pEGFP-Q74 Citations (45)
Originally described in: A molecular investigation of true dominance in Huntington's disease.Narain Y, Wyttenbach A, Rankin J, Furlong RA, Rubinsztein DC J Med Genet. 1999 Oct;36(10):739-46. PubMed Journal
Articles Citing pEGFP-Q74
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| Sigma-1 receptor is involved in degradation of intranuclear inclusions in a cellular model of Huntington's disease. Miki Y, Tanji K, Mori F, Wakabayashi K. Neurobiol Dis. 2015 Feb;74:25-31. doi: 10.1016/j.nbd.2014.11.005. Epub 2014 Nov 14. PubMed |
| HDAC6 inhibition induces mitochondrial fusion, autophagic flux and reduces diffuse mutant huntingtin in striatal neurons. Guedes-Dias P, de Proenca J, Soares TR, Leitao-Rocha A, Pinho BR, Duchen MR, Oliveira JM. Biochim Biophys Acta. 2015 Nov;1852(11):2484-93. doi: 10.1016/j.bbadis.2015.08.012. Epub 2015 Aug 21. PubMed |
| The Social Amoeba Dictyostelium discoideum Is Highly Resistant to Polyglutamine Aggregation. Santarriaga S, Petersen A, Ndukwe K, Brandt A, Gerges N, Bruns Scaglione J, Scaglione KM. J Biol Chem. 2015 Oct 16;290(42):25571-8. doi: 10.1074/jbc.M115.676247. Epub 2015 Sep 1. PubMed |
| Blocking the association of HDAC4 with MAP1S accelerates autophagy clearance of mutant Huntingtin. Yue F, Li W, Zou J, Chen Q, Xu G, Huang H, Xu Z, Zhang S, Gallinari P, Wang F, McKeehan WL, Liu L. Aging (Albany NY). 2015 Oct;7(10):839-53. PubMed |
| The role of NUB1 in alpha-synuclein degradation in Lewy body disease model mice. Tanji K, Miki Y, Maruyama A, Mori F, Mimura J, Itoh K, Kamitani T, Wakabayashi K. Biochem Biophys Res Commun. 2016 Jan 18. pii: S0006-291X(16)30093-6. doi: 10.1016/j.bbrc.2016.01.093. PubMed |
| C/EBPbeta regulates sensitivity to bortezomib in prostate cancer cells by inducing REDD1 and autophagosome-lysosome fusion. Barakat DJ, Mendonca J, Barberi T, Zhang J, Kachhap SK, Paz-Priel I, Friedman AD. Cancer Lett. 2016 May 28;375(1):152-61. doi: 10.1016/j.canlet.2016.03.005. Epub 2016 Mar 8. PubMed |
| Bromodomain Protein BRD4 Is a Transcriptional Repressor of Autophagy and Lysosomal Function. Sakamaki JI, Wilkinson S, Hahn M, Tasdemir N, O'Prey J, Clark W, Hedley A, Nixon C, Long JS, New M, Van Acker T, Tooze SA, Lowe SW, Dikic I, Ryan KM. Mol Cell. 2017 May 18;66(4):517-532.e9. doi: 10.1016/j.molcel.2017.04.027. PubMed |
| The molecular chaperones DNAJB6 and Hsp70 cooperate to suppress alpha-synuclein aggregation. Aprile FA, Kallstig E, Limorenko G, Vendruscolo M, Ron D, Hansen C. Sci Rep. 2017 Aug 22;7(1):9039. doi: 10.1038/s41598-017-08324-z. PubMed |
A Method for the Acute and Rapid Degradation of Endogenous Proteins.
Clift D, McEwan WA, Labzin LI, Konieczny V, Mogessie B, James LC, Schuh M.
Cell. 2017 Nov 13. pii: S0092-8674(17)31255-2. doi: 10.1016/j.cell.2017.10.033.
PubMed
Associated Plasmids |
| Inhibition of PIP4Kgamma ameliorates the pathological effects of mutant huntingtin protein. Al-Ramahi I, Panapakkam Giridharan SS, Chen YC, Patnaik S, Safren N, Hasegawa J, de Haro M, Wagner Gee AK, Titus SA, Jeong H, Clarke J, Krainc D, Zheng W, Irvine RF, Barmada S, Ferrer M, Southall N, Weisman LS, Botas J, Marugan JJ. Elife. 2017 Dec 26;6. pii: 29123. doi: 10.7554/eLife.29123. PubMed |
| YOD1 attenuates neurogenic proteotoxicity through its deubiquitinating activity. Tanji K, Mori F, Miki Y, Utsumi J, Sasaki H, Kakita A, Takahashi H, Wakabayashi K. Neurobiol Dis. 2018 Apr;112:14-23. doi: 10.1016/j.nbd.2018.01.006. Epub 2018 Jan 10. PubMed |
| Striatal neurons directly converted from Huntington's disease patient fibroblasts recapitulate age-associated disease phenotypes. Victor MB, Richner M, Olsen HE, Lee SW, Monteys AM, Ma C, Huh CJ, Zhang B, Davidson BL, Yang XW, Yoo AS. Nat Neurosci. 2018 Mar;21(3):341-352. doi: 10.1038/s41593-018-0075-7. Epub 2018 Feb 5. PubMed |
| Correction of Huntington's Disease Phenotype by Genistein-Induced Autophagy in the Cellular Model. Pierzynowska K, Gaffke L, Hac A, Mantej J, Niedzialek N, Brokowska J, Wegrzyn G. Neuromolecular Med. 2018 Mar;20(1):112-123. doi: 10.1007/s12017-018-8482-1. Epub 2018 Feb 12. PubMed |
| A Split Transcriptional Repressor That Links Protein Solubility to an Orthogonal Genetic Circuit. Zeng Y, Jones AM, Thomas EE, Nassif B, Silberg JJ, Segatori L. ACS Synth Biol. 2018 Sep 21;7(9):2126-2138. doi: 10.1021/acssynbio.8b00129. Epub 2018 Aug 23. PubMed |
| TRIM16 controls assembly and degradation of protein aggregates by modulating the p62-NRF2 axis and autophagy. Jena KK, Kolapalli SP, Mehto S, Nath P, Das B, Sahoo PK, Ahad A, Syed GH, Raghav SK, Senapati S, Chauhan S, Chauhan S. EMBO J. 2018 Sep 14;37(18). pii: embj.201798358. doi: 10.15252/embj.201798358. Epub 2018 Aug 24. PubMed |
| Heat shock promotes inclusion body formation of mutant huntingtin (mHtt) and alleviates mHtt-induced transcription factor dysfunction. Chen JY, Parekh M, Seliman H, Bakshinskaya D, Dai W, Kwan K, Chen KY, Liu AYC. J Biol Chem. 2018 Oct 5;293(40):15581-15593. doi: 10.1074/jbc.RA118.002933. Epub 2018 Aug 24. PubMed |
| GLP-1 Analogue Liraglutide Attenuates Mutant Huntingtin-Induced Neurotoxicity by Restoration of Neuronal Insulin Signaling. Chang CC, Lin TC, Ho HL, Kuo CY, Li HH, Korolenko TA, Chen WJ, Lai TJ, Ho YJ, Lin CL. Int J Mol Sci. 2018 Aug 24;19(9). pii: ijms19092505. doi: 10.3390/ijms19092505. PubMed |
| Mitochondrial superoxide generation induces a parkinsonian phenotype in zebrafish and huntingtin aggregation in human cells. Pinho BR, Reis SD, Hartley RC, Murphy MP, Oliveira JMA. Free Radic Biol Med. 2019 Jan;130:318-327. doi: 10.1016/j.freeradbiomed.2018.10.446. Epub 2018 Oct 31. PubMed |
| The sensitivity to Hsp90 inhibitors of both normal and oncogenically transformed cells is determined by the equilibrium between cellular quiescence and activity. Echeverria PC, Bhattacharya K, Joshi A, Wang T, Picard D. PLoS One. 2019 Feb 6;14(2):e0208287. doi: 10.1371/journal.pone.0208287. eCollection 2019. PubMed |
| Phosphorylated NUB1 distinguishes alpha-synuclein in Lewy bodies from that in glial cytoplasmic inclusions in multiple system atrophy. Tanji K, Miki Y, Mori F, Kon T, Kakita A, Takahashi H, Wakabayashi K. Brain Pathol. 2019 Apr 21. doi: 10.1111/bpa.12728. PubMed |
| Molecular mechanisms of heterogeneous oligomerization of huntingtin proteins. Bonfanti S, Lionetti MC, Fumagalli MR, Chirasani VR, Tiana G, Dokholyan NV, Zapperi S, La Porta CAM. Sci Rep. 2019 May 20;9(1):7615. doi: 10.1038/s41598-019-44151-0. PubMed |
| The cholesterol 24-hydroxylase activates autophagy and decreases mutant huntingtin build-up in a neuroblastoma culture model of Huntington's disease. Nobrega C, Conceicao A, Costa RG, Koppenol R, Sequeira RL, Nunes R, Carmo-Silva S, Marcelo A, Matos CA, Betuing S, Caboche J, Cartier N, Alves S. BMC Res Notes. 2020 Apr 10;13(1):210. doi: 10.1186/s13104-020-05053-x. PubMed |
| MEF2 impairment underlies skeletal muscle atrophy in polyglutamine disease. Nath SR, Lieberman ML, Yu Z, Marchioretti C, Jones ST, Danby ECE, Van Pelt KM, Soraru G, Robins DM, Bates GP, Pennuto M, Lieberman AP. Acta Neuropathol. 2020 Jul;140(1):63-80. doi: 10.1007/s00401-020-02156-4. Epub 2020 Apr 18. PubMed |
| ATP and spontaneous calcium oscillations control neural stem cell fate determination in Huntington's disease: a novel approach for cell clock research. Glaser T, Shimojo H, Ribeiro DE, Martins PPL, Beco RP, Kosinski M, Sampaio VFA, Correa-Velloso J, Oliveira-Giacomelli A, Lameu C, de Jesus Santos AP, de Souza HDN, Teng YD, Kageyama R, Ulrich H. Mol Psychiatry. 2020 Apr 29. pii: 10.1038/s41380-020-0717-5. doi: 10.1038/s41380-020-0717-5. PubMed |
| Co-chaperones DNAJA1 and DNAJB6 are critical for regulation of polyglutamine aggregation. Rodriguez-Gonzalez C, Lin S, Arkan S, Hansen C. Sci Rep. 2020 May 18;10(1):8130. doi: 10.1038/s41598-020-65046-5. PubMed |
| Osmolytes dynamically regulate mutant Huntingtin aggregation and CREB function in Huntington's disease cell models. Aravindan S, Chen S, Choudhry H, Molfetta C, Chen KY, Liu AYC. Sci Rep. 2020 Sep 23;10(1):15511. doi: 10.1038/s41598-020-72613-3. PubMed |
| Titration of SF3B1 Activity Reveals Distinct Effects on the Transcriptome and Cell Physiology. Kim Guisbert KS, Mossiah I, Guisbert E. Int J Mol Sci. 2020 Dec 17;21(24). pii: ijms21249641. doi: 10.3390/ijms21249641. PubMed |
| Random Lasing Detection of Mutant Huntingtin Expression in Cells. de Armas-Rillo S, Fumagallo-Reading F, Luis-Ravelo D, Abdul-Jalbar B, Gonzalez-Hernandez T, Lahoz F. Sensors (Basel). 2021 May 31;21(11). pii: s21113825. doi: 10.3390/s21113825. PubMed |
| DNAzyme Cleavage of CAG Repeat RNA in Polyglutamine Diseases. Zhang N, Bewick B, Schultz J, Tiwari A, Krencik R, Zhang A, Adachi K, Xia G, Yun K, Sarkar P, Ashizawa T. Neurotherapeutics. 2021 Jun 23. pii: 10.1007/s13311-021-01075-w. doi: 10.1007/s13311-021-01075-w. PubMed |
| Fluc-EGFP reporter mice reveal differential alterations of neuronal proteostasis in aging and disease. Blumenstock S, Schulz-Trieglaff EK, Voelkl K, Bolender AL, Lapios P, Lindner J, Hipp MS, Hartl FU, Klein R, Dudanova I. EMBO J. 2021 Oct 1;40(19):e107260. doi: 10.15252/embj.2020107260. Epub 2021 Aug 19. PubMed |
| DNAJB6b-enriched small extracellular vesicles decrease polyglutamine aggregation in in vitro and in vivo models of Huntington disease. Joshi BS, Youssef SA, Bron R, de Bruin A, Kampinga HH, Zuhorn IS. iScience. 2021 Oct 14;24(11):103282. doi: 10.1016/j.isci.2021.103282. eCollection 2021 Nov 19. PubMed |
| Polygala saponins inhibit NLRP3 inflammasome-mediated neuroinflammation via SHP-2-Mediated mitophagy. Qiu WQ, Ai W, Zhu FD, Zhang Y, Guo MS, Law BY, Wu JM, Wong VK, Tang Y, Yu L, Chen Q, Yu CL, Liu J, Qin DL, Zhou XG, Wu AG. Free Radic Biol Med. 2022 Feb 1;179:76-94. doi: 10.1016/j.freeradbiomed.2021.12.263. Epub 2021 Dec 20. PubMed |
| Defective repair of topoisomerase I induced chromosomal damage in Huntington's disease. Palminha NM, Dos Santos Souza C, Griffin J, Liao C, Ferraiuolo L, El-Khamisy SF. Cell Mol Life Sci. 2022 Feb 28;79(3):160. doi: 10.1007/s00018-022-04204-6. PubMed |
| Sequestration of TDP-43(216-414) Aggregates by Cytoplasmic Expression of the proSAAS Chaperone. Peinado JR, Chaplot K, Jarvela TS, Barbieri EM, Shorter J, Lindberg I. ACS Chem Neurosci. 2022 Jun 1;13(11):1651-1665. doi: 10.1021/acschemneuro.2c00156. Epub 2022 May 12. PubMed |
| Praja1 RING-finger E3 ubiquitin ligase is a common suppressor of neurodegenerative disease-associated protein aggregation. Watabe K, Niida-Kawaguchi M, Tada M, Kato Y, Murata M, Tanji K, Wakabayashi K, Yamada M, Kakita A, Shibata N. Neuropathology. 2022 Jun 14. doi: 10.1111/neup.12840. PubMed |
| GRASP55 regulates the unconventional secretion and aggregation of mutant huntingtin. Ahat E, Bui S, Zhang J, da Veiga Leprevost F, Sharkey L, Reid W, Nesvizhskii AI, Paulson HL, Wang Y. J Biol Chem. 2022 Aug;298(8):102219. doi: 10.1016/j.jbc.2022.102219. Epub 2022 Jul 1. PubMed |
| DNAJB6-Containing Extracellular Vesicles as Chaperone Delivery Systems: A Proteomic Analysis. Joshi BS, Garcia Romeu H, Aliyandi A, de Vries MP, Zuhorn IS. Pharmaceutics. 2022 Nov 17;14(11):2485. doi: 10.3390/pharmaceutics14112485. PubMed |
| Mechanistic Insight into the Suppression of Polyglutamine Aggregation by SRCP1. Haver HN, Wedemeyer M, Butcher E, Peterson FC, Volkman BF, Scaglione KM. ACS Chem Biol. 2023 Mar 17;18(3):549-560. doi: 10.1021/acschembio.2c00893. Epub 2023 Feb 15. PubMed |
| Preparation of chaperone-loaded neural stem cell-derived extracellular vesicles to reduce protein aggregation in Huntington's disease cellular models. Joshi BS, Zuhorn IS. STAR Protoc. 2023 Feb 24;4(1):102134. doi: 10.1016/j.xpro.2023.102134. PubMed |
| Tumor suppressor p53 regulates heat shock factor 1 protein degradation in Huntington's disease. Mansky RH, Greguske EA, Yu D, Zarate N, Intihar TA, Tsai W, Brown TG, Thayer MN, Kumar K, Gomez-Pastor R. Cell Rep. 2023 Mar 28;42(3):112198. doi: 10.1016/j.celrep.2023.112198. Epub 2023 Mar 3. PubMed |
| NAADP-Evoked Ca(2+) Signaling Leads to Mutant Huntingtin Aggregation and Autophagy Impairment in Murine Astrocytes. Pereira CAS, Medaglia NC, Ureshino RP, Bincoletto C, Antonioli M, Fimia GM, Piacentini M, Pereira GJDS, Erustes AG, Smaili SS. Int J Mol Sci. 2023 Mar 15;24(6):5593. doi: 10.3390/ijms24065593. PubMed |
| Size distributions of intracellular condensates reflect competition between coalescence and nucleation. Lee DSW, Choi CH, Sanders DW, Beckers L, Riback JA, Brangwynne CP, Wingreen NS. Nat Phys. 2023;19(4):586-596. doi: 10.1038/s41567-022-01917-0. Epub 2023 Feb 2. PubMed |
| In planta expression of human polyQ-expanded huntingtin fragment reveals mechanisms to prevent disease-related protein aggregation. Llamas E, Koyuncu S, Lee HJ, Wehrmann M, Gutierrez-Garcia R, Dunken N, Charura N, Torres-Montilla S, Schlimgen E, Mandel AM, Theile EB, Grossbach J, Wagle P, Lackmann JW, Schermer B, Benzing T, Beyer A, Pulido P, Rodriguez-Concepcion M, Zuccaro A, Vilchez D. Nat Aging. 2023 Nov;3(11):1345-1357. doi: 10.1038/s43587-023-00502-1. Epub 2023 Oct 2. PubMed |
| A multi-layered network model identifies Akt1 as a common modulator of neurodegeneration. Na D, Lim DH, Hong JS, Lee HM, Cho D, Yu MS, Shaker B, Ren J, Lee B, Song JG, Oh Y, Lee K, Oh KS, Lee MY, Choi MS, Choi HS, Kim YH, Bui JM, Lee K, Kim HW, Lee YS, Gsponer J. Mol Syst Biol. 2023 Dec 6;19(12):e11801. doi: 10.15252/msb.202311801. Epub 2023 Nov 20. PubMed |
| Detecting material state changes in the nucleolus by label-free digital holographic microscopy. Zorbas C, Soenmez A, Leger J, De Vleeschouwer C, Lafontaine DL. EMBO Rep. 2024 Jun;25(6):2786-2811. doi: 10.1038/s44319-024-00134-5. Epub 2024 Apr 23. PubMed |
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