, Chaudhury A, Klisch TJ, di Ronza A, Neilson JR, Rodney GG, Sardiello M. Nat Commun. 2018 Oct 19;9(1):4351. doi: 10.1038/s41467-018-06844-4. PubMed |
| Functional screening of GATOR1 complex variants reveals a role for mTORC1 deregulation in FCD and focal epilepsy. Dawson RE, Nieto Guil AF, Robertson LJ, Piltz SG, Hughes JN, Thomas PQ. Neurobiol Dis. 2020 Feb;134:104640. doi: 10.1016/j.nbd.2019.104640. Epub 2019 Oct 19. PubMed |
| Brain-enriched RagB isoforms regulate the dynamics of mTORC1 activity through GATOR1 inhibition. Figlia G, Muller S, Hagenston AM, Kleber S, Roiuk M, Quast JP, Ten Bosch N, Carvajal Ibanez D, Mauceri D, Martin-Villalba A, Teleman AA. Nat Cell Biol. 2022 Sep;24(9):1407-1421. doi: 10.1038/s41556-022-00977-x. Epub 2022 Sep 12. PubMed |
| CDK5-PRMT1-WDR24 signaling cascade promotes mTORC1 signaling and tumor growth. Yin S, Liu L, Ball LE, Wang Y, Bedford MT, Duncan SA, Wang H, Gan W. Cell Rep. 2023 Apr 25;42(4):112316. doi: 10.1016/j.celrep.2023.112316. Epub 2023 Mar 29. PubMed |
If you have published an article using this material, please email us at [email protected] to have your article added to this page.