pLIX_403 Citations (49)
Originally described in: Root Lab pLEX and pLIX Gateway backbonesUnpublished
Articles Citing pLIX_403
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| The genetic landscape of clinical resistance to RAF inhibition in metastatic melanoma. Van Allen EM, Wagle N, Sucker A, Treacy DJ, Johannessen CM, Goetz EM, Place CS, Taylor-Weiner A, Whittaker S, Kryukov GV, Hodis E, Rosenberg M, McKenna A, Cibulskis K, Farlow D, Zimmer L, Hillen U, Gutzmer R, Goldinger SM, Ugurel S, Gogas HJ, Egberts F, Berking C, Trefzer U, Loquai C, Weide B, Hassel JC, Gabriel SB, Carter SL, Getz G, Garraway LA, Schadendorf D. Cancer Discov. 2014 Jan;4(1):94-109. doi: 10.1158/2159-8290.CD-13-0617. Epub 2013 Nov 21. PubMed |
| KANK1 inhibits cell growth by inducing apoptosis though regulating CXXC5 in human malignant peripheral nerve sheath tumors. Cui Z, Shen Y, Chen KH, Mittal SK, Yang JY, Zhang G. Sci Rep. 2017 Jan 9;7:40325. doi: 10.1038/srep40325. PubMed |
Nitric oxide-regulated proteolysis of human CYP2B6 via the ubiquitin-proteasome system.
Lee CM, Tripathi S, Morgan ET.
Free Radic Biol Med. 2017 Jul;108:478-486. doi: 10.1016/j.freeradbiomed.2017.04.015. Epub 2017 Apr 17.
PubMed
Associated Plasmids |
| Intratumoural heterogeneity generated by Notch signalling promotes small-cell lung cancer. Lim JS, Ibaseta A, Fischer MM, Cancilla B, O'Young G, Cristea S, Luca VC, Yang D, Jahchan NS, Hamard C, Antoine M, Wislez M, Kong C, Cain J, Liu YW, Kapoun AM, Garcia KC, Hoey T, Murriel CL, Sage J. Nature. 2017 May 18;545(7654):360-364. doi: 10.1038/nature22323. Epub 2017 May 10. PubMed |
Regulation of DNA repair pathway choice in S and G2 phases by the NHEJ inhibitor CYREN.
Arnoult N, Correia A, Ma J, Merlo A, Garcia-Gomez S, Maric M, Tognetti M, Benner CW, Boulton SJ, Saghatelian A, Karlseder J.
Nature. 2017 Sep 20;549(7673):548-552. doi: 10.1038/nature24023.
PubMed
Associated Plasmids |
Context-Dependent and Disease-Specific Diversity in Protein Interactions within Stress Granules.
Markmiller S, Soltanieh S, Server KL, Mak R, Jin W, Fang MY, Luo EC, Krach F, Yang D, Sen A, Fulzele A, Wozniak JM, Gonzalez DJ, Kankel MW, Gao FB, Bennett EJ, Lecuyer E, Yeo GW.
Cell. 2018 Jan 25;172(3):590-604.e13. doi: 10.1016/j.cell.2017.12.032.
PubMed
Associated Plasmids |
| Systematic genetic mapping of necroptosis identifies SLC39A7 as modulator of death receptor trafficking. Fauster A, Rebsamen M, Willmann KL, Cesar-Razquin A, Girardi E, Bigenzahn JW, Schischlik F, Scorzoni S, Bruckner M, Konecka J, Hormann K, Heinz LX, Boztug K, Superti-Furga G. Cell Death Differ. 2018 Sep 20. pii: 10.1038/s41418-018-0192-6. doi: 10.1038/s41418-018-0192-6. PubMed |
| Inhibition of CPAP-tubulin interaction prevents proliferation of centrosome-amplified cancer cells. Mariappan A, Soni K, Schorpp K, Zhao F, Minakar A, Zheng X, Mandad S, Macheleidt I, Ramani A, Kubelka T, Dawidowski M, Golfmann K, Wason A, Yang C, Simons J, Schmalz HG, Hyman AA, Aneja R, Ullrich R, Urlaub H, Odenthal M, Buttner R, Li H, Sattler M, Hadian K, Gopalakrishnan J. EMBO J. 2019 Jan 15;38(2). pii: embj.201899876. doi: 10.15252/embj.201899876. Epub 2018 Dec 10. PubMed |
| Depletion of dAKAP1-protein kinase A signaling islands from the outer mitochondrial membrane alters breast cancer cell metabolism and motility. Aggarwal S, Gabrovsek L, Langeberg LK, Golkowski M, Ong SE, Smith FD, Scott JD. J Biol Chem. 2019 Mar 1;294(9):3152-3168. doi: 10.1074/jbc.RA118.006741. Epub 2018 Dec 31. PubMed |
| p53 Is a Master Regulator of Proteostasis in SMARCB1-Deficient Malignant Rhabdoid Tumors. Carugo A, Minelli R, Sapio L, Soeung M, Carbone F, Robinson FS, Tepper J, Chen Z, Lovisa S, Svelto M, Amin S, Srinivasan S, Del Poggetto E, Loponte S, Puca F, Dey P, Malouf GG, Su X, Li L, Lopez-Terrada D, Rakheja D, Lazar AJ, Netto GJ, Rao P, Sgambato A, Maitra A, Tripathi DN, Walker CL, Karam JA, Heffernan TP, Viale A, Roberts CWM, Msaouel P, Tannir NM, Draetta GF, Genovese G. Cancer Cell. 2019 Feb 11;35(2):204-220.e9. doi: 10.1016/j.ccell.2019.01.006. PubMed |
Induced Neurons for the Study of Neurodegenerative and Neurodevelopmental Disorders.
Sauter EJ, Kutsche LK, Klapper SD, Busskamp V.
Methods Mol Biol. 2019;1942:101-121. doi: 10.1007/978-1-4939-9080-1_9.
PubMed
Associated Plasmids |
| Inducible overexpression of zebrafish microRNA-722 suppresses chemotaxis of human neutrophil like cells. Hsu AY, Liu S, Syahirah R, Brasseale KA, Wan J, Deng Q. Mol Immunol. 2019 Aug;112:206-214. doi: 10.1016/j.molimm.2019.06.001. Epub 2019 Jun 5. PubMed |
| Pancreatic Ductal Organoids React Kras Dependent to the Removal of Tumor Suppressive Roadblocks. Perkhofer L, Engler M, Gout J, Arnold F, Morawe M, Breunig M, Seufferlein T, Kleger A, Frappart PO. Stem Cells Int. 2019 May 19;2019:2079742. doi: 10.1155/2019/2079742. eCollection 2019. PubMed |
Phenotypical microRNA screen reveals a noncanonical role of CDK2 in regulating neutrophil migration.
Hsu AY, Wang D, Liu S, Lu J, Syahirah R, Bennin DA, Huttenlocher A, Umulis DM, Wan J, Deng Q.
Proc Natl Acad Sci U S A. 2019 Aug 26. pii: 1905221116. doi: 10.1073/pnas.1905221116.
PubMed
Associated Plasmids |
| Wild-type TP53 defined gamma-secretase inhibitor sensitivity and synergistic activity with doxorubicin in GSCs. Zhang C, Martinez-Ledesma E, Gao F, Zhang W, Ding J, Wu S, Li X, Wu J, Yuan Y, Koul D, Alfred Yung WK. Am J Cancer Res. 2019 Aug 1;9(8):1734-1745. eCollection 2019. PubMed |
| Epigenomic Profiling Discovers Trans-lineage SOX2 Partnerships Driving Tumor Heterogeneity in Lung Squamous Cell Carcinoma. Sato T, Yoo S, Kong R, Sinha A, Chandramani-Shivalingappa P, Patel A, Fridrikh M, Nagano O, Masuko T, Beasley MB, Powell CA, Zhu J, Watanabe H. Cancer Res. 2019 Dec 15;79(24):6084-6100. doi: 10.1158/0008-5472.CAN-19-2132. Epub 2019 Sep 24. PubMed |
| Direct RNA sequencing enables m(6)A detection in endogenous transcript isoforms at base-specific resolution. Lorenz DA, Sathe S, Einstein JM, Yeo GW. RNA. 2020 Jan;26(1):19-28. doi: 10.1261/rna.072785.119. Epub 2019 Oct 17. PubMed |
| Aberrant expression of embryonic mesendoderm factor MESP1 promotes tumorigenesis. Tandon N, Goller K, Wang F, Soibam B, Gagea M, Jain AK, Schwartz RJ, Liu Y. EBioMedicine. 2019 Dec;50:55-66. doi: 10.1016/j.ebiom.2019.11.012. Epub 2019 Nov 21. PubMed |
| The alternative cap-binding complex is required for antiviral defense in vivo. Gebhardt A, Bergant V, Schnepf D, Moser M, Meiler A, Togbe D, Mackowiak C, Reinert LS, Paludan SR, Ryffel B, Stukalov A, Staeheli P, Pichlmair A. PLoS Pathog. 2019 Dec 19;15(12):e1008155. doi: 10.1371/journal.ppat.1008155. eCollection 2019 Dec. PubMed |
| Rapid non-uniform adaptation to conformation-specific KRAS(G12C) inhibition. Xue JY, Zhao Y, Aronowitz J, Mai TT, Vides A, Qeriqi B, Kim D, Li C, de Stanchina E, Mazutis L, Risso D, Lito P. Nature. 2020 Jan;577(7790):421-425. doi: 10.1038/s41586-019-1884-x. Epub 2020 Jan 8. PubMed |
| Expression of the Long Noncoding RNA DINO in Human Papillomavirus-Positive Cervical Cancer Cells Reactivates the Dormant TP53 Tumor Suppressor through ATM/CHK2 Signaling. Sharma S, Munger K. mBio. 2020 Jun 16;11(3). pii: mBio.01190-20. doi: 10.1128/mBio.01190-20. PubMed |
| DeltaNp63 regulated epithelial-to-mesenchymal transition state heterogeneity confers a leader-follower relationship that drives collective invasion. Westcott JM, Camacho S, Nasir A, Huysman ME, Rahhal R, Dang TT, Riegel AT, Brekken RA, Pearson GW. Cancer Res. 2020 Jul 13. pii: 0008-5472.CAN-20-0014. doi: 10.1158/0008-5472.CAN-20-0014. PubMed |
| Distinct genetic pathways define pre-malignant versus compensatory clonal hematopoiesis in Shwachman-Diamond syndrome. Kennedy AL, Myers KC, Bowman J, Gibson CJ, Camarda ND, Furutani E, Muscato GM, Klein RH, Ballotti K, Liu S, Harris CE, Galvin A, Malsch M, Dale D, Gansner JM, Nakano TA, Bertuch A, Vlachos A, Lipton JM, Castillo P, Connelly J, Churpek J, Edwards JR, Hijiya N, Ho RH, Hofmann I, Huang JN, Keel S, Lamble A, Lau BW, Norkin M, Stieglitz E, Stock W, Walkovich K, Boettcher S, Brendel C, Fleming MD, Davies SM, Weller EA, Bahl C, Carter SL, Shimamura A, Lindsley RC. Nat Commun. 2021 Feb 26;12(1):1334. doi: 10.1038/s41467-021-21588-4. PubMed |
Robust single-cell discovery of RNA targets of RNA-binding proteins and ribosomes.
Brannan KW, Chaim IA, Marina RJ, Yee BA, Kofman ER, Lorenz DA, Jagannatha P, Dong KD, Madrigal AA, Underwood JG, Yeo GW.
Nat Methods. 2021 May;18(5):507-519. doi: 10.1038/s41592-021-01128-0. Epub 2021 May 7.
PubMed
Associated Plasmids |
| Targeting Gi/o protein-coupled receptor signaling blocks HER2-induced breast cancer development and enhances HER2-targeted therapy. Lyu C, Ye Y, Lensing MM, Wagner KU, Weigel RJ, Chen S. JCI Insight. 2021 Sep 22;6(18). pii: e150532. doi: 10.1172/jci.insight.150532. PubMed |
| Soluble guanylate cyclase signalling mediates etoposide resistance in progressing small cell lung cancer. Schenk MW, Humphrey S, Hossain ASMM, Revill M, Pearsall S, Lallo A, Brown S, Bratt S, Galvin M, Descamps T, Zhou C, Pearce SP, Priest L, Greenhalgh M, Chaturvedi A, Kerr A, Blackhall F, Dive C, Frese KK. Nat Commun. 2021 Nov 17;12(1):6652. doi: 10.1038/s41467-021-26823-6. PubMed |
Breakage of cytoplasmic chromosomes by pathological DNA base excision repair.
Tang S, Stokasimov E, Cui Y, Pellman D.
Nature. 2022 Jun;606(7916):930-936. doi: 10.1038/s41586-022-04767-1. Epub 2022 Apr 27.
PubMed
Associated Plasmids |
| Y Chromosome Genes May Play Roles in the Development of Neural Rosettes from Human Embryonic Stem Cells. Khani F, Nafian S, Mollamohammadi S, Nemati S, Shokoohian B, Hassani SN, Baharvand H, Soleimanpour-Lichaei HR, Salekdeh GH. Stem Cell Rev Rep. 2022 Jun 3. pii: 10.1007/s12015-022-10392-2. doi: 10.1007/s12015-022-10392-2. PubMed |
| Ets1 mediates sorafenib resistance by regulating mitochondrial ROS pathway in hepatocellular carcinoma. Vishnoi K, Ke R, Viswakarma N, Srivastava P, Kumar S, Das S, Singh SK, Principe DR, Rana A, Rana B. Cell Death Dis. 2022 Jul 4;13(7):581. doi: 10.1038/s41419-022-05022-1. PubMed |
| Epithelial-mesenchymal plasticity determines estrogen receptor positive breast cancer dormancy and epithelial reconversion drives recurrence. Aouad P, Zhang Y, De Martino F, Stibolt C, Ali S, Ambrosini G, Mani SA, Maggs K, Quinn HM, Sflomos G, Brisken C. Nat Commun. 2022 Aug 25;13(1):4975. doi: 10.1038/s41467-022-32523-6. PubMed |
VRK1 as a synthetic lethal target in VRK2 promoter-methylated cancers of the nervous system.
So J, Mabe NW, Englinger B, Chow KH, Moyer SM, Yerrum S, Trissal MC, Marques JG, Kwon JJ, Shim B, Pal S, Panditharatna E, Quinn T, Schaefer DA, Jeong D, Mayhew DL, Hwang J, Beroukhim R, Ligon KL, Stegmaier K, Filbin MG, Hahn WC.
JCI Insight. 2022 Oct 10;7(19):e158755. doi: 10.1172/jci.insight.158755.
PubMed
Associated Plasmids |
| BTG1 inactivation drives lymphomagenesis and promotes lymphoma dissemination through activation of BCAR1. Delage L, Lambert M, Bardel E, Kundlacz C, Chartoire D, Conchon A, Peugnet AL, Gorka L, Auberger P, Jacquel A, Soussain C, Destaing O, Delecluse HJ, Delecluse S, Merabet S, Traverse-Glehen A, Salles G, Bachy E, Billaud M, Ghesquieres H, Genestier L, Rouault JP, Sujobert P. Blood. 2023 Mar 9;141(10):1209-1220. doi: 10.1182/blood.2022016943. PubMed |
| Tuning the 3D microenvironment of reprogrammed tubule cells enhances biomimetic modeling of polycystic kidney disease. Pichler R, Rizzo L, Trondle K, Buhler M, Brucker H, Muller AL, Grand K, Fare S, Viau A, Kaminski MM, Kuehn EW, Koch F, Zimmermann S, Koltay P, Lienkamp SS. Biomaterials. 2022 Dec;291:121910. doi: 10.1016/j.biomaterials.2022.121910. Epub 2022 Nov 8. PubMed |
| Tumor necrosis factor is a necroptosis-associated alarmin. Pinci F, Gaidt MM, Jung C, Nagl D, Kuut G, Hornung V. Front Immunol. 2022 Dec 12;13:1074440. doi: 10.3389/fimmu.2022.1074440. eCollection 2022. PubMed |
| A Live Cell Protein Complementation Assay for ORFeome-Wide Probing of Human HOX Interactomes. Jia Y, Reboulet J, Gillet B, Hughes S, Forcet C, Tribollet V, Hajj Sleiman N, Kundlacz C, Vanacker JM, Bleicher F, Merabet S. Cells. 2023 Jan 3;12(1):200. doi: 10.3390/cells12010200. PubMed |
| Destabilizing NF1 variants act in a dominant negative manner through neurofibromin dimerization. Young LC, Goldstein de Salazar R, Han SW, Huang ZYS, Merk A, Drew M, Darling J, Wall V, Grisshammer R, Cheng A, Allison MR, Sale MJ, Nissley DV, Esposito D, Ognjenovic J, McCormick F. Proc Natl Acad Sci U S A. 2023 Jan 31;120(5):e2208960120. doi: 10.1073/pnas.2208960120. Epub 2023 Jan 23. PubMed |
| Pathogenic tau decreases nuclear tension in cultured neurons. Sohn C, Ma J, Ray WJ, Frost B. Front Aging. 2023 Jan 23;4:1058968. doi: 10.3389/fragi.2023.1058968. eCollection 2023. PubMed |
| Microenvironment-Driven Dynamic Chromatin Changes in Glioblastoma Recapitulate Early Neural Development at Single-Cell Resolution. Pine AR, Cirigliano SM, Singhania R, Nicholson J, da Silva B, Leslie CS, Fine HA. Cancer Res. 2023 May 15;83(10):1581-1595. doi: 10.1158/0008-5472.CAN-22-2872. PubMed |
| The APE2 nuclease is essential for DNA double-strand break repair by microhomology-mediated end joining. Fleury H, MacEachern MK, Stiefel CM, Anand R, Sempeck C, Nebenfuehr B, Maurer-Alcala K, Ball K, Proctor B 3rd, Belan O, Taylor E, Ortega R, Dodd B, Weatherly L, Dansoko D, Leung JW, Boulton SJ, Arnoult N. Mol Cell. 2023 May 4;83(9):1429-1445.e8. doi: 10.1016/j.molcel.2023.03.017. Epub 2023 Apr 11. PubMed |
| Hepatocyte differentiation from mouse liver ductal organoids by transducing 4 liver-specific transcription factors. Tomofuji K, Kondo J, Onuma K, Coppo R, Horie H, Oyama K, Miyoshi E, Fukumitsu K, Ishii T, Hatano E, Inoue M. Hepatol Commun. 2023 Apr 14;7(5):e0134. doi: 10.1097/HC9.0000000000000134. eCollection 2023 May 1. PubMed |
| Pan-KRAS inhibitor disables oncogenic signalling and tumour growth. Kim D, Herdeis L, Rudolph D, Zhao Y, Bottcher J, Vides A, Ayala-Santos CI, Pourfarjam Y, Cuevas-Navarro A, Xue JY, Mantoulidis A, Broker J, Wunberg T, Schaaf O, Popow J, Wolkerstorfer B, Kropatsch KG, Qu R, de Stanchina E, Sang B, Li C, McConnell DB, Kraut N, Lito P. Nature. 2023 Jul;619(7968):160-166. doi: 10.1038/s41586-023-06123-3. Epub 2023 May 31. PubMed |
| Lineage Plasticity in SCLC Generates Non-Neuroendocrine Cells Primed for Vasculogenic Mimicry. Pearsall SM, Williamson SC, Humphrey S, Hughes E, Morgan D, Garcia Marques FJ, Awanis G, Carroll R, Burks L, Shue YT, Bermudez A, Frese KK, Galvin M, Carter M, Priest L, Kerr A, Zhou C, Oliver TG, Humphries JD, Humphries MJ, Blackhall F, Cannell IG, Pitteri SJ, Hannon GJ, Sage J, Dive C, Simpson KL. J Thorac Oncol. 2023 Oct;18(10):1362-1385. doi: 10.1016/j.jtho.2023.07.012. Epub 2023 Jul 16. PubMed |
| Atypical peripheral actin band formation via overactivation of RhoA and nonmuscle myosin II in mitofusin 2-deficient cells. Wang Y, Troughton LD, Xu F, Chatterjee A, Ding C, Zhao H, Cifuentes LP, Wagner RB, Wang T, Tan S, Chen J, Li L, Umulis D, Kuang S, Suter DM, Yuan C, Chan D, Huang F, Oakes PW, Deng Q. Elife. 2023 Sep 19;12:e88828. doi: 10.7554/eLife.88828. PubMed |
| A conformation-locking inhibitor of SLC15A4 with TASL proteostatic anti-inflammatory activity. Boeszoermenyi A, Bernaleau L, Chen X, Kartnig F, Xie M, Zhang H, Zhang S, Delacretaz M, Koren A, Hopp AK, Dvorak V, Kubicek S, Aletaha D, Yang M, Rebsamen M, Heinz LX, Superti-Furga G. Nat Commun. 2023 Oct 20;14(1):6626. doi: 10.1038/s41467-023-42070-3. PubMed |
| ZNF524 directly interacts with telomeric DNA and supports telomere integrity. Braun H, Xu Z, Chang F, Viceconte N, Rane G, Levin M, Lototska L, Roth F, Hillairet A, Fradera-Sola A, Khanchandani V, Sin ZW, Yong WK, Dreesen O, Yang Y, Shi Y, Li F, Butter F, Kappei D. Nat Commun. 2023 Dec 12;14(1):8252. doi: 10.1038/s41467-023-43397-7. PubMed |
| RBFOX2 deregulation promotes pancreatic cancer progression and metastasis through alternative splicing. Maurin M, Ranjouri M, Megino-Luque C, Newberg JY, Du D, Martin K, Miner RE 3rd, Prater MS, Wee DKB, Centeno B, Pruett-Miller SM, Stewart P, Fleming JB, Yu X, Bravo-Cordero JJ, Guccione E, Black MA, Mann KM. Nat Commun. 2023 Dec 19;14(1):8444. doi: 10.1038/s41467-023-44126-w. PubMed |
| EZH2 inhibition reactivates epigenetically silenced FMR1 and normalizes molecular and electrophysiological abnormalities in fragile X syndrome neurons. Fang M, Deibler SK, Krishnamurthy PM, Wang F, Rodriguez P, Banday S, Virbasius CM, Sena-Esteves M, Watts JK, Green MR. Front Neurosci. 2024 Feb 21;18:1348478. doi: 10.3389/fnins.2024.1348478. eCollection 2024. PubMed |
| Transcription elongation defects link oncogenic SF3B1 mutations to targetable alterations in chromatin landscape. Boddu PC, Gupta AK, Roy R, De La Pena Avalos B, Olazabal-Herrero A, Neuenkirchen N, Zimmer JT, Chandhok NS, King D, Nannya Y, Ogawa S, Lin H, Simon MD, Dray E, Kupfer GM, Verma A, Neugebauer KM, Pillai MM. Mol Cell. 2024 Apr 18;84(8):1475-1495.e18. doi: 10.1016/j.molcel.2024.02.032. Epub 2024 Mar 22. PubMed |
| Regulation by the RNA-binding protein Unkempt at its effector interface. Shah K, He S, Turner DJ, Corbo J, Rebbani K, Dominguez D, Bateman JM, Cheloufi S, Igreja C, Valkov E, Murn J. Nat Commun. 2024 Apr 11;15(1):3159. doi: 10.1038/s41467-024-47449-4. PubMed |
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