pCW57.1-4EBP1_4xAla Citations (13)

Originally described in: A unifying model for mTORC1-mediated regulation of mRNA translation.
Thoreen CC, Chantranupong L, Keys HR, Wang T, Gray NS, Sabatini DM Nature. 2012 May 2;485(7396):109-13. doi: 10.1038/nature11083. PubMed Journal

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Articles Citing pCW57.1-4EBP1_4xAla

Articles
MNK1 pathway activity maintains protein synthesis in rapalog-treated gliomas. Grzmil M, Huber RM, Hess D, Frank S, Hynx D, Moncayo G, Klein D, Merlo A, Hemmings BA. J Clin Invest. 2014 Feb;124(2):742-54. doi: 10.1172/JCI70198. Epub 2014 Jan 9. PubMed
mTORC1 upregulation via ERK-dependent gene expression change confers intrinsic resistance to MEK inhibitors in oncogenic KRas-mutant cancer cells. Komatsu N, Fujita Y, Matsuda M, Aoki K. Oncogene. 2015 Feb 23. doi: 10.1038/onc.2015.16. PubMed
Heightening Energetic Stress Selectively Targets LKB1-Deficient Non-Small Cell Lung Cancers. Momcilovic M, McMickle R, Abt E, Seki A, Simko SA, Magyar C, Stout DB, Fishbein MC, Walser TC, Dubinett SM, Shackelford DB. Cancer Res. 2015 Nov 15;75(22):4910-22. doi: 10.1158/0008-5472.CAN-15-0797. PubMed
Stabilization of p21 by mTORC1/4E-BP1 predicts clinical outcome of head and neck cancers. Llanos S, Garcia-Pedrero JM, Morgado-Palacin L, Rodrigo JP, Serrano M. Nat Commun. 2016 Feb 2;7:10438. doi: 10.1038/ncomms10438. PubMed
Coordinated Regulation of Cap-Dependent Translation and MicroRNA Function by Convergent Signaling Pathways. Olejniczak SH, La Rocca G, Radler MR, Egan SM, Xiang Q, Garippa R, Thompson CB. Mol Cell Biol. 2016 Aug 26;36(18):2360-73. doi: 10.1128/MCB.01011-15. Print 2016 Sep 15. PubMed
Amino acid-dependent signaling via S6K1 and MYC is essential for regulation of rDNA transcription. Kang J, Kusnadi EP, Ogden AJ, Hicks RJ, Bammert L, Kutay U, Hung S, Sanij E, Hannan RD, Hannan KM, Pearson RB. Oncotarget. 2016 Aug 2;7(31):48887-48904. doi: 10.18632/oncotarget.10346. PubMed
Dual function of the PI3K-Akt-mTORC1 axis in myelination of the peripheral nervous system. Figlia G, Norrmen C, Pereira JA, Gerber D, Suter U. Elife. 2017 Sep 7;6. doi: 10.7554/eLife.29241. PubMed
The mTORC1/4E-BP1 axis represents a critical signaling node during fibrogenesis. Woodcock HV, Eley JD, Guillotin D, Plate M, Nanthakumar CB, Martufi M, Peace S, Joberty G, Poeckel D, Good RB, Taylor AR, Zinn N, Redding M, Forty EJ, Hynds RE, Swanton C, Karsdal M, Maher TM, Bergamini G, Marshall RP, Blanchard AD, Mercer PF, Chambers RC. Nat Commun. 2019 Jan 2;10(1):6. doi: 10.1038/s41467-018-07858-8. PubMed
Novel AU-rich proximal UTR sequences (APS) enhance CXCL8 synthesis upon the induction of rpS6 phosphorylation. Ang Z, Koean RAG, Er JZ, Lee LT, Tam JKC, Guo H, Ding JL. PLoS Genet. 2019 Apr 10;15(4):e1008077. doi: 10.1371/journal.pgen.1008077. eCollection 2019 Apr. PubMed
STAT3-mediated MLST8 gene expression regulates cap-dependent translation in cancer cells. Lee H, Chin H, Kim H, Jung H, Lee D. Mol Oncol. 2020 Aug;14(8):1850-1867. doi: 10.1002/1878-0261.12735. Epub 2020 Jun 29. PubMed
mTORC1 couples cyst(e)ine availability with GPX4 protein synthesis and ferroptosis regulation. Zhang Y, Swanda RV, Nie L, Liu X, Wang C, Lee H, Lei G, Mao C, Koppula P, Cheng W, Zhang J, Xiao Z, Zhuang L, Fang B, Chen J, Qian SB, Gan B. Nat Commun. 2021 Mar 11;12(1):1589. doi: 10.1038/s41467-021-21841-w. PubMed
Selective inhibitors of mTORC1 activate 4EBP1 and suppress tumor growth. Lee BJ, Boyer JA, Burnett GL, Thottumkara AP, Tibrewal N, Wilson SL, Hsieh T, Marquez A, Lorenzana EG, Evans JW, Hulea L, Kiss G, Liu H, Lee D, Larsson O, McLaughlan S, Topisirovic I, Wang Z, Wang Z, Zhao Y, Wildes D, Aggen JB, Singh M, Gill AL, Smith JAM, Rosen N. Nat Chem Biol. 2021 Oct;17(10):1065-1074. doi: 10.1038/s41589-021-00813-7. Epub 2021 Jun 24. PubMed
ID1 and CEBPA coordinate epidermal progenitor cell differentiation. Kantzer CG, Yang W, Grommisch D, Vikhe Patil K, Mak KH, Shirokova V, Genander M. Development. 2022 Nov 15;149(22):dev201262. doi: 10.1242/dev.201262. Epub 2022 Nov 16. PubMed

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