pimEJ5GFP Citations (65)
Originally described in: Alternative-NHEJ is a mechanistically distinct pathway of mammalian chromosome break repair.Bennardo N, Cheng A, Huang N, Stark JM PLoS Genet. 2008 Jun 27;4(6):e1000110. doi: 10.1371/journal.pgen.1000110. PubMed Journal
Articles Citing pimEJ5GFP
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| Targeting of beta1 integrins impairs DNA repair for radiosensitization of head and neck cancer cells. Dickreuter E, Eke I, Krause M, Borgmann K, van Vugt MA, Cordes N. Oncogene. 2015 Jun 15. doi: 10.1038/onc.2015.212. PubMed |
| Combined Effects of Suberoylanilide Hydroxamic Acid and Cisplatin on Radiation Sensitivity and Cancer Cell Invasion in Non-Small Cell Lung Cancer. Feng J, Zhang S, Wu K, Wang B, Wong JY, Jiang H, Xu R, Ying L, Huang H, Zheng X, Chen X, Ma S. Mol Cancer Ther. 2016 May;15(5):842-53. doi: 10.1158/1535-7163.MCT-15-0445. Epub 2016 Feb 2. PubMed |
| Histone deacetylase inhibitors decrease NHEJ both by acetylation of repair factors and trapping of PARP1 at DNA double-strand breaks in chromatin. Robert C, Nagaria PK, Pawar N, Adewuyi A, Gojo I, Meyers DJ, Cole PA, Rassool FV. Leuk Res. 2016 Jun;45:14-23. doi: 10.1016/j.leukres.2016.03.007. Epub 2016 Mar 30. PubMed |
| Cyclin A2 promotes DNA repair in the brain during both development and aging. Gygli PE, Chang JC, Gokozan HN, Catacutan FP, Schmidt TA, Kaya B, Goksel M, Baig FS, Chen S, Griveau A, Michowski W, Wong M, Palanichamy K, Sicinski P, Nelson RJ, Czeisler C, Otero JJ. Aging (Albany NY). 2016 Jul;8(7):1540-70. doi: 10.18632/aging.100990. PubMed |
| Epigenetic therapy potential of suberoylanilide hydroxamic acid on invasive human non-small cell lung cancer cells. Zhang S, Wu K, Feng J, Wu Z, Deng Q, Guo C, Xia B, Zhang J, Huang H, Zhu L, Zhang K, Shen B, Chen X, Ma S. Oncotarget. 2016 Oct 18;7(42):68768-68780. doi: 10.18632/oncotarget.11967. PubMed |
| High-Fidelity Reprogrammed Human IPSCs Have a High Efficacy of DNA Repair and Resemble hESCs in Their MYC Transcriptional Signature. Nagaria PK, Robert C, Park TS, Huo JS, Zambidis ET, Rassool FV. Stem Cells Int. 2016;2016:3826249. doi: 10.1155/2016/3826249. Epub 2016 Sep 1. PubMed |
| Quercetin alters the DNA damage response in human hematopoietic stem and progenitor cells via TopoII- and PI3K-dependent mechanisms synergizing in leukemogenic rearrangements. Biechonski S, Gourevich D, Rall M, Aqaqe N, Yassin M, Zipin-Roitman A, Trakhtenbrot L, Olender L, Raz Y, Jaffa AJ, Grisaru D, Wiesmuller L, Elad D, Milyavsky M. Int J Cancer. 2017 Feb 15;140(4):864-876. doi: 10.1002/ijc.30497. Epub 2016 Nov 22. PubMed |
| TDP1 is required for efficient non-homologous end joining in human cells. Li J, Summerlin M, Nitiss KC, Nitiss JL, Hanakahi LA. DNA Repair (Amst). 2017 Dec;60:40-49. doi: 10.1016/j.dnarep.2017.10.003. Epub 2017 Oct 16. PubMed |
Targeting the MALAT1/PARP1/LIG3 complex induces DNA damage and apoptosis in multiple myeloma.
Hu Y, Lin J, Fang H, Fang J, Li C, Chen W, Liu S, Ondrejka S, Gong Z, Reu F, Maciejewski J, Yi Q, Zhao JJ.
Leukemia. 2018 Mar 22. pii: 10.1038/s41375-018-0104-2. doi: 10.1038/s41375-018-0104-2.
PubMed
Associated Plasmids |
| Attenuated DNA damage responses and increased apoptosis characterize human hematopoietic stem cells exposed to irradiation. Biechonski S, Olender L, Zipin-Roitman A, Yassin M, Aqaqe N, Marcu-Malina V, Rall-Scharpf M, Trottier M, Meyn MS, Wiesmuller L, Beider K, Raz Y, Grisaru D, Nagler A, Milyavsky M. Sci Rep. 2018 Apr 17;8(1):6071. doi: 10.1038/s41598-018-24440-w. PubMed |
| ATR-mediated proteome remodeling is a major determinant of homologous recombination capacity in cancer cells. Kim D, Liu Y, Oberly S, Freire R, Smolka MB. Nucleic Acids Res. 2018 Sep 19;46(16):8311-8325. doi: 10.1093/nar/gky625. PubMed |
| AIMP3 Deletion Induces Acute Radiation Syndrome-like Phenotype in Mice. Kim D, Kim S, Oh Y, Park S, Jeon Y, Kim H, Lee H, Kim S. Sci Rep. 2018 Oct 9;8(1):15025. doi: 10.1038/s41598-018-33303-3. PubMed |
| NF-kappaB and Poly (ADP-ribose) Polymerase 1 Form a Positive Feedback Loop that Regulates DNA Repair in Acute Myeloid Leukemia Cells. Li D, Luo Y, Chen X, Zhang L, Wang T, Zhuang Y, Fan Y, Xu J, Chen Y, Wu L. Mol Cancer Res. 2019 Mar;17(3):761-772. doi: 10.1158/1541-7786.MCR-18-0523. Epub 2018 Dec 17. PubMed |
| NR4A Nuclear Receptors Target Poly-ADP-Ribosylated DNA-PKcs Protein to Promote DNA Repair. Munnur D, Somers J, Skalka G, Weston R, Jukes-Jones R, Bhogadia M, Dominguez C, Cain K, Ahel I, Malewicz M. Cell Rep. 2019 Feb 19;26(8):2028-2036.e6. doi: 10.1016/j.celrep.2019.01.083. PubMed |
| Nonhomologous end joining key factor XLF enhances both 5-florouracil and oxaliplatin resistance in colorectal cancer. Liu Z, Yu M, Fei B, Sun J, Wang D. Onco Targets Ther. 2019 Mar 20;12:2095-2104. doi: 10.2147/OTT.S192923. eCollection 2019. PubMed |
| Pellino1 regulates reversible ATM activation via NBS1 ubiquitination at DNA double-strand breaks. Ha GH, Ji JH, Chae S, Park J, Kim S, Lee JK, Kim Y, Min S, Park JM, Kang TH, Lee H, Cho H, Lee CW. Nat Commun. 2019 Apr 5;10(1):1577. doi: 10.1038/s41467-019-09641-9. PubMed |
| RB1 Deletion in Retinoblastoma Protein Pathway-Disrupted Cells Results in DNA Damage and Cancer Progression. Marshall AE, Roes MV, Passos DT, DeWeerd MC, Chaikovsky AC, Sage J, Howlett CJ, Dick FA. Mol Cell Biol. 2019 Jul 29;39(16). pii: MCB.00105-19. doi: 10.1128/MCB.00105-19. Print 2019 Aug 15. PubMed |
| Bromodomain and extraterminal domain inhibition synergizes with WEE1-inhibitor AZD1775 effect by impairing nonhomologous end joining and enhancing DNA damage in nonsmall cell lung cancer. Takashima Y, Kikuchi E, Kikuchi J, Suzuki M, Kikuchi H, Maeda M, Shoji T, Furuta M, Kinoshita I, Dosaka-Akita H, Sakakibara-Konishi J, Konno S. Int J Cancer. 2019 Jun 14. doi: 10.1002/ijc.32515. PubMed |
| Activation of Wnt signaling promotes olaparib resistant ovarian cancer. Yamamoto TM, McMellen A, Watson ZL, Aguilera J, Ferguson R, Nurmemmedov E, Thakar T, Moldovan GL, Kim H, Cittelly DM, Joglar AM, Brennecke EP, Wilson H, Behbakht K, Sikora MJ, Bitler BG. Mol Carcinog. 2019 Jun 10. doi: 10.1002/mc.23064. PubMed |
| LMO2 Confers Synthetic Lethality to PARP Inhibition in DLBCL. Parvin S, Ramirez-Labrada A, Aumann S, Lu X, Weich N, Santiago G, Cortizas EM, Sharabi E, Zhang Y, Sanchez-Garcia I, Gentles AJ, Roberts E, Bilbao-Cortes D, Vega F, Chapman JR, Verdun RE, Lossos IS. Cancer Cell. 2019 Sep 16;36(3):237-249.e6. doi: 10.1016/j.ccell.2019.07.007. Epub 2019 Aug 22. PubMed |
| Chromatin-bound cGAS is an inhibitor of DNA repair and hence accelerates genome destabilization and cell death. Jiang H, Xue X, Panda S, Kawale A, Hooy RM, Liang F, Sohn J, Sung P, Gekara NO. EMBO J. 2019 Oct 4;38(21):e102718. doi: 10.15252/embj.2019102718. Epub 2019 Sep 23. PubMed |
| Synergism between ATM and PARP1 Inhibition Involves DNA Damage and Abrogating the G2 DNA Damage Checkpoint. Mak JPY, Ma HT, Poon RYC. Mol Cancer Ther. 2020 Jan;19(1):123-134. doi: 10.1158/1535-7163.MCT-19-0474. Epub 2019 Oct 9. PubMed |
| Histone methyltransferases EHMT1 and EHMT2 (GLP/G9A) maintain PARP inhibitor resistance in high-grade serous ovarian carcinoma. Watson ZL, Yamamoto TM, McMellen A, Kim H, Hughes CJ, Wheeler LJ, Post MD, Behbakht K, Bitler BG. Clin Epigenetics. 2019 Nov 27;11(1):165. doi: 10.1186/s13148-019-0758-2. PubMed |
| Identification Of Natural Compound Derivative For Inhibition Of XLF And Overcoming Chemoresistance In Colorectal Cancer Cells. Liu Z, Yu M, Fei B, Sun J, Wang D. Drug Des Devel Ther. 2019 Nov 6;13:3823-3834. doi: 10.2147/DDDT.S215967. eCollection 2019. PubMed |
| Dipeptide repeat proteins inhibit homology-directed DNA double strand break repair in C9ORF72 ALS/FTD. Andrade NS, Ramic M, Esanov R, Liu W, Rybin MJ, Gaidosh G, Abdallah A, Del'Olio S, Huff TC, Chee NT, Anatha S, Gendron TF, Wahlestedt C, Zhang Y, Benatar M, Mueller C, Zeier Z. Mol Neurodegener. 2020 Feb 24;15(1):13. doi: 10.1186/s13024-020-00365-9. PubMed |
| Histone demethylase JMJD1A promotes expression of DNA repair factors and radio-resistance of prostate cancer cells. Fan L, Xu S, Zhang F, Cui X, Fazli L, Gleave M, Clark DJ, Yang A, Hussain A, Rassool F, Qi J. Cell Death Dis. 2020 Apr 1;11(4):214. doi: 10.1038/s41419-020-2405-4. PubMed |
| Characterisation of Ovarian Cancer Cell Line NIH-OVCAR3 and Implications of Genomic, Transcriptomic, Proteomic and Functional DNA Damage Response Biomarkers for Therapeutic Targeting. Bradbury A, O'Donnell R, Drew Y, Curtin NJ, Sharma Saha S. Cancers (Basel). 2020 Jul 17;12(7). pii: cancers12071939. doi: 10.3390/cancers12071939. PubMed |
| Metastasis Suppressor NME1 Modulates Choice of Double-Strand Break Repair Pathways in Melanoma Cells by Enhancing Alternative NHEJ while Inhibiting NHEJ and HR. Puts G, Jarrett S, Leonard M, Matsangos N, Snyder D, Wang Y, Vincent R, Portney B, Abbotts R, McLaughlin L, Zalzman M, Rassool F, Kaetzel D. Int J Mol Sci. 2020 Aug 17;21(16). pii: ijms21165896. doi: 10.3390/ijms21165896. PubMed |
| DDX5 resolves R-loops at DNA double-strand breaks to promote DNA repair and avoid chromosomal deletions. Yu Z, Mersaoui SY, Guitton-Sert L, Coulombe Y, Song J, Masson JY, Richard S. NAR Cancer. 2020 Sep;2(3):zcaa028. doi: 10.1093/narcan/zcaa028. Epub 2020 Sep 25. PubMed |
| TGFbetaR-SMAD3 Signaling Induces Resistance to PARP Inhibitors in the Bone Marrow Microenvironment. Le BV, Podszywalow-Bartnicka P, Maifrede S, Sullivan-Reed K, Nieborowska-Skorska M, Golovine K, Yao JC, Nejati R, Cai KQ, Caruso LB, Swatler J, Dabrowski M, Lian Z, Valent P, Paietta EM, Levine RL, Fernandez HF, Tallman MS, Litzow MR, Huang J, Challen GA, Link D, Tempera I, Wasik MA, Piwocka K, Skorski T. Cell Rep. 2020 Oct 6;33(1):108221. doi: 10.1016/j.celrep.2020.108221. PubMed |
| ATM-Dependent Recruitment of BRD7 is required for Transcriptional Repression and DNA Repair at DNA Breaks Flanking Transcriptional Active Regions. Hu K, Li Y, Wu W, Xie L, Yan H, Cai Y, Chen D, Jiang Q, Lin L, Chen Z, Liao JY, Zhang Y, Koeffler HP, Yin D, Song E. Adv Sci (Weinh). 2020 Sep 3;7(20):2000157. doi: 10.1002/advs.202000157. eCollection 2020 Oct. PubMed |
| Age-associated deficient recruitment of 53BP1 in G1 cells directs DNA double-strand break repair to BRCA1/CtIP-mediated DNA-end resection. Anglada T, Genesca A, Martin M. Aging (Albany NY). 2020 Dec 27;12(24):24872-24893. doi: 10.18632/aging.202419. Epub 2020 Dec 27. PubMed |
| Genomic, Transcriptomic, and Functional Alterations in DNA Damage Response Pathways as Putative Biomarkers of Chemotherapy Response in Ovarian Cancer. Sharma Saha S, Gentles L, Bradbury A, Brecht D, Robinson R, O'Donnell R, Curtin NJ, Drew Y. Cancers (Basel). 2021 Mar 20;13(6). pii: cancers13061420. doi: 10.3390/cancers13061420. PubMed |
| ULK1 inhibition overcomes compromised antigen presentation and restores antitumor immunity in LKB1 mutant lung cancer. Deng J, Thennavan A, Dolgalev I, Chen T, Li J, Marzio A, Poirier JT, Peng D, Bulatovic M, Mukhopadhyay S, Silver H, Papadopoulos E, Pyon V, Thakurdin C, Han H, Li F, Li S, Ding H, Hu H, Pan Y, Weerasekara V, Jiang B, Wang ES, Ahearn I, Philips M, Papagiannakopoulos T, Tsirigos A, Rothenberg E, Gainor J, Freeman GJ, Rudin CM, Gray NS, Hammerman PS, Pagano M, Heymach JV, Perou CM, Bardeesy N, Wong KK. Nat Cancer. 2021 May;2(5):503-514. doi: 10.1038/s43018-021-00208-6. Epub 2021 May 17. PubMed |
| Long noncoding RNA NIHCOLE promotes ligation efficiency of DNA double-strand breaks in hepatocellular carcinoma. Unfried JP, Marin-Baquero M, Rivera-Calzada A, Razquin N, Martin-Cuevas EM, de Braganca S, Aicart-Ramos C, McCoy C, Prats-Mari L, Arribas-Bosacoma R, Lee L, Caruso S, Zucman-Rossi J, Sangro B, Williams G, Moreno-Herrero F, Llorca O, Lees-Miller SP, Fortes P. Cancer Res. 2021 Jul 28. pii: 0008-5472.CAN-21-0463. doi: 10.1158/0008-5472.CAN-21-0463. PubMed |
| Pim kinase inhibitor co-treatment decreases alternative non-homologous end-joining DNA repair and genomic instability induced by topoisomerase 2 inhibitors in cells with FLT3 internal tandem duplication. Scarpa M, Kapoor S, Tvedte ES, Doshi KA, Zou YS, Singh P, Lee JK, Chatterjee A, Ali MKM, Bromley RE, Hotopp JCD, Rassool FV, Baer MR. Oncotarget. 2021 Aug 31;12(18):1763-1779. doi: 10.18632/oncotarget.28042. eCollection 2021 Aug 31. PubMed |
| Shift in MSL1 alternative polyadenylation in response to DNA damage protects cancer cells from chemotherapeutic agent-induced apoptosis. Kunisky AK, Anyaeche VI, Herron RS, Park CY, Hwang HW. Cell Rep. 2021 Oct 12;37(2):109815. doi: 10.1016/j.celrep.2021.109815. PubMed |
| SARS-CoV-2 Spike Impairs DNA Damage Repair and Inhibits V(D)J Recombination In Vitro. Jiang H, Mei YF. Viruses. 2021 Oct 13;13(10). pii: v13102056. doi: 10.3390/v13102056. PubMed |
| Inhibition of histone acetyltransferase function radiosensitizes CREBBP/EP300 mutants via repression of homologous recombination, potentially targeting a gain of function. Kumar M, Molkentine D, Molkentine J, Bridges K, Xie T, Yang L, Hefner A, Gao M, Bahri R, Dhawan A, Frederick MJ, Seth S, Abdelhakiem M, Beadle BM, Johnson F, Wang J, Shen L, Heffernan T, Sheth A, Ferris RL, Myers JN, Pickering CR, Skinner HD. Nat Commun. 2021 Nov 3;12(1):6340. doi: 10.1038/s41467-021-26570-8. PubMed |
| MLK4 regulates DNA damage response and promotes triple-negative breast cancer chemoresistance. Mehlich D, Lomiak M, Sobiborowicz A, Mazan A, Dymerska D, Szewczyk LM, Mehlich A, Borowiec A, Prelowska MK, Gorczynski A, Jablonski P, Izycka-Swieszewska E, Nowis D, Marusiak AA. Cell Death Dis. 2021 Nov 27;12(12):1111. doi: 10.1038/s41419-021-04405-0. PubMed |
| Restoration of DNA repair mitigates genome instability and increases productivity of Chinese hamster ovary cells. Spahn PN, Zhang X, Hu Q, Lu H, Hamaker NK, Hefzi H, Li S, Kuo CC, Huang Y, Lee JC, Davis AJ, Ly P, Lee KH, Lewis NE. Biotechnol Bioeng. 2022 Mar;119(3):963-982. doi: 10.1002/bit.28016. Epub 2022 Jan 5. PubMed |
| TEX10 Promotes the Tumorigenesis and Radiotherapy Resistance of Urinary Bladder Carcinoma by Stabilizing XRCC6. Luo S, Wang W, Feng J, Li R. J Immunol Res. 2021 Dec 20;2021:5975893. doi: 10.1155/2021/5975893. eCollection 2021. PubMed |
| Cancer-Associated SF3B1 Mutations Confer a BRCA-Like Cellular Phenotype and Synthetic Lethality to PARP Inhibitors. Lappin KM, Barros EM, Jhujh SS, Irwin GW, McMillan H, Liberante FG, Latimer C, La Bonte MJ, Mills KI, Harkin DP, Stewart GS, Savage KI. Cancer Res. 2022 Mar 1;82(5):819-830. doi: 10.1158/0008-5472.CAN-21-1843. PubMed |
| CDK5RAP3, a New BRCA2 Partner That Regulates DNA Repair, Is Associated with Breast Cancer Survival. Minguillon J, Ramirez MJ, Rovirosa L, Bustamante-Madrid P, Camps-Fajol C, Ruiz de Garibay G, Shimelis H, Montanuy H, Pujol R, Hernandez G, Bogliolo M, Castillo P, Soucy P, Martrat G, Gomez A, Cuadras D, Garcia MJ, Gayarre J, Cimba, Lazaro C, Benitez J, Couch FJ, Pujana MA, Surralles J. Cancers (Basel). 2022 Jan 12;14(2). pii: cancers14020353. doi: 10.3390/cancers14020353. PubMed |
| DNA damage repair promotion in colonic epithelial cells by andrographolide downregulated cGAS‒STING pathway activation and contributed to the relief of CPT-11-induced intestinal mucositis. Wang Y, Wei B, Wang D, Wu J, Gao J, Zhong H, Sun Y, Xu Q, Liu W, Gu Y, Guo W. Acta Pharm Sin B. 2022 Jan;12(1):262-273. doi: 10.1016/j.apsb.2021.03.043. Epub 2021 Apr 29. PubMed |
| Cancer-associated fibroblast-induced lncRNA UPK1A-AS1 confers platinum resistance in pancreatic cancer via efficient double-strand break repair. Zhang X, Zheng S, Hu C, Li G, Lin H, Xia R, Ye Y, He R, Li Z, Lin Q, Chen R, Zhou Q. Oncogene. 2022 Apr;41(16):2372-2389. doi: 10.1038/s41388-022-02253-6. Epub 2022 Mar 9. PubMed |
| Loss of Claudin-4 Reduces DNA Damage Repair and Increases Sensitivity to PARP Inhibitors. Yamamoto TM, Webb PG, Davis DM, Baumgartner HK, Woodruff ER, Guntupalli SR, Neville M, Behbakht K, Bitler BG. Mol Cancer Ther. 2022 Apr 1;21(4):647-657. doi: 10.1158/1535-7163.MCT-21-0827. PubMed |
| BRCA2 C-Terminal RAD51-Binding Domain Confers Resistance to DNA-Damaging Agents. Zhu Z, Kitano T, Morimatsu M, Tanaka A, Morioka R, Lin X, Orino K, Yoshikawa Y. Int J Mol Sci. 2022 Apr 6;23(7). pii: ijms23074060. doi: 10.3390/ijms23074060. PubMed |
| MicroRNA-145 Impairs Classical Non-Homologous End-Joining in Response to Ionizing Radiation-Induced DNA Double-Strand Breaks via Targeting DNA-PKcs. Sudhanva MS, Hariharasudhan G, Jun S, Seo G, Kamalakannan R, Kim HH, Lee JH. Cells. 2022 Apr 30;11(9). pii: cells11091509. doi: 10.3390/cells11091509. PubMed |
| Retraction: Jiang, H.; Mei, Y.-F. SARS-CoV-2 Spike Impairs DNA Damage Repair and Inhibits V(D)J Recombination In Vitro. Viruses 2021, 13, 2056. Jiang H, Mei YF. Viruses. 2022 May 10;14(5):1011. doi: 10.3390/v14051011. PubMed |
| Assessing the Effect of Histone Deacetylase Inhibitors on DNA Double-Strand Break Repair by Nonhomologous End Joining. Kramer OH, Diehl T, Roos WP. Methods Mol Biol. 2023;2589:293-302. doi: 10.1007/978-1-0716-2788-4_19. PubMed |
| NQO1 regulates cell cycle progression at the G2/M phase. Oh ET, Kim HG, Kim CH, Lee J, Kim C, Lee JS, Cho Y, Park HJ. Theranostics. 2023 Jan 10;13(3):873-895. doi: 10.7150/thno.77444. eCollection 2023. PubMed |
| HNF1A regulates oxaliplatin resistance in pancreatic cancer by targeting 53BP1. Xia R, Hu C, Ye Y, Zhang X, Li T, He R, Zheng S, Wen X, Chen R. Int J Oncol. 2023 Apr;62(4):45. doi: 10.3892/ijo.2023.5493. Epub 2023 Feb 24. PubMed |
| Heavy metal ions exchange driven protein phosphorylation cascade functions in genomic instability in spermatocytes and male infertility. Li RY, Yang D, He YJ, Zhou Y, Li CC, Li LB, Liao MX, Deng ZL, Zhao LT, Zhang TF, Luo Y, Wang YX, Gao YF. Nucleic Acids Res. 2023 Apr 24;51(7):3150-3165. doi: 10.1093/nar/gkad128. PubMed |
| LncRNA CACClnc promotes chemoresistance of colorectal cancer by modulating alternative splicing of RAD51. Zhang X, Ma D, Xuan B, Shi D, He J, Yu M, Xiong H, Ma Y, Shen C, Guo F, Cao Y, Yan Y, Gao Z, Tong T, Zhu X, Fang JY, Chen H, Hong J. Oncogene. 2023 Apr;42(17):1374-1391. doi: 10.1038/s41388-023-02657-y. Epub 2023 Mar 11. PubMed |
| Kaempferol inhibits non-homologous end joining repair via regulating Ku80 stability in glioma cancer. Chen M, Zhao E, Li M, Xu M, Hao S, Gao Y, Wu X, Li X, Yu Y, Yu Z, Yin Y. Phytomedicine. 2023 Jul 25;116:154876. doi: 10.1016/j.phymed.2023.154876. Epub 2023 May 12. PubMed |
| Nuclear DJ-1 Regulates DNA Damage Repair via the Regulation of PARP1 Activity. Wang ZX, Liu Y, Li YL, Wei Q, Lin RR, Kang R, Ruan Y, Lin ZH, Xue NJ, Zhang BR, Pu JL. Int J Mol Sci. 2023 May 12;24(10):8651. doi: 10.3390/ijms24108651. PubMed |
| The hydrophilic extract from a new tomato genotype (named DHO) kills cancer cell lines through the modulation of the DNA damage response induced by Campthotecin treatment. Barone D, Iannuzzi CA, Forte IM, Ragosta MC, Cuomo M, Dell'Aquila M, Altieri A, Caporaso A, Camerlingo R, Rigano MM, Monti DM, Barone A, Imbimbo P, Frusciante L, Monda M, D'Angelo M, De Laurentiis M, Giordano A, Alfano L. Front Oncol. 2023 Jun 20;13:1117262. doi: 10.3389/fonc.2023.1117262. eCollection 2023. PubMed |
| PC4-mediated Ku complex PARylation facilitates NHEJ-dependent DNA damage repair. Pan Q, Luo P, Shi C. J Biol Chem. 2023 Jul 10;299(8):105032. doi: 10.1016/j.jbc.2023.105032. PubMed |
| Targeting phosphomevalonate kinase enhances radiosensitivity via ubiquitination of the replication protein A1 in lung cancer cells. Park SS, Kwon MR, Ju EJ, Shin SH, Park J, Ko EJ, Son GW, Lee HW, Kim YJ, Moon GJ, Park YY, Song SY, Jeong SY, Choi EK. Cancer Sci. 2023 Sep;114(9):3583-3594. doi: 10.1111/cas.15896. Epub 2023 Jul 5. PubMed |
| FAK Drives Resistance to Therapy in HPV-Negative Head and Neck Cancer in a p53-Dependent Manner. Pifer PM, Yang L, Kumar M, Xie T, Frederick M, Hefner A, Beadle B, Molkentine D, Molkentine J, Dhawan A, Abdelhakiem M, Osman AA, Leibowitz BJ, Myers JN, Pickering CR, Sandulache VC, Heymach J, Skinner HD. Clin Cancer Res. 2024 Jan 5;30(1):187-197. doi: 10.1158/1078-0432.CCR-23-0964. PubMed |
| Repression of LSD1 potentiates homologous recombination-proficient ovarian cancer to PARP inhibitors through down-regulation of BRCA1/2 and RAD51. Tao L, Zhou Y, Pan X, Luo Y, Qiu J, Zhou X, Chen Z, Li Y, Xu L, Zhou Y, Zuo Z, Liu C, Wang L, Liu X, Tian X, Su N, Yang Z, Zhang Y, Gou K, Sang N, Liu H, Zou J, Xiao Y, Zhong X, Xu J, Yang X, Xiao K, Liu Y, Yang S, Peng Y, Han J, Cen X, Zhao Y. Nat Commun. 2023 Nov 16;14(1):7430. doi: 10.1038/s41467-023-42850-x. PubMed |
| Extracellular vesicle-packaged circBIRC6 from cancer-associated fibroblasts induce platinum resistance via SUMOylation modulation in pancreatic cancer. Zheng S, Tian Q, Yuan Y, Sun S, Li T, Xia R, He R, Luo Y, Lin Q, Fu Z, Zhou Y, Chen R, Hu C. J Exp Clin Cancer Res. 2023 Nov 28;42(1):324. doi: 10.1186/s13046-023-02854-3. PubMed |
| CDK9-55 guides the anaphase-promoting complex/cyclosome (APC/C) in choosing the DNA repair pathway choice. Alfano L, Iannuzzi CA, Barone D, Forte IM, Ragosta MC, Cuomo M, Mazzarotti G, Dell'Aquila M, Altieri A, Caporaso A, Roma C, Marra L, Boffo S, Indovina P, De Laurentiis M, Giordano A. Oncogene. 2024 Apr;43(17):1263-1273. doi: 10.1038/s41388-024-02982-w. Epub 2024 Mar 4. PubMed |
| Repression of the SUMO-conjugating enzyme UBC9 is associated with lowered double minutes and reduced tumor progression. Wang Y, Zou H, Ji W, Huang M, You B, Sun N, Qiao Y, Liu P, Xu L, Zhang X, Cai M, Kuang Y, Fu S, Sun W, Jia X, Wu J. Cancer Biol Ther. 2024 Dec 31;25(1):2323768. doi: 10.1080/15384047.2024.2323768. Epub 2024 Mar 11. PubMed |
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