Skip to main content
Addgene

pLEX_307 Citations (77)

Originally described in: Root Lab pLEX and pLIX Gateway backbones
Unpublished

Articles Citing pLEX_307

Articles
Prostate cancer. Ubiquitylome analysis identifies dysregulation of effector substrates in SPOP-mutant prostate cancer. Theurillat JP, Udeshi ND, Errington WJ, Svinkina T, Baca SC, Pop M, Wild PJ, Blattner M, Groner AC, Rubin MA, Moch H, Prive GG, Carr SA, Garraway LA. Science. 2014 Oct 3;346(6205):85-9. doi: 10.1126/science.1250255. Epub 2014 Oct 2. PubMed
MEK and TAK1 Regulate Apoptosis in Colon Cancer Cells with KRAS-Dependent Activation of Proinflammatory Signaling. McNew KL, Whipple WJ, Mehta AK, Grant TJ, Ray L, Kenny C, Singh A. Mol Cancer Res. 2016 Dec;14(12):1204-1216. Epub 2016 Sep 21. PubMed
Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in beta-Catenin-Active Cancers. Rosenbluh J, Mercer J, Shrestha Y, Oliver R, Tamayo P, Doench JG, Tirosh I, Piccioni F, Hartenian E, Horn H, Fagbami L, Root DE, Jaffe J, Lage K, Boehm JS, Hahn WC. Cell Syst. 2016 Sep 28;3(3):302-316.e4. doi: 10.1016/j.cels.2016.09.001. PubMed

Associated Plasmids
Astrocyte pathology in a human neural stem cell model of frontotemporal dementia caused by mutant TAU protein. Hallmann AL, Arauzo-Bravo MJ, Mavrommatis L, Ehrlich M, Ropke A, Brockhaus J, Missler M, Sterneckert J, Scholer HR, Kuhlmann T, Zaehres H, Hargus G. Sci Rep. 2017 Mar 3;7:42991. doi: 10.1038/srep42991. PubMed
Pyroptosis and Apoptosis Pathways Engage in Bidirectional Crosstalk in Monocytes and Macrophages. Taabazuing CY, Okondo MC, Bachovchin DA. Cell Chem Biol. 2017 Apr 20;24(4):507-514.e4. doi: 10.1016/j.chembiol.2017.03.009. Epub 2017 Apr 6. PubMed
Opposing effects of cancer-type-specific SPOP mutants on BET protein degradation and sensitivity to BET inhibitors. Janouskova H, El Tekle G, Bellini E, Udeshi ND, Rinaldi A, Ulbricht A, Bernasocchi T, Civenni G, Losa M, Svinkina T, Bielski CM, Kryukov GV, Cascione L, Napoli S, Enchev RI, Mutch DG, Carney ME, Berchuck A, Winterhoff BJN, Broaddus RR, Schraml P, Moch H, Bertoni F, Catapano CV, Peter M, Carr SA, Garraway LA, Wild PJ, Theurillat JP. Nat Med. 2017 Sep;23(9):1046-1054. doi: 10.1038/nm.4372. Epub 2017 Aug 14. PubMed
Kinesin superfamily protein Kif26b links Wnt5a-Ror signaling to the control of cell and tissue behaviors in vertebrates. Susman MW, Karuna EP, Kunz RC, Gujral TS, Cantu AV, Choi SS, Jong BY, Okada K, Scales MK, Hum J, Hu LS, Kirschner MW, Nishinakamura R, Yamada S, Laird DJ, Jao LE, Gygi SP, Greenberg ME, Ho HH. Elife. 2017 Sep 8;6. pii: e26509. doi: 10.7554/eLife.26509. PubMed

Associated Plasmids
Transcriptional regulation of endothelial cell behavior during sprouting angiogenesis. Jeong HW, Hernandez-Rodriguez B, Kim J, Kim KP, Enriquez-Gasca R, Yoon J, Adams S, Scholer HR, Vaquerizas JM, Adams RH. Nat Commun. 2017 Sep 28;8(1):726. doi: 10.1038/s41467-017-00738-7. PubMed
STK38L kinase ablation promotes loss of cell viability in a subset of KRAS-dependent pancreatic cancer cell lines. Grant TJ, Mehta AK, Gupta A, Sharif AAD, Arora KS, Deshpande V, Ting DT, Bardeesy N, Ganem NJ, Hergovich A, Singh A. Oncotarget. 2017 Sep 11;8(45):78556-78572. doi: 10.18632/oncotarget.20833. eCollection 2017 Oct 3. PubMed
A Map of Human Mitochondrial Protein Interactions Linked to Neurodegeneration Reveals New Mechanisms of Redox Homeostasis and NF-kappaB Signaling. Malty RH, Aoki H, Kumar A, Phanse S, Amin S, Zhang Q, Minic Z, Goebels F, Musso G, Wu Z, Abou-Tok H, Meyer M, Deineko V, Kassir S, Sidhu V, Jessulat M, Scott NE, Xiong X, Vlasblom J, Prasad B, Foster LJ, Alberio T, Garavaglia B, Yu H, Bader GD, Nakamura K, Parkinson J, Babu M. Cell Syst. 2017 Nov 7. pii: S2405-4712(17)30447-7. doi: 10.1016/j.cels.2017.10.010. PubMed

Associated Plasmids
Inhibition of Dpp8/9 Activates the Nlrp1b Inflammasome. Okondo MC, Rao SD, Taabazuing CY, Chui AJ, Poplawski SE, Johnson DC, Bachovchin DA. Cell Chem Biol. 2018 Mar 15;25(3):262-267.e5. doi: 10.1016/j.chembiol.2017.12.013. Epub 2018 Jan 27. PubMed
Generation of a human embryonic stem cell line expressing tetrameric Zoanthus sp. green fluorescent protein: NERCe002-A-1. Duan X, Xie M, Peng Y, Hu L, Yu J, Zeng S, Wang Y, Lu G, Lin G, Sun Y. Stem Cell Res. 2018 Apr;28:6-10. doi: 10.1016/j.scr.2018.01.033. Epub 2018 Jan 31. PubMed
Generation of a luciferase-expressing human embryonic stem cell line: NERCe002-A-2. Peng Y, Xie M, Duan X, Hu L, Yu J, Zeng S, Wang Y, Ouyang Q, Lu G, Lin G, Sun Y. Stem Cell Res. 2018 Apr;28:172-176. doi: 10.1016/j.scr.2018.02.010. Epub 2018 Feb 15. PubMed
Transcriptome-pathology correlation identifies interplay between TDP-43 and the expression of its kinase CK1E in sporadic ALS. Krach F, Batra R, Wheeler EC, Vu AQ, Wang R, Hutt K, Rabin SJ, Baughn MW, Libby RT, Diaz-Garcia S, Stauffer J, Pirie E, Saberi S, Rodriguez M, Madrigal AA, Kohl Z, Winner B, Yeo GW, Ravits J. Acta Neuropathol. 2018 Sep;136(3):405-423. doi: 10.1007/s00401-018-1870-7. Epub 2018 Jun 7. PubMed
X chromosome protects against bladder cancer in females via a KDM6A-dependent epigenetic mechanism. Kaneko S, Li X. Sci Adv. 2018 Jun 13;4(6):eaar5598. doi: 10.1126/sciadv.aar5598. eCollection 2018 Jun. PubMed
FGFR2-activating mutations disrupt cell polarity to potentiate migration and invasion in endometrial cancer cell models. Stehbens SJ, Ju RJ, Adams MN, Perry SR, Haass NK, Bryant DM, Pollock PM. J Cell Sci. 2018 Aug 10;131(15). pii: jcs.213678. doi: 10.1242/jcs.213678. PubMed
A feed forward loop enforces YAP/TAZ signaling during tumorigenesis. Gill MK, Christova T, Zhang YY, Gregorieff A, Zhang L, Narimatsu M, Song S, Xiong S, Couzens AL, Tong J, Krieger JR, Moran MF, Zlotta AR, van der Kwast TH, Gingras AC, Sicheri F, Wrana JL, Attisano L. Nat Commun. 2018 Aug 29;9(1):3510. doi: 10.1038/s41467-018-05939-2. PubMed
Microcephaly Modeling of Kinetochore Mutation Reveals a Brain-Specific Phenotype. Omer Javed A, Li Y, Muffat J, Su KC, Cohen MA, Lungjangwa T, Aubourg P, Cheeseman IM, Jaenisch R. Cell Rep. 2018 Oct 9;25(2):368-382.e5. doi: 10.1016/j.celrep.2018.09.032. PubMed
A distinct isoform of ZNF207 controls self-renewal and pluripotency of human embryonic stem cells. Fang F, Xia N, Angulo B, Carey J, Cady Z, Durruthy-Durruthy J, Bennett T, Sebastiano V, Reijo Pera RA. Nat Commun. 2018 Oct 22;9(1):4384. doi: 10.1038/s41467-018-06908-5. PubMed
Whole genome variant association across 100 dogs identifies a frame shift mutation in DISHEVELLED 2 which contributes to Robinow-like syndrome in Bulldogs and related screw tail dog breeds. Mansour TA, Lucot K, Konopelski SE, Dickinson PJ, Sturges BK, Vernau KL, Choi S, Stern JA, Thomasy SM, Doring S, Verstraete FJM, Johnson EG, York D, Rebhun RB, Ho HH, Brown CT, Bannasch DL. PLoS Genet. 2018 Dec 6;14(12):e1007850. doi: 10.1371/journal.pgen.1007850. eCollection 2018 Dec. PubMed
Identification and Characterization of Oncogenic SOS1 Mutations in Lung Adenocarcinoma. Cai D, Choi PS, Gelbard M, Meyerson M. Mol Cancer Res. 2019 Apr;17(4):1002-1012. doi: 10.1158/1541-7786.MCR-18-0316. Epub 2019 Jan 11. PubMed
MicroRNA-Mediated Suppression of the TGF-beta Pathway Confers Transmissible and Reversible CDK4/6 Inhibitor Resistance. Cornell L, Wander SA, Visal T, Wagle N, Shapiro GI. Cell Rep. 2019 Mar 5;26(10):2667-2680.e7. doi: 10.1016/j.celrep.2019.02.023. PubMed
LRRK2 modifies alpha-syn pathology and spread in mouse models and human neurons. Bieri G, Brahic M, Bousset L, Couthouis J, Kramer NJ, Ma R, Nakayama L, Monbureau M, Defensor E, Schule B, Shamloo M, Melki R, Gitler AD. Acta Neuropathol. 2019 Jun;137(6):961-980. doi: 10.1007/s00401-019-01995-0. Epub 2019 Mar 29. PubMed
A Chemical Strategy for Protease Substrate Profiling. Griswold AR, Cifani P, Rao SD, Axelrod AJ, Miele MM, Hendrickson RC, Kentsis A, Bachovchin DA. Cell Chem Biol. 2019 Jun 20;26(6):901-907.e6. doi: 10.1016/j.chembiol.2019.03.007. Epub 2019 Apr 18. PubMed
Epigenomic Profiling Discovers Trans-lineage SOX2 Partnerships Driving Tumor Heterogeneity in Lung Squamous Cell Carcinoma. Sato T, Yoo S, Kong R, Sinha A, Chandramani-Shivalingappa P, Patel A, Fridrikh M, Nagano O, Masuko T, Beasley MB, Powell CA, Zhu J, Watanabe H. Cancer Res. 2019 Dec 15;79(24):6084-6100. doi: 10.1158/0008-5472.CAN-19-2132. Epub 2019 Sep 24. PubMed
PRMT5 methylome profiling uncovers a direct link to splicing regulation in acute myeloid leukemia. Radzisheuskaya A, Shliaha PV, Grinev V, Lorenzini E, Kovalchuk S, Shlyueva D, Gorshkov V, Hendrickson RC, Jensen ON, Helin K. Nat Struct Mol Biol. 2019 Nov;26(11):999-1012. doi: 10.1038/s41594-019-0313-z. Epub 2019 Oct 14. PubMed
The molecular function of kallikrein-related peptidase 14 demonstrates a key modulatory role in advanced prostate cancer. Kryza T, Bock N, Lovell S, Rockstroh A, Lehman ML, Lesner A, Panchadsaram J, Silva LM, Srinivasan S, Snell CE, Williams ED, Fazli L, Gleave M, Batra J, Nelson C, Tate EW, Harris J, Hooper JD, Clements JA. Mol Oncol. 2020 Jan;14(1):105-128. doi: 10.1002/1878-0261.12587. Epub 2019 Nov 28. PubMed
Phosphorylation of TFCP2L1 by CDK1 is required for stem cell pluripotency and bladder carcinogenesis. Heo J, Noh BJ, Lee S, Lee HY, Kim Y, Lim J, Ju H, Yu HY, Ryu CM, Lee PC, Jeong H, Oh Y, Kim K, Kim SY, Son J, Hong B, Kim JS, Cho YM, Shin DM. EMBO Mol Med. 2020 Jan 9;12(1):e10880. doi: 10.15252/emmm.201910880. Epub 2019 Nov 11. PubMed
Multiple interaction nodes define the postreplication repair response to UV-induced DNA damage that is defective in melanomas and correlated with UV signature mutation load. Pavey S, Pinder A, Fernando W, D'Arcy N, Matigian N, Skalamera D, Le Cao KA, Loo-Oey D, Hill MM, Stark M, Kimlin M, Burgess A, Cloonan N, Sturm RA, Gabrielli B. Mol Oncol. 2020 Jan;14(1):22-41. doi: 10.1002/1878-0261.12601. Epub 2019 Dec 19. PubMed
Genome-wide synthetic lethal CRISPR screen identifies FIS1 as a genetic interactor of ALS-linked C9ORF72. Chai N, Haney MS, Couthouis J, Morgens DW, Benjamin A, Wu K, Ousey J, Fang S, Finer S, Bassik MC, Gitler AD. Brain Res. 2020 Feb 1;1728:146601. doi: 10.1016/j.brainres.2019.146601. Epub 2019 Dec 13. PubMed
Treatment-Induced Tumor Dormancy through YAP-Mediated Transcriptional Reprogramming of the Apoptotic Pathway. Kurppa KJ, Liu Y, To C, Zhang T, Fan M, Vajdi A, Knelson EH, Xie Y, Lim K, Cejas P, Portell A, Lizotte PH, Ficarro SB, Li S, Chen T, Haikala HM, Wang H, Bahcall M, Gao Y, Shalhout S, Boettcher S, Shin BH, Thai T, Wilkens MK, Tillgren ML, Mushajiang M, Xu M, Choi J, Bertram AA, Ebert BL, Beroukhim R, Bandopadhayay P, Awad MM, Gokhale PC, Kirschmeier PT, Marto JA, Camargo FD, Haq R, Paweletz CP, Wong KK, Barbie DA, Long HW, Gray NS, Janne PA. Cancer Cell. 2020 Jan 13;37(1):104-122.e12. doi: 10.1016/j.ccell.2019.12.006. PubMed
Effective targeting of intact and proteolysed CDCP1 for imaging and treatment of pancreatic ductal adenocarcinoma. Kryza T, Khan T, Puttick S, Li C, Sokolowski KA, Tse BW, Cuda T, Lyons N, Gough M, Yin J, Parkin A, Deryugina EI, Quigley JP, Law RHP, Whisstock JC, Riddell AD, Barbour AP, Wyld DK, Thomas PA, Rose S, Snell CE, Pajic M, He Y, Hooper JD. Theranostics. 2020 Mar 4;10(9):4116-4133. doi: 10.7150/thno.43589. eCollection 2020. PubMed
PLX3397 treatment inhibits constitutive CSF1R-induced oncogenic ERK signaling, reduces tumor growth, and metastatic burden in osteosarcoma. Smeester BA, Slipek NJ, Pomeroy EJ, Laoharawee K, Osum SH, Larsson AT, Williams KB, Stratton N, Yamamoto K, Peterson JJ, Rathe SK, Mills LJ, Hudson WA, Crosby MR, Wang M, Rahrmann EP, Moriarity BS, Largaespada DA. Bone. 2020 Jul;136:115353. doi: 10.1016/j.bone.2020.115353. Epub 2020 Apr 3. PubMed
Competition between maturation and degradation drives human snRNA 3' end quality control. Lardelli RM, Lykke-Andersen J. Genes Dev. 2020 Jul 1;34(13-14):989-1001. doi: 10.1101/gad.336891.120. Epub 2020 Jun 4. PubMed
NLRP7 plays a functional role in regulating BMP4 signaling during differentiation of patient-derived trophoblasts. Alici-Garipcan A, Ozcimen B, Suder I, Ulker V, Onder TT, Ozoren N. Cell Death Dis. 2020 Aug 19;11(8):658. doi: 10.1038/s41419-020-02884-1. PubMed
Profiling of immune related genes silenced in EBV-positive gastric carcinoma identified novel restriction factors of human gammaherpesviruses. Fiches GN, Zhou D, Kong W, Biswas A, Ahmed EH, Baiocchi RA, Zhu J, Santoso N. PLoS Pathog. 2020 Aug 25;16(8):e1008778. doi: 10.1371/journal.ppat.1008778. eCollection 2020 Aug. PubMed
A simplified cell-based assay to identify coronavirus 3CL protease inhibitors. Resnick SJ, Iketani S, Hong SJ, Zask A, Liu H, Kim S, Melore S, Nair MS, Huang Y, Tay NES, Rovis T, Yang HW, Stockwell BR, Ho DD, Chavez A. bioRxiv. 2020 Aug 29. doi: 10.1101/2020.08.29.272864. PubMed
A non-canonical role for the autophagy machinery in anti-retroviral signaling mediated by TRIM5alpha. Saha B, Chisholm D, Kell AM, Mandell MA. PLoS Pathog. 2020 Oct 14;16(10):e1009017. doi: 10.1371/journal.ppat.1009017. eCollection 2020 Oct. PubMed
SHOC2 Is a Critical Modulator of Sensitivity to EGFR-TKIs in Non-Small Cell Lung Cancer Cells. Terai H, Hamamoto J, Emoto K, Masuda T, Manabe T, Kuronuma S, Kobayashi K, Masuzawa K, Ikemura S, Nakayama S, Kawada I, Suzuki Y, Takeuchi O, Suzuki Y, Ohtsuki S, Yasuda H, Soejima K, Fukunaga K. Mol Cancer Res. 2021 Feb;19(2):317-328. doi: 10.1158/1541-7786.MCR-20-0664. Epub 2020 Oct 26. PubMed
Small-molecule-induced polymerization triggers degradation of BCL6. Slabicki M, Yoon H, Koeppel J, Nitsch L, Roy Burman SS, Di Genua C, Donovan KA, Sperling AS, Hunkeler M, Tsai JM, Sharma R, Guirguis A, Zou C, Chudasama P, Gasser JA, Miller PG, Scholl C, Frohling S, Nowak RP, Fischer ES, Ebert BL. Nature. 2020 Dec;588(7836):164-168. doi: 10.1038/s41586-020-2925-1. Epub 2020 Nov 18. PubMed

Associated Plasmids
T cell receptor-dependent S-acylation of ZAP-70 controls activation of T cells. Tewari R, Shayahati B, Fan Y, Akimzhanov AM. J Biol Chem. 2021 Jan-Jun;296:100311. doi: 10.1016/j.jbc.2021.100311. Epub 2021 Jan 19. PubMed
Prototypical oncogene family Myc defines unappreciated distinct lineage states of small cell lung cancer. Patel AS, Yoo S, Kong R, Sato T, Sinha A, Karam S, Bao L, Fridrikh M, Emoto K, Nudelman G, Powell CA, Beasley MB, Zhu J, Watanabe H. Sci Adv. 2021 Jan 29;7(5). pii: 7/5/eabc2578. doi: 10.1126/sciadv.abc2578. Print 2021 Jan. PubMed
Dual functions of SPOP and ERG dictate androgen therapy responses in prostate cancer. Bernasocchi T, El Tekle G, Bolis M, Mutti A, Vallerga A, Brandt LP, Spriano F, Svinkina T, Zoma M, Ceserani V, Rinaldi A, Janouskova H, Bossi D, Cavalli M, Mosole S, Geiger R, Dong Z, Yang CG, Albino D, Rinaldi A, Schraml P, Linder S, Carbone GM, Alimonti A, Bertoni F, Moch H, Carr SA, Zwart W, Kruithof-de Julio M, Rubin MA, Udeshi ND, Theurillat JP. Nat Commun. 2021 Feb 2;12(1):734. doi: 10.1038/s41467-020-20820-x. PubMed
DPP9 sequesters the C terminus of NLRP1 to repress inflammasome activation. Hollingsworth LR, Sharif H, Griswold AR, Fontana P, Mintseris J, Dagbay KB, Paulo JA, Gygi SP, Bachovchin DA, Wu H. Nature. 2021 Mar 17. pii: 10.1038/s41586-021-03350-4. doi: 10.1038/s41586-021-03350-4. PubMed

Associated Plasmids
Inhibitors of Coronavirus 3CL Proteases Protect Cells from Protease-Mediated Cytotoxicity. Resnick SJ, Iketani S, Hong SJ, Zask A, Liu H, Kim S, Melore S, Lin FY, Nair MS, Huang Y, Lee S, Tay NES, Rovis T, Yang HW, Xing L, Stockwell BR, Ho DD, Chavez A. J Virol. 2021 Jun 24;95(14):e0237420. doi: 10.1128/JVI.02374-20. Epub 2021 Jun 24. PubMed

Associated Plasmids
Notch regulates vascular collagen IV basement membrane through modulation of lysyl hydroxylase 3 trafficking. Gross SJ, Webb AM, Peterlin AD, Durrant JR, Judson RJ, Raza Q, Kitajewski JK, Kushner EJ. Angiogenesis. 2021 Nov;24(4):789-805. doi: 10.1007/s10456-021-09791-9. Epub 2021 May 6. PubMed
SARS-CoV-2 Nsp14 activates NF-kappaB signaling and induces IL-8 upregulation. Li T, Kenney AD, Liu H, Fiches GN, Zhou D, Biswas A, Que J, Santoso N, Yount JS, Zhu J. bioRxiv. 2021 May 26. doi: 10.1101/2021.05.26.445787. PubMed
AF10 (MLLT10) prevents somatic cell reprogramming through regulation of DOT1L-mediated H3K79 methylation. Ugurlu-Cimen D, Odluyurt D, Sevinc K, Ozkan-Kucuk NE, Ozcimen B, Demirtas D, Enustun E, Aztekin C, Philpott M, Oppermann U, Ozlu N, Onder TT. Epigenetics Chromatin. 2021 Jul 2;14(1):32. doi: 10.1186/s13072-021-00406-7. PubMed
Methylation of dual-specificity phosphatase 4 controls cell differentiation. Su H, Jiang M, Senevirathne C, Aluri S, Zhang T, Guo H, Xavier-Ferrucio J, Jin S, Tran NT, Liu SM, Sun CW, Zhu Y, Zhao Q, Chen Y, Cable L, Shen Y, Liu J, Qu CK, Han X, Klug CA, Bhatia R, Chen Y, Nimer SD, Zheng YG, Iancu-Rubin C, Jin J, Deng H, Krause DS, Xiang J, Verma A, Luo M, Zhao X. Cell Rep. 2021 Jul 27;36(4):109421. doi: 10.1016/j.celrep.2021.109421. PubMed
SKAP2 as a new regulator of oligodendroglial migration and myelin sheath formation. Ghelman J, Grewing L, Windener F, Albrecht S, Zarbock A, Kuhlmann T. Glia. 2021 Nov;69(11):2699-2716. doi: 10.1002/glia.24066. Epub 2021 Jul 29. PubMed
A Bioluminescent 3CL(Pro) Activity Assay to Monitor SARS-CoV-2 Replication and Identify Inhibitors. Mathieu C, Touret F, Jacquemin C, Janin YL, Nougairede A, Brailly M, Mazelier M, Decimo D, Vasseur V, Hans A, Valle-Casuso JC, de Lamballerie X, Horvat B, Andre P, Si-Tahar M, Lotteau V, Vidalain PO. Viruses. 2021 Sep 12;13(9). pii: v13091814. doi: 10.3390/v13091814. PubMed
Deciphering cell signaling networks with massively multiplexed biosensor barcoding. Yang JM, Chi WY, Liang J, Takayanagi S, Iglesias PA, Huang CH. Cell. 2021 Dec 9;184(25):6193-6206.e14. doi: 10.1016/j.cell.2021.11.005. Epub 2021 Nov 26. PubMed

Associated Plasmids
Pharmacological inhibition of LSD1 triggers myeloid differentiation by targeting GSE1 oncogenic functions in AML. Nicosia L, Boffo FL, Ceccacci E, Conforti F, Pallavicini I, Bedin F, Ravasio R, Massignani E, Somervaille TCP, Minucci S, Bonaldi T. Oncogene. 2022 Feb;41(6):878-894. doi: 10.1038/s41388-021-02123-7. Epub 2021 Dec 3. PubMed
Targetable HER3 functions driving tumorigenic signaling in HER2-amplified cancers. Campbell MR, Ruiz-Saenz A, Peterson E, Agnew C, Ayaz P, Garfinkle S, Littlefield P, Steri V, Oeffinger J, Sampang M, Shan Y, Shaw DE, Jura N, Moasser MM. Cell Rep. 2022 Feb 1;38(5):110291. doi: 10.1016/j.celrep.2021.110291. PubMed
Extensive conformational and physical plasticity protects HER2-HER3 tumorigenic signaling. Campbell MR, Ruiz-Saenz A, Zhang Y, Peterson E, Steri V, Oeffinger J, Sampang M, Jura N, Moasser MM. Cell Rep. 2022 Feb 1;38(5):110285. doi: 10.1016/j.celrep.2021.110285. PubMed
Nucleoporin-93 reveals a common feature of aggressive breast cancers: robust nucleocytoplasmic transport of transcription factors. Nataraj NB, Noronha A, Lee JS, Ghosh S, Mohan Raju HR, Sekar A, Zuckerman B, Lindzen M, Tarcitano E, Srivastava S, Selitrennik M, Livneh I, Drago-Garcia D, Rueda O, Caldas C, Lev S, Geiger T, Ciechanover A, Ulitsky I, Seger R, Ruppin E, Yarden Y. Cell Rep. 2022 Feb 22;38(8):110418. doi: 10.1016/j.celrep.2022.110418. PubMed
Enhanced antigen cross-presentation in human colorectal cancer-associated fibroblasts through upregulation of the lysosomal protease cathepsin S. Harryvan TJ, Visser M, de Bruin L, Plug L, Griffioen L, Mulder A, van Veelen PA, van der Heden van Noort GJ, Jongsma ML, Meeuwsen MH, Wiertz EJ, Santegoets SJ, Hardwick JC, Van Hall T, Neefjes J, Van der Burg SH, Hawinkels LJ, Verdegaal EM. J Immunother Cancer. 2022 Mar;10(3). pii: jitc-2021-003591. doi: 10.1136/jitc-2021-003591. PubMed
Development of optimized drug-like small molecule inhibitors of the SARS-CoV-2 3CL protease for treatment of COVID-19. Liu H, Iketani S, Zask A, Khanizeman N, Bednarova E, Forouhar F, Fowler B, Hong SJ, Mohri H, Nair MS, Huang Y, Tay NES, Lee S, Karan C, Resnick SJ, Quinn C, Li W, Shion H, Xia X, Daniels JD, Bartolo-Cruz M, Farina M, Rajbhandari P, Jurtschenko C, Lauber MA, McDonald T, Stokes ME, Hurst BL, Rovis T, Chavez A, Ho DD, Stockwell BR. Nat Commun. 2022 Apr 7;13(1):1891. doi: 10.1038/s41467-022-29413-2. PubMed
Interactomic analysis reveals a homeostatic role for the HIV restriction factor TRIM5alpha in mitophagy. Saha B, Salemi M, Williams GL, Oh S, Paffett ML, Phinney B, Mandell MA. Cell Rep. 2022 May 10;39(6):110797. doi: 10.1016/j.celrep.2022.110797. PubMed
Combined analysis of T cell activation and T cell-mediated cytotoxicity by imaging cytometry. Chanda MK, Shudde CE, Piper TL, Zheng Y, Courtney AH. J Immunol Methods. 2022 Jul;506:113290. doi: 10.1016/j.jim.2022.113290. Epub 2022 May 27. PubMed
The CDK1/TFCP2L1/ID2 cascade offers a novel combination therapy strategy in a preclinical model of bladder cancer. Heo J, Lee J, Nam YJ, Kim Y, Yun H, Lee S, Ju H, Ryu CM, Jeong SM, Lee J, Lim J, Cho YM, Jeong EM, Hong B, Son J, Shin DM. Exp Mol Med. 2022 Jun;54(6):801-811. doi: 10.1038/s12276-022-00786-0. Epub 2022 Jun 21. PubMed
Transition to a mesenchymal state in neuroblastoma confers resistance to anti-GD2 antibody via reduced expression of ST8SIA1. Mabe NW, Huang M, Dalton GN, Alexe G, Schaefer DA, Geraghty AC, Robichaud AL, Conway AS, Khalid D, Mader MM, Belk JA, Ross KN, Sheffer M, Linde MH, Ly N, Yao W, Rotiroti MC, Smith BAH, Wernig M, Bertozzi CR, Monje M, Mitsiades CS, Majeti R, Satpathy AT, Stegmaier K, Majzner RG. Nat Cancer. 2022 Aug;3(8):976-993. doi: 10.1038/s43018-022-00405-x. Epub 2022 Jul 11. PubMed
Cardiac ultrastructure inspired matrix induces advanced metabolic and functional maturation of differentiated human cardiomyocytes. Afzal J, Liu Y, Du W, Suhail Y, Zong P, Feng J, Ajeti V, Sayyad WA, Nikolaus J, Yankova M, Deymier AC, Yue L, Kshitiz. Cell Rep. 2022 Jul 26;40(4):111146. doi: 10.1016/j.celrep.2022.111146. PubMed
VRK1 as a synthetic lethal target in VRK2 promoter-methylated cancers of the nervous system. So J, Mabe NW, Englinger B, Chow KH, Moyer SM, Yerrum S, Trissal MC, Marques JG, Kwon JJ, Shim B, Pal S, Panditharatna E, Quinn T, Schaefer DA, Jeong D, Mayhew DL, Hwang J, Beroukhim R, Ligon KL, Stegmaier K, Filbin MG, Hahn WC. JCI Insight. 2022 Oct 10;7(19):e158755. doi: 10.1172/jci.insight.158755. PubMed

Associated Plasmids
The balance between NANOG and SOX17 mediated by TET proteins regulates specification of human primordial germ cell fate. Li Z, Fang F, Long Y, Zhao Q, Wang X, Ye Z, Meng T, Gu X, Xiang W, Xiong C, Li H. Cell Biosci. 2022 Nov 4;12(1):181. doi: 10.1186/s13578-022-00917-0. PubMed
The NLRP1 and CARD8 inflammasomes detect reductive stress. Wang Q, Hsiao JC, Yardeny N, Huang HC, O'Mara CM, Orth-He EL, Ball DP, Zhang Z, Bachovchin DA. Cell Rep. 2023 Jan 31;42(1):111966. doi: 10.1016/j.celrep.2022.111966. Epub 2023 Jan 16. PubMed
Protein folding stress potentiates NLRP1 and CARD8 inflammasome activation. Orth-He EL, Huang HC, Rao SD, Wang Q, Chen Q, O'Mara CM, Chui AJ, Saoi M, Griswold AR, Bhattacharjee A, Ball DP, Cross JR, Bachovchin DA. Cell Rep. 2023 Jan 31;42(1):111965. doi: 10.1016/j.celrep.2022.111965. Epub 2023 Jan 16. PubMed
BTG1 mutation yields supercompetitive B cells primed for malignant transformation. Mlynarczyk C, Teater M, Pae J, Chin CR, Wang L, Arulraj T, Barisic D, Papin A, Hoehn KB, Kots E, Ersching J, Bandyopadhyay A, Barin E, Poh HX, Evans CM, Chadburn A, Chen Z, Shen H, Isles HM, Pelzer B, Tsialta I, Doane AS, Geng H, Rehman MH, Melnick J, Morgan W, Nguyen DTT, Elemento O, Kharas MG, Jaffrey SR, Scott DW, Khelashvili G, Meyer-Hermann M, Victora GD, Melnick A. Science. 2023 Jan 20;379(6629):eabj7412. doi: 10.1126/science.abj7412. Epub 2023 Jan 20. PubMed
BdLT-Seq as a barcode decay-based method to unravel lineage-linked transcriptome plasticity. Shlyakhtina Y, Bloechl B, Portal MM. Nat Commun. 2023 Feb 25;14(1):1085. doi: 10.1038/s41467-023-36744-1. PubMed
Acetyl-CoA biosynthesis drives resistance to histone acetyltransferase inhibition. Bishop TR, Subramanian C, Bilotta EM, Garnar-Wortzel L, Ramos AR, Zhang Y, Asiaban JN, Ott CJ, Rock CO, Erb MA. Nat Chem Biol. 2023 May 1. doi: 10.1038/s41589-023-01320-7. PubMed
AR activates YAP/TAZ differentially in prostate cancer. Salem O, Jia S, Qian BZ, Hansen CG. Life Sci Alliance. 2023 Jun 29;6(9):e202201620. doi: 10.26508/lsa.202201620. Print 2023 Sep. PubMed
MTGR1 is required to maintain small intestinal stem cell populations. Williams C, Brown R, Zhao Y, Wang J, Chen Z, Blunt K, Pilat J, Parang B, Choksi Y, Lau K, Hiebert S, Short S, Jacobse J, Xu Y, Yang Y, Goettel J. Res Sq [Preprint]. 2023 Sep 21:rs.3.rs-3315071. doi: 10.21203/rs.3.rs-3315071/v1. PubMed
SND1 binds SARS-CoV-2 negative-sense RNA and promotes viral RNA synthesis through NSP9. Schmidt N, Ganskih S, Wei Y, Gabel A, Zielinski S, Keshishian H, Lareau CA, Zimmermann L, Makroczyova J, Pearce C, Krey K, Hennig T, Stegmaier S, Moyon L, Horlacher M, Werner S, Aydin J, Olguin-Nava M, Potabattula R, Kibe A, Dolken L, Smyth RP, Caliskan N, Marsico A, Krempl C, Bodem J, Pichlmair A, Carr SA, Chlanda P, Erhard F, Munschauer M. Cell. 2023 Oct 26;186(22):4834-4850.e23. doi: 10.1016/j.cell.2023.09.002. Epub 2023 Oct 3. PubMed
ORAOV1, CCND1, and MIR548K Are the Driver Oncogenes of the 11q13 Amplicon in Squamous Cell Carcinoma. Mahieu CI, Mancini AG, Vikram EP, Planells-Palop V, Joseph NM, Tward AD. Mol Cancer Res. 2024 Feb 1;22(2):152-168. doi: 10.1158/1541-7786.MCR-23-0746. PubMed
RAD54L2-mediated DNA damage avoidance pathway specifically preserves genome integrity in response to topoisomerase 2 poisons. Zhang H, Xiong Y, Sun Y, Park JM, Su D, Feng X, Keast S, Tang M, Huang M, Wang C, Srivastava M, Yang C, Zhu D, Chen Z, Li S, Yin L, Pommier Y, Chen J. Sci Adv. 2023 Dec 8;9(49):eadi6681. doi: 10.1126/sciadv.adi6681. Epub 2023 Dec 6. PubMed
PRRX1-TOP2A interaction is a malignancy-promoting factor in human malignant peripheral nerve sheath tumours. Takihira S, Yamada D, Osone T, Takao T, Sakaguchi M, Hakozaki M, Itano T, Nakata E, Fujiwara T, Kunisada T, Ozaki T, Takarada T. Br J Cancer. 2024 May;130(9):1493-1504. doi: 10.1038/s41416-024-02632-8. Epub 2024 Mar 6. PubMed
Comprehensive mutational scanning of EGFR reveals TKI sensitivities of extracellular domain mutants. Hayes TK, Aquilanti E, Persky NS, Yang X, Kim EE, Brenan L, Goodale AB, Alan D, Sharpe T, Shue RE, Westlake L, Golomb L, Silverman BR, Morris MD, Fisher TR, Beyene E, Li YY, Cherniack AD, Piccioni F, Hicks JK, Chi AS, Cahill DP, Dietrich J, Batchelor TT, Root DE, Johannessen CM, Meyerson M. Nat Commun. 2024 Mar 28;15(1):2742. doi: 10.1038/s41467-024-45594-4. PubMed

If you have published an article using this material, please email us at [email protected] to have your article added to this page.