pEGFP-N1-TFEB Citations (71)
Originally described in: The Transcription Factor TFEB Links mTORC1 Signaling to Transcriptional Control of Lysosome Homeostasis.Roczniak-Ferguson A, Petit CS, Froehlich F, Qian S, Ky J, Angarola B, Walther TC, Ferguson SM Sci Signal. 2012 Jun 12;5(228):ra42. PubMed Journal
Articles Citing pEGFP-N1-TFEB
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| p62/SQSTM1 synergizes with autophagy for tumor growth in vivo. Wei H, Wang C, Croce CM, Guan JL. Genes Dev. 2014 Jun 1;28(11):1204-16. doi: 10.1101/gad.237354.113. PubMed |
| Rag GTPases are cardioprotective by regulating lysosomal function. Kim YC, Park HW, Sciarretta S, Mo JS, Jewell JL, Russell RC, Wu X, Sadoshima J, Guan KL. Nat Commun. 2014 Jul 1;5:4241. doi: 10.1038/ncomms5241. PubMed |
| Activation of Master Autophagy Regulator TFEB During Systemic LPS Administration in the Cornea. Uchida K, Unuma K, Funakoshi T, Aki T, Uemura K. J Toxicol Pathol. 2014 Jul;27(2):153-8. doi: 10.1293/tox.2014-0004. Epub 2014 Apr 17. PubMed |
| Glycogen synthase kinase-3 (GSK3) inhibition induces prosurvival autophagic signals in human pancreatic cancer cells. Marchand B, Arsenault D, Raymond-Fleury A, Boisvert FM, Boucher MJ. J Biol Chem. 2015 Feb 27;290(9):5592-605. doi: 10.1074/jbc.M114.616714. Epub 2015 Jan 5. PubMed |
| MiT/TFE transcription factors are activated during mitophagy downstream of Parkin and Atg5. Nezich CL, Wang C, Fogel AI, Youle RJ. J Cell Biol. 2015 Aug 3;210(3):435-50. doi: 10.1083/jcb.201501002. PubMed |
| Induction of autophagy improves hepatic lipid metabolism in glucose-6-phosphatase deficiency. Farah BL, Landau DJ, Sinha RA, Brooks ED, Wu Y, Fung SY, Tanaka T, Hirayama M, Bay BH, Koeberl DD, Yen PM. J Hepatol. 2016 Feb;64(2):370-9. doi: 10.1016/j.jhep.2015.10.008. Epub 2015 Oct 20. PubMed |
| Intracellular sphingosine releases calcium from lysosomes. Hoglinger D, Haberkant P, Aguilera-Romero A, Riezman H, Porter FD, Platt FM, Galione A, Schultz C. Elife. 2015 Nov 27;4. pii: e10616. doi: 10.7554/eLife.10616. PubMed |
| An Evolutionarily Conserved PLC-PKD-TFEB Pathway for Host Defense. Najibi M, Labed SA, Visvikis O, Irazoqui JE. Cell Rep. 2016 May 24;15(8):1728-42. doi: 10.1016/j.celrep.2016.04.052. Epub 2016 May 12. PubMed |
| Loss of C9orf72 Enhances Autophagic Activity via Deregulated mTOR and TFEB Signaling. Ugolino J, Ji YJ, Conchina K, Chu J, Nirujogi RS, Pandey A, Brady NR, Hamacher-Brady A, Wang J. PLoS Genet. 2016 Nov 22;12(11):e1006443. doi: 10.1371/journal.pgen.1006443. eCollection 2016 Nov. PubMed |
| Hyperhomocysteinemia causes ER stress and impaired autophagy that is reversed by Vitamin B supplementation. Tripathi M, Zhang CW, Singh BK, Sinha RA, Moe KT, DeSilva DA, Yen PM. Cell Death Dis. 2016 Dec 8;7(12):e2513. doi: 10.1038/cddis.2016.374. PubMed |
| TFEB ameliorates the impairment of the autophagy-lysosome pathway in neurons induced by doxorubicin. Moruno-Manchon JF, Uzor NE, Kesler SR, Wefel JS, Townley DM, Nagaraja AS, Pradeep S, Mangala LS, Sood AK, Tsvetkov AS. Aging (Albany NY). 2016 Dec 16;8(12):3507-3519. doi: 10.18632/aging.101144. PubMed |
| mTOR complex 1 activity is required to maintain the canonical endocytic recycling pathway against lysosomal delivery. Dauner K, Eid W, Raghupathy R, Presley JF, Zha X. J Biol Chem. 2017 Apr 7;292(14):5737-5747. doi: 10.1074/jbc.M116.771451. Epub 2017 Feb 14. PubMed |
| Rescue of Pink1 Deficiency by Stress-Dependent Activation of Autophagy. Zhang Y, Nguyen DT, Olzomer EM, Poon GP, Cole NJ, Puvanendran A, Phillips BR, Hesselson D. Cell Chem Biol. 2017 Apr 20;24(4):471-480.e4. doi: 10.1016/j.chembiol.2017.03.005. Epub 2017 Mar 30. PubMed |
| Janus Kinase 2 Regulates Transcription Factor EB Expression and Autophagy Completion in Glomerular Podocytes. Alghamdi TA, Majumder S, Thieme K, Batchu SN, White KE, Liu Y, Brijmohan AS, Bowskill BB, Advani SL, Woo M, Advani A. J Am Soc Nephrol. 2017 Sep;28(9):2641-2653. doi: 10.1681/ASN.2016111208. Epub 2017 Apr 19. PubMed |
| Bromodomain Protein BRD4 Is a Transcriptional Repressor of Autophagy and Lysosomal Function. Sakamaki JI, Wilkinson S, Hahn M, Tasdemir N, O'Prey J, Clark W, Hedley A, Nixon C, Long JS, New M, Van Acker T, Tooze SA, Lowe SW, Dikic I, Ryan KM. Mol Cell. 2017 May 18;66(4):517-532.e9. doi: 10.1016/j.molcel.2017.04.027. PubMed |
| NOX2-Mediated TFEB Activation and Vacuolization Regulate Lysosome-Associated Cell Death Induced by Gypenoside L, a Saponin Isolated from Gynostemma pentaphyllum. Zheng K, Jiang Y, Liao C, Hu X, Li Y, Zeng Y, Zhang J, Wu X, Wu H, Liu L, Wang Y, He Z. J Agric Food Chem. 2017 Aug 9;65(31):6625-6637. doi: 10.1021/acs.jafc.7b02296. Epub 2017 Jul 28. PubMed |
| Silver nanoparticles induce lysosomal-autophagic defects and decreased expression of transcription factor EB in A549 human lung adenocarcinoma cells. Miyayama T, Fujiki K, Matsuoka M. Toxicol In Vitro. 2018 Feb;46:148-154. doi: 10.1016/j.tiv.2017.10.009. Epub 2017 Oct 5. PubMed |
| TFEB activation protects against cardiac proteotoxicity via increasing autophagic flux. Pan B, Zhang H, Cui T, Wang X. J Mol Cell Cardiol. 2017 Dec;113:51-62. doi: 10.1016/j.yjmcc.2017.10.003. Epub 2017 Oct 7. PubMed |
| Rheb localized on the Golgi membrane activates lysosome-localized mTORC1 at the Golgi-lysosome contact site. Hao F, Kondo K, Itoh T, Ikari S, Nada S, Okada M, Noda T. J Cell Sci. 2018 Jan 29;131(3). pii: jcs.208017. doi: 10.1242/jcs.208017. PubMed |
| Dysfunctional autophagy following exposure to pro-inflammatory cytokines contributes to pancreatic beta-cell apoptosis. Lambelet M, Terra LF, Fukaya M, Meyerovich K, Labriola L, Cardozo AK, Allagnat F. Cell Death Dis. 2018 Jan 24;9(2):96. doi: 10.1038/s41419-017-0121-5. PubMed |
| Evaluation of autophagy inducers in epithelial cells carrying the DeltaF508 mutation of the cystic fibrosis transmembrane conductance regulator CFTR. Zhang S, Stoll G, Pedro JMBS, Sica V, Sauvat A, Obrist F, Kepp O, Li Y, Maiuri L, Zamzami N, Kroemer G. Cell Death Dis. 2018 Feb 7;9(2):191. doi: 10.1038/s41419-017-0235-9. PubMed |
| Glycogen synthase kinase-3beta inhibition promotes lysosome-dependent degradation of c-FLIPL in hepatocellular carcinoma. Zhang N, Liu X, Liu L, Deng Z, Zeng Q, Pang W, Liu Y, Song D, Deng H. Cell Death Dis. 2018 Feb 14;9(2):230. doi: 10.1038/s41419-018-0309-3. PubMed |
| Intracellular Trafficking and Persistence of Acinetobacter baumannii Requires Transcription Factor EB. Parra-Millan R, Guerrero-Gomez D, Ayerbe-Algaba R, Pachon-Ibanez ME, Miranda-Vizuete A, Pachon J, Smani Y. mSphere. 2018 Mar 28;3(2). pii: mSphere00106-18. doi: 10.1128/mSphere.00106-18. eCollection 2018 Mar-Apr. PubMed |
| PEX5 regulates autophagy via the mTORC1-TFEB axis during starvation. Eun SY, Lee JN, Nam IK, Liu ZQ, So HS, Choe SK, Park R. Exp Mol Med. 2018 Apr 6;50(4):4. doi: 10.1038/s12276-017-0007-8. PubMed |
| Interleukin-like EMT inducer (ILEI) promotes melanoma invasiveness and is transcriptionally up-regulated by upstream stimulatory factor-1 (USF-1). Noguchi K, Dincman TA, Dalton AC, Howley BV, McCall BJ, Mohanty BK, Howe PH. J Biol Chem. 2018 Jul 20;293(29):11401-11414. doi: 10.1074/jbc.RA118.003616. Epub 2018 Jun 5. PubMed |
| MTMR4, a phosphoinositide-specific 3'-phosphatase, regulates TFEB activity and the endocytic and autophagic pathways. Pham HQ, Yoshioka K, Mohri H, Nakata H, Aki S, Ishimaru K, Takuwa N, Takuwa Y. Genes Cells. 2018 Jul 2. doi: 10.1111/gtc.12609. PubMed |
| Glutamine-dependent lysosome homeostatic changes induced by starvation and lysosome inhibition. Wilden AR, Molina JA, Feuerborn M, Boyle D, Lee SY. Biochim Biophys Acta Mol Cell Res. 2018 Sep;1865(9):1356-1367. doi: 10.1016/j.bbamcr.2018.06.014. Epub 2018 Jun 30. PubMed |
| MITF-MIR211 axis is a novel autophagy amplifier system during cellular stress. Ozturk DG, Kocak M, Akcay A, Kinoglu K, Kara E, Buyuk Y, Kazan H, Gozuacik D. Autophagy. 2019 Mar;15(3):375-390. doi: 10.1080/15548627.2018.1531197. Epub 2018 Oct 16. PubMed |
| Lysosomotropic drugs activate TFEB via lysosomal membrane fluidization and consequent inhibition of mTORC1 activity. Zhitomirsky B, Yunaev A, Kreiserman R, Kaplan A, Stark M, Assaraf YG. Cell Death Dis. 2018 Dec 13;9(12):1191. doi: 10.1038/s41419-018-1227-0. PubMed |
| Type 2 diabetes is associated with suppression of autophagy and lipid accumulation in beta-cells. Ji J, Petropavlovskaia M, Khatchadourian A, Patapas J, Makhlin J, Rosenberg L, Maysinger D. J Cell Mol Med. 2019 Apr;23(4):2890-2900. doi: 10.1111/jcmm.14172. Epub 2019 Feb 1. PubMed |
| SA-49, a novel aloperine derivative, induces MITF-dependent lysosomal degradation of PD-L1. Zhang N, Dou Y, Liu L, Zhang X, Liu X, Zeng Q, Liu Y, Yin M, Liu X, Deng H, Song D. EBioMedicine. 2019 Feb;40:151-162. doi: 10.1016/j.ebiom.2019.01.054. Epub 2019 Jan 31. PubMed |
| Squaramide-based synthetic chloride transporters activate TFEB but block autophagic flux. Zhang S, Wang Y, Xie W, Howe ENW, Busschaert N, Sauvat A, Leduc M, Gomes-da-Silva LC, Chen G, Martins I, Deng X, Maiuri L, Kepp O, Soussi T, Gale PA, Zamzami N, Kroemer G. Cell Death Dis. 2019 Mar 11;10(3):242. doi: 10.1038/s41419-019-1474-8. PubMed |
| Cross-regulation of defective endolysosome trafficking and enhanced autophagy through TFEB in UNC13D deficiency. Zhang J, He J, Johnson JL, Napolitano G, Ramadass M, Rahman F, Catz SD. Autophagy. 2019 Oct;15(10):1738-1756. doi: 10.1080/15548627.2019.1596475. Epub 2019 Apr 5. PubMed |
| Ginseng metabolite Protopanaxadiol induces Sestrin2 expression and AMPK activation through GCN2 and PERK. Jin HR, Du CH, Wang CZ, Yuan CS, Du W. Cell Death Dis. 2019 Apr 5;10(4):311. doi: 10.1038/s41419-019-1548-7. PubMed |
| Ligand-activated progesterone receptor B activates transcription factor EB to promote autophagy in human breast cancer cells. Tan S, Bajalovic N, Wong ESP, Lin VCL. Exp Cell Res. 2019 Sep 1;382(1):111433. doi: 10.1016/j.yexcr.2019.05.014. Epub 2019 May 14. PubMed |
| Nutrient deprivation and lysosomal stress induce activation of TFEB in retinal pigment epithelial cells. Pan HY, Alamri AH, Valapala M. Cell Mol Biol Lett. 2019 May 27;24:33. doi: 10.1186/s11658-019-0159-8. eCollection 2019. PubMed |
| An mTORC1-to-CDK1 Switch Maintains Autophagy Suppression during Mitosis. Odle RI, Walker SA, Oxley D, Kidger AM, Balmanno K, Gilley R, Okkenhaug H, Florey O, Ktistakis NT, Cook SJ. Mol Cell. 2020 Jan 16;77(2):228-240.e7. doi: 10.1016/j.molcel.2019.10.016. Epub 2019 Nov 13. PubMed |
| Regulation of PGC-1alpha expression by a GSK-3beta-TFEB signaling axis in skeletal muscle. Theeuwes WF, Gosker HR, Schols AMWJ, Langen RCJ, Remels AHV. Biochim Biophys Acta Mol Cell Res. 2020 Feb;1867(2):118610. doi: 10.1016/j.bbamcr.2019.118610. Epub 2019 Nov 16. PubMed |
| Restriction of intracellular Salmonella replication by restoring TFEB-mediated xenophagy. Ammanathan V, Mishra P, Chavalmane AK, Muthusamy S, Jadhav V, Siddamadappa C, Manjithaya R. Autophagy. 2019 Nov 19:1-14. doi: 10.1080/15548627.2019.1689770. PubMed |
| Mechanism of conditional partner selectivity in MITF/TFE family transcription factors with a conserved coiled coil stammer motif. Pogenberg V, Ballesteros-Alvarez J, Schober R, Sigvaldadottir I, Obarska-Kosinska A, Milewski M, Schindl R, Ogmundsdottir MH, Steingrimsson E, Wilmanns M. Nucleic Acids Res. 2020 Jan 24;48(2):934-948. doi: 10.1093/nar/gkz1104. PubMed |
| Isorhamnetin, a 3'-methoxylated flavonol, enhances the lysosomal proteolysis in J774.1 murine macrophages in a TFEB-independent manner. Sakai M, Ohnishi K, Masuda M, Ohminami H, Yamanaka-Okumura H, Hara T, Taketani Y. Biosci Biotechnol Biochem. 2020 Jun;84(6):1221-1231. doi: 10.1080/09168451.2020.1727309. Epub 2020 Feb 12. PubMed |
| Optical induction of autophagy via Transcription factor EB (TFEB) reduces pathological tau in neurons. Binder JL, Chander P, Deretic V, Weick JP, Bhaskar K. PLoS One. 2020 Mar 24;15(3):e0230026. doi: 10.1371/journal.pone.0230026. eCollection 2020. PubMed |
| Blue light-emitting diode irradiation promotes transcription factor EB-mediated lysosome biogenesis and lysosomal cell death in murine photoreceptor-derived cells. Otsu W, Ishida K, Nakamura S, Shimazawa M, Tsusaki H, Hara H. Biochem Biophys Res Commun. 2020 May 28;526(2):479-484. doi: 10.1016/j.bbrc.2020.03.118. Epub 2020 Mar 28. PubMed |
| Mycobacterium tuberculosis (Mtb) lipid mediated lysosomal rewiring in infected macrophages modulates intracellular Mtb trafficking and survival. Sachdeva K, Goel M, Sudhakar M, Mehta M, Raju R, Raman K, Singh A, Sundaramurthy V. J Biol Chem. 2020 Jul 3;295(27):9192-9210. doi: 10.1074/jbc.RA120.012809. Epub 2020 May 18. PubMed |
| Poly (ADP-ribose) polymerase 1 inhibition prevents neurodegeneration and promotes alpha-synuclein degradation via transcription factor EB-dependent autophagy in mutant alpha-synucleinA53T model of Parkinson's disease. Mao K, Chen J, Yu H, Li H, Ren Y, Wu X, Wen Y, Zou F, Li W. Aging Cell. 2020 Jun;19(6):e13163. doi: 10.1111/acel.13163. Epub 2020 May 31. PubMed |
| Sulforaphane Inhibits Autophagy and Induces Exosome-Mediated Paracrine Senescence via Regulating mTOR/TFE3. Zheng K, Ma J, Wang Y, He Z, Deng K. Mol Nutr Food Res. 2020 Jul;64(14):e1901231. doi: 10.1002/mnfr.201901231. Epub 2020 Jun 10. PubMed |
| Dual Targeting of BRAF and mTOR Signaling in Melanoma Cells with Pyridinyl Imidazole Compounds. Palusova V, Renzova T, Verlande A, Vaclova T, Medkova M, Cetlova L, Sedlackova M, Hribkova H, Slaninova I, Kruta M, Rotrekl V, Uhlirova H, Krizova A, Chmelik R, Vesely P, Krafcikova M, Trantirek L, Schink KO, Uldrijan S. Cancers (Basel). 2020 Jun 10;12(6). pii: cancers12061516. doi: 10.3390/cancers12061516. PubMed |
| MITF and TFEB cross-regulation in melanoma cells. Ballesteros-Alvarez J, Dilshat R, Fock V, Moller K, Karl L, Larue L, Ogmundsdottir MH, Steingrimsson E. PLoS One. 2020 Sep 3;15(9):e0238546. doi: 10.1371/journal.pone.0238546. eCollection 2020. PubMed |
| Differential Sensitivity of Wild-Type and BRAF-Mutated Cells to Combined BRAF and Autophagy Inhibition. Yeom H, Hwang SH, Han BI, Lee M. Biomol Ther (Seoul). 2021 Jul 1;29(4):434-444. doi: 10.4062/biomolther.2020.203. PubMed |
| Macrophage SR-BI modulates autophagy via VPS34 complex and PPARalpha transcription of Tfeb in atherosclerosis. Tao H, Yancey PG, Blakemore JL, Zhang Y, Ding L, Jerome WG, Brown JD, Vickers KC, Linton MF. J Clin Invest. 2021 Apr 1;131(7). pii: 94229. doi: 10.1172/JCI94229. PubMed |
| Coxsackievirus B3 targets TFEB to disrupt lysosomal function. Mohamud Y, Tang H, Xue YC, Liu H, Ng CS, Bahreyni A, Luo H. Autophagy. 2021 Mar 10:1-15. doi: 10.1080/15548627.2021.1896925. PubMed |
| PARsylated transcription factor EB (TFEB) regulates the expression of a subset of Wnt target genes by forming a complex with beta-catenin-TCF/LEF1. Kim S, Song G, Lee T, Kim M, Kim J, Kwon H, Kim J, Jeong W, Lee U, Na C, Kang S, Kim W, Seong JK, Jho EH. Cell Death Differ. 2021 Sep;28(9):2555-2570. doi: 10.1038/s41418-021-00770-7. Epub 2021 Mar 22. PubMed |
| A NOVEL NOX/PHOX-CD38-NAADP-TFEB AXIS IMPORTANT FOR MACROPHAGE ACTIVATION DURING BACTERIAL PHAGOCYTOSIS. Najibi M, Honwad HH, Moreau JA, Becker SM, Irazoqui JE. Autophagy. 2022 Jan;18(1):124-141. doi: 10.1080/15548627.2021.1911548. Epub 2021 Apr 13. PubMed |
| Rapalogs downmodulate intrinsic immunity and promote cell entry of SARS-CoV-2. Shi G, Chiramel AI, Majdoul S, Lai KK, Das S, Beare PA, Andresson T, Best SM, Compton AA. bioRxiv. 2021 Apr 16. doi: 10.1101/2021.04.15.440067. PubMed |
| TSC2 regulates lysosome biogenesis via a non-canonical RAGC and TFEB-dependent mechanism. Alesi N, Akl EW, Khabibullin D, Liu HJ, Nidhiry AS, Garner ER, Filippakis H, Lam HC, Shi W, Viswanathan SR, Morroni M, Ferguson SM, Henske EP. Nat Commun. 2021 Jul 12;12(1):4245. doi: 10.1038/s41467-021-24499-6. PubMed |
| Exendin-4 stimulates autophagy in pancreatic beta-cells via the RAPGEF/EPAC-Ca(2+)-PPP3/calcineurin-TFEB axis. Zummo FP, Krishnanda SI, Georgiou M, O'Harte FP, Parthsarathy V, Cullen KS, Honkanen-Scott M, Shaw JA, Lovat PE, Arden C. Autophagy. 2022 Apr;18(4):799-815. doi: 10.1080/15548627.2021.1956123. Epub 2021 Aug 2. PubMed |
| TFEB phosphorylation on Serine 211 is induced by autophagy in human synovial fibroblasts and by p62/SQSTM1 overexpression in HEK293 cells. Relic B, Deroyer C, Malaise O, Plener Z, Gillet P, de Seny D, Malaise MG. Biochem J. 2021 Aug 27;478(16):3145-3155. doi: 10.1042/BCJ20210174. PubMed |
| Tubeimoside-1 induces TFEB-dependent lysosomal degradation of PD-L1 and promotes antitumor immunity by targeting mTOR. Liu X, Yin M, Dong J, Mao G, Min W, Kuang Z, Yang P, Liu L, Zhang N, Deng H. Acta Pharm Sin B. 2021 Oct;11(10):3134-3149. doi: 10.1016/j.apsb.2021.03.039. Epub 2021 Apr 1. PubMed |
| Translation Inhibitors Activate Autophagy Master Regulators TFEB and TFE3. Dang TT, Back SH. Int J Mol Sci. 2021 Nov 8;22(21). pii: ijms222112083. doi: 10.3390/ijms222112083. PubMed |
| Increase in the sensitivity to PLX4720 through inhibition of transcription factor EB-dependent autophagy in BRAF inhibitor-resistant cells. Yeom H, Hwang SH, Kim HG, Lee M. Toxicol Res. 2021 Oct 11;38(1):35-44. doi: 10.1007/s43188-021-00109-x. eCollection 2022 Jan. PubMed |
| Ceria-Zirconia nanoparticles reduce intracellular globotriaosylceramide accumulation and attenuate kidney injury by enhancing the autophagy flux in cellular and animal models of Fabry disease. An JH, Hong SE, Yu SL, Kang J, Park CG, Lee HY, Lee SK, Lee DC, Park HW, Hwang WM, Yun SR, Park Y, Park MH, Yoon KR, Yoon SH. J Nanobiotechnology. 2022 Mar 9;20(1):125. doi: 10.1186/s12951-022-01318-8. PubMed |
| Lysosomal ATP Transporter SLC17A9 Controls Cell Viability via Regulating Cathepsin D. Huang P, Cao Q, Xu M, Dong XP. Cells. 2022 Mar 4;11(5). pii: cells11050887. doi: 10.3390/cells11050887. PubMed |
| Autophagy Alteration in ApoA-I Related Systemic Amyloidosis. Del Giudice R, Imbimbo P, Pietrocola F, Martins I, De Palma FDE, Bravo-San Pedro JM, Kroemer G, Maiuri MC, Monti DM. Int J Mol Sci. 2022 Mar 23;23(7). pii: ijms23073498. doi: 10.3390/ijms23073498. PubMed |
| Pathogenic variants of Valosin-containing protein induce lysosomal damage and transcriptional activation of autophagy regulators in neuronal cells. Ferrari V, Cristofani R, Cicardi ME, Tedesco B, Crippa V, Chierichetti M, Casarotto E, Cozzi M, Mina F, Galbiati M, Piccolella M, Carra S, Vaccari T, Nalbandian A, Kimonis V, Fortuna TR, Pandey UB, Gagliani MC, Cortese K, Rusmini P, Poletti A. Neuropathol Appl Neurobiol. 2022 Aug;48(5):e12818. doi: 10.1111/nan.12818. Epub 2022 May 15. PubMed |
| Inhibition of lipid kinase PIKfyve reveals a role for phosphatase Inpp4b in the regulation of PI(3)P-mediated lysosome dynamics through VPS34 activity. Saffi GT, Wang CA, Mangialardi EM, Vacher J, Botelho RJ, Salmena L. J Biol Chem. 2022 Aug;298(8):102187. doi: 10.1016/j.jbc.2022.102187. Epub 2022 Jun 26. PubMed |
| VEGF-Mediated Augmentation of Autophagic and Lysosomal Activity in Endothelial Cells Defends against Intracellular Streptococcus pyogenes. Lu SL, Omori H, Zhou Y, Lin YS, Liu CC, Wu JJ, Noda T. mBio. 2022 Aug 30;13(4):e0123322. doi: 10.1128/mbio.01233-22. Epub 2022 Jul 5. PubMed |
| Transcription factor EB regulates phosphatidylinositol-3-phosphate levels that control lysosome positioning in the bladder cancer model. Mathur P, De Barros Santos C, Lachuer H, Patat J, Latge B, Radvanyi F, Goud B, Schauer K. Commun Biol. 2023 Jan 28;6(1):114. doi: 10.1038/s42003-023-04501-1. PubMed |
| Induction of lysosomal and mitochondrial biogenesis by AMPK phosphorylation of FNIP1. Malik N, Ferreira BI, Hollstein PE, Curtis SD, Trefts E, Weiser Novak S, Yu J, Gilson R, Hellberg K, Fang L, Sheridan A, Hah N, Shadel GS, Manor U, Shaw RJ. Science. 2023 Apr 21;380(6642):eabj5559. doi: 10.1126/science.abj5559. Epub 2023 Apr 21. PubMed |
| Regulation of self-renewal in ovarian cancer stem cells by fructose via chaperone-mediated autophagy. Sohn EJ, Kim JH, Oh SO, Kim JY. Biochim Biophys Acta Mol Basis Dis. 2023 Aug;1869(6):166723. doi: 10.1016/j.bbadis.2023.166723. Epub 2023 Apr 21. PubMed |
| TFEB drives mTORC1 hyperactivation and kidney disease in Tuberous Sclerosis Complex. Alesi N, Khabibullin D, Rosenthal DM, Akl EW, Cory PM, Alchoueiry M, Salem S, Daou M, Gibbons WF, Chen JA, Zhang L, Filippakis H, Graciotti L, Miceli C, Monfregola J, Vilardo C, Morroni M, Di Malta C, Napolitano G, Ballabio A, Henske EP. Nat Commun. 2024 Jan 9;15(1):406. doi: 10.1038/s41467-023-44229-4. PubMed |
| Tamoxifen Activates Transcription Factor EB and Triggers Protective Autophagy in Breast Cancer Cells by Inducing Lysosomal Calcium Release: A Gateway to the Onset of Endocrine Resistance. Boretto C, Actis C, Faris P, Cordero F, Beccuti M, Ferrero G, Muzio G, Moccia F, Autelli R. Int J Mol Sci. 2023 Dec 29;25(1):458. doi: 10.3390/ijms25010458. PubMed |
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