pcDNA3/Myc-DNMT1 Citations (30)
Originally described in: The histone methyltransferase SETDB1 and the DNA methyltransferase DNMT3A interact directly and localize to promoters silenced in cancer cells.Li H, Rauch T, Chen ZX, Szabo PE, Riggs AD, Pfeifer GP J Biol Chem. 2006 Jul 14;281(28):19489-500. Epub 2006 May 8. PubMed Journal
Articles Citing pcDNA3/Myc-DNMT1
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| Interactome of the negative regulator of nuclear import BRCA1-binding protein 2. Fatima S, Wagstaff KM, Loveland KL, Jans DA. Sci Rep. 2015 Mar 30;5:9459. doi: 10.1038/srep09459. PubMed |
| Targeted disruption of DNMT1, DNMT3A and DNMT3B in human embryonic stem cells. Liao J, Karnik R, Gu H, Ziller MJ, Clement K, Tsankov AM, Akopian V, Gifford CA, Donaghey J, Galonska C, Pop R, Reyon D, Tsai SQ, Mallard W, Joung JK, Rinn JL, Gnirke A, Meissner A. Nat Genet. 2015 May;47(5):469-78. doi: 10.1038/ng.3258. Epub 2015 Mar 30. PubMed |
| Design and synthesis of N-benzoyl amino acid derivatives as DNA methylation inhibitors. Garella D, Atlante S, Borretto E, Cocco M, Giorgis M, Costale A, Stevanato L, Miglio G, Cencioni C, Fernandez-de Gortari E, Medina-Franco JL, Spallotta F, Gaetano C, Bertinaria M. Chem Biol Drug Des. 2016 May 26. doi: 10.1111/cbdd.12794. PubMed |
| GAD1 Upregulation Programs Aggressive Features of Cancer Cell Metabolism in the Brain Metastatic Microenvironment. Schnepp PM, Lee DD, Guldner IH, O'Tighearnaigh TK, Howe EN, Palakurthi B, Eckert KE, Toni TA, Ashfeld BL, Zhang S. Cancer Res. 2017 Jun 1;77(11):2844-2856. doi: 10.1158/0008-5472.CAN-16-2289. Epub 2017 Apr 11. PubMed |
| CDK4/6 inhibition triggers anti-tumour immunity. Goel S, DeCristo MJ, Watt AC, BrinJones H, Sceneay J, Li BB, Khan N, Ubellacker JM, Xie S, Metzger-Filho O, Hoog J, Ellis MJ, Ma CX, Ramm S, Krop IE, Winer EP, Roberts TM, Kim HJ, McAllister SS, Zhao JJ. Nature. 2017 Aug 24;548(7668):471-475. doi: 10.1038/nature23465. Epub 2017 Aug 16. PubMed |
| 3,6-Dihydroxyflavone regulates microRNA-34a through DNA methylation. Peng X, Chang H, Chen J, Zhang Q, Yu X, Mi M. BMC Cancer. 2017 Sep 5;17(1):619. doi: 10.1186/s12885-017-3638-1. PubMed |
| Matrix stiffness determines the phenotype of vascular smooth muscle cell in vitro and in vivo: Role of DNA methyltransferase 1. Xie SA, Zhang T, Wang J, Zhao F, Zhang YP, Yao WJ, Hur SS, Yeh YT, Pang W, Zheng LS, Fan YB, Kong W, Wang X, Chiu JJ, Zhou J. Biomaterials. 2018 Feb;155:203-216. doi: 10.1016/j.biomaterials.2017.11.033. Epub 2017 Nov 21. PubMed |
| The epithelial-to-mesenchymal transition activator ZEB1 initiates a prometastatic competing endogenous RNA network. Tan X, Banerjee P, Liu X, Yu J, Gibbons DL, Wu P, Scott KL, Diao L, Zheng X, Wang J, Jalali A, Suraokar M, Fujimoto J, Behrens C, Liu X, Liu CG, Creighton CJ, Wistuba II, Kurie JM. J Clin Invest. 2018 Apr 2;128(4):1267-1282. doi: 10.1172/JCI97225. Epub 2018 Feb 26. PubMed |
| miR-148a suppresses cell invasion and migration in gastric cancer by targeting DNA methyltransferase 1. Shi H, Chen X, Jiang H, Wang X, Yu H, Sun P, Sui X. Oncol Lett. 2018 Apr;15(4):4944-4950. doi: 10.3892/ol.2018.7907. Epub 2018 Jan 31. PubMed |
Genome-wide determination of on-target and off-target characteristics for RNA-guided DNA methylation by dCas9 methyltransferases.
Lin L, Liu Y, Xu F, Huang J, Daugaard TF, Petersen TS, Hansen B, Ye L, Zhou Q, Fang F, Yang L, Li S, Floe L, Jensen KT, Shrock E, Chen F, Yang H, Wang J, Liu X, Xu X, Bolund L, Nielsen AL, Luo Y.
Gigascience. 2018 Mar 1;7(3):1-19. doi: 10.1093/gigascience/giy011.
PubMed
Associated Plasmids |
| The Curcumin Analog CH-5 Exerts Anticancer Effects in Human Osteosarcoma Cells via Modulation of Transcription Factors p53/Sp1. Lima FT, Seba V, Silva G, Torrezan GS, Polaquini CR, Pinhanelli VC, Baek SJ, Fachin AL, Regasini LO, Marins M. Int J Mol Sci. 2018 Jun 29;19(7). pii: ijms19071909. doi: 10.3390/ijms19071909. PubMed |
| Epigenetic targeting DNMT1 of pancreatic ductal adenocarcinoma using interstitial control release biodegrading polymer reduced tumor growth through hedgehog pathway inhibition. Huang MH, Chou YW, Li MH, Shih TE, Lin SZ, Chuang HM, Chiou TW, Su HL, Harn HJ. Pharmacol Res. 2019 Jan;139:50-61. doi: 10.1016/j.phrs.2018.10.015. Epub 2018 Oct 29. PubMed |
| Metastasis-related methyltransferase 1 (Merm1) represses the methyltransferase activity of Dnmt3a and facilitates RNA polymerase I transcriptional elongation. Lyu G, Zong L, Zhang C, Huang X, Xie W, Fang J, Guan Y, Zhang L, Ni T, Gu J, Tao W. J Mol Cell Biol. 2019 Jan 1;11(1):78-90. doi: 10.1093/jmcb/mjy023. PubMed |
| Neurog3-Independent Methylation Is the Earliest Detectable Mark Distinguishing Pancreatic Progenitor Identity. Liu J, Banerjee A, Herring CA, Attalla J, Hu R, Xu Y, Shao Q, Simmons AJ, Dadi PK, Wang S, Jacobson DA, Liu B, Hodges E, Lau KS, Gu G. Dev Cell. 2019 Jan 7;48(1):49-63.e7. doi: 10.1016/j.devcel.2018.11.048. PubMed |
| DNA methyltransferase 1 and Kruppel-like factor 4 axis regulates macrophage inflammation and atherosclerosis. Tang RZ, Zhu JJ, Yang FF, Zhang YP, Xie SA, Liu YF, Yao WJ, Pang W, Han LL, Kong W, Wang YX, Zhang T, Zhou J. J Mol Cell Cardiol. 2019 Mar;128:11-24. doi: 10.1016/j.yjmcc.2019.01.009. Epub 2019 Jan 16. PubMed |
| Hypermethylation of mitochondrial DNA in vascular smooth muscle cells impairs cell contractility. Liu YF, Zhu JJ, Yu Tian X, Liu H, Zhang T, Zhang YP, Xie SA, Zheng M, Kong W, Yao WJ, Pang W, Zhao CR, Tang YJ, Zhou J. Cell Death Dis. 2020 Jan 20;11(1):35. doi: 10.1038/s41419-020-2240-7. PubMed |
| Epigenetic engineering of yeast reveals dynamic molecular adaptation to methylation stress and genetic modulators of specific DNMT3 family members. Finnegan AI, Kim S, Jin H, Gapinske M, Woods WS, Perez-Pinera P, Song JS. Nucleic Acids Res. 2020 May 7;48(8):4081-4099. doi: 10.1093/nar/gkaa161. PubMed |
| Hypermethylation of Hepatic Mitochondrial ND6 Provokes Systemic Insulin Resistance. Cao K, Lv W, Wang X, Dong S, Liu X, Yang T, Xu J, Zeng M, Zou X, Zhao D, Ma Q, Lin M, Long J, Zang W, Gao F, Feng Z, Liu J. Adv Sci (Weinh). 2021 May 2;8(11):2004507. doi: 10.1002/advs.202004507. eCollection 2021 Jun. PubMed |
| TXNIP, a novel key factor to cause Schwann cell dysfunction in diabetic peripheral neuropathy, under the regulation of PI3K/Akt pathway inhibition-induced DNMT1 and DNMT3a overexpression. Zhang X, Zhao S, Yuan Q, Zhu L, Li F, Wang H, Kong D, Hao J. Cell Death Dis. 2021 Jun 23;12(7):642. doi: 10.1038/s41419-021-03930-2. PubMed |
| Kaiso Regulates DNA Methylation Homeostasis. Kaplun D, Starshin A, Sharko F, Gainova K, Filonova G, Zhigalova N, Mazur A, Prokhortchouk E, Zhenilo S. Int J Mol Sci. 2021 Jul 15;22(14). pii: ijms22147587. doi: 10.3390/ijms22147587. PubMed |
| Gene body methylation safeguards ribosomal DNA transcription by preventing PHF6-mediated enrichment of repressive histone mark H4K20me3. Huang X, Zhang X, Zong L, Gao Q, Zhang C, Wei R, Guan Y, Huang L, Zhang L, Lyu G, Tao W. J Biol Chem. 2021 Oct;297(4):101195. doi: 10.1016/j.jbc.2021.101195. Epub 2021 Sep 11. PubMed |
| Matrix stiffness exacerbates the proinflammatory responses of vascular smooth muscle cell through the DDR1-DNMT1 mechanotransduction axis. Wang J, Xie SA, Li N, Zhang T, Yao W, Zhao H, Pang W, Han L, Liu J, Zhou J. Bioact Mater. 2022 Jan 14;17:406-424. doi: 10.1016/j.bioactmat.2022.01.012. eCollection 2022 Nov. PubMed |
| Re-Expression of ERalpha and AR in Receptor Negative Endocrine Cancers via GSK3 Inhibition. Sharma V, Joshi J, Yeh IJ, Doughman Y, Blankenberg D, Wald D, Montano MM. Front Oncol. 2022 Mar 24;12:824594. doi: 10.3389/fonc.2022.824594. eCollection 2022. PubMed |
| NOS2 and S-nitrosothiol signaling induces DNA hypomethylation and LINE-1 retrotransposon expression. Switzer CH, Cho HJ, Eykyn TR, Lavender P, Eaton P. Proc Natl Acad Sci U S A. 2022 May 24;119(21):e2200022119. doi: 10.1073/pnas.2200022119. Epub 2022 May 18. PubMed |
| Geometric Constraints Regulate Energy Metabolism and Cellular Contractility in Vascular Smooth Muscle Cells by Coordinating Mitochondrial DNA Methylation. Liu H, Liu Y, Wang H, Zhao Q, Zhang T, Xie SA, Liu Y, Tang Y, Peng Q, Pang W, Yao W, Zhou J. Adv Sci (Weinh). 2022 Nov;9(32):e2203995. doi: 10.1002/advs.202203995. Epub 2022 Sep 14. PubMed |
| Pivotal role for S-nitrosylation of DNA methyltransferase 3B in epigenetic regulation of tumorigenesis. Okuda K, Nakahara K, Ito A, Iijima Y, Nomura R, Kumar A, Fujikawa K, Adachi K, Shimada Y, Fujio S, Yamamoto R, Takasugi N, Onuma K, Osaki M, Okada F, Ukegawa T, Takeuchi Y, Yasui N, Yamashita A, Marusawa H, Matsushita Y, Katagiri T, Shibata T, Uchida K, Niu SY, Lang NB, Nakamura T, Zhang KYJ, Lipton SA, Uehara T. Nat Commun. 2023 Feb 4;14(1):621. doi: 10.1038/s41467-023-36232-6. PubMed |
| Inhibition of DNMT1 methyltransferase activity via glucose-regulated O-GlcNAcylation alters the epigenome. Shin H, Leung A, Costello KR, Senapati P, Kato H, Moore RE, Lee M, Lin D, Tang X, Pirrotte P, Bouman Chen Z, Schones DE. Elife. 2023 Jul 20;12:e85595. doi: 10.7554/eLife.85595. PubMed |
| Targeting DNA methylation and B7-H3 in RB1-deficient and neuroendocrine prostate cancer. Yamada Y, Venkadakrishnan VB, Mizuno K, Bakht M, Ku SY, Garcia MM, Beltran H. Sci Transl Med. 2023 Nov 15;15(722):eadf6732. doi: 10.1126/scitranslmed.adf6732. Epub 2023 Nov 15. PubMed |
| Stroke Causes DNA Methylation at Ncx1 Heart Promoter in the Brain Via DNMT1/MeCP2/REST Epigenetic Complex. Guida N, Serani A, Sanguigno L, Mascolo L, Cuomo O, Fioriniello S, Marano D, Ragione FD, Anzilotti S, Brancaccio P, Molinaro P, Pignataro G, Annunziato L, Formisano L. J Am Heart Assoc. 2024 Mar 19;13(6):e030460. doi: 10.1161/JAHA.123.030460. Epub 2024 Mar 8. PubMed |
| Targeting DNMT3A-mediated oxidative phosphorylation to overcome ibrutinib resistance in mantle cell lymphoma. Hoang NM, Liu Y, Bates PD, Heaton AR, Lopez AF, Liu P, Zhu F, Chen R, Kondapelli A, Zhang X, Selberg PE, Ngo VN, Skala MC, Capitini CM, Rui L. Cell Rep Med. 2024 Apr 16;5(4):101484. doi: 10.1016/j.xcrm.2024.101484. Epub 2024 Mar 29. PubMed |
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