8xGTIIC-luciferase Citations (189)
Originally described in: Role of YAP/TAZ in mechanotransduction.Dupont S, Morsut L, Aragona M, Enzo E, Giulitti S, Cordenonsi M, Zanconato F, Le Digabel J, Forcato M, Bicciato S, Elvassore N, Piccolo S Nature. 2011 Jun 8;474(7350):179-83. doi: 10.1038/nature10137. PubMed Journal
Articles Citing 8xGTIIC-luciferase
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| A mechanical checkpoint controls multicellular growth through YAP/TAZ regulation by actin-processing factors. Aragona M, Panciera T, Manfrin A, Giulitti S, Michielin F, Elvassore N, Dupont S, Piccolo S. Cell. 2013 Aug 29;154(5):1047-59. doi: 10.1016/j.cell.2013.07.042. Epub 2013 Aug 15. PubMed |
| Angiomotins link F-actin architecture to Hippo pathway signaling. Mana-Capelli S, Paramasivam M, Dutta S, McCollum D. Mol Biol Cell. 2014 May;25(10):1676-85. doi: 10.1091/mbc.E13-11-0701. Epub 2014 Mar 19. PubMed |
| Evolutionary and molecular facts link the WWC protein family to Hippo signaling. Wennmann DO, Schmitz J, Wehr MC, Krahn MP, Koschmal N, Gromnitza S, Schulze U, Weide T, Chekuri A, Skryabin BV, Gerke V, Pavenstadt H, Duning K, Kremerskothen J. Mol Biol Evol. 2014 Jul;31(7):1710-23. doi: 10.1093/molbev/msu115. Epub 2014 Mar 27. PubMed |
| Alpha-tubulin K40 acetylation is required for contact inhibition of proliferation and cell-substrate adhesion. Aguilar A, Becker L, Tedeschi T, Heller S, Iomini C, Nachury MV. Mol Biol Cell. 2014 Jun 15;25(12):1854-66. doi: 10.1091/mbc.E13-10-0609. Epub 2014 Apr 17. PubMed |
| Pax3 and hippo signaling coordinate melanocyte gene expression in neural crest. Manderfield LJ, Engleka KA, Aghajanian H, Gupta M, Yang S, Li L, Baggs JE, Hogenesch JB, Olson EN, Epstein JA. Cell Rep. 2014 Dec 11;9(5):1885-95. doi: 10.1016/j.celrep.2014.10.061. Epub 2014 Nov 26. PubMed |
| Aerobic glycolysis tunes YAP/TAZ transcriptional activity. Enzo E, Santinon G, Pocaterra A, Aragona M, Bresolin S, Forcato M, Grifoni D, Pession A, Zanconato F, Guzzo G, Bicciato S, Dupont S. EMBO J. 2015 May 12;34(10):1349-70. doi: 10.15252/embj.201490379. Epub 2015 Mar 21. PubMed |
| Actin remodelling factors control ciliogenesis by regulating YAP/TAZ activity and vesicle trafficking. Kim J, Jo H, Hong H, Kim MH, Kim JM, Lee JK, Heo WD, Kim J. Nat Commun. 2015 Apr 7;6:6781. doi: 10.1038/ncomms7781. PubMed |
| NOS1AP Functionally Associates with YAP To Regulate Hippo Signaling. Clattenburg L, Wigerius M, Qi J, Rainey JK, Rourke JL, Muruganandan S, Sinal CJ, Fawcett JP. Mol Cell Biol. 2015 Jul 1;35(13):2265-77. doi: 10.1128/MCB.00062-15. Epub 2015 Apr 27. PubMed |
| Yes-associated protein regulates endothelial cell contact-mediated expression of angiopoietin-2. Choi HJ, Zhang H, Park H, Choi KS, Lee HW, Agrawal V, Kim YM, Kwon YG. Nat Commun. 2015 May 12;6:6943. doi: 10.1038/ncomms7943. PubMed |
| beta-Catenin destruction complex-independent regulation of Hippo-YAP signaling by APC in intestinal tumorigenesis. Cai J, Maitra A, Anders RA, Taketo MM, Pan D. Genes Dev. 2015 Jul 15;29(14):1493-506. doi: 10.1101/gad.264515.115. Epub 2015 Jul 20. PubMed |
| Small molecules inhibiting the nuclear localization of YAP/TAZ for chemotherapeutics and chemosensitizers against breast cancers. Oku Y, Nishiya N, Shito T, Yamamoto R, Yamamoto Y, Oyama C, Uehara Y. FEBS Open Bio. 2015 Jun 22;5:542-9. doi: 10.1016/j.fob.2015.06.007. eCollection 2015. PubMed |
| CDK1 phosphorylation of TAZ in mitosis inhibits its oncogenic activity. Zhang L, Chen X, Stauffer S, Yang S, Chen Y, Dong J. Oncotarget. 2015 Oct 13;6(31):31399-412. doi: 10.18632/oncotarget.5189. PubMed |
| Active YAP promotes pancreatic cancer cell motility, invasion and tumorigenesis in a mitotic phosphorylation-dependent manner through LPAR3. Yang S, Zhang L, Purohit V, Shukla SK, Chen X, Yu F, Fu K, Chen Y, Solheim J, Singh PK, Song W, Dong J. Oncotarget. 2015 Nov 3;6(34):36019-31. doi: 10.18632/oncotarget.5935. PubMed |
| Sclerostin Enhances Adipocyte Differentiation in 3T3-L1 Cells. Ukita M, Yamaguchi T, Ohata N, Tamura M. J Cell Biochem. 2015 Nov 10. doi: 10.1002/jcb.25432. PubMed |
| The Hippo pathway mediates inhibition of vascular smooth muscle cell proliferation by cAMP. Kimura TE, Duggirala A, Smith MC, White S, Sala-Newby GB, Newby AC, Bond M. J Mol Cell Cardiol. 2016 Jan;90:1-10. doi: 10.1016/j.yjmcc.2015.11.024. Epub 2015 Nov 25. PubMed |
| Actin remodeling confers BRAF inhibitor resistance to melanoma cells through YAP/TAZ activation. Kim MH, Kim J, Hong H, Lee SH, Lee JK, Jung E, Kim J. EMBO J. 2016 Mar 1;35(5):462-78. doi: 10.15252/embj.201592081. Epub 2015 Dec 14. PubMed |
| Human pluripotent stem cell culture density modulates YAP signaling. Hsiao C, Lampe M, Nillasithanukroh S, Han W, Lian X, Palecek SP. Biotechnol J. 2016 Jan 14. doi: 10.1002/biot.201500374. PubMed |
| The characterisation of LATS2 kinase regulation in Hippo-YAP signalling. Hoa L, Kulaberoglu Y, Gundogdu R, Cook D, Mavis M, Gomez M, Gomez V, Hergovich A. Cell Signal. 2016 May;28(5):488-97. doi: 10.1016/j.cellsig.2016.02.012. Epub 2016 Feb 18. PubMed |
| RAC-LATS1/2 signaling regulates YAP activity by switching between the YAP-binding partners TEAD4 and RUNX3. Jang JW, Kim MK, Lee YS, Lee JW, Kim DM, Song SH, Lee JY, Choi BY, Min B, Chi XZ, Bae SC. Oncogene. 2016 Jul 18. doi: 10.1038/onc.2016.266. PubMed |
| IQGAP1 Binds to Yes-associated Protein (YAP) and Modulates Its Transcriptional Activity. Sayedyahossein S, Li Z, Hedman AC, Morgan CJ, Sacks DB. J Biol Chem. 2016 Sep 9;291(37):19261-73. doi: 10.1074/jbc.M116.732529. Epub 2016 Jul 20. PubMed |
| Regulation of cellular quiescence by YAP/TAZ and Cyclin E1 in colon cancer cells: Implication in chemoresistance and cancer relapse. Corvaisier M, Bauzone M, Corfiotti F, Renaud F, El Amrani M, Monte D, Truant S, Leteurtre E, Formstecher P, Van Seuningen I, Gespach C, Huet G. Oncotarget. 2016 Aug 30;7(35):56699-56712. doi: 10.18632/oncotarget.11057. PubMed |
| p66Shc couples mechanical signals to RhoA through FAK-dependent recruitment of p115-RhoGEF and GEF-H1. Wu RF, Liao C, Fu G, Hayenga HN, Yang K, Ma Z, Liu Z, Terada LS. Mol Cell Biol. 2016 Aug 29. pii: MCB.00194-16. PubMed |
| BET bromodomain is a novel regulator of TAZ and its activity. Duan Q, Xiao Y, Zhu L, Liu Z, Mao X, Zhou Z, Liao C, Cai J, Huang F, Liu Z, Zeng J, Xia K, Chang C, Qi J, Chen Z, Huang H, Yang T. Biochim Biophys Acta. 2016 Dec;1859(12):1527-1537. doi: 10.1016/j.bbagrm.2016.10.001. Epub 2016 Oct 4. PubMed |
| A feed-forward loop between lncARSR and YAP activity promotes expansion of renal tumour-initiating cells. Qu L, Wu Z, Li Y, Xu Z, Liu B, Liu F, Bao Y, Wu D, Liu J, Wang A, Chu X, Sun Y, Chen C, Zhang Z, Wang L. Nat Commun. 2016 Nov 25;7:12692. doi: 10.1038/ncomms12692. PubMed |
| Inactivation of ABL kinases suppresses non-small cell lung cancer metastasis. Gu JJ, Rouse C, Xu X, Wang J, Onaitis MW, Pendergast AM. JCI Insight. 2016 Dec 22;1(21):e89647. doi: 10.1172/jci.insight.89647. PubMed |
| DUB3 Deubiquitylating Enzymes Regulate Hippo Pathway Activity by Regulating the Stability of ITCH, LATS and AMOT Proteins. Nguyen HT, Kugler JM, Cohen SM. PLoS One. 2017 Jan 6;12(1):e0169587. doi: 10.1371/journal.pone.0169587. eCollection 2017. PubMed |
| Systematic morphological profiling of human gene and allele function via Cell Painting. Rohban MH, Singh S, Wu X, Berthet JB, Bray MA, Shrestha Y, Varelas X, Boehm JS, Carpenter AE. Elife. 2017 Mar 18;6. pii: e24060. doi: 10.7554/eLife.24060. PubMed |
| A genome-wide screen identifies YAP/WBP2 interplay conferring growth advantage on human epidermal stem cells. Walko G, Woodhouse S, Pisco AO, Rognoni E, Liakath-Ali K, Lichtenberger BM, Mishra A, Telerman SB, Viswanathan P, Logtenberg M, Renz LM, Donati G, Quist SR, Watt FM. Nat Commun. 2017 Mar 23;8:14744. doi: 10.1038/ncomms14744. PubMed |
| YAP regulates cell mechanics by controlling focal adhesion assembly. Nardone G, Oliver-De La Cruz J, Vrbsky J, Martini C, Pribyl J, Skladal P, Pesl M, Caluori G, Pagliari S, Martino F, Maceckova Z, Hajduch M, Sanz-Garcia A, Pugno NM, Stokin GB, Forte G. Nat Commun. 2017 May 15;8:15321. doi: 10.1038/ncomms15321. PubMed |
| YAP/TAZ link cell mechanics to Notch signalling to control epidermal stem cell fate. Totaro A, Castellan M, Battilana G, Zanconato F, Azzolin L, Giulitti S, Cordenonsi M, Piccolo S. Nat Commun. 2017 May 17;8:15206. doi: 10.1038/ncomms15206. PubMed |
| Role of TAZ in Lysophosphatidic Acid-Induced Migration and Proliferation of Human Adipose-Derived Mesenchymal Stem Cells. Mo WM, Kwon YW, Jang IH, Choi EJ, Kwon SM, Kim JH. Biomol Ther (Seoul). 2017 Jul 1;25(4):354-361. doi: 10.4062/biomolther.2016.263. PubMed |
| Tumor cell-derived lactate induces TAZ-dependent upregulation of PD-L1 through GPR81 in human lung cancer cells. Feng J, Yang H, Zhang Y, Wei H, Zhu Z, Zhu B, Yang M, Cao W, Wang L, Wu Z. Oncogene. 2017 Oct 19;36(42):5829-5839. doi: 10.1038/onc.2017.188. Epub 2017 Jun 12. PubMed |
| Arterial stiffness induces remodeling phenotypes in pulmonary artery smooth muscle cells via YAP/TAZ-mediated repression of cyclooxygenase-2. Dieffenbach PB, Haeger CM, Coronata AMF, Choi KM, Varelas X, Tschumperlin DJ, Fredenburgh LE. Am J Physiol Lung Cell Mol Physiol. 2017 Sep 1;313(3):L628-L647. doi: 10.1152/ajplung.00173.2017. Epub 2017 Jun 22. PubMed |
| Panobinostat sensitizes KRAS-mutant non-small-cell lung cancer to gefitinib by targeting TAZ. Lee WY, Chen PC, Wu WS, Wu HC, Lan CH, Huang YH, Cheng CH, Chen KC, Lin CW. Int J Cancer. 2017 Nov 1;141(9):1921-1931. doi: 10.1002/ijc.30888. Epub 2017 Jul 28. PubMed |
| Tankyrase inhibitors suppress hepatocellular carcinoma cell growth via modulating the Hippo cascade. Jia J, Qiao Y, Pilo MG, Cigliano A, Liu X, Shao Z, Calvisi DF, Chen X. PLoS One. 2017 Sep 6;12(9):e0184068. doi: 10.1371/journal.pone.0184068. eCollection 2017. PubMed |
| USP21 regulates Hippo pathway activity by mediating MARK protein turnover. Nguyen HT, Kugler JM, Loya AC, Cohen SM. Oncotarget. 2017 Jul 18;8(38):64095-64105. doi: 10.18632/oncotarget.19322. eCollection 2017 Sep 8. PubMed |
| Mechano-Signal Transduction in Mesenchymal Stem Cells Induces Prosaposin Secretion to Drive the Proliferation of Breast Cancer Cells. Ishihara S, Inman DR, Li WJ, Ponik SM, Keely PJ. Cancer Res. 2017 Nov 15;77(22):6179-6189. doi: 10.1158/0008-5472.CAN-17-0569. Epub 2017 Sep 28. PubMed |
| Endosomal phosphatidylserine is critical for the YAP signalling pathway in proliferating cells. Matsudaira T, Mukai K, Noguchi T, Hasegawa J, Hatta T, Iemura SI, Natsume T, Miyamura N, Nishina H, Nakayama J, Semba K, Tomita T, Murata S, Arai H, Taguchi T. Nat Commun. 2017 Nov 1;8(1):1246. doi: 10.1038/s41467-017-01255-3. PubMed |
| YAP1 is essential for tumor growth and is a potential therapeutic target for EGFR-dependent lung adenocarcinomas. Lee TF, Tseng YC, Chang WC, Chen YC, Kao YR, Chou TY, Ho CC, Wu CW. Oncotarget. 2017 Jul 27;8(52):89539-89551. doi: 10.18632/oncotarget.19647. eCollection 2017 Oct 27. PubMed |
| Mammalian display screening of diverse cystine-dense peptides for difficult to drug targets. Crook ZR, Sevilla GP, Friend D, Brusniak MY, Bandaranayake AD, Clarke M, Gewe M, Mhyre AJ, Baker D, Strong RK, Bradley P, Olson JM. Nat Commun. 2017 Dec 21;8(1):2244. doi: 10.1038/s41467-017-02098-8. PubMed |
| Enhanced YAP expression leads to EGFR TKI resistance in lung adenocarcinomas. Lee TF, Tseng YC, Nguyen PA, Li YC, Ho CC, Wu CW. Sci Rep. 2018 Jan 10;8(1):271. doi: 10.1038/s41598-017-18527-z. PubMed |
| Metformin inhibits glioma cells stemness and epithelial-mesenchymal transition via regulating YAP activity. Yuan X, Wei W, Bao Q, Chen H, Jin P, Jiang W. Biomed Pharmacother. 2018 Jun;102:263-270. doi: 10.1016/j.biopha.2018.03.031. Epub 2018 Mar 22. PubMed |
| Knockdown of HuR represses osteosarcoma cells migration, invasion and stemness through inhibition of YAP activation and increases susceptibility to chemotherapeutic agents. Xu W, Chen C, Xu R, Li Y, Hu R, Li Z, Zhu X. Biomed Pharmacother. 2018 Jun;102:587-593. doi: 10.1016/j.biopha.2018.03.098. Epub 2018 Apr 5. PubMed |
| Toward the Discovery of a Novel Class of YAP(-)TEAD Interaction Inhibitors by Virtual Screening Approach Targeting YAP(-)TEAD Protein(-)Protein Interface. Gibault F, Coevoet M, Sturbaut M, Farce A, Renault N, Allemand F, Guichou JF, Drucbert AS, Foulon C, Magnez R, Thuru X, Corvaisier M, Huet G, Chavatte P, Melnyk P, Bailly F, Cotelle P. Cancers (Basel). 2018 May 8;10(5). pii: cancers10050140. doi: 10.3390/cancers10050140. PubMed |
| miR-550a-3-5p acts as a tumor suppressor and reverses BRAF inhibitor resistance through the direct targeting of YAP. Choe MH, Yoon Y, Kim J, Hwang SG, Han YH, Kim JS. Cell Death Dis. 2018 May 29;9(6):640. doi: 10.1038/s41419-018-0698-3. PubMed |
| Tanshinone IIA inhibits cervix carcinoma stem cells migration and invasion via inhibiting YAP transcriptional activity. Qin J, Shi H, Xu Y, Zhao F, Wang Q. Biomed Pharmacother. 2018 Sep;105:758-765. doi: 10.1016/j.biopha.2018.06.028. Epub 2018 Jun 14. PubMed |
| A tightly controlled Src-YAP signaling axis determines therapeutic response to dasatinib in renal cell carcinoma. Sun J, Wang X, Tang B, Liu H, Zhang M, Wang Y, Ping F, Ding J, Shen A, Geng M. Theranostics. 2018 May 11;8(12):3256-3267. doi: 10.7150/thno.23964. eCollection 2018. PubMed |
| LncRNA THOR attenuates cisplatin sensitivity of nasopharyngeal carcinoma cells via enhancing cells stemness. Gao L, Cheng XL, Cao H. Biochimie. 2018 Sep;152:63-72. doi: 10.1016/j.biochi.2018.06.015. Epub 2018 Jun 26. PubMed |
| Structural Basis for Auto-Inhibition of the NDR1 Kinase Domain by an Atypically Long Activation Segment. Xiong S, Lorenzen K, Couzens AL, Templeton CM, Rajendran D, Mao DYL, Juang YC, Chiovitti D, Kurinov I, Guettler S, Gingras AC, Sicheri F. Structure. 2018 Aug 7;26(8):1101-1115.e6. doi: 10.1016/j.str.2018.05.014. Epub 2018 Jul 5. PubMed |
| Assembly and activation of the Hippo signalome by FAT1 tumor suppressor. Martin D, Degese MS, Vitale-Cross L, Iglesias-Bartolome R, Valera JLC, Wang Z, Feng X, Yeerna H, Vadmal V, Moroishi T, Thorne RF, Zaida M, Siegele B, Cheong SC, Molinolo AA, Samuels Y, Tamayo P, Guan KL, Lippman SM, Lyons JG, Gutkind JS. Nat Commun. 2018 Jul 9;9(1):2372. doi: 10.1038/s41467-018-04590-1. PubMed |
| Contact inhibition controls cell survival and proliferation via YAP/TAZ-autophagy axis. Pavel M, Renna M, Park SJ, Menzies FM, Ricketts T, Fullgrabe J, Ashkenazi A, Frake RA, Lombarte AC, Bento CF, Franze K, Rubinsztein DC. Nat Commun. 2018 Jul 27;9(1):2961. doi: 10.1038/s41467-018-05388-x. PubMed |
| Cirrhotic stiffness affects the migration of hepatocellular carcinoma cells and induces sorafenib resistance through YAP. Gao J, Rong Y, Huang Y, Shi P, Wang X, Meng X, Dong J, Wu C. J Cell Physiol. 2019 Mar;234(3):2639-2648. doi: 10.1002/jcp.27078. Epub 2018 Aug 26. PubMed |
| Transcriptional effects of actin-binding compounds: the cytoplasm sets the tone. Gegenfurtner FA, Zisis T, Al Danaf N, Schrimpf W, Kliesmete Z, Ziegenhain C, Enard W, Kazmaier U, Lamb DC, Vollmar AM, Zahler S. Cell Mol Life Sci. 2018 Dec;75(24):4539-4555. doi: 10.1007/s00018-018-2919-4. Epub 2018 Sep 11. PubMed |
| STARD13 is positively correlated with good prognosis and enhances 5-FU sensitivity via suppressing cancer stemness in hepatocellular carcinoma cells. Gao F, Yu X, Meng R, Wang J, Jia L. Onco Targets Ther. 2018 Aug 31;11:5371-5381. doi: 10.2147/OTT.S170775. eCollection 2018. PubMed |
| Decursin inhibits the growth of HepG2 hepatocellular carcinoma cells via Hippo/YAP signaling pathway. Li J, Wang H, Wang L, Tan R, Zhu M, Zhong X, Zhang Y, Chen B, Wang L. Phytother Res. 2018 Dec;32(12):2456-2465. doi: 10.1002/ptr.6184. Epub 2018 Sep 24. PubMed |
| Myt1 and Myt1l transcription factors limit proliferation in GBM cells by repressing YAP1 expression. Melhuish TA, Kowalczyk I, Manukyan A, Zhang Y, Shah A, Abounader R, Wotton D. Biochim Biophys Acta Gene Regul Mech. 2018 Nov;1861(11):983-995. doi: 10.1016/j.bbagrm.2018.10.005. Epub 2018 Oct 10. PubMed |
| The SCRIB Paralog LANO/LRRC1 Regulates Breast Cancer Stem Cell Fate through WNT/beta-Catenin Signaling. Lopez Almeida L, Sebbagh M, Bertucci F, Finetti P, Wicinski J, Marchetto S, Castellano R, Josselin E, Charafe-Jauffret E, Ginestier C, Borg JP, Santoni MJ. Stem Cell Reports. 2018 Nov 13;11(5):1040-1050. doi: 10.1016/j.stemcr.2018.09.008. Epub 2018 Oct 18. PubMed |
| Analysis of the relationship between the KRAS G12V oncogene and the Hippo effector YAP1 in embryonal rhabdomyosarcoma. Mohamed AD, Shah N, Hettmer S, Vargesson N, Wackerhage H. Sci Rep. 2018 Oct 23;8(1):15674. doi: 10.1038/s41598-018-33852-7. PubMed |
| TNF-alpha-Induced YAP/TAZ Activity Mediates Leukocyte-Endothelial Adhesion by Regulating VCAM1 Expression in Endothelial Cells. Choi HJ, Kim NE, Kim BM, Seo M, Heo JH. Int J Mol Sci. 2018 Nov 1;19(11). pii: ijms19113428. doi: 10.3390/ijms19113428. PubMed |
| Caveolin-1 Modulates Mechanotransduction Responses to Substrate Stiffness through Actin-Dependent Control of YAP. Moreno-Vicente R, Pavon DM, Martin-Padura I, Catala-Montoro M, Diez-Sanchez A, Quilez-Alvarez A, Lopez JA, Sanchez-Alvarez M, Vazquez J, Strippoli R, Del Pozo MA. Cell Rep. 2018 Nov 6;25(6):1622-1635.e6. doi: 10.1016/j.celrep.2018.10.024. PubMed |
| Apigenin suppresses the stem cell-like properties of triple-negative breast cancer cells by inhibiting YAP/TAZ activity. Li YW, Xu J, Zhu GY, Huang ZJ, Lu Y, Li XQ, Wang N, Zhang FX. Cell Death Discov. 2018 Nov 20;4:105. doi: 10.1038/s41420-018-0124-8. eCollection 2018. PubMed |
| Robo signalling controls pancreatic progenitor identity by regulating Tead transcription factors. Escot S, Willnow D, Naumann H, Di Francescantonio S, Spagnoli FM. Nat Commun. 2018 Nov 30;9(1):5082. doi: 10.1038/s41467-018-07474-6. PubMed |
| Luciferase Reporter Assays to Determine YAP/TAZ Activity in Mammalian Cells. Dupont S. Methods Mol Biol. 2019;1893:121-135. doi: 10.1007/978-1-4939-8910-2_11. PubMed |
| Dickkopf-3 links HSF1 and YAP/TAZ signalling to control aggressive behaviours in cancer-associated fibroblasts. Ferrari N, Ranftl R, Chicherova I, Slaven ND, Moeendarbary E, Farrugia AJ, Lam M, Semiannikova M, Westergaard MCW, Tchou J, Magnani L, Calvo F. Nat Commun. 2019 Jan 10;10(1):130. doi: 10.1038/s41467-018-07987-0. PubMed |
| Antiproliferative and Antimigratory Effects of a Novel YAP-TEAD Interaction Inhibitor Identified Using in Silico Molecular Docking. Smith SA, Sessions RB, Shoemark DK, Williams C, Ebrahimighaei R, McNeill MC, Crump MP, McKay TR, Harris G, Newby AC, Bond M. J Med Chem. 2019 Feb 14;62(3):1291-1305. doi: 10.1021/acs.jmedchem.8b01402. Epub 2019 Jan 31. PubMed |
| TRAF6 regulates YAP signaling by promoting the ubiquitination and degradation of MST1 in pancreatic cancer. Li JA, Kuang T, Pu N, Fang Y, Han X, Zhang L, Xu X, Wu W, Wang D, Lou W, Rong Y. Clin Exp Med. 2019 May;19(2):211-218. doi: 10.1007/s10238-018-00543-6. Epub 2019 Jan 23. PubMed |
Extracellular matrix mechanical cues regulate lipid metabolism through Lipin-1 and SREBP.
Romani P, Brian I, Santinon G, Pocaterra A, Audano M, Pedretti S, Mathieu S, Forcato M, Bicciato S, Manneville JB, Mitro N, Dupont S.
Nat Cell Biol. 2019 Mar;21(3):338-347. doi: 10.1038/s41556-018-0270-5. Epub 2019 Feb 4.
PubMed
Associated Plasmids |
| A Platform of Synthetic Lethal Gene Interaction Networks Reveals that the GNAQ Uveal Melanoma Oncogene Controls the Hippo Pathway through FAK. Feng X, Arang N, Rigiracciolo DC, Lee JS, Yeerna H, Wang Z, Lubrano S, Kishore A, Pachter JA, Konig GM, Maggiolini M, Kostenis E, Schlaepfer DD, Tamayo P, Chen Q, Ruppin E, Gutkind JS. Cancer Cell. 2019 Mar 18;35(3):457-472.e5. doi: 10.1016/j.ccell.2019.01.009. Epub 2019 Feb 14. PubMed |
| MST1 Suppresses Pancreatic Cancer Progression via ROS-Induced Pyroptosis. Cui J, Zhou Z, Yang H, Jiao F, Li N, Gao Y, Wang L, Chen J, Quan M. Mol Cancer Res. 2019 Jun;17(6):1316-1325. doi: 10.1158/1541-7786.MCR-18-0910. Epub 2019 Feb 22. PubMed |
| SS18-SSX-Dependent YAP/TAZ Signaling in Synovial Sarcoma. Isfort I, Cyra M, Elges S, Kailayangiri S, Altvater B, Rossig C, Steinestel K, Grunewald I, Huss S, Esseling E, Mikesch JH, Hafner S, Simmet T, Wozniak A, Schoffski P, Larsson O, Wardelmann E, Trautmann M, Hartmann W. Clin Cancer Res. 2019 Jun 15;25(12):3718-3731. doi: 10.1158/1078-0432.CCR-17-3553. Epub 2019 Feb 27. PubMed |
| miR-7977 inhibits the Hippo-YAP signaling pathway in bone marrow mesenchymal stromal cells. Yoshida M, Horiguchi H, Kikuchi S, Iyama S, Ikeda H, Goto A, Kawano Y, Murase K, Takada K, Miyanishi K, Kato J, Kobune M. PLoS One. 2019 Mar 5;14(3):e0213220. doi: 10.1371/journal.pone.0213220. eCollection 2019. PubMed |
| Lovastatin attenuates angiotensin II induced cardiovascular fibrosis through the suppression of YAP/TAZ signaling. Wu P, Liu Z, Zhao T, Xia F, Gong L, Zheng Z, Chen Z, Yang T, Duan Q. Biochem Biophys Res Commun. 2019 May 14;512(4):736-741. doi: 10.1016/j.bbrc.2019.03.158. Epub 2019 Mar 27. PubMed |
| Up-regulation of FOXD1 by YAP alleviates senescence and osteoarthritis. Fu L, Hu Y, Song M, Liu Z, Zhang W, Yu FX, Wu J, Wang S, Izpisua Belmonte JC, Chan P, Qu J, Tang F, Liu GH. PLoS Biol. 2019 Apr 1;17(4):e3000201. doi: 10.1371/journal.pbio.3000201. eCollection 2019 Apr. PubMed |
| The mevalonate coordinates energy input and cell proliferation. Gong L, Xiao Y, Xia F, Wu P, Zhao T, Xie S, Wang R, Wen Q, Zhou W, Xu H, Zhu L, Zheng Z, Yang T, Chen Z, Duan Q. Cell Death Dis. 2019 Apr 11;10(4):327. doi: 10.1038/s41419-019-1544-y. PubMed |
| Proximity biotinylation identifies a set of conformation-specific interactions between Merlin and cell junction proteins. Hennigan RF, Fletcher JS, Guard S, Ratner N. Sci Signal. 2019 Apr 23;12(578):eaau8749. doi: 10.1126/scisignal.aau8749. PubMed |
| A RASSF1A-HIF1alpha loop drives Warburg effect in cancer and pulmonary hypertension. Dabral S, Muecke C, Valasarajan C, Schmoranzer M, Wietelmann A, Semenza GL, Meister M, Muley T, Seeger-Nukpezah T, Samakovlis C, Weissmann N, Grimminger F, Seeger W, Savai R, Pullamsetti SS. Nat Commun. 2019 May 13;10(1):2130. doi: 10.1038/s41467-019-10044-z. PubMed |
| FRMPD1 activates the Hippo pathway via interaction with WWC3 to suppress the proliferation and invasiveness of lung cancer cells. Rong X, Han Q, Lin X, Kremerskothen J, Wang E. Cancer Manag Res. 2019 Apr 18;11:3395-3410. doi: 10.2147/CMAR.S194512. eCollection 2019. PubMed |
| Long noncoding RNA MALAT1 promotes the stemness of esophageal squamous cell carcinoma by enhancing YAP transcriptional activity. Yao Q, Yang J, Liu T, Zhang J, Zheng Y. FEBS Open Bio. 2019 Aug;9(8):1392-1402. doi: 10.1002/2211-5463.12676. Epub 2019 Jun 11. PubMed |
| Metastatic Colorectal Cancer Rewrites Metabolic Program Through a Glut3-YAP-dependent Signaling Circuit. Kuo CC, Ling HH, Chiang MC, Chung CH, Lee WY, Chu CY, Wu YC, Chen CH, Lai YW, Tsai IL, Cheng CH, Lin CW. Theranostics. 2019 Apr 13;9(9):2526-2540. doi: 10.7150/thno.32915. eCollection 2019. PubMed |
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| YAP mediates the positive regulation of hnRNPK on the lung adenocarcinoma H1299 cell growth. Xu L, Zhang T, Huang W, Liu X, Lu J, Gao X, Zhang YF, Liu L. Acta Biochim Biophys Sin (Shanghai). 2019 Jul 10;51(7):677-687. doi: 10.1093/abbs/gmz053. PubMed |
| HDAC Inhibition Enhances the In Vivo Efficacy of MEK Inhibitor Therapy in Uveal Melanoma. Faiao-Flores F, Emmons MF, Durante MA, Kinose F, Saha B, Fang B, Koomen JM, Chellappan SP, Maria-Engler SS, Rix U, Licht JD, Harbour JW, Smalley KSM. Clin Cancer Res. 2019 Jun 21. pii: 1078-0432.CCR-18-3382. doi: 10.1158/1078-0432.CCR-18-3382. PubMed |
| Molecular Mechanisms of Tyrosine Kinase Inhibitor Resistance Induced by Membranous/Cytoplasmic/Nuclear Translocation of Epidermal Growth Factor Receptor. Rong X, Liang Y, Han Q, Zhao Y, Jiang G, Zhang X, Lin X, Liu Y, Zhang Y, Han X, Zhang M, Luo Y, Li P, Wei L, Yan T, Wang E. J Thorac Oncol. 2019 Jun 19. pii: S1556-0864(19)30480-0. doi: 10.1016/j.jtho.2019.06.014. PubMed |
| YAP promotes neural crest emigration through interactions with BMP and Wnt activities. Kumar D, Nitzan E, Kalcheim C. Cell Commun Signal. 2019 Jun 22;17(1):69. doi: 10.1186/s12964-019-0383-x. PubMed |
| The protein secretion modulator TMED9 drives CNIH4/TGFalpha/GLI signaling opposing TMED3-WNT-TCF to promote colon cancer metastases. Mishra S, Bernal C, Silvano M, Anand S, Ruiz I Altaba A. Oncogene. 2019 Jul;38(29):5817-5837. doi: 10.1038/s41388-019-0845-z. Epub 2019 Jun 28. PubMed |
| Elevated cyclic-AMP represses expression of exchange protein activated by cAMP (EPAC1) by inhibiting YAP-TEAD activity and HDAC-mediated histone deacetylation. Ebrahimighaei R, McNeill MC, Smith SA, Wray JP, Ford KL, Newby AC, Bond M. Biochim Biophys Acta Mol Cell Res. 2019 Oct;1866(10):1634-1649. doi: 10.1016/j.bbamcr.2019.06.013. Epub 2019 Jun 28. PubMed |
| YAP-Induced Endothelial-Mesenchymal Transition in Oral Submucous Fibrosis. Li J, Yao M, Zhu X, Li Q, He J, Chen L, Wang W, Zhu C, Shen T, Cao R, Fang C. J Dent Res. 2019 Jul;98(8):920-929. doi: 10.1177/0022034519851804. PubMed |
| Intercellular interaction dictates cancer cell ferroptosis via NF2-YAP signalling. Wu J, Minikes AM, Gao M, Bian H, Li Y, Stockwell BR, Chen ZN, Jiang X. Nature. 2019 Aug;572(7769):402-406. doi: 10.1038/s41586-019-1426-6. Epub 2019 Jul 24. PubMed |
| Nuclear envelope deformation controls cell cycle progression in response to mechanical force. Aureille J, Buffiere-Ribot V, Harvey BE, Boyault C, Pernet L, Andersen T, Bacola G, Balland M, Fraboulet S, Van Landeghem L, Guilluy C. EMBO Rep. 2019 Sep;20(9):e48084. doi: 10.15252/embr.201948084. Epub 2019 Aug 1. PubMed |
| Targeting the Mevalonate Pathway to Overcome Acquired Anti-HER2 Treatment Resistance in Breast Cancer. Sethunath V, Hu H, De Angelis C, Veeraraghavan J, Qin L, Wang N, Simon LM, Wang T, Fu X, Nardone A, Pereira R, Nanda S, Griffith OL, Tsimelzon A, Shaw C, Chamness GC, Reis-Filho JS, Weigelt B, Heiser LM, Hilsenbeck SG, Huang S, Rimawi MF, Gray JW, Osborne CK, Schiff R. Mol Cancer Res. 2019 Nov;17(11):2318-2330. doi: 10.1158/1541-7786.MCR-19-0756. Epub 2019 Aug 16. PubMed |
| Impaired Mitochondrial ATP Production Downregulates Wnt Signaling via ER Stress Induction. Costa R, Peruzzo R, Bachmann M, Monta GD, Vicario M, Santinon G, Mattarei A, Moro E, Quintana-Cabrera R, Scorrano L, Zeviani M, Vallese F, Zoratti M, Paradisi C, Argenton F, Brini M, Cali T, Dupont S, Szabo I, Leanza L. Cell Rep. 2019 Aug 20;28(8):1949-1960.e6. doi: 10.1016/j.celrep.2019.07.050. PubMed |
| Verteporfin targeting YAP1/TAZ-TEAD transcriptional activity inhibits the tumorigenic properties of gastric cancer stem cells. Giraud J, Molina-Castro S, Seeneevassen L, Sifre E, Izotte J, Tiffon C, Staedel C, Boeuf H, Fernandez S, Barthelemy P, Megraud F, Lehours P, Dubus P, Varon C. Int J Cancer. 2020 Apr 15;146(8):2255-2267. doi: 10.1002/ijc.32667. Epub 2019 Sep 30. PubMed |
| Insulin suppresses transcriptional activity of yes-associated protein in insulin target cells. Sayedyahossein S, Hedman AC, Sacks DB. Mol Biol Cell. 2020 Jan 15;31(2):131-141. doi: 10.1091/mbc.E19-04-0205. Epub 2019 Nov 6. PubMed |
| DUSP10 Is a Regulator of YAP1 Activity Promoting Cell Proliferation and Colorectal Cancer Progression. Jimenez-Martinez M, Ostale CM, van der Burg LR, Galan-Martinez J, Hardwick JCH, Lopez-Perez R, Hawinkels LJAC, Stamatakis K, Fresno M. Cancers (Basel). 2019 Nov 9;11(11). pii: cancers11111767. doi: 10.3390/cancers11111767. PubMed |
| YAP/TAZ Activation Drives Uveal Melanoma Initiation and Progression. Li H, Li Q, Dang K, Ma S, Cotton JL, Yang S, Zhu LJ, Deng AC, Ip YT, Johnson RL, Wu X, Punzo C, Mao J. Cell Rep. 2019 Dec 3;29(10):3200-3211.e4. doi: 10.1016/j.celrep.2019.03.021. PubMed |
| Hexokinase 2 couples glycolysis with the profibrotic actions of TGF-beta. Yin X, Choudhury M, Kang JH, Schaefbauer KJ, Jung MY, Andrianifahanana M, Hernandez DM, Leof EB. Sci Signal. 2019 Dec 17;12(612). pii: 12/612/eaax4067. doi: 10.1126/scisignal.aax4067. PubMed |
| Prevalence of the Hippo Effectors YAP1/TAZ in Tumors of Soft Tissue and Bone. Isfort I, Elges S, Cyra M, Berthold R, Renner M, Mechtersheimer G, Aman P, Larsson O, Ratner N, Hafner S, Simmet T, Schliemann C, Rossig C, Dirksen U, Grunewald I, Wardelmann E, Huss S, Hartmann W, Trautmann M. Sci Rep. 2019 Dec 23;9(1):19704. doi: 10.1038/s41598-019-56247-8. PubMed |
| Hippo pathway effectors YAP1/TAZ induce an EWS-FLI1-opposing gene signature and associate with disease progression in Ewing sarcoma. Rodriguez-Nunez P, Romero-Perez L, Amaral AT, Puerto-Camacho P, Jordan C, Marcilla D, Grunewald TG, Alonso J, de Alava E, Diaz-Martin J. J Pathol. 2020 Apr;250(4):374-386. doi: 10.1002/path.5379. Epub 2020 Feb 4. PubMed |
| Dynein-mediated nuclear translocation of yes-associated protein through microtubule acetylation controls fibroblast activation. You E, Ko P, Jeong J, Keum S, Kim JW, Seo YJ, Song WK, Rhee S. Cell Mol Life Sci. 2020 Jan 7. pii: 10.1007/s00018-019-03412-x. doi: 10.1007/s00018-019-03412-x. PubMed |
| Lysine demethylase 2 (KDM2B) regulates hippo pathway via MOB1 to promote pancreatic ductal adenocarcinoma (PDAC) progression. Quan M, Chen Z, Jiao F, Xiao X, Xia Q, Chen J, Chao Q, Li Y, Gao Y, Yang H, Wang L, Cui J. J Exp Clin Cancer Res. 2020 Jan 15;39(1):13. doi: 10.1186/s13046-019-1489-0. PubMed |
| YAP-dependent necrosis occurs in early stages of Alzheimer's disease and regulates mouse model pathology. Tanaka H, Homma H, Fujita K, Kondo K, Yamada S, Jin X, Waragai M, Ohtomo G, Iwata A, Tagawa K, Atsuta N, Katsuno M, Tomita N, Furukawa K, Saito Y, Saito T, Ichise A, Shibata S, Arai H, Saido T, Sudol M, Muramatsu SI, Okano H, Mufson EJ, Sobue G, Murayama S, Okazawa H. Nat Commun. 2020 Jan 24;11(1):507. doi: 10.1038/s41467-020-14353-6. PubMed |
| Furry protein suppresses nuclear localization of yes-associated protein (YAP) by activating NDR kinase and binding to YAP. Irie K, Nagai T, Mizuno K. J Biol Chem. 2020 Mar 6;295(10):3017-3028. doi: 10.1074/jbc.RA119.010783. Epub 2020 Jan 29. PubMed |
| RhoBTB Proteins Regulate the Hippo Pathway by Antagonizing Ubiquitination of LKB1. Nguyen TH, Ralbovska A, Kugler JM. G3 (Bethesda). 2020 Apr 9;10(4):1319-1325. doi: 10.1534/g3.120.401038. PubMed |
| Nuclear actin regulates cell proliferation and migration via inhibition of SRF and TEAD. McNeill MC, Wray J, Sala-Newby GB, Hindmarch CCT, Smith SA, Ebrahimighaei R, Newby AC, Bond M. Biochim Biophys Acta Mol Cell Res. 2020 Jul;1867(7):118691. doi: 10.1016/j.bbamcr.2020.118691. Epub 2020 Feb 28. PubMed |
| Piezo1/2 mediate mechanotransduction essential for bone formation through concerted activation of NFAT-YAP1-ss-catenin. Zhou T, Gao B, Fan Y, Liu Y, Feng S, Cong Q, Zhang X, Zhou Y, Yadav PS, Lin J, Wu N, Zhao L, Huang D, Zhou S, Su P, Yang Y. Elife. 2020 Mar 18;9. pii: 52779. doi: 10.7554/eLife.52779. PubMed |
| FOXM1 facilitates breast cancer cell stemness and migration in YAP1-dependent manner. Sun HL, Men JR, Liu HY, Liu MY, Zhang HS. Arch Biochem Biophys. 2020 May 30;685:108349. doi: 10.1016/j.abb.2020.108349. Epub 2020 Mar 21. PubMed |
| Lats1/2 Sustain Intestinal Stem Cells and Wnt Activation through TEAD-Dependent and Independent Transcription. Li Q, Sun Y, Jarugumilli GK, Liu S, Dang K, Cotton JL, Xiol J, Chan PY, DeRan M, Ma L, Li R, Zhu LJ, Li JH, Leiter AB, Ip YT, Camargo FD, Luo X, Johnson RL, Wu X, Mao J. Cell Stem Cell. 2020 May 7;26(5):675-692.e8. doi: 10.1016/j.stem.2020.03.002. Epub 2020 Apr 6. PubMed |
| The WW domains dictate isoform-specific regulation of YAP1 stability and pancreatic cancer cell malignancy. Guo Q, Quan M, Dong J, Bai J, Wang J, Han R, Wang W, Cai Y, Lv YQ, Chen Q, Xu H, Lyu HD, Deng L, Zhou D, Xiao X, De Langhe S, Billadeau DD, Lou Z, Zhang JS. Theranostics. 2020 Mar 15;10(10):4422-4436. doi: 10.7150/thno.42795. eCollection 2020. PubMed |
| IGF-1/IGF-1R/FAK/YAP Transduction Signaling Prompts Growth Effects in Triple-Negative Breast Cancer (TNBC) Cells. Rigiracciolo DC, Nohata N, Lappano R, Cirillo F, Talia M, Scordamaglia D, Gutkind JS, Maggiolini M. Cells. 2020 Apr 18;9(4). pii: cells9041010. doi: 10.3390/cells9041010. PubMed |
| Tankyrase inhibition sensitizes melanoma to PD-1 immune checkpoint blockade in syngeneic mouse models. Waaler J, Mygland L, Tveita A, Strand MF, Solberg NT, Olsen PA, Aizenshtadt A, Fauskanger M, Lund K, Brinch SA, Lycke M, Dybing E, Nygaard V, Boe SL, Heintz KM, Hovig E, Hammarstrom C, Corthay A, Krauss S. Commun Biol. 2020 Apr 24;3(1):196. doi: 10.1038/s42003-020-0916-2. PubMed |
| The Long Non-Coding RNA MALAT1 Enhances Ovarian Cancer Cell Stemness by Inhibiting YAP Translocation from Nucleus to Cytoplasm. Wu X, Wang Y, Zhong W, Cheng H, Tian Z. Med Sci Monit. 2020 May 20;26:e922012. doi: 10.12659/MSM.922012. PubMed |
| Pivotal role of the transcriptional co-activator YAP in trophoblast stemness of the developing human placenta. Meinhardt G, Haider S, Kunihs V, Saleh L, Pollheimer J, Fiala C, Hetey S, Feher Z, Szilagyi A, Than NG, Knofler M. Proc Natl Acad Sci U S A. 2020 Jun 16;117(24):13562-13570. doi: 10.1073/pnas.2002630117. Epub 2020 Jun 1. PubMed |
| Luteolin suppresses epithelial-mesenchymal transition and migration of triple-negative breast cancer cells by inhibiting YAP/TAZ activity. Cao D, Zhu GY, Lu Y, Yang A, Chen D, Huang HJ, Peng SX, Chen LW, Li YW. Biomed Pharmacother. 2020 Sep;129:110462. doi: 10.1016/j.biopha.2020.110462. Epub 2020 Jul 6. PubMed |
| RNA-binding protein Musashi2 regulates Hippo signaling via SAV1 and MOB1 in pancreatic cancer. Yang H, Hu J, Chen J, Chen Z, Jiao F, Cui J, Quan M, Wang L. Med Oncol. 2020 Aug 11;37(9):84. doi: 10.1007/s12032-020-01384-8. PubMed |
| VAV2 signaling promotes regenerative proliferation in both cutaneous and head and neck squamous cell carcinoma. Lorenzo-Martin LF, Fernandez-Parejo N, Menacho-Marquez M, Rodriguez-Fdez S, Robles-Valero J, Zumalave S, Fabbiano S, Pascual G, Garcia-Pedrero JM, Abad A, Garcia-Macias MC, Gonzalez N, Lorenzano-Menna P, Pavon MA, Gonzalez-Sarmiento R, Segrelles C, Paramio JM, Tubio JMC, Rodrigo JP, Benitah SA, Cuadrado M, Bustelo XR. Nat Commun. 2020 Sep 22;11(1):4788. doi: 10.1038/s41467-020-18524-3. PubMed |
| Volumetric Compression Induces Intracellular Crowding to Control Intestinal Organoid Growth via Wnt/beta-Catenin Signaling. Li Y, Chen M, Hu J, Sheng R, Lin Q, He X, Guo M. Cell Stem Cell. 2021 Jan 7;28(1):63-78.e7. doi: 10.1016/j.stem.2020.09.012. Epub 2020 Oct 13. PubMed |
| PWP1 Promotes the Malignant Phenotypes of Lung Cancer Cells by Interacting with DVL2 and Merlin. Wei L, Li P, Luo Y, Zhang M, Yan T, Yang Y, Han Y, Liu S, Wang E. Onco Targets Ther. 2020 Oct 8;13:10025-10037. doi: 10.2147/OTT.S263815. eCollection 2020. PubMed |
| PNPLA3 I148M Up-Regulates Hedgehog and Yap Signaling in Human Hepatic Stellate Cells. Bruschi FV, Tardelli M, Einwallner E, Claudel T, Trauner M. Int J Mol Sci. 2020 Nov 18;21(22). pii: ijms21228711. doi: 10.3390/ijms21228711. PubMed |
| Proline-rich tyrosine kinase 2 mediates transforming growth factor-beta-induced hepatic stellate cell activation and liver fibrosis. Kim J, Kang W, Kang SH, Park SH, Kim JY, Yang S, Ha SY, Paik YH. Sci Rep. 2020 Dec 3;10(1):21018. doi: 10.1038/s41598-020-78056-0. PubMed |
| Crosstalk between YAP and TGFbeta regulates SERPINE1 expression in mesenchymal lung cancer cells. Kong HJ, Kwon EJ, Kwon OS, Lee H, Choi JY, Kim YJ, Kim W, Cha HJ. Int J Oncol. 2021 Jan;58(1):111-121. doi: 10.3892/ijo.2020.5153. Epub 2020 Nov 27. PubMed |
| The YAP/TEAD Axis as a New Therapeutic Target in Osteosarcoma: Effect of Verteporfin and CA3 on Primary Tumor Growth. Morice S, Mullard M, Brion R, Dupuy M, Renault S, Tesfaye R, Brounais-Le Royer B, Ory B, Redini F, Verrecchia F. Cancers (Basel). 2020 Dec 20;12(12). pii: cancers12123847. doi: 10.3390/cancers12123847. PubMed |
| Scaffolding Protein IQGAP1 Is Dispensable, but Its Overexpression Promotes Hepatocellular Carcinoma via YAP1 Signaling. Delgado ER, Erickson HL, Tao J, Monga SP, Duncan AW, Anakk S. Mol Cell Biol. 2021 Mar 24;41(4). pii: MCB.00596-20. doi: 10.1128/MCB.00596-20. Print 2021 Mar 24. PubMed |
| A novel isoform of Homeodomain-interacting protein kinase-2 promotes YAP/TEAD transcriptional activity in NSCLC cells. Dai Y, Kyoyama H, Yang YL, Wang Y, Liu S, Wang Y, Mao JH, Xu Z, Uematsu K, Jablons DM, You L. Oncotarget. 2021 Feb 2;12(3):173-184. doi: 10.18632/oncotarget.27871. eCollection 2021 Feb 2. PubMed |
| Differentiated glioblastoma cells accelerate tumor progression by shaping the tumor microenvironment via CCN1-mediated macrophage infiltration. Uneda A, Kurozumi K, Fujimura A, Fujii K, Ishida J, Shimazu Y, Otani Y, Tomita Y, Hattori Y, Matsumoto Y, Tsuboi N, Makino K, Hirano S, Kamiya A, Date I. Acta Neuropathol Commun. 2021 Feb 22;9(1):29. doi: 10.1186/s40478-021-01124-7. PubMed |
| IQGAP1 Is a Scaffold of the Core Proteins of the Hippo Pathway and Negatively Regulates the Pro-Apoptotic Signal Mediated by This Pathway. Quinn NP, Garcia-Gutierrez L, Doherty C, von Kriegsheim A, Fallahi E, Sacks DB, Matallanas D. Cells. 2021 Feb 23;10(2). pii: cells10020478. doi: 10.3390/cells10020478. PubMed |
| Evidence for discrete modes of YAP1 signaling via mRNA splice isoforms in development and diseases. Vrbsky J, Vinarsky V, Perestrelo AR, De La Cruz JO, Martino F, Pompeiano A, Izzi V, Hlinomaz O, Rotrekl V, Sudol M, Pagliari S, Forte G. Genomics. 2021 May;113(3):1349-1365. doi: 10.1016/j.ygeno.2021.03.009. Epub 2021 Mar 11. PubMed |
| alpha-Catenin levels determine direction of YAP/TAZ response to autophagy perturbation. Pavel M, Park SJ, Frake RA, Son SM, Manni MM, Bento CF, Renna M, Ricketts T, Menzies FM, Tanasa R, Rubinsztein DC. Nat Commun. 2021 Mar 17;12(1):1703. doi: 10.1038/s41467-021-21882-1. PubMed |
| Critical role of the BAF chromatin remodeling complex during murine neural crest development. Bi-Lin KW, Seshachalam PV, Tuoc T, Stoykova A, Ghosh S, Singh MK. PLoS Genet. 2021 Mar 22;17(3):e1009446. doi: 10.1371/journal.pgen.1009446. eCollection 2021 Mar. PubMed |
| WBP2 negatively regulates the Hippo pathway by competitively binding to WWC3 with LATS1 to promote non-small cell lung cancer progression. Han Q, Rong X, Lin X, Zhang X, Fan C, Zhao H, Wang E. Cell Death Dis. 2021 Apr 9;12(4):384. doi: 10.1038/s41419-021-03600-3. PubMed |
| Targeting the ILK/YAP axis by LFG-500 blocks epithelial-mesenchymal transition and metastasis. Li CL, Li J, Gong SY, Huang M, Li R, Xiong GX, Wang F, Zou QM, Qi Q, Yin XX. Acta Pharmacol Sin. 2021 Nov;42(11):1847-1859. doi: 10.1038/s41401-021-00655-y. Epub 2021 Apr 20. PubMed |
| Circulating Small Extracellular Vesicles Activate TYRO3 to Drive Cancer Metastasis and Chemoresistance. Park M, Kim JW, Kim KM, Kang S, Kim W, Kim JK, Cho Y, Lee H, Baek MC, Bae JH, Lee SH, Jeong SB, Lim SC, Jun DW, Cho SY, Kim Y, Choi YJ, Kang KW. Cancer Res. 2021 Jul 1;81(13):3539-3553. doi: 10.1158/0008-5472.CAN-20-3320. Epub 2021 Apr 28. PubMed |
| Oxidative Stress-Mediated YAP Dysregulation Contributes to the Pathogenesis of Pemphigus Vulgaris. Huang Y, Jedlickova H, Cai Y, Rehman A, Gammon L, Ahmad US, Uttagomol J, Parkinson EK, Fortune F, Wan H. Front Immunol. 2021 Apr 19;12:649502. doi: 10.3389/fimmu.2021.649502. eCollection 2021. PubMed |
| VGLL4 inhibits YAP1/TEAD signaling to suppress the epidermal squamous cell carcinoma cancer phenotype. Mickle M, Adhikary G, Shrestha S, Xu W, Eckert RL. Mol Carcinog. 2021 Jul;60(7):497-507. doi: 10.1002/mc.23307. Epub 2021 May 18. PubMed |
| YAP inactivation in estrogen receptor alpha-positive hepatocellular carcinoma with less aggressive behavior. Jeon Y, Yoo JE, Rhee H, Kim YJ, Il Kim G, Chung T, Yoon S, Shin B, Woo HG, Park YN. Exp Mol Med. 2021 Jun;53(6):1055-1067. doi: 10.1038/s12276-021-00639-2. Epub 2021 Jun 18. PubMed |
| Identification of response signatures for tankyrase inhibitor treatment in tumor cell lines. Mygland L, Brinch SA, Strand MF, Olsen PA, Aizenshtadt A, Lund K, Solberg NT, Lycke M, Thorvaldsen TE, Espada S, Misaghian D, Page CM, Agafonov O, Nygard S, Chi NW, Lin E, Tan J, Yu Y, Costa M, Krauss S, Waaler J. iScience. 2021 Jul 1;24(7):102807. doi: 10.1016/j.isci.2021.102807. eCollection 2021 Jul 23. PubMed |
| KCTD11 inhibits progression of lung cancer by binding to beta-catenin to regulate the activity of the Wnt and Hippo pathways. Yang M, Han YM, Han Q, Rong XZ, Liu XF, Ln XY. J Cell Mol Med. 2021 Oct;25(19):9411-9426. doi: 10.1111/jcmm.16883. Epub 2021 Aug 28. PubMed |
| LncRNA coordinates Hippo and mTORC1 pathway activation in cancer. Zhang S, Liang S, Wu D, Guo H, Ma K, Liu L. Cell Death Dis. 2021 Aug 30;12(9):822. doi: 10.1038/s41419-021-04112-w. PubMed |
| Programmed cell death 10 promotes metastasis and epithelial-mesenchymal transition of hepatocellular carcinoma via PP2Ac-mediated YAP activation. Sun B, Zhong FJ, Xu C, Li YM, Zhao YR, Cao MM, Yang LY. Cell Death Dis. 2021 Sep 14;12(9):849. doi: 10.1038/s41419-021-04139-z. PubMed |
| TAZ inhibits glucocorticoid receptor and coordinates hepatic glucose homeostasis in normal physiological states. Xu S, Liu Y, Hu R, Wang M, Stohr O, Xiong Y, Chen L, Kang H, Zheng L, Cai S, He L, Wang C, Copps KD, White MF, Miao J. Elife. 2021 Oct 8;10. pii: 57462. doi: 10.7554/eLife.57462. PubMed |
| YAP1-mediated regulation of mitochondrial dynamics in IDH1 mutant gliomas. Patrick S, Gowda P, Lathoria K, Suri V, Sen E. J Cell Sci. 2021 Nov 15;134(22). pii: 273515. doi: 10.1242/jcs.259188. Epub 2021 Nov 24. PubMed |
| Involvement of the TGF-beta Signaling Pathway in the Development of YAP-Driven Osteosarcoma Lung Metastasis. Morice S, Danieau G, Tesfaye R, Mullard M, Brion R, Dupuy M, Ory B, Brounais-Le Royer B, Corre I, Redini F, Verrecchia F. Front Oncol. 2021 Oct 26;11:765711. doi: 10.3389/fonc.2021.765711. eCollection 2021. PubMed |
| Vinexin contributes to autophagic decline in brain ageing across species. Park SJ, Frake RA, Karabiyik C, Son SM, Siddiqi FH, Bento CF, Sterk P, Vicinanza M, Pavel M, Rubinsztein DC. Cell Death Differ. 2022 May;29(5):1055-1070. doi: 10.1038/s41418-021-00903-y. Epub 2021 Nov 30. PubMed |
| Oncogenic Activation of YAP Signaling Sensitizes Ferroptosis of Hepatocellular Carcinoma via ALOXE3-Mediated Lipid Peroxidation Accumulation. Qin Y, Pei Z, Feng Z, Lin P, Wang S, Li Y, Huo F, Wang Q, Wang Z, Chen ZN, Wu J, Wang YF. Front Cell Dev Biol. 2021 Dec 16;9:751593. doi: 10.3389/fcell.2021.751593. eCollection 2021. PubMed |
| Desmoglein-3 induces YAP phosphorylation and inactivation during collective migration of oral carcinoma cells. Ahmad US, Parkinson EK, Wan H. Mol Oncol. 2022 Apr;16(8):1625-1649. doi: 10.1002/1878-0261.13177. Epub 2022 Mar 1. PubMed |
| Tumor collection/processing under physioxia uncovers highly relevant signaling networks and drug sensitivity. Kumar B, Adebayo AK, Prasad M, Capitano ML, Wang R, Bhat-Nakshatri P, Anjanappa M, Simpson E, Chen D, Liu Y, Schilder JM, Colter AB, Maguire C, Temm CJ, Sandusky G, Doud EH, Wijeratne AB, Mosley AL, Broxmeyer HE, Nakshatri H. Sci Adv. 2022 Jan 14;8(2):eabh3375. doi: 10.1126/sciadv.abh3375. Epub 2022 Jan 12. PubMed |
| Signaling by the tyrosine kinase Yes promotes liver cancer development. Guegan JP, Lapouge M, Voisin L, Saba-El-Leil MK, Tanguay PL, Levesque K, Bregeon J, Mes-Masson AM, Lamarre D, Haibe-Kains B, Trinh VQ, Soucy G, Bilodeau M, Meloche S. Sci Signal. 2022 Jan 18;15(717):eabj4743. doi: 10.1126/scisignal.abj4743. Epub 2022 Jan 18. PubMed |
| RICH1 inhibits breast cancer stem cell traits through activating kinases cascade of Hippo signaling by competing with Merlin for binding to Amot-p80. Tian Q, Gao H, Zhou Y, Zhu L, Yang J, Wang B, Liu P, Yang J. Cell Death Dis. 2022 Jan 21;13(1):71. doi: 10.1038/s41419-022-04516-2. PubMed |
| Lovastatin Inhibits RhoA to Suppress Canonical Wnt/beta-Catenin Signaling and Alternative Wnt-YAP/TAZ Signaling in Colon Cancer. Xiao Y, Liu Q, Peng N, Li Y, Qiu D, Yang T, Kang R, Usmani A, Amadasu E, Borlongan CV, Yu G. Cell Transplant. 2022 Jan-Dec;31:9636897221075749. doi: 10.1177/09636897221075749. PubMed |
| HTLV-1 activates YAP via NF-kappaB/p65 to promote oncogenesis. Zhao T, Wang Z, Fang J, Cheng W, Zhang Y, Huang J, Xu L, Gou H, Zeng L, Jin Z, Matsuoka M. Proc Natl Acad Sci U S A. 2022 Mar 1;119(9). pii: 2115316119. doi: 10.1073/pnas.2115316119. PubMed |
| Ionizing radiation-induced long noncoding RNA CRYBG3 regulates YAP/TAZ through mechanotransduction. Zheng L, Luo C, Yang N, Pei H, Ji M, Shu Y, Zhang Z, Dong S, Wang X, Li X, Zhang W, Wang Y, Li B, Hei TK, Zhou G, Chang L. Cell Death Dis. 2022 Mar 4;13(3):209. doi: 10.1038/s41419-022-04650-x. PubMed |
| Mechanical control of nuclear import by Importin-7 is regulated by its dominant cargo YAP. Garcia-Garcia M, Sanchez-Perales S, Jarabo P, Calvo E, Huyton T, Fu L, Ng SC, Sotodosos-Alonso L, Vazquez J, Casas-Tinto S, Gorlich D, Echarri A, Del Pozo MA. Nat Commun. 2022 Mar 4;13(1):1174. doi: 10.1038/s41467-022-28693-y. PubMed |
| Identification of Small-molecule YAP-TEAD inhibitors by High-throughput docking for the Treatment of colorectal cancer. Li L, Li R, Wang Y. Bioorg Chem. 2022 May;122:105707. doi: 10.1016/j.bioorg.2022.105707. Epub 2022 Feb 26. PubMed |
| HDAC11 activity contributes to MEK inhibitor escape in uveal melanoma. Sriramareddy SN, Faiao-Flores F, Emmons MF, Saha B, Chellappan S, Wyatt C, Smalley I, Licht JD, Durante MA, Harbour JW, Smalley KSM. Cancer Gene Ther. 2022 Mar 24. pii: 10.1038/s41417-022-00452-7. doi: 10.1038/s41417-022-00452-7. PubMed |
| Recurrent WWTR1 S89W mutations and Hippo pathway deregulation in clear cell carcinomas of the cervix. Kim SH, Basili T, Dopeso H, Da Cruz Paula A, Bi R, Issa Bhaloo S, Pareja F, Li Q, da Silva EM, Zhu Y, Hoang T, Selenica P, Murali R, Chan E, Wu M, Derakhshan F, Maroldi A, Hanlon E, Ferreira CG, Lapa E Silva JR, Abu-Rustum NR, Zamarin D, Chandarlapaty S, Matrai C, Yoon JY, Reis-Filho JS, Park KJ, Weigelt B. J Pathol. 2022 Aug;257(5):635-649. doi: 10.1002/path.5910. Epub 2022 May 20. PubMed |
| Yap is essential for uterine decidualization through Rrm2/GSH/ROS pathway in response to Bmp2. Yu HF, Yang ZQ, Xu MY, Huang JC, Yue ZP, Guo B. Int J Biol Sci. 2022 Mar 6;18(6):2261-2276. doi: 10.7150/ijbs.67756. eCollection 2022. PubMed |
| Fusion protein-driven IGF-IR/PI3K/AKT signals deregulate Hippo pathway promoting oncogenic cooperation of YAP1 and FUS-DDIT3 in myxoid liposarcoma. Berthold R, Isfort I, Erkut C, Heinst L, Grunewald I, Wardelmann E, Kindler T, Aman P, Grunewald TGP, Cidre-Aranaz F, Trautmann M, Frohling S, Scholl C, Hartmann W. Oncogenesis. 2022 Apr 22;11(1):20. doi: 10.1038/s41389-022-00394-7. PubMed |
| Focal Adhesion Kinase (FAK)-Hippo/YAP transduction signaling mediates the stimulatory effects exerted by S100A8/A9-RAGE system in triple-negative breast cancer (TNBC). Rigiracciolo DC, Nohata N, Lappano R, Cirillo F, Talia M, Adame-Garcia SR, Arang N, Lubrano S, De Francesco EM, Belfiore A, Gutkind JS, Maggiolini M. J Exp Clin Cancer Res. 2022 Jun 3;41(1):193. doi: 10.1186/s13046-022-02396-0. PubMed |
| RBFOX2-regulated TEAD1 alternative splicing plays a pivotal role in Hippo-YAP signaling. Choi S, Lee HS, Cho N, Kim I, Cheon S, Park C, Kim EM, Kim W, Kim KK. Nucleic Acids Res. 2022 Aug 26;50(15):8658-8673. doi: 10.1093/nar/gkac509. PubMed |
| YAP Inhibition by Verteporfin Causes Downregulation of Desmosomal Genes and Proteins Leading to the Disintegration of Intercellular Junctions. Huang Y, Ahmad US, Rehman A, Uttagomol J, Wan H. Life (Basel). 2022 May 26;12(6). pii: life12060792. doi: 10.3390/life12060792. PubMed |
| PFKFB3 regulates cancer stemness through the hippo pathway in small cell lung carcinoma. Thirusangu P, Ray U, Sarkar Bhattacharya S, Oien DB, Jin L, Staub J, Kannan N, Molina JR, Shridhar V. Oncogene. 2022 Aug;41(33):4003-4017. doi: 10.1038/s41388-022-02391-x. Epub 2022 Jul 8. PubMed |
| Combined role for YAP-TEAD and YAP-RUNX2 signalling in substrate-stiffness regulation of cardiac fibroblast proliferation. Ebrahimighaei R, Sala-Newby GB, Hudson C, Kimura TE, Hathway T, Hawkins J, McNeill MC, Richardson R, Newby AC, Bond M. Biochim Biophys Acta Mol Cell Res. 2022 Nov;1869(11):119329. doi: 10.1016/j.bbamcr.2022.119329. Epub 2022 Jul 26. PubMed |
| The deubiquitinase USP7 promotes HNSCC progression via deubiquitinating and stabilizing TAZ. Li J, Dai Y, Ge H, Guo S, Zhang W, Wang Y, Liu L, Cheng J, Jiang H. Cell Death Dis. 2022 Aug 5;13(8):677. doi: 10.1038/s41419-022-05113-z. PubMed |
| CK2-induced cooperation of HHEX with the YAP-TEAD4 complex promotes colorectal tumorigenesis. Guo Y, Zhu Z, Huang Z, Cui L, Yu W, Hong W, Zhou Z, Du P, Liu CY. Nat Commun. 2022 Aug 25;13(1):4995. doi: 10.1038/s41467-022-32674-6. PubMed |
| APE1 redox function is required for activation of Yes-associated protein 1 under reflux conditions in Barrett's-associated esophageal adenocarcinomas. Ballout F, Lu H, Chen L, Sriramajayam K, Que J, Meng Z, Wang TC, Giordano S, Zaika A, McDonald O, Peng D, El-Rifai W. J Exp Clin Cancer Res. 2022 Sep 1;41(1):264. doi: 10.1186/s13046-022-02472-5. PubMed |
| TROP2 Represents a Negative Prognostic Factor in Colorectal Adenocarcinoma and Its Expression Is Associated with Features of Epithelial-Mesenchymal Transition and Invasiveness. Svec J, Stastna M, Janeckova L, Hrckulak D, Vojtechova M, Onhajzer J, Kriz V, Galuskova K, Sloncova E, Kubovciak J, Pfeiferova L, Hrudka J, Matej R, Waldauf P, Havluj L, Kolar M, Korinek V. Cancers (Basel). 2022 Aug 26;14(17):4137. doi: 10.3390/cancers14174137. PubMed |
| A calpain-6/YAP axis in sarcoma stem cells that drives the outgrowth of tumors and metastases. Tchicaya-Bouanga J, Hung YJ, Schwartz JM, Yoon DJY, Chotard E, Marty C, Odri GA, de Pinieux G, Cohen-Solal M, Modrowski D. Cell Death Dis. 2022 Sep 24;13(9):819. doi: 10.1038/s41419-022-05244-3. PubMed |
| Capicua suppresses YAP1 to limit tumorigenesis and maintain drug sensitivity in human cancer. Kim JW, Luck C, Wu W, Ponce RK, Lin YK, Gupta N, Okimoto RA. Cell Rep. 2022 Oct 4;41(1):111443. doi: 10.1016/j.celrep.2022.111443. PubMed |
| YAP promotes cell-autonomous immune responses to tackle intracellular Staphylococcus aureus in vitro. Caire R, Audoux E, Thomas M, Dalix E, Peyron A, Rodriguez K, Pordone N, Guillemot J, Dickerscheit Y, Marotte H, Vandenesch F, Laurent F, Josse J, Verhoeven PO. Nat Commun. 2022 Nov 16;13(1):6995. doi: 10.1038/s41467-022-34432-0. PubMed |
| Chloroquine induces transitory attenuation of proliferation of human lung cancer cells through regulation of mutant P53 and YAP. Saini H, Choudhary M, Sharma H, Chowdhury S, Mukherjee S, Chowdhury R. Mol Biol Rep. 2023 Feb;50(2):1045-1058. doi: 10.1007/s11033-022-08072-y. Epub 2022 Nov 16. PubMed |
| Curaxin CBL0137 inhibits endothelial inflammation and atherogenesis via suppression of the Src-YAP signalling axis. Ding H, Jiang M, Lau CW, Luo J, Chan AM, Wang L, Huang Y. Br J Pharmacol. 2023 Apr;180(8):1168-1185. doi: 10.1111/bph.16007. Epub 2022 Dec 29. PubMed |
| Loss of CDKN2A cooperates with WWTR1(TAZ)-CAMTA1 gene fusion to promote tumor progression in epithelioid hemangioendothelioma. Seavey CN, Hallett A, Li S, Che K, Pobbati AV, Ma S, Burtscher A, Kanai R, Lamar JM, Rubin BP. Clin Cancer Res. 2023 Jan 4:CCR-22-2497. doi: 10.1158/1078-0432.CCR-22-2497. PubMed |
| Extracellular signal-Regulated Kinase 5 (ERK5) is required for the Yes-associated protein (YAP) co-transcriptional activity. Ippolito F, Consalvi V, Noce V, Battistelli C, Cicchini C, Tripodi M, Amicone L, Marchetti A. Cell Death Dis. 2023 Jan 17;14(1):32. doi: 10.1038/s41419-023-05569-7. PubMed |
| PXR triggers YAP-TEAD binding and Sirt2-driven YAP deacetylation and polyubiquitination to promote liver enlargement and regeneration in mice. Zhang S, Guo M, Jiang X, Tang L, Wu T, Bi G, Yang X, Fan S, Bi H. Pharmacol Res. 2023 Feb;188:106666. doi: 10.1016/j.phrs.2023.106666. Epub 2023 Jan 16. PubMed |
| Skeletal diseases caused by mutations in PTH1R show aberrant differentiation of skeletal progenitors due to dysregulation of DEPTOR. Csukasi F, Bosakova M, Barta T, Martin JH, Arcedo J, Barad M, Rico-Llanos GA, Zieba J, Becerra J, Krejci P, Duran I, Krakow D. Front Cell Dev Biol. 2023 Jan 16;10:963389. doi: 10.3389/fcell.2022.963389. eCollection 2022. PubMed |
| TRIM40 is a pathogenic driver of inflammatory bowel disease subverting intestinal barrier integrity. Kang S, Kim J, Park A, Koh M, Shin W, Park G, Lee TA, Kim HJ, Han H, Kim Y, Choi MK, Park JH, Lee E, Cho HS, Park HW, Cheon JH, Lee S, Park B. Nat Commun. 2023 Feb 9;14(1):700. doi: 10.1038/s41467-023-36424-0. PubMed |
| Zinc finger and SCAN domain containing 1, ZSCAN1, is a novel stemness-related tumor suppressor and transcriptional repressor in breast cancer targeting TAZ. Chu J, Li Y, He M, Zhang H, Yang L, Yang M, Liu J, Cui C, Hong L, Hu X, Zhou L, Li T, Li C, Fan H, Jiang G, Lang T. Front Oncol. 2023 Feb 27;13:1041688. doi: 10.3389/fonc.2023.1041688. eCollection 2023. PubMed |
| Thioridazine protects against disturbed flow-induced atherosclerosis by inhibiting RhoA/YAP-mediated endothelial inflammation. Jiang MC, Ding HY, Huang YH, Cheng CK, Lau CW, Xia Y, Yao XQ, Wang L, Huang Y. Acta Pharmacol Sin. 2023 Oct;44(10):1977-1988. doi: 10.1038/s41401-023-01102-w. Epub 2023 May 22. PubMed |
| A Syx-RhoA-Dia1 signaling axis regulates cell cycle progression, DNA damage, and therapy resistance in glioblastoma. Lin WH, Feathers RW, Cooper LM, Lewis-Tuffin LJ, Chen J, Sarkaria JN, Anastasiadis PZ. JCI Insight. 2023 Jul 10;8(13):e157491. doi: 10.1172/jci.insight.157491. PubMed |
| Cardiomyocyte proliferation is suppressed by ARID1A-mediated YAP inhibition during cardiac maturation. Boogerd CJ, Perini I, Kyriakopoulou E, Han SJ, La P, van der Swaan B, Berkhout JB, Versteeg D, Monshouwer-Kloots J, van Rooij E. Nat Commun. 2023 Aug 5;14(1):4716. doi: 10.1038/s41467-023-40203-2. PubMed |
| A Novel Irreversible TEAD Inhibitor, SWTX-143, Blocks Hippo Pathway Transcriptional Output and Causes Tumor Regression in Preclinical Mesothelioma Models. Hillen H, Candi A, Vanderhoydonck B, Kowalczyk W, Sansores-Garcia L, Kesikiadou EC, Van Huffel L, Spiessens L, Nijs M, Soons E, Haeck W, Klaassen H, Smets W, Spieser SA, Marchand A, Chaltin P, Ciesielski F, Debaene F, Chen L, Kamal A, Gwaltney SL, Versele M, Halder GA. Mol Cancer Ther. 2024 Jan 3;23(1):3-13. doi: 10.1158/1535-7163.MCT-22-0681. PubMed |
| Role of the YAP/TAZ-TEAD Transcriptional Complex in the Metabolic Control of TRAIL Sensitivity by the Mevalonate Pathway in Cancer Cells. El Yousfi Y, Mora-Molina R, Lopez-Rivas A, Yerbes R. Cells. 2023 Sep 27;12(19):2370. doi: 10.3390/cells12192370. PubMed |
| Extracellular matrix stiffness controls cardiac fibroblast proliferation via the nuclear factor-Y (NF-Y) transcription factor. Ebrahimighaei R, Tarassova N, Bond SC, McNeill MC, Hathway T, Vohra H, Newby AC, Bond M. Biochim Biophys Acta Mol Cell Res. 2024 Feb;1871(2):119640. doi: 10.1016/j.bbamcr.2023.119640. Epub 2023 Nov 22. PubMed |
| The AMPK-Sirtuin 1-YAP axis is regulated by fluid flow intensity and controls autophagy flux in kidney epithelial cells. Claude-Taupin A, Isnard P, Bagattin A, Kuperwasser N, Roccio F, Ruscica B, Goudin N, Garfa-Traore M, Regnier A, Turinsky L, Burtin M, Foretz M, Pontoglio M, Morel E, Viollet B, Terzi F, Codogno P, Dupont N. Nat Commun. 2023 Dec 5;14(1):8056. doi: 10.1038/s41467-023-43775-1. PubMed |
| CSN6-SPOP-HMGCS1 Axis Promotes Hepatocellular Carcinoma Progression via YAP1 Activation. Li K, Zhang J, Lyu H, Yang J, Wei W, Wang Y, Luo H, Zhang Y, Jiang X, Yi H, Wang M, Zhang C, Wu K, Xiao L, Wen W, Xu H, Li G, Wan Y, Yang F, Yang R, Fu X, Qin B, Zhou Z, Zhang H, Lee MH. Adv Sci (Weinh). 2024 Apr;11(14):e2306827. doi: 10.1002/advs.202306827. Epub 2024 Feb 2. PubMed |
| TRIM21 is critical in regulating hepatocellular carcinoma growth and response to therapy by altering the MST1/YAP pathway. Shu B, Zhou Y, Lei G, Peng Y, Ding C, Li Z, He C. Cancer Sci. 2024 May;115(5):1476-1491. doi: 10.1111/cas.16134. Epub 2024 Mar 12. PubMed |
| RNF166 promotes colorectal cancer progression by recognizing and destabilizing poly-ADP-ribosylated angiomotins. Li Y, Zhang X, Liu N, Liu R, Zhang W, Chen L, Chen Y. Cell Death Dis. 2024 Mar 13;15(3):211. doi: 10.1038/s41419-024-06595-9. PubMed |
| Targeting CD73 with flavonoids inhibits cancer stem cells and increases lymphocyte infiltration in a triple-negative breast cancer mouse model. Mediratta K, El-Sahli S, Marotel M, Awan MZ, Kirkby M, Salkini A, Kurdieh R, Abdisalam S, Shrestha A, Di Censo C, Sulaiman A, McGarry S, Lavoie JR, Liu Z, Lee SH, Li X, Sciume G, D'Costa VM, Ardolino M, Wang L. Front Immunol. 2024 Mar 27;15:1366197. doi: 10.3389/fimmu.2024.1366197. eCollection 2024. PubMed |
| Genome-wide CRISPR screens identify the YAP/TEAD axis as a driver of persister cells in EGFR mutant lung cancer. Pfeifer M, Brammeld JS, Price S, Pilling J, Bhavsar D, Farcas A, Bateson J, Sundarrajan A, Miragaia RJ, Guan N, Arnold S, Tariq L, Grondine M, Talbot S, Guerriero ML, O'Neill DJ, Young J, Company C, Dunn S, Thorpe H, Martin MJ, Maratea K, Barrell D, Ahdesmaki M, Mettetal JT, Brownell J, McDermott U. Commun Biol. 2024 Apr 24;7(1):497. doi: 10.1038/s42003-024-06190-w. PubMed |
| TM7SF3 controls TEAD1 splicing to prevent MASH-induced liver fibrosis. Isaac R, Bandyopadhyay G, Rohm TV, Kang S, Wang J, Pokhrel N, Sakane S, Zapata R, Libster AM, Vinik Y, Berhan A, Kisseleva T, Borok Z, Zick Y, Telese F, Webster NJG, Olefsky JM. Cell Metab. 2024 May 7;36(5):1030-1043.e7. doi: 10.1016/j.cmet.2024.04.003. Epub 2024 Apr 25. PubMed |
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